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Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia (2020)
Journal Article
Lugo Leija, H. A., Velickovic, K., Bloor, I., Sacks, H., Symonds, M. E., & Sottile, V. (in press). Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia. Journal of Cellular and Molecular Medicine,

Beige adipocytes possess the morphological and biochemical characteristics of brown adipocytes, including the mitochondrial uncoupling protein (UCP)1. Mesenchymal stem cells (MSCs) are somatic multipotent progenitors which differentiate into lipid-la... Read More about Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review. (2020)
Other
Marsh, R. J., Ng, C., Major, G., Rivett, D. W., Smyth, A. R., & Gast, C. V. D. Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review

Background Patients with cystic fibrosis (CF) are characterised by abnormalities of the intestinal tract relating to gut motility and physiological issues, with daily symptoms of disease including abdominal pain, flatulence, bloating, and constipatio... Read More about Persistent intestinal abnormalities and symptoms in cystic fibrosis: The underpinning mechanisms impacting gut health and motility. Protocol for a systematic review..

Metabolism based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential (2020)
Journal Article
Smith, S. J., Rowlinson, J., Estevez-Cebrero, M., Onion, D., Ritchie, A., Clarke, P., …Rahman, R. (2020). Metabolism based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential. Neuro-Oncology Advances, https://doi.org/10.1093/noajnl/vdaa087

Background Glioblastoma (GBM) is a highly aggressive brain tumor with rapid subclonal diversification, harboring molecular abnormalities that vary temporo-spatially, a contributor to therapy resistance. Fluorescence guided neurosurgical resection ut... Read More about Metabolism based isolation of invasive glioblastoma cells with specific gene signatures and tumorigenic potential.

Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics (2020)
Journal Article
Furse, S., Watkins, A. J., & Koulman, A. (2020). Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics. Molecules, 25(14), https://doi.org/10.3390/molecules25143192

Extraction of the lipid fraction is a key part of acquiring lipidomics data. High-throughput lipidomics, the extraction of samples in 96w plates that are then run on 96 or 384w plates, has particular requirements that mean special development work is... Read More about Extraction of Lipids from Liquid Biological Samples for High-Throughput Lipidomics.

NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat (2020)
Journal Article
Evans, D. G., Azizi, A. A., Walker, D. A., Liu, J., Sehested, A., Jaspan, T., …Opocher, E. (2020). NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat. Neuro-Oncology, https://doi.org/10.1093/neuonc/noaa153

Background The aim of the project was to identify risk factors associated with visual progression and treatment indications in pediatric patients with Neurofibromatosis type 1 associated optic pathway gliomas (NF1-OPG). Methods A multi-disciplin... Read More about NF1 optic pathway glioma. Analysing risk factors for visual outcome and indications to treat.

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations (2020)
Journal Article
Morris, B., Curtin, L., Hawkins-Daarud, A., Hubbard, M. E., Rahman, R., Smith, S. J., …Owen, M. R. (in press). Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations. Mathematical Biosciences and Engineering,

Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t... Read More about Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations.

A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups (2020)
Journal Article
Ritzmann, T. A., Rogers, H. A., Paine, S. M., Storer, L. C., Jacques, T. S., Chapman, R. J., …Grundy, R. G. (2020). A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups. Pediatric Blood and Cancer, 67(9), https://doi.org/10.1002/pbc.28426

Background Relapse occurs in 50% of pediatric ependymoma cases and has poor prognosis. Few studies have investigated the clinical progress of relapsed disease, and treatment lacks a standardized approach. Methods and materials We analyzed 302 pe... Read More about A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups.

Antimicrobial resistance: Concerns of healthcare providers and people with CF (2020)
Journal Article
Bullington, W., Hempstead, S., Smyth, A. R., Drevinek, P., Saiman, L., Waters, V. J., …Antimicrobial Resistance International Working Group in Cystic Fibrosis, . (2020). Antimicrobial resistance: Concerns of healthcare providers and people with CF. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2020.05.009

Background Chronic lung infections and their treatment pose risks for the development of antimicrobial resistance (AMR) in people with cystic fibrosis (PWCF). In this study, we evaluated the attitudes of healthcare providers’ (HCP) and PWCF or their... Read More about Antimicrobial resistance: Concerns of healthcare providers and people with CF.

Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging (2020)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C. L., Marciani, L., Ban, L., Prayle, A. P., …Smyth, A. R. (2020). Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2020.06.004

Background Cystic fibrosis (CF) is a multi-system genetic disorder affecting >72,000 people worldwide. Most CF patients experience gastrointestinal symptoms and can develop complications. However, the mechanisms of CF gut disease are not well unders... Read More about Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging.

Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system (2020)
Journal Article
Mistry, H. D., Hott Ogalde, M. V., Broughton Pipkin, F., Escher, G., & Kurlak, L. O. (2020). Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system. Frontiers in Medicine, 7, https://doi.org/10.3389/fmed.2020.00270

Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that... Read More about Maternal, fetal and placental selectins in women with pre-eclampsia: association with the renin-angiotensin-system.

Low protein diet and methyl-donor supplements modify testicular physiology in mice (2020)
Journal Article
Morgan, H. L., Ampong, I., Eid, N., Rouillon, C., Griffiths, H. R., & Watkins, A. J. (2020). Low protein diet and methyl-donor supplements modify testicular physiology in mice. Reproduction, 159(5), 627-641. https://doi.org/10.1530/rep-19-0435

The link between male diet and sperm quality has received significant investigation. However, the impact diet and dietary supplements have on the testicular environment has been examined to a lesser extent. Here, we establish the impact of a sub-opti... Read More about Low protein diet and methyl-donor supplements modify testicular physiology in mice.

Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals (2020)
Journal Article
Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., …Maslove, D. M. (2020). Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. Critical Care Medicine, 48(5), 623-633. https://doi.org/10.1097/ccm.0000000000004246

Prediction models aim to use available data to predict a health state or outcome that has not yet been observed. Prediction is primarily relevant to clinical practice, but is also used in research, and administration. While prediction modeling involv... Read More about Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals.

Phenotypic and genetic spectrum of epilepsy with myoclonic atonic seizures (2020)
Journal Article
Tang, S., Addis, L., Smith, A., Topp, S. D., Pendziwiat, M., Mei, D., …Pal, D. K. (2020). Phenotypic and genetic spectrum of epilepsy with myoclonic atonic seizures. Epilepsia, 61(5), 995-1007. https://doi.org/10.1111/epi.16508

Objective: We aimed to describe the extent of neurodevelopmental impairments and identify the genetic etiologies in a large cohort of patients with epilepsy with myoclonic atonic seizures (MAE). Methods: We deeply phenotyped MAE patients for epile... Read More about Phenotypic and genetic spectrum of epilepsy with myoclonic atonic seizures.

The haemodynamics of the human placenta in utero (2020)
Journal Article
Dellschaft, N. S., Hutchinson, G., Shah, S., Jones, N. W., Bradley, C., Leach, L., …Gowland, P. A. (2020). The haemodynamics of the human placenta in utero. PLoS Biology, 18(5), https://doi.org/10.1371/journal.pbio.3000676

© 2020 Dellschaft et al. We have used magnetic resonance imaging (MRI) to provide important new insights into the function of the human placenta in utero. We have measured slow net flow and high net oxygenation in the placenta in vivo, which are cons... Read More about The haemodynamics of the human placenta in utero.

Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas (2020)
Journal Article
Martin, S., Yao, A., Storr, S. J., Al-Hadyan, K., Rahman, R., Smith, S., …Paine, S. (2020). Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas. Molecular Neurobiology, 57(7), 2889–2901. https://doi.org/10.1007/s12035-020-01928-z

The thioredoxin (Trx) system is an important enzyme family that regulates cellular redox homeostasis. Protein expression of Trx system family members has been assessed in various cancers and linked to various clinicopathological variables, disease pr... Read More about Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas.

Regulatory mechanisms for natriuretic peptide signalling in sheep granulosa cells (2020)
Journal Article
Alhamdan, R., Maalouf, W. E., Campbell, B. K., Hernandez-Medrano, J., & Marsters, P. (2020). Regulatory mechanisms for natriuretic peptide signalling in sheep granulosa cells. Journal of Molecular Endocrinology, 64(4), 223-234. https://doi.org/10.1530/jme-20-0034

Natriuretic peptides (NPs) have been reported to have critical roles in follicular development and oocyte maturation in rodents. This study aimed to extend our current understanding of NP-mediated signalling pathways and mechanisms of action in the f... Read More about Regulatory mechanisms for natriuretic peptide signalling in sheep granulosa cells.


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