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All Outputs (40)

Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial (2018)
Journal Article
Irtan, S., Messahel, B., Moroz, V., Taylor, R. E., Grundy, R., Kelsey, A., …Pritchard-Jones, K. (2019). Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial. Radiotherapy and Oncology, 131, 1-7. https://doi.org/10.1016/j.radonc.2018.10.026

© 2018 Background and purpose: To describe the outcome of patients with stage III Wilms tumours (WT) treated in the UKW3 trial. Material and methods: Patients with a pathologically confirmed stage III non-anaplastic WT at nephrectomy (Group A) or wit... Read More about Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial.

Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes (2018)
Journal Article
Symonds, M. E., Farhat, G., Aldiss, P., Pope, M., & Budge, H. (2019). Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes. Adipocyte, 8(1), 46-50. https://doi.org/10.1080/21623945.2018.1551689

There is increasing evidence that the global rise in temperature is contributing to the onset of diabetes, which could be mediated by a concomitant reduction in brown fat activity. Brown (and beige) fat are characterised as possessing a unique mitoch... Read More about Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes.

Postnatal gestational age estimation of newborns using Small Sample Deep Learning (2018)
Journal Article
Torres Torres, M., Valstar, M., Henry, C., Ward, C., & Sharkey, D. (2019). Postnatal gestational age estimation of newborns using Small Sample Deep Learning. Image and Vision Computing, 83-84, 87-99. https://doi.org/10.1016/j.imavis.2018.09.003

© 2018 A baby's gestational age determines whether or not they are premature, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these are expensive, require traine... Read More about Postnatal gestational age estimation of newborns using Small Sample Deep Learning.

Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates (2018)
Journal Article
Szatkowski, L., McClaughry, R., Clarkson, M., & Sharkey, D. (2019). Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates. European Respiratory Journal, 53(3), Article 1801874. https://doi.org/10.1183/13993003.01874-2018

Restricting visitors on the neonatal intensive care unit to parents only during a worldwide pandemic resulted in a 39% reduction in nosocomial viral respiratory tract infections in neonatal patients. These findings need validating in a prospective tr... Read More about Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates.

The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta (2018)
Journal Article
Martino, J., Segura, M., García-Valdés, L., Padilla, M., Rueda, R., McArdle, H., …Campoy, C. (2018). The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta. Nutrients, 10(11), Article 1750. https://doi.org/10.3390/nu10111750

Dietary methyl donors, including folate, may modify the placenta and size at birth but the influence of maternal body weight has not been widely investigated. We therefore examined whether maternal or fetal folate status, together with indices of pla... Read More about The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta.

Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia (2018)
Journal Article
Hentchke, M. R., da Cunha Filho, E. V., Vieira, M. C., Paula, L. G., Mistry, H. D., Pinheiro da Costa, B. E., & Poli-de-Figueiredo, C. E. (2018). Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia, 40(10), 593-598. https://doi.org/10.1055/s-0038-1670713

Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE). Methods: Case-control study c... Read More about Negative correlation between Placental Growth Factor and Endocan-1 in women with preeclampsia.

The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data (2018)
Journal Article
Rodríguez-Calá, F., Suárez-Medina, R., Josefina Venero-Fernández, S., Smyth, A., Carr, S. B., & Fogarty, A. W. (2019). The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data. Journal of Cystic Fibrosis, 18(4), 522-524. https://doi.org/10.1016/j.jcf.2018.10.007

Background: We aimed to establish a national cystic fibrosis (CF) registry for Cuba, a developing country. Methods: Regional centres that deliver care for all CF patients provided information for a national database. Findings: The prevalence of CF... Read More about The prevalence, clinical status and genotype of cystic fibrosis patients living in Cuba using national registry data.

Epilepsy and associated mortality in patients with multiple sclerosis (2018)
Journal Article
Chou, I. J., Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., & Whitehouse, W. P. (2018). Epilepsy and associated mortality in patients with multiple sclerosis. European Journal of Neurology, 26(2), 342-e23. https://doi.org/10.1111/ene.13821

Background and purpose: We aimed to determine the prevalence of epilepsy in patients with multiple sclerosis (MS) at diagnosis, the risk of developing epilepsy after the diagnosis of MS and the relative risk of mortality associated with epilepsy. Me... Read More about Epilepsy and associated mortality in patients with multiple sclerosis.

Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review (2018)
Journal Article
Rowbotham, N., Smith, S., Robinson, K., & Smyth, A. (2019). Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review. Thorax, 74(3), 229-236. https://doi.org/10.1136/thoraxjnl-2017-210858

Introduction:Cystic fibrosis (CF) is a multisystem disorder. Treatment is complex and evidence for treatment decisions may be absent. Characterising gaps in the research evidence will highlight treatment uncertainties and help prioritise research que... Read More about Gaps in the evidence for treatment decisions in cystic fibrosis: a systematic review.

Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed (2018)
Journal Article
Retzler, J., Johnson, S., Groom, M., Hollis, C., Budge, H., & Cragg, L. (2019). Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed. Child Neuropsychology, 25(5), 617-635. https://doi.org/10.1080/09297049.2018.1510908

Background: Inattention is one of the most common neurobehavioural problems following very preterm birth. Attention problems can persist into adulthood and are associated with negative socio-emotional and educational outcomes. This study aimed to det... Read More about Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed.

