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Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells (2019)
Journal Article
De Melo, N., McGinlay, S., Markus, R., Macri-Pellizzeri, L., Symonds, M. E., Ahmed, I., & Sottile, V. (2019). Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells. Biomimetics, 4(3), 1-10. doi:10.3390/biomimetics4030048

Mesenchymal stem cells (MSCs) are progenitors for bone-forming osteoblasts and lipid-storing adipocytes, two major lineages co-existing in bone marrow. When isolated in vitro, these stem cells recapitulate osteoblast or adipocyte formation if treated... Read More

The influence of seminal plasma on offspring development and health (2019)
Journal Article
Morgan, H. L., & Watkins, A. J. (2019). The influence of seminal plasma on offspring development and health. Seminars in Cell and Developmental Biology, doi:10.1016/j.semcdb.2019.06.008

The concept that a father’s wellbeing at the time of conception influences the development and long-term health of his offspring is now well established. However, the mechanisms underlying the paternal programming of offspring health are not fully de... Read More

Improved cryopreservation of spermatozoa using vitrification: comparison of cryoprotectants and a novel device for long-term storage (2019)
Journal Article
O’Neill, H. C., Nikoloska, M., Ho, H., Doshi, A., & Maalouf, W. (2019). Improved cryopreservation of spermatozoa using vitrification: comparison of cryoprotectants and a novel device for long-term storage. Journal of Assisted Reproduction and Genetics, 1-8. doi:10.1007/s10815-019-01505-x

Study question Does cryoprotection of spermatozoa using a vitrification protocol with improved cryoprotective agents and a novel device for large storage lead to better outcomes than conventional slow freezing? Summary answer Vitrification of hu... Read More

Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications (2019)
Journal Article
Mistry, H. D., Kurlak, L. O., Gardner, D. S., Torffvit, O., Hansen, A., Broughton Pipkin, F., & Strevens, H. (2019). Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications. Journal of the American Heart Association, 8(13), 1-11. doi:10.1161/JAHA.119.012611

Background-—AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angiotensin... Read More

Periconceptional environment and the developmental origins of disease (2019)
Journal Article
Velazquez, M. A., Fleming, T. P., & Watkins, A. J. (2019). Periconceptional environment and the developmental origins of disease. Journal of Endocrinology, 242(1), T33-T49. doi:10.1530/joe-18-0676

The concept emerging from Professor David Barker’s seminal research on the developmental origins of later-life disease has progressed in many directions since it was first published. One critical question being when during gestation might environment... Read More

Advanced maternal age (2019)
Journal Article
Walker, K. F., & Thornton, J. G. (2019). Advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine, 29(9), 259-263. doi:10.1016/j.ogrm.2019.06.001

The average age of women at childbirth in industrialised nations has been increasing steadily for approximately 30 years. Women aged 35 years or over have an increased risk of gestational hypertensive disease, gestational diabetes, placenta praevia,... Read More

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo (2019)
Journal Article
Velickovic, K., Wayne, D., Lugo Leija, H. A., Bloor, I., Morris, D. E., Law, J., …Sottile, V. (2019). Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Scientific Reports, 9, doi:10.1038/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nut... Read More

Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review (2019)
Journal Article
Kalaitzis, I., Rowbotham, N., Smith, S., & Smyth, A. (2019). Do current clinical trials in cystic fibrosis match the priorities of patients and clinicans? A systematic review. Journal of Cystic Fibrosis, doi:10.1016/j.jcf.2019.06.005

There are many uncertainties regarding Cystic Fibrosis (CF) treatment. Recently, the first James Lind Alliance (JLA) Priority Setting Partnership (PSP) in CF was completed, bringing clinicians, patients and carers together to identify the Top 10 rese... Read More

The European Society of Paediatric Oncology Ependymoma-II program Core-Plus model: Development and initial implementation of a cognitive test protocol for an international brain tumour trial (2019)
Journal Article
Thomas, S., Reynolds, D., Morrall, M., Limond, J., Chevignard, M., Calaminus, G., …Grundy, R. (2019). The European Society of Paediatric Oncology Ependymoma-II program Core-Plus model: Development and initial implementation of a cognitive test protocol for an international brain tumour trial. European Journal of Paediatric Neurology, 23(4), 560-570. doi:10.1016/j.ejpn.2019.05.009

The Effects of Developmental Programming upon Neonatal Mortality (2019)
Journal Article
Perry, V., Copping, K., Miguel-Pacheco, G., & Hernandez- Medrano, J. (2019). The Effects of Developmental Programming upon Neonatal Mortality. Veterinary Clinics of North America: Food Animal Practice, 35(2), 289-302. doi:10.1016/j.cvfa.2019.02.002

KEY POINTS - The maternal environment (nutrition and physiologic status) can influence neonatal mortality and morbidity. - The effects of gestational nutrition on birth weight, dystocia, and calf survival vary with the timing and duration of dietar... Read More

Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma (2019)
Journal Article
Howarth, A., Madureira, P. A., Lockwood, G., Storer, L. C. D., Grundy, R., Rahman, R., …Hill, R. (2019). Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma. Brain Pathology, doi:10.1111/bpa.12729

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process... Read More

Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation (2019)
Journal Article
Islam, N., Sunday Paul, U., Alhamdan, R., Hernandez-Medrano, J., Campbell, B. K., Marsters, P., & Maalouf, W. E. (2019). Steroids and miRNAs in assessment of ovarian tissue damage following cryopreservation. Journal of Molecular Endocrinology, 62(4), 207-216. doi:10.1530/jme-18-0237

Ovarian cortical tissue cryopreservation is a relatively novel approach to preserving fertility in women diagnosed with cancer. However, the effects of freezing-thawing are not fully understood, mainly due to the lack of suitable methods to assess ti... Read More

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines (2019)
Journal Article
Adhikaree, J., Franks, H. A., Televantos, C., Vaghela, P., Kaur, A. P., Walker, D., …Patel, P. M. (2019). Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines. OncoImmunology, 8(7), doi:10.1080/2162402X.2019.1593803

Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumour immune responses. The greater potency of circulating den... Read More

Sexual dimorphism of brown adipose tissue function (2019)
Journal Article
Robinson, L. J., Law, J., Astle, V., Gutiérrez García, M., Ohja, S., Symonds, M. E., …Budge, H. (2019). Sexual dimorphism of brown adipose tissue function. Journal of Pediatrics, 210, 166-172.e1. doi:10.1016/j.jpeds.2019.03.003

Objective To determine whether brown adipose tissue (BAT) activity in school-age children differs between the sexes and to explore the impact of dietary intake, sedentary behavior, and picky/fussy eating. Study design Children aged 8.5-11.8 year... Read More