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The Effects of Developmental Programming upon Neonatal Mortality (2019)
Journal Article
Perry, V., Copping, K., Miguel-Pacheco, G., & Hernandez- Medrano, J. (2019). The Effects of Developmental Programming upon Neonatal Mortality. Veterinary Clinics of North America: Food Animal Practice, 35(2), 289-302. https://doi.org/10.1016/j.cvfa.2019.02.002

KEY POINTS - The maternal environment (nutrition and physiologic status) can influence neonatal mortality and morbidity. - The effects of gestational nutrition on birth weight, dystocia, and calf survival vary with the timing and duration of dietar... Read More about The Effects of Developmental Programming upon Neonatal Mortality.

Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet (2019)
Journal Article
Aldiss, P., Lewis, J., Boocock, D., Miles, A., Bloor, I., Ebling, F., …Symonds, M. (2019). Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet. Nutrients, 11(5), Article 1065. https://doi.org/10.3390/nu11051065

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Brown adipose tissue (BAT) function may depend on its anatomical location and developmental origin. Interscapular BAT (iBAT) regulates acute macronutrient metabolism, whilst perivascular BAT (... Read More about Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet.

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma (2019)
Journal Article
Howarth, A., Madureira, P. A., Lockwood, G., Storer, L. C. D., Grundy, R., Rahman, R., …Hill, R. (2019). Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma. Brain Pathology, 29(6), 707-725. https://doi.org/10.1111/bpa.12729

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process... Read More about Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma.

Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation (2019)
Journal Article
Islam, N., Sunday Paul, U., Alhamdan, R., Hernandez-Medrano, J., Campbell, B. K., Marsters, P., & Maalouf, W. E. (2019). Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation. Journal of Molecular Endocrinology, 62(4), 207-216. https://doi.org/10.1530/jme-18-0237

Ovarian cortical tissue cryopreservation is a relatively novel approach to preserving fertility in women diagnosed with cancer. However, the effects of freezing-thawing are not fully understood, mainly due to the lack of suitable methods to assess ti... Read More about Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation.

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines (2019)
Journal Article
Adhikaree, J., Franks, H. A., Televantos, C., Vaghela, P., Kaur, A. P., Walker, D., …Patel, P. M. (2019). Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines. OncoImmunology, 8(7), 1-12. https://doi.org/10.1080/2162402X.2019.1593803

Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumour immune responses. The greater potency of circulating den... Read More about Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines.

Sexual dimorphism of brown adipose tissue function (2019)
Journal Article
Robinson, L. J., Law, J., Astle, V., Gutiérrez García, M., Ohja, S., Symonds, M. E., …Budge, H. (2019). Sexual dimorphism of brown adipose tissue function. Journal of Pediatrics, 210, 166-172.e1. https://doi.org/10.1016/j.jpeds.2019.03.003

Objective To determine whether brown adipose tissue (BAT) activity in school-age children differs between the sexes and to explore the impact of dietary intake, sedentary behavior, and picky/fussy eating. Study design Children aged 8.5-11.8 year... Read More about Sexual dimorphism of brown adipose tissue function.

An ex vivocystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection (2019)
Other
Sweeney, E., Hassan, M. M., Harrington, N. E., Smyth, A. R., Hurley, M. N., Tormo-Mas, M. Á., & Harrison, F. (2019). An ex vivocystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

Staphylococcus aureus is one of the most prevalent organisms isolated from the airways of people with cystic fibrosis (CF), predominantly early in life. Yet its role in the pathology of lung disease is poorly understood. Clinical studies are limited... Read More about An ex vivocystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection.

Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article
Shipley, L. J., Gyorkos, T., Jon, D., Tata, L. J., Lisa, S., & Sharkey, D. (2019). Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age. Pediatric Critical Care Medicine, 20(7), 638-644. https://doi.org/10.1097/PCC.0000000000001937

Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More about Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age.

Is it time to ban oxytocin for poor labour progress? (2019)
Journal Article
Walker, K. F., & Bugg, G. (2019). Is it time to ban oxytocin for poor labour progress?. Obstetrics, Gynaecology and Reproductive Medicine, 29(6), 175-176. https://doi.org/10.1016/j.ogrm.2019.03.002

Oxytocin causes myometrial contractions and prostaglandin release. It is commonly used as an intervention for women in established labour with slow progress. However recent large randomised trials of oxytocin for this indication have shown no differe... Read More about Is it time to ban oxytocin for poor labour progress?.

Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD (2019)
Journal Article
Wiles, K., Bramham, K., Seed, P. T., Kurlak, L. O., Mistry, H. D., Nelson-Piercy, C., …Chappell, L. C. (2019). Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD. Kidney International Reports, 4(6), 842-853. https://doi.org/10.1016/j.ekir.2019.03.012

© 2019 International Society of Nephrology Introduction: Diagnosis of superimposed preeclampsia in women with chronic kidney disease (CKD)is complicated by the presence of hypertension and proteinuria due to renal disease. The aims of this study were... Read More about Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD.

Infection prevention and control in cystic fibrosis: a systematic review of interventions (2019)
Journal Article
Rowbotham, N. J., Palser, S. C., Smith, S. J., & Smyth, A. R. (2019). Infection prevention and control in cystic fibrosis: a systematic review of interventions. Expert Review of Respiratory Medicine, 13(5), 425-434. https://doi.org/10.1080/17476348.2019.1595594

Introduction: Cystic fibrosis is a life-limiting genetic condition characterized by recurrent pulmonary infection. Acquisition of infection can occur from environmental reservoirs, person-to-person transmission and from the healthcare environment. Pr... Read More about Infection prevention and control in cystic fibrosis: a systematic review of interventions.

Higher education outreach: examining key challenges for academics (2019)
Journal Article
Johnson, M., Danvers, E., Hinton-Smith, T., Atkinson, K., Bowden, G., Foster, J., …Williams, S. (2019). Higher education outreach: examining key challenges for academics. British Journal of Educational Studies, 1-23. https://doi.org/10.1080/00071005.2019.1572101

How should academic staff engage in outreach with communities outside of the university? The need of academics to answer this question has intensified in the UK given the changing priorities of academic job roles, shaped by increasing institutional c... Read More about Higher education outreach: examining key challenges for academics.

Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters (2019)
Journal Article
Lee, S. T., Rahman, R., Muthoosamy, K., Mohamed, N. A. H., Mohamed, H., Su, X. D., …New, S. Y. (2019). Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters. Microchimica Acta, 186(2), Article 81. https://doi.org/10.1007/s00604-018-3194-7

A fluorogenic probe has been developed for determination of telomerase activity using chimeric DNA-templated silver nanoclusters (AgNCs). The formation of AgNCs was investigated before (route A) and after (route B) telomerase elongation reaction. Bot... Read More about Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters.

Periconceptional environment and the developmental origins of disease (2019)
Journal Article
Velazquez, M. A., Fleming, T. P., & Watkins, A. J. (2019). Periconceptional environment and the developmental origins of disease. Journal of Endocrinology, 242(1), T33-T49. https://doi.org/10.1530/JOE-18-0676

© 2019 Society for Endocrinology Published by Bioscientifica Ltd. The concept emerging from Professor David Barker's seminal research on the developmental origins of later-life disease has progressed in many directions since it was first published. O... Read More about Periconceptional environment and the developmental origins of disease.

Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial (2018)
Journal Article
Irtan, S., Messahel, B., Moroz, V., Taylor, R. E., Grundy, R., Kelsey, A., …Pritchard-Jones, K. (2019). Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial. Radiotherapy and Oncology, 131, 1-7. https://doi.org/10.1016/j.radonc.2018.10.026

© 2018 Background and purpose: To describe the outcome of patients with stage III Wilms tumours (WT) treated in the UKW3 trial. Material and methods: Patients with a pathologically confirmed stage III non-anaplastic WT at nephrectomy (Group A) or wit... Read More about Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial.

Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes (2018)
Journal Article
Symonds, M. E., Farhat, G., Aldiss, P., Pope, M., & Budge, H. (2019). Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes. Adipocyte, 8(1), 46-50. https://doi.org/10.1080/21623945.2018.1551689

There is increasing evidence that the global rise in temperature is contributing to the onset of diabetes, which could be mediated by a concomitant reduction in brown fat activity. Brown (and beige) fat are characterised as possessing a unique mitoch... Read More about Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes.

Postnatal gestational age estimation of newborns using Small Sample Deep Learning (2018)
Journal Article
Torres Torres, M., Valstar, M., Henry, C., Ward, C., & Sharkey, D. (2019). Postnatal gestational age estimation of newborns using Small Sample Deep Learning. Image and Vision Computing, 83-84, 87-99. https://doi.org/10.1016/j.imavis.2018.09.003

© 2018 A baby's gestational age determines whether or not they are premature, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these are expensive, require traine... Read More about Postnatal gestational age estimation of newborns using Small Sample Deep Learning.