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Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

Imaging of nuclear magnetic resonance spin-lattice relaxation activation energy in cartilage (2018)
Journal Article
Foster, R. J., Damion, R. A., Ries, M. E., Smye, S. W., McGonagle, D. G., Binks, D. A., & Radjenovic, A. (2018). Imaging of nuclear magnetic resonance spin-lattice relaxation activation energy in cartilage. Royal Society Open Science, 5(7), https://doi.org/10.1098/rsos.180221

Samples of human and bovine cartilage have been examined using magnetic resonance imaging to determine the proton nuclearmagnetic resonance spin-lattice relaxation time, T1, as a function of depth within the cartilage tissue. T1 was measured at five... Read More about Imaging of nuclear magnetic resonance spin-lattice relaxation activation energy in cartilage.

A comparison of two different software packages for the analysis of body composition using computed tomography images (2018)
Journal Article
Rollins, K. E., Awwad, A., MacDonald, I. A., & Lobo, D. N. (2019). A comparison of two different software packages for the analysis of body composition using computed tomography images. Nutrition, 57, 92-96. https://doi.org/10.1016/j.nut.2018.06.003

Objectives: Body composition analysis from computed tomography (CT) imaging has become widespread. However, the methodology used is far from established. Two main software packages are in common usage for body composition analysis, with results used... Read More about A comparison of two different software packages for the analysis of body composition using computed tomography images.

Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease (2018)
Journal Article
Song, D., Mohammed, I., Bhuyan, R., Miwa, T., Williams, A. L., Gullipalli, D., …Song, W.-C. (2018). Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease. Investigative Ophthalmology & Visual Science, 59(8), 3405-3415. https://doi.org/10.1167/iovs.18-24133

Purpose: Dense deposit disease (DDD) is caused by dysregulation of the alternative pathway of the complement cascade and characterized by electron-dense deposits in the kidney glomerular basement membrane (GBM) and drusen in Bruch's membrane (BrM). C... Read More about Retinal basal laminar deposits in complement fH/fP mouse model of dense deposit disease.

Development of the Social Participation Restrictions Questionnaire (SPaRQ) through consultation with adults with hearing loss, researchers, and clinicians: a content evaluation study (2018)
Journal Article
Heffernan, E., Coulson, N. S., & Ferguson, M. (in press). Development of the Social Participation Restrictions Questionnaire (SPaRQ) through consultation with adults with hearing loss, researchers, and clinicians: a content evaluation study. International Journal of Audiology, https://doi.org/10.1080/14992027.2018.1483585

Objective - This research aimed to evaluate the content of the Social Participation Restrictions Questionnaire (SPaRQ) in terms of its relevance, clarity, comprehensiveness, acceptability to adults with hearing loss, and responsiveness.

Design -... Read More about Development of the Social Participation Restrictions Questionnaire (SPaRQ) through consultation with adults with hearing loss, researchers, and clinicians: a content evaluation study.

An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation (2018)
Journal Article
Saffaran, S., Wang, W., Das, A., Schmitt, W., Becker-Pelster, E.-M., Hardman, J. G., …Bates, D. G. (2018). An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation. CPT: Pharmacometrics and Systems Pharmacology, 7(8), 491-498. https://doi.org/10.1002/psp4.12308

This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypert... Read More about An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation.

Feasibility and effectiveness of Ida Telecare tools for audiology patients (2018)
Data
Henshaw, H. Feasibility and effectiveness of Ida Telecare tools for audiology patients. [Dataset]. https://doi.org/10.1186/isrctn11296341

Plain English summary as of 24/09/2018:
Background and study aims
The Ida Institute has developed a range of easy-to-use online tools designed to help people with hearing loss prepare for audiology appointments, make important decisions related to... Read More about Feasibility and effectiveness of Ida Telecare tools for audiology patients.

Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex (2018)
Journal Article
Harvey, P., Nonat, A., Platas-Iglesias, C., Natrajan, L. S., & Charbonnière, L. J. (2018). Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex. Angewandte Chemie, 130(31), 10069-10072. https://doi.org/10.1002/ange.201805316

The release of uranyl(VI) is a hazardous environmental issue, with limited ways to monitor accumulation in situ. Here, we present a method for the detection of uranyl(VI) ions through the utilization of a unique fluorescence energy transfer process t... Read More about Sensing Uranyl(VI) Ions by Coordination and Energy Transfer to a Luminescent Europium(III) Complex.

Evaluating a stroke-specific version of the Illness Perception Questionnaire–Revised, using the Think-Aloud method (2018)
Journal Article
Aujla, N., Vedhara, K., Walker, M., & Sprigg, N. (2020). Evaluating a stroke-specific version of the Illness Perception Questionnaire–Revised, using the Think-Aloud method. Journal of Health Psychology, 25(12), 1989-2005. https://doi.org/10.1177/1359105318781942

The main purpose was to evaluate, using the Think-Aloud method, a version of the Illness Perception Questionnaire-Revised (IPQ-R) for stroke survivors (the Stroke IPQ-R). Six stroke survivors (mean age=58.8 years, range=31 to 78 years, SD=18.9 years)... Read More about Evaluating a stroke-specific version of the Illness Perception Questionnaire–Revised, using the Think-Aloud method.

