Skip to main content

Research Repository

Advanced Search

All Outputs (485)

Follicle development and selection: past, present and future (2016)
Journal Article
Webb, R., Buratini, J., Hernandez-Medrano, J. H., Gutierrez, C. G., & Campbell, B. K. (2016). Follicle development and selection: past, present and future. Animal reproduction / Colegio Brasileiro de Reproducao Animal, 13(3), 234-249. https://doi.org/10.21451/1984-3143-AR883

This paper reviews progress that has been made over the last 50 years and discusses how the development and application of new technologies have been utilized to increase our understanding of the development and selection of the dominant follicle. Ou... Read More about Follicle development and selection: past, present and future.

WNT5A: a motility-promoting factor in Hodgkin lymphoma (2016)
Journal Article
Linke, F., Zaunig, S., Nietert, M. M., von Bonin, F., Lutz, S., Dullin, C., …Kube, D. (2017). WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene, 36(1), 13-23. https://doi.org/10.1038/onc.2016.183

Classical Hodgkin lymphoma (cHL) has a typical clinical manifestation, with dissemination involving functionally neighboring lymph nodes. The factors involved in the spread of lymphoma cells are poorly understood. Here we show that cHL cell lines mig... Read More about WNT5A: a motility-promoting factor in Hodgkin lymphoma.

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices (2016)
Journal Article
Chou, I., Wang, H., Whitehouse, W. P., & Constantinescu, C. S. (in press). Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16(7), https://doi.org/10.1007/s11910-016-0663-4

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term... Read More about Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices.

Metformin for endometrial hyperplasia (protocol) (2016)
Journal Article
Clement, N., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2016). Metformin for endometrial hyperplasia (protocol). Cochrane Database of Systematic Reviews, 5, Article CD012214. https://doi.org/10.1002/14651858

To determine the efficacy and safety of metformin in treating women with endometrial hyperplasia

Induction of labour at or near term for suspected fetal macrosomia (2016)
Journal Article
Boulvain, M., Irion, O., Dowswell, T., & Thornton, J. (in press). Induction of labour at or near term for suspected fetal macrosomia. Cochrane Database of Systematic Reviews, Article CD000938. https://doi.org/10.1002/14651858.CD000938.pub2

Background: Women with a suspected large-for-dates fetus or a fetus with suspected macrosomia (birthweight greater than 4000 g) are at risk of operative birth or caesarean section. The baby is also at increased risk of shoulder dystocia and trauma, i... Read More about Induction of labour at or near term for suspected fetal macrosomia.

Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos (2016)
Journal Article
Sepulveda-Rincon, L. P., Solanas, E. D. L., Serrano-Revuelta, E., Ruddick, L., Maalouf, W. E., & Beaujean, N. (2016). Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology, 86(1), 91-98. https://doi.org/10.1016/j.theriogenology.2016.04.022

Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of... Read More about Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos.

Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio (2016)
Journal Article
Hardy, I. C., & Maalouf, W. E. (in press). Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio. Journal of Biosocial Science, https://doi.org/10.1017/S0021932016000146

Infertility affects around 15% of human couples and in many countries approximately 1–4% of babies are born following Assisted Reproductive Technologies (ART). Several ART techniques are used and these differentially affect the sex ratio of offspring... Read More about Partially-constrained sex allocation and the indirect effects of assisted reproductive technologies on the human sex ratio.

Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation (2016)
Journal Article
Denisenko, O., Lucas, E. S., Sun, C., Watkins, A. J., Mar, D., Bomsztyk, K., & Fleming, T. P. (2016). Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation. BBA - Biochimica et Biophysica Acta, 1859(7), 906-913. https://doi.org/10.1016/j.bbagrm.2016.04.001

Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined the effect of maternal dietary restriction o... Read More about Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.

Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours (2016)
Journal Article
Nailor, A., Walker, D. A., Jacques, T. S., Warren, K. E., Brem, H., Kearns, P. R., …Kilday, J. (2016). Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours. ecancermedicalscience, 10(630), https://doi.org/10.3332/ecancer.2016.630

The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leadi... Read More about Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours.

