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All Outputs (65)

The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness (2022)
Journal Article
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Hogan, N., …for the Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) initiative. (2022). The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness. Trials, 23(1), Article 764. https://doi.org/10.1186/s13063-022-06702-1

Background: Single-sided deafness (SSD) has functional, psychological, and social consequences. Interventions for adults with SSD include hearing aids and auditory implants. Benefits and harms (outcome domains) of these interventions are until now re... Read More about The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness.

Tinnitus prevalence in Europe: a multi-country cross-sectional population study (2021)
Journal Article
Biswas, R., Lugo, A., Akeroyd, M., Schlee, W., Gallus, S., & Hall, D. (2022). Tinnitus prevalence in Europe: a multi-country cross-sectional population study. Lancet Regional Health – Europe, 12, Article 100250. https://doi.org/10.1016/j.lanepe.2021.100250

Background Tinnitus prevalence studies report large variability across countries that might be due to inconsistent research methods. Our study aimed to report a single Pan-European estimate for tinnitus prevalence and investigate the effect of indiv... Read More about Tinnitus prevalence in Europe: a multi-country cross-sectional population study.

Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI (2021)
Journal Article
Dewey, R. S., Hall, D. A., Plack, C. J., & Francis, S. T. (2021). Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI. Magnetic Resonance in Medicine, 86(5), 2577-2588. https://doi.org/10.1002/mrm.28902

Purpose Detecting sound-related activity using functional MRI requires the auditory stimulus to be more salient than the intense background scanner acoustic noise. Various strategies can reduce the impact of scanner acoustic noise, including “sparse... Read More about Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI.

Systematic review of outcome domains and instruments used in designs of clinical trials for interventions that seek to restore bilateral and binaural hearing in adults with unilateral severe to profound sensorineural hearing loss (‘single-sided deafness’) (2021)
Journal Article
Katiri, R., Hall, D. A., Killan, C. F., Smith, S., Prayuenyong, P., & Kitterick, P. T. (2021). Systematic review of outcome domains and instruments used in designs of clinical trials for interventions that seek to restore bilateral and binaural hearing in adults with unilateral severe to profound sensorineural hearing loss (‘single-sided deafness’). Trials, 22, Article 220. https://doi.org/10.1186/s13063-021-05160-5

Background: This systematic review aimed to identify, compare and contrast outcome domains and outcome instruments reported in studies investigating interventions that seek to restore bilateral (two-sided) and/or binaural (both ears) hearing in adult... Read More about Systematic review of outcome domains and instruments used in designs of clinical trials for interventions that seek to restore bilateral and binaural hearing in adults with unilateral severe to profound sensorineural hearing loss (‘single-sided deafness’).

Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study (2021)
Working Paper
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Buggy, N., …Core Rehabilitation Outcome Set For Single-Sided Deafness (CROSSSD) Initiative, . Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study

Background: Clinical trials that assess the benefits and harms of an intervention do so by measuring and reporting outcomes. Inconsistent selection and diversity in the choice of outcomes makes it challenging to directly compare interventions. To... Read More about Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study.

Using Gap-Induced Inhibition of the Post-Auricular Muscle Response as an Objective Measure of Tinnitus in Humans (2020)
Journal Article
Wilson, C. A., Berger, J. I., De Boer, J., Sereda, M., Hall, D. A., & Wallace, M. N. (2020). Using Gap-Induced Inhibition of the Post-Auricular Muscle Response as an Objective Measure of Tinnitus in Humans. Acta Scientific Otolaryngology, 2(12), 40-52

A widely used method for detecting tinnitus in rodents is the gap pre-pulse inhibition of the acoustic startle (GPIAS). One variant uses the Preyer reflex to assess the startle response and a component of this can be measured as a small muscle pote... Read More about Using Gap-Induced Inhibition of the Post-Auricular Muscle Response as an Objective Measure of Tinnitus in Humans.

Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study (2020)
Journal Article
Conlon, B., Langguth, B., Hamilton, C., Hughes, S., Meade, E., Connor, C. O., …Lim, H. H. (2020). Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study. Science Translational Medicine, 12(564), Article eabb2830. https://doi.org/10.1126/scitranslmed.abb2830

Tinnitus is a phantom auditory perception coded in the brain that can be bothersome or debilitating, affecting 10 to 15% of the population. Currently, there is no clinically recommended drug or device treatment for this major health condition. Animal... Read More about Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study.

The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus (2020)
Journal Article
Taylor, J. A., Thompson, D. M., Hall, D. A., Walker, D., McMurran, M., Casey, A., …Hoare, D. J. (2020). The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus. International Journal of Audiology, 59(12), 905-914. https://doi.org/10.1080/14992027.2020.1788730

Objective: To develop a manualised psychological treatment for tinnitus that could enhance audiologist usual care, and to test feasibility of evaluating it in a randomised controlled trial. Design: Feasibility trial, random allocation of patients to... Read More about The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus.

Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity (2020)
Journal Article
Prayuenyong, P., Kasbekar, A. V., Hall, D. A., & Baguley, D. M. (2020). Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity. European Archives of Oto-Rhino-Laryngology, 277, 3283–3293. https://doi.org/10.1007/s00405-020-06033-4

Purpose Vestibulotoxicity associated with cisplatin chemotherapy is known to exist, but the extent, severity, and impact is unclear from the literature. This study explored knowledge, experiences, and opinions of audiovestibular professionals abou... Read More about Audiovestibular clinician experiences and opinions about cisplatin vestibulotoxicity.

