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All Outputs (485)

Tissue cell stress response to obesity and its interaction with late gestational diet (2017)
Journal Article
Saroha, V., Dellschaft, N. S., Keisler, D. H., Gardner, D. S., Budge, H., Sebert, S. P., & Symonds, M. E. (2018). Tissue cell stress response to obesity and its interaction with late gestational diet. Reproduction, Fertility and Development, 30, https://doi.org/10.1071/RD16494

Intra-uterine growth restriction in late pregnancy can contribute to adverse long term metabolic health in the offspring. We utilised an animal (sheep) model of maternal dietary manipulation in late pregnancy, combined with exposure of the offspring... Read More about Tissue cell stress response to obesity and its interaction with late gestational diet.

Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology (2017)
Journal Article
Prior, M., Bagness, C., Brewin, J., Coomarasamy, A., Easthope, L., Hepworth-Jones, B., …Metcalf, L. (2017). Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology. BMJ Open, 7, Article e016571. https://doi.org/10.1136/bmjopen-2017-016571

Objectives: To identify and prioritise important research questions for miscarriage. Design: A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance. Setting: United Kin... Read More about Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology.

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome (2017)
Journal Article
Atiomo, W., Shafiee, M. N., Chapman, C., Metzler, V. M., Abouzeid, J., Latif, A., …Mongan, N. P. (2017). Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome. Clinical Endocrinology, 87(5), 557-565. https://doi.org/10.1111/cen.13436

OBJECTIVE: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). AIM: To investigate whether the endometrium of women with PCOS possess gene expression changes similar to those found in EC.... Read More about Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome.

Multicentre prospective observational study of feeding practices in 30–33 weeks preterm infants (2017)
Journal Article
Kwok, T., Kwok, T., Dorling, J., Dorling, J., Ojha, S., & Ojha, S. (2017). Multicentre prospective observational study of feeding practices in 30–33 weeks preterm infants. BMJ Paediatrics Open, 1(1), 1-4. https://doi.org/10.1136/bmjpo-2017-000040

Background: Current evidence supports progressive feeding in preterm infants. Due to lower necrotising enterocolitis risk, recent studies suggest starting total enteral feeding from birth in 30–33 weeks preterm infants. The feasibility of this practi... Read More about Multicentre prospective observational study of feeding practices in 30–33 weeks preterm infants.

Small Sample Deep Learning for Newborn Gestational Age Estimation (2017)
Conference Proceeding
Torres Torres, M., Valstar, M. F., Henry, C., Ward, C., & Sharkey, D. (2017). Small Sample Deep Learning for Newborn Gestational Age Estimation. In Proceedings - 12th IEEE International Conference on Automatic Face and Gesture Recognition (FG 2017) (79-86). https://doi.org/10.1109/FG.2017.19

A baby’s gestational age determines whether or not they are preterm, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these machines are expensive, require traine... Read More about Small Sample Deep Learning for Newborn Gestational Age Estimation.

A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (?16 years) low grade glioma: a final report (2017)
Journal Article
Gnekow, A. K., Walker, D. A., Kandels, D., Picton, S., Perilongo, G., Grill, J., …De Salvo, G. L. (2017). A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (≤16 years) low grade glioma: a final report. European Journal of Cancer, 81, https://doi.org/10.1016/j.ejca.2017.04.019

Background The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration of 12 months of treatment after resection. Me... Read More about A European randomised controlled trial of the addition of etoposide to standard vincristine and carboplatin induction as part of an 18-month treatment programme for childhood (?16 years) low grade glioma: a final report.

Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia (2017)
Journal Article
Mistry, H. D., Kurlak, L., Mansour, Y., Zurkinden, L., Mohaupt, M., & Escher, G. (2017). Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia. Journal of Lipid Research, 58, https://doi.org/10.1194/jlr.M071985

Preeclampsia is a pregnancy-specific condition that leads to increased cardiovascular risk in later life. A decrease in cholesterol efflux capacity is linked to CVD. We hypothesized that in preeclampsia there would be a disruption of maternal/fetal p... Read More about Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre-eclampsia.

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours (2017)
Journal Article
Haque, F., Varlet, P., Puntonet, J., Storer, L., Bountali, A., Rahman, R., …Grundy, R. G. (2017). Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours. Acta Neuropathologica Communications, 5, 1-9. https://doi.org/10.1186/s40478-017-0449-1

Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) as well as a subset of adult glioblastoma... Read More about Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours.

Beyond obesity - thermogenic adipocytes and cardiometabolic health (2017)
Journal Article
Aldiss, P., Dellschaft, N. S., Sacks, H., Budge, H., & Symonds, M. E. (in press). Beyond obesity - thermogenic adipocytes and cardiometabolic health. Hormone Molecular Biology and Clinical Investigation, 31(2), https://doi.org/10.1515/hmbci-2017-0007

The global prevalence of obesity and related cardiometabolic disease continues to increase through the 21st century. Whilst multi-factorial, obesity is ultimately caused by chronic caloric excess. However, despite numerous interventions focussing on... Read More about Beyond obesity - thermogenic adipocytes and cardiometabolic health.

