Research Repository

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Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS) (2019)
Journal Article
Moppett, I. (in press). Short-term morbidity factors associated with length of hospital stay (LOS): development and validation of a hip fracture specific postoperative morbidity survey (HF-POMS). Injury,

Background: We aimed to describe and quantify postoperative complications in the older hip fracture population, develop and validate a hip fracture postoperative morbidity survey tool (HF–POMS). Methods: A prospective clinical observation study o... Read More

MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury (2019)
Journal Article
Lawrence, T. P., Steel, A., Ezra, M., Speirs, M., Pretorius, P. M., Douaud, G., …Voets, N. L. (2019). MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury. Brain Injury, doi:10.1080/02699052.2019.1584332

The posterior cingulate cortex (PCC) and corpus callosum (CC) are susceptible to trauma, but injury often evades detection. PCC Metabolic disruption may predict CC white matter tract injury and the secondary cascade responsible for progression. While... Read More

The genetic vulnerability to cisplatin ototoxicity: a systematic review (2019)
Journal Article
Tserga, E., Nandwani, T., Edvall, N. K., Bulla, J., Patel, P., Canlon, B., …Baguley, D. M. (2019). The genetic vulnerability to cisplatin ototoxicity: a systematic review. Scientific Reports, 9, doi:10.1038/s41598-019-40138-z

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of g... Read More

Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation (2019)
Journal Article
Xing, Y., Tench, C., Wongwandee, M., Schwarz, S., Bajaj, N., & Auer, D. (2019). Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation. Brain Imaging and Behavior, doi:10.1007/s11682-019-00061-3

Objective To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson’s (PwP), aiming to differentiate disease-specific features from treatment effects. Methods A co-ordinate-based-meta-analysis (CBMA... Read More

Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model (2019)
Journal Article
Morales, M. L. O., Marsit, N. M., McIntosh, O. D., Hopkinson, A., & Sidney, L. E. (2019). Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model. World Journal of Stem Cells, 11(2), 84-99. doi:10.4252/wjsc.v11.i2.84

BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells (hCEC). AIM To investigate whether corneal-stroma derived stem cells (CSSC) seeded on an amniotic membrane (AM) construct m... Read More

Effects of tinnitus on cochlear implant programming (2019)
Journal Article
Pierzycki, R. H., Corner, C., Fielden, C. A., & Kitterick, P. T. (in press). Effects of tinnitus on cochlear implant programming. Trends in Hearing,

Clinical observations suggest that tinnitus may interfere with programming cochlear implants (CIs), the process of optimizing the transmission of acoustic information to support speech perception with a CI. Despite tinnitus being highly prevalent amo... Read More

The cost-effectiveness of bimodal stimulation compared to unilateral and bilateral cochlear implant use in adults with bilateral severe to profound deafness (2019)
Journal Article
Theriou, C., Fielden, C. A., & Kitterick, P. T. (in press). The cost-effectiveness of bimodal stimulation compared to unilateral and bilateral cochlear implant use in adults with bilateral severe to profound deafness. Ear and Hearing,

Objectives: An increasing number of severe-profoundly deaf adult unilateral cochlear implant (CI) users receive bimodal stimulation; that is, they use a conventional acoustic hearing aid (HA) in their non-implanted ear. The combination of electric an... Read More

Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international randomised, open-label, blinded-endpoint phase 3 trial (2019)
Journal Article
Anderson, C. S., Huang, Y., Lindley, R. I., Chen, X., Arima, H., Chen, G., …ENCHANTED Investigators and Coordinators, . (2019). Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international randomised, open-label, blinded-endpoint phase 3 trial. Lancet, 393(10174), 877-888. doi:10.1016/S0140-6736(19)30038-8

Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics (2019)
Journal Article
Demirtas, M., Burt, J. B., Helmer, M., Ji, J. L., Adkinson, B. D., Glasser, M. F., …Murray, J. D. (2019). Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics. Neuron, 101, 1-14. doi:10.1016/j.neuron.2019.01.017

The large-scale organization of dynamical neural activity across cortex emerges through long-range interactions among local circuits. We hypothesized that large-scale dynamics are also shaped by heterogeneity of intrinsic local properties across cort... Read More

Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage (2019)
Journal Article
Pszczolkowski, S., Law, Z. K., Gallagher, R. G., Meng, D., Swienton, D. J., Morgan, P. S., …Dineen, R. A. (2019). Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage. Computers in Biology and Medicine, 106, 126-139. doi:10.1016/j.compbiomed.2019.01.022

Background Spontaneous intracerebral haemorrhage (SICH) is a common condition with high morbidity and mortality. Segmentation of haematoma and perihaematoma oedema on medical images provides quantitative outcome measures for clinical trials and may... Read More

Mobile applications for management of tinnitus: users' survey, quality assessment and content analysis (2019)
Journal Article
Sereda, M., Smith, S., Newton, K., & Stockdale, D. (2019). Mobile applications for management of tinnitus: users' survey, quality assessment and content analysis. Journal of International Medical Research, 7(1), doi:10.2196/10353

Background: Tinnitus is the perception of a sound without any outside source. It affects 6 million people in the UK. Sound therapy is a core component of many tinnitus management programmes. Potential mechanisms of benefit include making tinnitus le... Read More

Discrimination of gain increments in speech-shaped noises (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. (2019). Discrimination of gain increments in speech-shaped noises. Trends in Hearing, doi:10.1177/2331216518820220

Frequency-dependent gain adjustments are routine in hearing-aid fittings, whether in matching to real-ear targets or fine-tuning to patient feedback. Patient feedback may be unreliable and fittings inefficient if adjustments are not discriminable. To... Read More

Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis (2019)
Journal Article
Gaunt, A. C., & Kitterick, P. T. (in press). Determining the sample size for future trials of hearing instruments for unilaterally deaf adults: an application of network meta-analysis. Otology and Neurotology,

Objective: Previous trials have compared the efficacy of hearing instruments to no intervention in adults with single- sided deafness (SSD) or the relative efficacy of different instruments. Network meta-analysis (NMA) was used to refine estimates of... Read More

Effect of glyceryl trinitrate on haemodynamics in acute stroke: data from the Efficacy of Nitric Oxide in Stroke trial (2019)
Journal Article
Appleton, J. P., Woodhouse, L. J., Bereczki, D., Berge, E., Christensen, H. K., Collins, R., …ENOS Investigators, . (2019). Effect of glyceryl trinitrate on haemodynamics in acute stroke: data from the Efficacy of Nitric Oxide in Stroke trial. Stroke, 50(2), doi:10.1161/STROKEAHA.118.023190

Background and Purpose: Increased blood pressure (BP), heart rate and their derivatives (variability, pulse pressure, rate-pressure product [RPP]) are associated with poor clinical outcome in acute stroke. We assessed the effects of glyceryl trinitra... Read More

Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss (2019)
Journal Article
Heffernan, E., Habib, A., & Ferguson, M. (2019). Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss. International Journal of Audiology, 58(1), 45-52. doi:10.1080/14992027.2018.1533257

This study aimed to evaluate the psychometric properties of a brief, hearing-specific outcome measure: the Social Isolation Measure (SIM). In Phase 1, adults with hearing loss were invited to complete an online survey that contained the SIM, a hearin... Read More

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, doi:10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More

The relationship between patients’ illness beliefs and recovery after stroke (2018)
Journal Article
Aujla, N., Walker, M., Vedhara, K., & Sprigg, N. (2018). The relationship between patients’ illness beliefs and recovery after stroke. Psychology, Health and Medicine, doi:10.1080/13548506.2018.1557712

The Common Sense Model (CSM) is a useful framework for understanding mood and treatment adherence amongst survivors in the acute phase of stroke. CSM stroke studies have thus far focused on the single outcomes, mood and medication adherence, neglecti... Read More

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article
Laviola, M., Das, A., Chikhani, M., Bates, D., & Hardman, J. (2019). Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea. British Journal of Anaesthesia, 122(3), 395-401. doi:10.1016/j.bja.2018.11.012

Background Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More

Aberrant visual pathway development in albinism: from retina to cortex (2018)
Journal Article
Ather, S., Proudlock, F. A., Welton, T., Morgan, P. S., Sheth, V., Gottlob, I., & Dineen, R. A. (2019). Aberrant visual pathway development in albinism: from retina to cortex. Human Brain Mapping, 40(3), 777-788. doi:10.1002/hbm.24411

Albinism refers to a group of genetic abnormalities in melanogenesis that are associated neuronal misrouting through the optic chiasm. Previous imaging studies have shown structural alterations at different points along the visual pathway of people w... Read More

Interim analysis of ambulance logistics and timings in patients recruited into the Rapid intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) (2018)
Conference Proceeding
Dixon, M., Scutt, P., Appleton, J. P., Spaight, R., Johnson, R., Siriwardena, A. N., & Bath, P. M. (2018). Interim analysis of ambulance logistics and timings in patients recruited into the Rapid intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)

Introduction: Stroke is a severe condition with high morbidity and mortality. Despite treatment effects in acute stroke being predominantly time dependent (e.g. thrombolysis and thrombectomy), proven treatments are hospital based and require prior br... Read More