Research Repository

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Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma (2019)
Journal Article
Howarth, A., Madureira, P. A., Lockwood, G., Storer, L. C. D., Grundy, R., Rahman, R., …Hill, R. (2019). Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma. Brain Pathology, doi:10.1111/bpa.12729

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process... Read More

Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation (2019)
Journal Article
Islam, N., Sunday Paul, U., Alhamdan, R., Hernandez-Medrano, J., Campbell, B. K., Marsters, P., & Maalouf, W. E. (2019). Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation. Journal of Molecular Endocrinology, 62(4), 207-216. doi:10.1530/jme-18-0237

Ovarian cortical tissue cryopreservation is a relatively novel approach to preserving fertility in women diagnosed with cancer. However, the effects of freezing-thawing are not fully understood, mainly due to the lack of suitable methods to assess ti... Read More

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines (2019)
Journal Article
Adhikaree, J., Franks, H. A., Televantos, C., Vaghela, P., Kaur, A. P., Walker, D., …Patel, P. M. (2019). Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines. OncoImmunology, 8(7), doi:10.1080/2162402X.2019.1593803

Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumour immune responses. The greater potency of circulating den... Read More

Sexual dimorphism of brown adipose tissue function (2019)
Journal Article
Robinson, L. J., Law, J., Astle, V., Gutiérrez García, M., Ohja, S., Symonds, M. E., …Budge, H. (2019). Sexual dimorphism of brown adipose tissue function. Journal of Pediatrics, doi:10.1016/j.jpeds.2019.03.003

Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article
Shipley, L. J., Gyorkos, T., Jon, D., Tata, L. J., Lisa, S., & Sharkey, D. (2019). Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age. Pediatric Critical Care Medicine, doi:10.1097/PCC.0000000000001937

Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More

Infection prevention and control in cystic fibrosis: a systematic review of interventions (2019)
Journal Article
Rowbotham, N. J., Palser, S. C., Smith, S. J., & Smyth, A. R. (2019). Infection prevention and control in cystic fibrosis: a systematic review of interventions. Expert Review of Respiratory Medicine, 13(5), 425-434. doi:10.1080/17476348.2019.1595594

Introduction: Cystic fibrosis is a life-limiting genetic condition characterized by recurrent pulmonary infection. Acquisition of infection can occur from environmental reservoirs, person-to-person transmission and from the healthcare environment. Pr... Read More

Higher education outreach: examining key challenges for academics (2019)
Journal Article
Johnson, M., Danvers, E., Hinton-Smith, T., Atkinson, K., Bowden, G., Foster, J., …Williams, S. (2019). Higher education outreach: examining key challenges for academics. British Journal of Educational Studies, 1-23. doi:10.1080/00071005.2019.1572101

How should academic staff engage in outreach with communities outside of the university? The need of academics to answer this question has intensified in the UK given the changing priorities of academic job roles, shaped by increasing institutional c... Read More

Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates (2018)
Journal Article
Szatkowski, L., McClaughry, R., Clarkson, M., & Sharkey, D. (2018). Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates. European Respiratory Journal, doi:10.1183/13993003.01874-2018

Restricting visitors on the neonatal intensive care unit to parents only during a worldwide pandemic resulted in a 39% reduction in nosocomial viral respiratory tract infections in neonatal patients. These findings need validating in a prospective tr... Read More

The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta (2018)
Journal Article
Martino, J., Segura, M., García-Valdés, L., Padilla, M., Rueda, R., McArdle, H., …Campoy, C. (2018). The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta. Nutrients, 10(11), doi:10.3390/nu10111750

Dietary methyl donors, including folate, may modify the placenta and size at birth but the influence of maternal body weight has not been widely investigated. We therefore examined whether maternal or fetal folate status, together with indices of pla... Read More

The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data (2018)
Journal Article
Rodríguez-Calá, F., Suárez-Medina, R., Josefina Venero-Fernández, S., Smyth, A., Carr, S. B., & Fogarty, A. W. (2018). The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data. Journal of Cystic Fibrosis, doi:10.1016/j.jcf.2018.10.007

