All Outputs (4)

Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma (2010)
Journal Article
Rahman, R., Smith, S., Rahman, C., & Grundy, R. (2010). Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma. Journal of Oncology, 2010, 1-16. https://doi.org/10.1155/2010/251231

Despite advances in surgery, radiation therapy, and chemotherapeutics, patients with malignant glioma have a dismal prognosis. The formations of aberrant tumour vasculature and glioma cell invasion are major obstacles for effective treatment. Angioge... Read More about Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.

Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells (2010)
Journal Article
Rahman, R., Osteso-Ibanez, T., Hirst, R. A., Levesley, J., Kilday, J., Quinn, S., …Grundy, R. G. (2010). Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells. Molecular Cancer Therapeutics, 9(9), 2568-2581. https://doi.org/10.1158/1535-7163.mct-10-0272

Aberrant epigenetic regulation of gene expression contributes to tumor initiation and progression. Studies from a plethora of hematologic and solid tumors support the use of histone deacetylase inhibitors (HDACi) as potent anticancer agents. However,... Read More about Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells.

Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human (2010)
Journal Article
Williams, P., Mistry, H., Innes, B., Bulmer, J., & Broughton Pipkin, F. (2010). Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human. Placenta, 31(5), https://doi.org/10.1016/j.placenta.2010.02.014

The placental renin-angiotensin system (RAS) is active from early pregnancy and may have a role in placentation. Angiotensin II (AngII) acts via binding to receptor types AT1R and AT2R. Recently smaller peptide members of the angiotensin family have... Read More about Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human.

Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy (2010)
Journal Article
Mistry, H., Kurlak, L., Williams, P., Ramsay, M., Symonds, M., & Broughton Pipkin, F. (2010). Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Placenta, 31(5), https://doi.org/10.1016/j.placenta.2010.02.011

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also predispose the mother and fetus to increased risks of adult cardiovascular disease. The selenopr... Read More about Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.