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants (2018)
Journal Article
Nasuf, A. W. A., Ojha, S., & Dorling, J. (2018). Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD011921.pub2

Background Placing a small volume of colostrum directly onto the buccal mucosa of preterm infants during the early neonatal period may provide immunological and growth factors that stimulate the immune system and enhance intestinal growth. These ben... Read More about Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.

Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles (2018)
Journal Article
Watkins, A., Pearce, G., Unak, P., Gulde, O., Yasakci, V., Akin, O., …Ma, X. (2018). Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles. Journal of Biomedical Nanotechnology, 14(11), 1979-1991. https://doi.org/10.1166/jbn.2018.2631

Fluorodeoxyglucose-conjugated magnetic nanoparticles, designed to target cancer cells with high specificity when heated by an alternating magnetic field, could provide a low-cost, non-toxic treatment for cancer. However, it is essential that the in v... Read More about Tissue Morphology and Gene Expression Characterisation of Transplantable Adenocarcinoma Bearing Mice Exposed to Fluorodeoxyglucose-Conjugated Magnetic Nanoparticles.

The development of a clinical interface for a novel newborn resuscitation device; a Human Factors approach to understand cognitive user requirements (2018)
Working Paper
Pickup, L., Lang, A., Shipley, L., Henry, C., Carpenter, J., McCartney, D., …Sharkey, D. The development of a clinical interface for a novel newborn resuscitation device; a Human Factors approach to understand cognitive user requirements

Background: A novel medical device has been developed to address an unmet need of standardizing and facilitating heart rate recording during neonatal resuscitation. In a time-critical emergency resuscitation, where failure can mean death of an in... Read More about The development of a clinical interface for a novel newborn resuscitation device; a Human Factors approach to understand cognitive user requirements.

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice (2018)
Journal Article
Watkins, A. J., Dias, I., Tsuro, H., Allen, D., Emes, R. D., Moreton, J., …Sinclair, K. D. (2018). Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice. Proceedings of the National Academy of Sciences, 115(40), 10064-10069. https://doi.org/10.1073/pnas.1806333115

© 2018 National Academy of Sciences. All rights reserved. The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesi... Read More about Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice.

An in-vivo pilot study into the effects of FDG-mNP in cancer in mice (2018)
Journal Article
Aras, O., Pearce, G., Watkins, A. J., Nurili, F., Medine, E. I., Guldu, O. K., …Akin, O. (2018). An in-vivo pilot study into the effects of FDG-mNP in cancer in mice. PLoS ONE, 13(8), Article e0202482. https://doi.org/10.1371/journal.pone.0202482

PURPOSE: Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was... Read More about An in-vivo pilot study into the effects of FDG-mNP in cancer in mice.

Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor? (2018)
Journal Article
Hurley, M. N., & Smyth, A. R. (2018). Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?. Current Opinion in Pulmonary Medicine, 24(6), 586-591. https://doi.org/10.1097/MCP.0000000000000518

Purpose of review: describe why this review is timely and relevant. The cystic fibrosis lung has long been appreciated as a competitive niche for complex interactions between bacterial species. The individual relationships between effects on the host... Read More about Staphylococcus aureus in cystic fibrosis: pivotal role or bit part actor?.

Leptin regulates neuropeptides associated with food intake and GnRH secretion (2018)
Journal Article
Guzmán, A., Hernández-Coronado, C. G., Rosales-Torres, A. M., & Hernández-Medrano, J. H. (2019). Leptin regulates neuropeptides associated with food intake and GnRH secretion. Annales d'Endocrinologie, 80(1), 38-46. https://doi.org/10.1016/j.ando.2018.07.012

© 2018 Elsevier Masson SAS The present review focused on the most important effects of leptin on the hypothalamus and on how leptin regulates neuropeptides associated with food intake and GnRH secretion. This review of the literature suggests that a... Read More about Leptin regulates neuropeptides associated with food intake and GnRH secretion.

Diencephalic syndrome in child with NF-1 and hypothalamic tumour (2018)
Journal Article
Pilotto, C., Thomas, A., Simon P.S., H., Didcock, L., Thomas, S., & Walker, D. A. (2018). Diencephalic syndrome in child with NF-1 and hypothalamic tumour. Journal of Neurology and Clinical Neuroscience, 2(3), 1-3

We describe a 20 month old boy with neuro-fibromatosis type 1 (NF-1) who presented with diencephalic syndrome due to a large hypothalamic tumour and developed massive necrosis after chemotherapy associated with severe encephalopathy. We report thi... Read More about Diencephalic syndrome in child with NF-1 and hypothalamic tumour.

Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy (2018)
Journal Article
Eisele, N., Klossner, R., Escher, G., Rudloff, S., Larionov, A., Theillg, F., …Gennari-Moser, C. (2018). Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy. Journal of the American Heart Association, 7(15), Article e008363. https://doi.org/10.1161/jaha.117.008363

Background In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (BP). Reducing BP by increasing Na+ intake via plasma volume expansion appears... Read More about Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy.