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All Outputs (11)

Universal automated classification of the acoustic startle reflex using machine learning (2022)
Journal Article
Fawcett, T. J., Longenecker, R. J., Brunelle, D. L., Berger, J. I., Wallace, M. N., Galazyuk, A. V., …Walton, J. P. (2023). Universal automated classification of the acoustic startle reflex using machine learning. Hearing Research, 428, Article 108667. https://doi.org/10.1016/j.heares.2022.108667

The startle reflex (SR), a robust, motor response elicited by an intense auditory, visual, or somatosensory stimulus has been widely used as a tool to assess psychophysiology in humans and animals for almost a century in diverse fields such as schizo... Read More about Universal automated classification of the acoustic startle reflex using machine learning.

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity (2022)
Journal Article
Wallace, M. N., Zobay, O., Hardman, E., Thompson, Z., Dobbs, P., Chakrabarti, L., & Palmer, A. R. (2022). The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity. Frontiers in Neuroanatomy, 16, Article 1034264. https://doi.org/10.3389/fnana.2022.1034264

Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution. We sought evidence of minicolumns in the primary visual c... Read More about The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.

Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus (2021)
Journal Article
Wallace, M. N., Shackleton, T. M., Thompson, Z., & Palmer, A. R. (2021). Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus. Frontiers in Neural Circuits, 15, 1-24. https://doi.org/10.3389/fncir.2021.721015

We reconstructed the intrinsic axons of 32 neurons in the guinea pig inferior colliculus (IC) following juxtacellular labeling. Biocytin was injected into cells in vivo, after first analyzing physiological response properties. Based on axonal morphol... Read More about Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus.

Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres (2021)
Journal Article
Wallace, M. N., Sumner, C. J., Berger, J. I., McNaughton, P. A., & Palmer, A. R. (2021). Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres. Neuroscience Letters, 747, Article 135705. https://doi.org/10.1016/j.neulet.2021.135705

Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in... Read More about Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres.

Using Gap-Induced Inhibition of the Post-Auricular Muscle Response as an Objective Measure of Tinnitus in Humans (2020)
Journal Article
Wilson, C. A., Berger, J. I., De Boer, J., Sereda, M., Hall, D. A., & Wallace, M. N. (2020). Using Gap-Induced Inhibition of the Post-Auricular Muscle Response as an Objective Measure of Tinnitus in Humans. Acta Scientific Otolaryngology, 2(12), 40-52

A widely used method for detecting tinnitus in rodents is the gap pre-pulse inhibition of the acoustic startle (GPIAS). One variant uses the Preyer reflex to assess the startle response and a component of this can be measured as a small muscle pote... Read More about Using Gap-Induced Inhibition of the Post-Auricular Muscle Response as an Objective Measure of Tinnitus in Humans.

Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus (2020)
Journal Article
Hockley, A., Berger, J. I., Palmer, A. R., & Wallace, M. N. (2020). Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus. European Journal of Neuroscience, 52(9), 4057-4080. https://doi.org/10.1111/ejn.14913

Previous work has led to the hypothesis that, during the production of noise?induced tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase the gain applied to a reduced input from the cochlea. To test this hypo... Read More about Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus.

Communication calls produced by electrical stimulation of four structures in the guinea pig brain (2018)
Journal Article
Green, D. B., Shackleton, T. M., Grimsley, J. M., Zobay, O., Wallace, M. N., & Palmer, A. R. (2018). Communication calls produced by electrical stimulation of four structures in the guinea pig brain. PLoS ONE, 13(3), Article e0194091. https://doi.org/10.1371/journal.pone.0194091

One of the main central processes affecting the cortical representation of conspecific vocalizations is the collateral output from the extended motor system for call generation. Before starting to study this interaction we sought to compare the chara... Read More about Communication calls produced by electrical stimulation of four structures in the guinea pig brain.

Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals (2017)
Journal Article
Berger, J. I., Owen, W., Wilson, C. A., Hockley, A., Coomber, B., Palmer, A. R., & Wallace, M. N. (2018). Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals. Brain Research, 1679, https://doi.org/10.1016/j.brainres.2017.11.026

Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over the validity of current behavioural methods for detecting tinnitus. Here, we applied a stimulus paradigm wid... Read More about Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals.

Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs (2017)
Journal Article
Berger, J. I., Coomber, B., Hill, S., Alexander, S., Owen, W., Palmer, A. R., & Wallace, M. N. (in press). Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs. Hearing Research, https://doi.org/10.1016/j.heares.2017.10.012

Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine... Read More about Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs.

Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs (2016)
Journal Article
Berger, J. I., Coomber, B., Wallace, M. N., & Palmer, A. R. (2017). Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs. European Journal of Neuroscience, 45(3), https://doi.org/10.1111/ejn.13474

Tinnitus chronically affects between 10–15% of the population but, despite its prevalence, the underlying mechanisms are still not properly understood. One experimental model involves administration of high doses of sodium salicylate, as this is know... Read More about Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs.

Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex (2016)
Journal Article
Wallace, M. N., Cronin, M. J., Bowtell, R. W., Scott, I., Palmer, A. R., & Gowland, P. A. (2016). Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex. Frontiers in Neuroscience, 10, Article 455. https://doi.org/10.3389/fnins.2016.00455

Functional magnetic resonance imaging (fMRI) studies of the auditory region of the temporal lobe would benefit from the availability of image contrast that allowed direct identification of the primary auditory cortex, as this region cannot be accurat... Read More about Histological basis of laminar MRI patterns in high resolution images of fixed human auditory cortex.