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Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke (2019)
Journal Article
Appleton, J. P., Woodhouse, L. J., Adami, A., Becker, J. L., Berge, E., Cala, L. A., …Wardlaw, J. M. (in press). Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke. Neurology,

Objective: We assessed the association of baseline imaging markers of cerebral small vessel disease (SVD) and ‘brain frailty’ with clinical outcome after acute stroke in the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Methods: ENOS randomis... Read More

Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936 (2019)
Journal Article
Okely, J. A., Akeroyd, M. A., Allerhand, M., Starr, J. M., & Deary, I. J. (2019). Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936. Psychology and Aging, doi:10.1037/pag0000385

Hearing impairment is associated with poorer cognitive function in later life. We tested for the potential contribution of childhood cognitive ability to this relationship. Childhood cognitive ability is strongly related to cognitive function in olde... Read More

Why Is There No Cure for Tinnitus? (2019)
Journal Article
McFerran, D. J., Stockdale, D., Holme, R., Large, C. H., & Baguley, D. M. (2019). Why Is There No Cure for Tinnitus?. Frontiers in Neuroscience, 13, doi:10.3389/fnins.2019.00802

Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended... Read More

Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children (2019)
Journal Article
Bagatto, M., DesGeorge, J., Kitterick, P., Laurnagaray, D., Roush, P., Sladen, D., & Tharpe, A. (in press). Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children. International Journal of Audiology,

Objective: Provide recommendations to audiologists for the management of children with unilateral hearing loss (UHL) and for needed research that can lend further insight on important unanswered questions. Design: An international panel of experts... Read More

Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus (2019)
Journal Article
Brennan-Jones, C. G., Thomas, A., Hoare, D. J., & Sereda, M. (2019). Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus. International Journal of Audiology, 1-5. doi:10.1080/14992027.2019.1643503

This Cochrane Corner features “Sound therapy (using amplification devices or sound generators) for tinnitus” published in 2018. Sereda et al. identified eight clinical trials including 590 participants receiving sound therapy for tinnitus. None of th... Read More

Internet-based interventions for adults with hearing loss, tinnitus, and vestibular disorders: a systematic review and meta-analysis (2019)
Journal Article
Beukes, E. W., Manchaiah, V., Allen, P. M., Baguley, D. M., & Andersson, G. (2019). Internet-based interventions for adults with hearing loss, tinnitus, and vestibular disorders: a systematic review and meta-analysis. Trends in Hearing, doi:10.1177/2331216519851749

Internet-based interventions have been developed to improve access to audiovestibular health care. This review aimed to identify outcomes of Internet interventions for adults with hearing loss, tinnitus, and vestibular disorders. Electronic databases... Read More

Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS (2019)
Journal Article
Mushtaq, F., Wiggins, I. M., Kitterick, P. T., Anderson, C. A., & Hartley, D. E. H. (2019). Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS. PLoS ONE, 14(7), doi:10.1371/journal.pone.0219927

Evidence using well-established imaging techniques, such as functional magnetic resonance imaging and electrocorticography, suggest that speech-specific cortical responses can be functionally localised by contrasting speech responses with an auditory... Read More

Joint modelling of diffusion MRI and microscopy (2019)
Journal Article
Howard, A. F., Mollink, J., Kleinnijenhuis, M., Pallebage-Gamarallage, M., Bastiani, M., Cottaar, M., …Jbabdi, S. (2019). Joint modelling of diffusion MRI and microscopy. NeuroImage, doi:10.1016/j.neuroimage.2019.116014

The combination of diffusion MRI with microscopy provides unique opportunities to study microstructural features of tissue, particularly when acquired in the same sample. Microscopy is frequently used to validate diffusion MRI microstructure models,... Read More

Evidence for an association between hearing impairment and disrupted sleep: scoping review 2 (2019)
Journal Article
Clarke, N. A., Hoare, D. J., & Killan, E. C. (in press). Evidence for an association between hearing impairment and disrupted sleep: scoping review 2. American Journal of Audiology,

Purpose: Hearing impairment (HI) is the most common sensory impairment and may negatively impact sleep through reduced auditory input. Factors associated with HI, such as anxiety regarding communication in daily life, may also adversely impact an ind... Read More

Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults (2019)
Journal Article
Anderson, C. A., Wiggins, I. M., Kitterick, P. T., & Hartley, D. E. (2019). Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults. Journal of the Association for Research in Otolaryngology, doi:10.1007/s10162-019-00729-z