A cross-sectional questionnaire study of tinnitus awareness and impact in a population of adult cochlear implant users (2018)
Journal Article
Gomersall, P. A., Baguley, D., & Carlyon, R. P. (2019). A cross-sectional questionnaire study of tinnitus awareness and impact in a population of adult cochlear implant users. Ear and Hearing, 40(1), 135-142. https://doi.org/10.1097/AUD.0000000000000601

Objectives: The primary aim was to identify the proportion of individuals within the adult cochlear implant population who are aware of tinnitus and those who report a negative impact from this perception, using a bespoke questionnaire designed to li... Read More about A cross-sectional questionnaire study of tinnitus awareness and impact in a population of adult cochlear implant users.

Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques (2018)
Journal Article
Eithne, H., David, M., Johanna, B., & Melanie, F. (2019). Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques. Ear and Hearing, 40(2), 328-339. https://doi.org/10.1097/AUD.0000000000000618

Objectives: The primary aim of this research was to refine and validate the Social Participation Restrictions Questionnaire (SPaRQ). The SPaRQ is a hearing-specific, patient-reported outcome measure that was originally developed through consultation... Read More about Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques.

Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial (2018)
Journal Article
Ovesen, C., Jakobsen, J. C., Gluud, C., Steiner, T., Law, Z., Flaherty, K., …Christensen, H. (2018). Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial. BMC Research Notes, 11, Article 379. https://doi.org/10.1186/s13104-018-3481-8

Objective

We present the statistical analysis plan of a prespecified Tranexamic Acid for Hyperacute Primary Intracerebral Haemorrhage (TICH)-2 sub-study aiming to investigate, if tranexamic acid has a different effect in intracerebral haemorrhage... Read More about Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial.

Pupil light reflex evoked by light-emitting diode and computer screen: methodology and association with need for recovery in daily life (2018)
Journal Article
Wang, Y., Zekveld, A. A., Wendt, D., Lunner, T., Naylor, G., & Kramer, S. E. (2018). Pupil light reflex evoked by light-emitting diode and computer screen: methodology and association with need for recovery in daily life. PLoS ONE, 13(6), Article e0197739. https://doi.org/10.1371/journal.pone.0197739

Objectives: Pupil light reflex (PLR) has been widely used as a method for evaluating parasympathetic activity. The first aim of the present study is to develop a PLR measurement using a computer screen set-up and compare its results with the PLR gene... Read More about Pupil light reflex evoked by light-emitting diode and computer screen: methodology and association with need for recovery in daily life.

Clinical evidence synopsis: hearing aids and health-related quality of life in adults with hearing loss (2018)
Journal Article
Kitterick, P. T., & Ferguson, M. A. (2018). Clinical evidence synopsis: hearing aids and health-related quality of life in adults with hearing loss. Journal of the American Medical Association, 319(21), https://doi.org/10.1001/jama.2018.5567

Clinical Question

Are hearing aids associated with improved health-related quality of life in adults with mild to moderate hearing loss?

Bottom Line


Compared with no hearing aids, the provision of hearing aids was associated with improveme... Read More about Clinical evidence synopsis: hearing aids and health-related quality of life in adults with hearing loss.

Does therapy with biofeedback improve swallowing in adults with dysphagia?: a systematic review and meta-analysis (2018)
Journal Article
Benfield, J. K., Everton, L. F., Bath, P. M., & England, T. J. (in press). Does therapy with biofeedback improve swallowing in adults with dysphagia?: a systematic review and meta-analysis. Archives of Physical Medicine and Rehabilitation, https://doi.org/10.1016/j.apmr.2018.04.031

Objective
To describe and systematically review the current evidence on the effects of swallow therapy augmented by biofeedback in adults with dysphagia (PROSPERO 2016:CRD42016052942).
Data sources
Two independent reviewers conducted searches whic... Read More about Does therapy with biofeedback improve swallowing in adults with dysphagia?: a systematic review and meta-analysis.

Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project (2018)
Journal Article
Bastiani, M., Andersson, J. L., Cordero-Grande, L., Murgasova, M., Hutter, J., Price, A. N., …Sotiropoulos, S. N. (2019). Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project. NeuroImage, 185, 750-763. https://doi.org/10.1016/j.neuroimage.2018.05.064

The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic... Read More about Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project.

ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity (2018)
Journal Article
Sollini, J., Chapuis, G. A., Clopath, C., & Chadderton, P. (2018). ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity. Nature Communications, 9, Article 2084. https://doi.org/10.1038/s41467-018-04548-3

Neurons in the auditory cortex exhibit distinct frequency tuning to the onset and offset of sounds, but the cause and significance of ON and OFF receptive field (RF) organisation are not understood. Here we demonstrate that distinct ON and OFF freque... Read More about ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity.

Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI (2018)
Journal Article
Schwarz, S. T., Mougin, O., Xing, Y., Blazejewska, A., Bajaj, N., Auer, D. P., & Gowland, P. (2018). Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI. NeuroImage: Clinical, 19, 683-689. https://doi.org/10.1016/j.nicl.2018.05.027

Improved markers for the progression of Parkinson's disease (PD) are required. Previous work has proven that iron dependent MRI scans can detect the largest Nigrosome (N1) within the substantia nigra (SN) pars compacta and changes in PD. Histopatholo... Read More about Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI.

Consent procedures and relationship with outcome in the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) (2018)
Presentation / Conference Contribution
Scutt, P., Dixon, M., Appleton, J. P., Howard, H., Havard, D., Woodhouse, L. J., & Bath, P. M. (2018). Consent procedures and relationship with outcome in the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).

Background: Obtaining consent in emergency situations is challenging. Proxy consent allows patients to be recruited when they lack capacity, a common scenario in stroke patients. The rapid intervention with glyceryl trinitrate in hypertensive stroke... Read More about Consent procedures and relationship with outcome in the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).