The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons (2020)
Working Paper
Genitsaridi, E., Kypraios, T., Edvall, N. K., Trpchevska, N., Canlon, B., Hoare, D. J., …Hall, D. A. The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons

The spatial percept of tinnitus is hypothesized as an important variable for tinnitus subtyping. Hearing asymmetry often associates with tinnitus laterality, but not always. One of the methodological limitations for cross-study comparisons is how the... Read More about The spatial percept of tinnitus is associated with hearing asymmetry: subgroup comparisons.

Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial) (2020)
Journal Article
Haines, R., White, J., Meakin, G., Tan, W., Hepburn, T., Leighton, P., …Sereda, M. (2020). Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial). Pilot and Feasibility Studies, 6, Article 41. https://doi.org/10.1186/s40814-020-00582-5

Background: The most common management strategy for tinnitus provided in UK audiology clinics is education and advice. This may also be combined with some form of sound therapy (e.g. digital hearing aids). While education and advice is generally prov... Read More about Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial).

A process for prioritising systematic reviews in tinnitus (2020)
Journal Article
Sereda, M., McFerran, D., Axon, E., Baguley, D. M., Hall, D. A., Potgieter, I., …Hoare, D. J. (2020). A process for prioritising systematic reviews in tinnitus. International Journal of Audiology, 59(8), 640-646. https://doi.org/10.1080/14992027.2020.1733677

© 2020 British Society of Audiology, International Society of Audiology, and Nordic Audiological Society. Objective: To develop an innovative prioritisation process to identify topics for new or updated systematic reviews of tinnitus research. Design... Read More about A process for prioritising systematic reviews in tinnitus.

Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey (2020)
Journal Article
Katiri, R., Hall, D. A., Buggy, N., Hogan, N., Horobin, A., van de Heyning, P., …Kitterick, P. T. (2020). Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey. Trials, 21(1), Article 238. https://doi.org/10.1186/s13063-020-4094-9

Background Single-sided deafness (SSD) describes the presence of a unilateral severe to profound sensorineural hearing loss. SSD disrupts spatial hearing and understanding speech in background noise. It has functional, psychological and social con... Read More about Core Rehabilitation Outcome Set for Single Sided Deafness (CROSSSD) study: protocol for an international consensus on outcome measures for single sided deafness interventions using a modified Delphi survey.

The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds (2019)
Journal Article
Dewey, R. S., Francis, S. T., Guest, H., Prendergast, G., Millman, R. E., Plack, C. J., & Hall, D. A. (2020). The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds. NeuroImage, 204, https://doi.org/10.1016/j.neuroimage.2019.116239

© 2019 In animal models, exposure to high noise levels can cause permanent damage to hair-cell synapses (cochlear synaptopathy) for high-threshold auditory nerve fibers without affecting sensitivity to quiet sounds. This has been confirmed in several... Read More about The association between subcortical and cortical fMRI and lifetime noise exposure in listeners with normal hearing thresholds.

How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin (2019)
Journal Article
Hall, D. A., Kitterick, P. T., Heffernan, E., Fackrell, K., Lucas, L., & Ferguson, M. (2019). How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin. Otology and Neurotology, 40(4), e474-e481. https://doi.org/10.1097/MAO.0000000000001937

This short review article gives an introduction to some of the fundamental concepts and challenges facing measurement in hearing healthcare practice and research. The impact of hearing loss almost always extends beyond the sensory impairment itself,... Read More about How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin.

Content validity and readability of patient-reported questionnaire instruments of hearing disability (2019)
Journal Article
Manchaiah, V., Granberg, S., Grover, V., Saunders, G., & Hall, D. (2019). Content validity and readability of patient-reported questionnaire instruments of hearing disability. International Journal of Audiology, 58(9), 565-575. https://doi.org/10.1080/14992027.2019.1602738

Objective: The current study evaluates the content validity (i.e., domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognized procedures and tools. Design: A review of the literature to... Read More about Content validity and readability of patient-reported questionnaire instruments of hearing disability.

A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial (2019)
Journal Article
Hall, D., Ray, J., Watson, J., Sharman, A., Hutchison, J., Harris, P., …Large, C. H. (2019). A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial. Hearing Research, 377, 153-166. https://doi.org/10.1016/j.heares.2019.03.018

AUT00063 is an experimental new medicine that has been demonstrated to suppress spontaneous hyperactivity by modulating the action of voltage-gated potassium-channels in central auditory cortical neurons of a rodent model. This neurobiological proper... Read More about A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: the QUIET-1 trial.

Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ) (2019)
Journal Article
Genitsaridi, E., Partyka, M., Gallus, S., Lopez-Escamez, J. A., Schecklmann, M., Mielczarek, M., …Hall, D. A. (2019). Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ). Hearing Research, 377, 353-359. https://doi.org/10.1016/j.heares.2019.02.017

Background The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced... Read More about Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study (2019)
Journal Article
Hu, S., Anschuetz, L., Huth, M. E., Sznitman, R., Blaser, D., Kompis, M., …Wimmer, W. (2019). Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study. JMIR Research Protocols, 8(1), Article e12270. https://doi.org/10.2196/12270

Background: Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the in... Read More about Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study.

Sound therapy (using amplification devices and/or sound generators) for tinnitus (2018)
Journal Article
Sereda, M., Xia, J., El Refaie, A., Hall, D. A., & Hoare, D. J. (2018). Sound therapy (using amplification devices and/or sound generators) for tinnitus. Cochrane Database of Systematic Reviews, 2018(12), https://doi.org/10.1002/14651858.CD013094.pub2

BACKGROUND: Tinnitus affects 10% to 15% of the adult population, with about 20% of these experiencing symptoms that negatively affect quality of life. In England alone there are an estimated ¾ million general practice consultations every year where t... Read More about Sound therapy (using amplification devices and/or sound generators) for tinnitus.