Currently it is not possible to accurately predict how well a deaf individual will be able to understand speech when hearing is (re)introduced via a cochlear implant. Differences in brain organisation following deafness are thought to contribute to v... Read More

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT (2019)
Journal Article
Sprigg, N., Flaherty, K., Appleton, J. P., Al-Shahi Salman, R., Bereczki, D., Beridze, M., …Bath, P. M. (2019). Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. Health Technology Assessment, 23(35), 1-48. doi:10.3310/hta23350

Background Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. Objective The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneo... Read More

Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial (2019)
Journal Article
Sandset, E. C., Appleton, J. P., Berge, E., Christensen, H., Gommans, J., Krishnan, K., …Bath, P. M. (2019). Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial. Journal of Hypertension, doi:10.1097/HJH.0000000000002154

Objectives: High blood pressure (BP) is associated with a poor outcome after acute stroke. Early reduction in blood pressure (BP) may be associated with fewer early adverse events and deaths, and improved functional outcome. Methods: Analyses used d... Read More

Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth (2019)
Journal Article
Loczenski-Brown, D. M., Jones, S., Luckett, J., Daniel, Z., Brearley, M. C., Ebling, F. J., …Brameld, J. M. (2019). Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth. PLoS ONE, 14(6), 1-12. doi:10.1371/journal.pone.0218970

We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist. To determine whether PEPCK-M had a causative role in modulating t... Read More

Modifiable risk factors for poor health outcomes in multiple sclerosis: the urgent need for research to maximise smoking cessation success (2019)
Journal Article
Marck, C. H., das Nair, R., Grech, L., Borland, R., & Constantinescu, C. S. (2019). Modifiable risk factors for poor health outcomes in multiple sclerosis: the urgent need for research to maximise smoking cessation success. Multiple Sclerosis, doi:10.1177/1352458519858730

Tobacco smoking is a well-established risk factor for multiple sclerosis (MS) onset, progression, and poor health outcomes in people with MS. Despite smoking being a modifiable risk factor, no research has been undertaken to understand how, or who is... Read More

Understanding user reactions and interactions with an Internet-based intervention for tinnitus self-management: Mixed-methods evaluation (2019)
Journal Article
Greenwell, K., Sereda, M., Coulson, N. S., & Hoare, D. J. (in press). Understanding user reactions and interactions with an Internet-based intervention for tinnitus self-management: Mixed-methods evaluation. American Journal of Audiology,

Purpose: Internet-based interventions have the potential to reduce the disparity in access to psychological therapy that people with tinnitus currently experience. One example is the Tinnitus E-Programme, which although freely available online, has n... Read More

Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data (2019)
Journal Article
Schindler, A., Schinner, R., Altaf, N., Hosseini, A. A., Simpson, R. J., Esposito-Bauer, L., …Saam, T. (2019). Prediction of Stroke Risk by Detection of Hemorrhage in Carotid Plaques: Meta-Analysis of Individual Patient Data. JACC: Cardiovascular Imaging, doi:10.1016/j.jcmg.2019.03.028

Objectives The goal of this study was to compare the risk of stroke between patients with carotid artery disease with and without the presence of intraplaque hemorrhage (IPH) on magnetic resonance imaging. Background IPH in carotid stenosis incr... Read More

Distinct mechanisms govern recalibration to audio-visual discrepancies in remote and recent history (2019)
Journal Article
Watson, D. M., Akeroyd, M. A., Roach, N. W., & Webb, B. S. (2019). Distinct mechanisms govern recalibration to audio-visual discrepancies in remote and recent history. Scientific Reports, 9, doi:10.1038/s41598-019-44984-9

To maintain perceptual coherence, the brain corrects for discrepancies between the senses. If, for example, lights are consistently offset from sounds, representations of auditory space are remapped to reduce this error (spatial recalibration). While... Read More

The effect of intravenous iron on erythropoiesis in older people with hip fracture (2019)
Journal Article
Moppett, I., Rowlands, M., Mannings, A., Marufu, T., Sahota, O., & Yeung, J. (2019). The effect of intravenous iron on erythropoiesis in older people with hip fracture. Age and Ageing, doi:10.1093/ageing/afz049

Background: Anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. Ther... Read More