Background: We aimed to establish a national cystic fibrosis (CF) registry for Cuba, a developing country. Methods: Regional centres that deliver care for all CF patients provided information for a national database. Findings: The prevalence of CF... Read More

Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia (2018)
Journal Article
Hentchke, M. R., da Cunha Filho, E. V., Vieira, M. C., Paula, L. G., Mistry, H. D., Pinheiro da Costa, B. E., & Poli-de-Figueiredo, C. E. (2018). Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia, 40(10), 593-598. doi:10.1055/s-0038-1670713

Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE). Methods: Case-control study c... Read More

Epilepsy and associated mortality in patients with multiple sclerosis (2018)
Journal Article
Chou, I. J., Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., & Whitehouse, W. P. (2018). Epilepsy and associated mortality in patients with multiple sclerosis. European Journal of Neurology, doi:10.1111/ene.13821

Background and purpose: We aimed to determine the prevalence of epilepsy in patients with multiple sclerosis (MS) at diagnosis, the risk of developing epilepsy after the diagnosis of MS and the relative risk of mortality associated with epilepsy. Me... Read More

Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review (2018)
Journal Article
Rowbotham, N., Smith, S., Robinson, K., & Smyth, A. (2019). Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review. Thorax, 74(3), 229-236. doi:10.1136/thoraxjnl-2017-210858

Introduction:Cystic fibrosis (CF) is a multisystem disorder. Treatment is complex and evidence for treatment decisions may be absent. Characterising gaps in the research evidence will highlight treatment uncertainties and help prioritise research que... Read More

Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed (2018)
Journal Article
Retzler, J., Johnson, S., Groom, M., Hollis, C., Budge, H., & Cragg, L. (2019). Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed. Child Neuropsychology, 25(5), 617-635. doi:10.1080/09297049.2018.1510908

Background: Inattention is one of the most common neurobehavioural problems following very preterm birth. Attention problems can persist into adulthood and are associated with negative socio-emotional and educational outcomes. This study aimed to det... Read More

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants (2018)
Journal Article
Nasuf, A. W. A., Ojha, S., & Dorling, J. (2018). Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants. Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD011921.pub2

Background Placing a small volume of colostrum directly onto the buccal mucosa of preterm infants during the early neonatal period may provide immunological and growth factors that stimulate the immune system and enhance intestinal growth. These ben... Read More

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice (2018)
Journal Article
Watkins, A. J., Dias, I., Tsuro, H., Allen, D., Emes, R. D., Moreton, J., …Sinclair, K. D. (2018). Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice. Proceedings of the National Academy of Sciences, 115(40), (10064–10069). doi:10.1073/pnas.1806333115. ISSN 1091-6490

The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesis. However, our understanding of the underlying mechanisms... Read More

An in-vivo pilot study into the effects of FDG-mNP in cancer in mice (2018)
Journal Article
Aras, O., Pearce, G., Watkins, A. J., Nurili, F., Medine, E. I., Guldu, O. K., …Akin, O. (2018). An in-vivo pilot study into the effects of FDG-mNP in cancer in mice. PLoS ONE, 13(8), doi:10.1371/journal.pone.0202482

PURPOSE: Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was... Read More

Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor? (2018)
Journal Article
Hurley, M. N., & Smyth, A. R. (2018). Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?. Current Opinion in Pulmonary Medicine, 24(6), (586–591). doi:10.1097/mcp.0000000000000518. ISSN 1070-5287

Purpose of review: describe why this review is timely and relevant. The cystic fibrosis lung has long been appreciated as a competitive niche for complex interactions between bacterial species. The individual relationships between effects on the host... Read More

Diencephalic syndrome in child with NF-1 and hypothalamic tumour (2018)
Journal Article
Pilotto, C., Thomas, A., Simon P.S., H., Didcock, L., Thomas, S., & Walker, D. A. (2018). Diencephalic syndrome in child with NF-1 and hypothalamic tumour. Journal of Neurology and Clinical Neuroscience, 2(3), 1-3

We describe a 20 month old boy with neuro-fibromatosis type 1 (NF-1) who presented with diencephalic syndrome due to a large hypothalamic tumour and developed massive necrosis after chemotherapy associated with severe encephalopathy. We report thi... Read More