Newborn infants with bilious vomiting: a national audit of neonatal transport services (2017)
Journal Article
Ojha, S., Sand, L., Ratnavel, N., Kempley, S., Sinha, A., Mohinuddin, S., …Leslie, A. (2017). Newborn infants with bilious vomiting: a national audit of neonatal transport services. Archives of Disease in Childhood, 102(6), Article F515-518. https://doi.org/10.1136/archdischild-2016-312208

Objective: The precautionary approach to urgently investigate infants with bilious vomiting has increased the numbers referred to transport teams and tertiary surgical centres. The aim of this national UK audit was to quantify referrals, determine th... Read More about Newborn infants with bilious vomiting: a national audit of neonatal transport services.

Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review (2017)
Journal Article
Prayle, A., Cox, T., Smith, S., Rycroft-Malone, J., Thomas, K. S., Hughes, D. A., & Smyth, A. R. (in press). Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review. Thorax, https://doi.org/10.1136/thoraxjnl-2016-208790

Cochrane Reviews summarise best evidence and should inform guidelines. We assessed the use of Cochrane Reviews in the UK guidelines for paediatric respiratory disease. We found 21 guidelines which made 1025 recommendations, of which 96 could be infor... Read More about Do guidelines for treating chest disease in children use Cochrane Reviews effectively?: a systematic review.

Ontogeny and thermogenic role for sternal fat in female sheep (2017)
Journal Article
Henry, B. A., Pope, M., Birtwistle, M., Loughnan, R., Alagal, R., Fuller-Jackson, J., …Symonds, M. E. (in press). Ontogeny and thermogenic role for sternal fat in female sheep. Endocrinology, 158(7), https://doi.org/10.1210/en.2017-00081

Brown adipose tissue acting through a unique uncoupling protein (UCP1) has a critical role in preventing hypothermia in new-born sheep but is then considered to rapidly disappear during postnatal life. The extent to which the anatomical location of f... Read More about Ontogeny and thermogenic role for sternal fat in female sheep.

Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study (2017)
Journal Article
Matthews, Y., Dean, F., Lim, M. J., Mclachlan, K., Rigby, A. S., Solanki, G. A., …Kennedy, C. R. (in press). Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. Archives of Disease in Childhood, 102(8), https://doi.org/10.1136/archdischild-2016-312238

AIM: To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16?years. METHODS: A national prospective population-based cohort study over 25?months. Newly diagnosed PTCS cases... Read More about Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study.

The placenta, maternal diet and adipose tissue development in the newborn (2017)
Journal Article
Symonds, M. E., Bloor, I., Ojha, S., & Budge, H. (2017). The placenta, maternal diet and adipose tissue development in the newborn. Annals of Nutrition and Metabolism, 70(3), 232-235. https://doi.org/10.1159/000464301

Background: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other orga... Read More about The placenta, maternal diet and adipose tissue development in the newborn.

Labour induction near term for women aged 35 or over: an economic evaluation (2017)
Journal Article
Walker, K. F., Dritsaki, M., Bugg, G., Macpherson, M., McCormick, C., Grace, N., …Thornton, J. (2017). Labour induction near term for women aged 35 or over: an economic evaluation. BJOG: An International Journal of Obstetrics and Gynaecology, 124(6), 929-934. https://doi.org/10.1111/1471-0528.14557

Objective Induction of labour at 39 weeks for nulliparous women aged 35 years and over may prevent stillbirths and does not increase caesarean births, so it may be popular. But the overall costs and benefits of such a policy have not been compared.... Read More about Labour induction near term for women aged 35 or over: an economic evaluation.

Paternal low protein diet programs preimplantation embryo gene expression, fetal growth and skeletal development in mice (2017)
Journal Article
Watkins, A. J., Sirovica, S., Stokes, B., Isaacs, M., Addison, O., & Martin, R. A. (2017). Paternal low protein diet programs preimplantation embryo gene expression, fetal growth and skeletal development in mice. BBA - Molecular Basis of Disease, 1863(6), 1371-1381. https://doi.org/10.1016/j.bbadis.2017.02.009

© 2017 Elsevier B.V. Defining the mechanisms underlying the programming of early life growth is fundamental for improving adult health and wellbeing. While the association between maternal diet, offspring growth and adult disease risk is well-establi... Read More about Paternal low protein diet programs preimplantation embryo gene expression, fetal growth and skeletal development in mice.

Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer (2017)
Journal Article
Shafiee, M. N., Mongan, N. P., Seedhouse, C., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2017). Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer. Acta Obstetricia et Gynecologica Scandinavica, 96(5), 556-562. https://doi.org/10.1111/aogs.13106

Introduction: Women with polycystic ovary syndrome (PCOS) have a 3-fold higher risk of endometrial cancer (EC). Insulin resistance and hyperlipidaemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to inves... Read More about Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer.

Heterozygous truncation mutations of the SMC1A gene cause a severe early onset epilepsy with cluster seizures in females: Detailed phenotyping of 10 new cases (2017)
Journal Article
Symonds, J. D., Joss, S., Metcalfe, K. A., Somarathi, S., Cruden, J., Devlin, A. M., …Zuberi, S. M. (2017). Heterozygous truncation mutations of the SMC1A gene cause a severe early onset epilepsy with cluster seizures in females: Detailed phenotyping of 10 new cases. Epilepsia, 58(4), 565-575. https://doi.org/10.1111/epi.13669

Wiley Periodicals, Inc. © 2017 International League Against Epilepsy Objective: The phenotype of seizure clustering with febrile illnesses in infancy/early childhood is well recognized. To date the only genetic epilepsy consistently associated with t... Read More about Heterozygous truncation mutations of the SMC1A gene cause a severe early onset epilepsy with cluster seizures in females: Detailed phenotyping of 10 new cases.