Randomized trial of labor induction in women 35 years of age or older (2016)
Journal Article
Walker, K. F., Bugg, G. J., Macpherson, M., McCormick, C., Grace, N., Wildsmith, C., …Thornton, J. (2016). Randomized trial of labor induction in women 35 years of age or older. New England Journal of Medicine, 374(9), https://doi.org/10.1056/NEJMoa1509117

BACKGROUND The risk of antepartum stillbirth at term is higher among women 35 years of age or older than among younger women. Labor induction may reduce the risk of stillbirth, but it also may increase the risk of cesarean delivery, which already is... Read More about Randomized trial of labor induction in women 35 years of age or older.

Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult (2016)
Journal Article
Kurlak, L., Mistry, H. D., Cindrova-Davies, T., Burton, G., & Broughton Pipkin, F. (2016). Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult. Journal of Physiology, 594(5), 1327-1340. https://doi.org/10.1113/JP271045

A functioning placental renin–angiotensin system (RAS) appears necessary for uncomplicated pregnancy and is present during placentation, which occurs under low oxygen tensions. Placental RAS is increased in pre-eclampsia (PE), characterised by placen... Read More about Human placental renin–angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia–reoxygenation insult.

Longitudinal analysis of the neurological features of ataxia-telangiectasia (2016)
Journal Article
Jackson, T. J., Chow, G., Suri, M., Byrd, P., Taylor, M. R., & Whitehouse, W. P. (2016). Longitudinal analysis of the neurological features of ataxia-telangiectasia. Developmental Medicine and Child Neurology, 58(7), 690-697. https://doi.org/10.1111/dmcn.13052

Aim: To assess the relationship between genotype and neurological progression in ataxia‐telangiectasia (A‐T). Methods: Clinical and laboratory data were extracted retrospectively from the records of patients attending the UK National Ataxia‐Telangie... Read More about Longitudinal analysis of the neurological features of ataxia-telangiectasia.

Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females (2016)
Journal Article
Robinson, L. J., Law, J., Symonds, M. E., & Budge, H. (2016). Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females. Experimental Physiology, 101(4), 549-557. https://doi.org/10.1113/EP085642

Brown adipose tissue (BAT) has been implicated in the pathogenesis of obesity, type 2 diabetes and the metabolic syndrome and is a potential therapeutic target. Brown adipose tissue can have a significant impact on energy balance and glucose homeosta... Read More about Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females.

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation (2016)
Journal Article
Eisele, N., Albrecht, C., Mistry, H. D., Dick, B., Baumann, M., Surbeck, D., …Gennari-Moser, C. (2016). Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation. Placenta, 40, https://doi.org/10.1016/j.placenta.2016.02.004

Aldosterone is an important factor supporting placental growth and fetal development. Recently, expression of placental growth factor (PlGF) has been observed in response to aldosterone exposure in different models of atherosclerosis. Thus, we hypoth... Read More about Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation.

A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT-1026) in stable cystic fibrosis patients (2016)
Journal Article
Flume, P., VanDevanter, D. R., Morgan, E., Dudley, M. N., Loutit, J. S., Bell, S. C., …Elborn, J. S. (2016). A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT-1026) in stable cystic fibrosis patients. Journal of Cystic Fibrosis, 15, https://doi.org/10.1016/j.jcf.2015.12.004

Rationale For patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standard of care to suppress chronic Pseudomonas airways infection. There are limited antibiotic options formulated and approved for inhaled use and antibi... Read More about A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT-1026) in stable cystic fibrosis patients.

Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer (2016)
Journal Article
Shafiee, M. N., Seedhouse, C., Mongan, N., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2016). Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer. Molecular and Cellular Endocrinology, 424, 94-101. https://doi.org/10.1016/j.mce.2016.01.019

BACKGROUND Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (E... Read More about Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer.

Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis (2016)
Journal Article
Malin, G., Bugg, G., Takwoingi, Y., Thornton, J., & Jones, N. W. (2016). Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 123(1), https://doi.org/10.1111/1471-0528.13517

BACKGROUND: Fetal macrosomia is associated with an increased risk of adverse maternal and neonatal outcomes. OBJECTIVES: To compare the accuracy of antenatal two-dimensional (2D) ultrasound, three-dimensional (3D) ultrasound, and magnetic... Read More about Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis.