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The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study (2013)
Journal Article
Amer, S. A., Mahran, A., Abdelmaged, A., El-Adawy, A. R., Eissa, M. K., & Shaw, R. W. (2013). The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study. Reproductive Biology and Endocrinology, 11(115), Article 115. https://doi.org/10.1186/1477-7827-11-115

Background Women with polycystic ovarian syndrome (PCOS) are known to have elevated circulating Anti-Müllerian hormone (AMH), which has been found to desensitize ovarian follicles to follicle stimulating hormone (FSH). The purpose of this study was... Read More about The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study.

Effects of dehydroepiandrosterone on in vivo ovine follicular development (2013)
Journal Article
Narkwichean, A., Jayaprakasan, K., Maalouf, W. E., Hernandez-Medrano, J., Pincott-Allen, C., & Campbell, B. K. (2014). Effects of dehydroepiandrosterone on in vivo ovine follicular development. Human Reproduction, 29(1), https://doi.org/10.1093/humrep/det408

STUDY QUESTION: What are the effects of exposure of ovarian tissue to dehydroepiandrosterone (DHEA) supplementation in vivo? SUMMARY ANSWER:DHEA exposure stimulates initiation of primordial follicles and development of gonadotrophin-responsive prean... Read More about Effects of dehydroepiandrosterone on in vivo ovine follicular development.

Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children (2013)
Journal Article
Robinson, L., Ojha, S., Symonds, M., & Budge, H. (2014). Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children. Journal of Pediatrics, 164(2), 318-322.e1. https://doi.org/10.1016/j.jpeds.2013.10.005

Objective To determine whether body mass index (BMI) percentile and ethnicity influence skin temperature overlying brown adipose tissue (BAT) depots in the supraclavicular region in healthy children. Study design Infrared thermography measured s... Read More about Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children.

Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review (2013)
Journal Article
Egunsola, O., & Oshikoya, K. A. (2013). Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review. Malaria Journal, 12(Novemb), Article 8. https://doi.org/10.1186/1475-2875-12-385

Background The purpose of the study was to compare the safety of artemether-lumefantrine (AL) with other artemisinin-based combinations in children. Methods A search of EMBASE (from 1974 to April 2013), MEDLINE (from 1946 to April 2013) and the... Read More about Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review.

Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort (2013)
Journal Article
Hacohen, Y., Whitehouse, W., Absoud, M., Woodhall, M., Cummins, C., De Goede, C. G., …Lim, M. (2014). Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort. Journal of Neurology, Neurosurgery and Psychiatry, 85(4), 456-461. https://doi.org/10.1136/jnnp-2013-306411

Background: Autoantibodies to glial, myelin and neuronal antigens have been reported in a range of central demyelination syndromes and autoimmune encephalopathies in children, but there has not been a systematic evaluation across the range of central... Read More about Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort.

Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix (2013)
Journal Article
Rahman, C. V., Smith, S. J., Morgan, P. S., Langmack, K. A., Clarke, P. A., Ritchie, A. A., …Rahman, R. (2013). Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PLoS ONE, 8(10), Article e77435. https://doi.org/10.1371/journal.pone.0077435

INTRODUCTION Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility... Read More about Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix.

Oxytocin Receptor Genotype Modulates Ventral Striatal Activity to Social Cues and Response to Stressful Life Events (2013)
Journal Article
Loth, E., Poline, J., Thyreau, B., Jia, T., Tao, C., Lourdusamy, A., …Schumann, G. (2014). Oxytocin Receptor Genotype Modulates Ventral Striatal Activity to Social Cues and Response to Stressful Life Events. Biological Psychiatry, 76(5), 367-376. https://doi.org/10.1016/j.biopsych.2013.07.043

Background Common variants in the oxytocin receptor gene (OXTR) have been shown to influence social and affective behavior and to moderate the effect of adverse experiences on risk for social-affective problems. However, the intermediate neurobiologi... Read More about Oxytocin Receptor Genotype Modulates Ventral Striatal Activity to Social Cues and Response to Stressful Life Events.

Heparin for assisted reproduction (Review) (2013)
Journal Article
Akhtar, M. A., Sur, S. D., Raine-Fenning, N., Jayaprakasan, K., Thornton, J., & Quenby, S. (2013). Heparin for assisted reproduction (Review). Cochrane Library, https://doi.org/10.1002/14651858.CD009452.pub2

Abstract BACKGROUND: Heparin as an adjunct in assisted reproduction (peri-implantation heparin) is given at or after egg collection or at embryo transfer during assisted reproduction. Heparin has been advocated to improve embryo implantation and cl... Read More about Heparin for assisted reproduction (Review).

Substandard and counterfeit medicines: a systematic review of the literature (2013)
Journal Article
Almuzaini, T., Choonara, I., & Sammons, H. (2013). Substandard and counterfeit medicines: a systematic review of the literature. BMJ Open, 3(8), Article e002923. https://doi.org/10.1136/bmjopen-2013-002923

Objective: To explore the evidence available of poor-quality (counterfeit and substandard) medicines in the literature. Design: Systematic review. Data sources: Databases used were EMBASE, MEDLINE, PubMed and the International Pharmaceutical Abstra... Read More about Substandard and counterfeit medicines: a systematic review of the literature.

Urine protein concentration estimation for biomarker discovery (2013)
Journal Article
Mistry, H. D., Bramham, K., Weston, A., Ward, M., Thompson, A., & Chappell, L. C. (2013). Urine protein concentration estimation for biomarker discovery. Pregnancy Hypertension, 3(4), https://doi.org/10.1016/j.preghy.2013.07.001

Recent advances have been made in the study of urinary proteomics as a diagnostic tool for renal disease and pre-eclampsia which requires accurate measurement of urinary protein. We compared different protein assays (Bicinchoninic acid (BCA), Lowry a... Read More about Urine protein concentration estimation for biomarker discovery.

Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype (2013)
Journal Article
Hentchke, M., Poli-de-Figueiredo, C., Pinheiro da Costa, B., Kurlak, L., Williams, P. J., & Mistry, H. D. (2013). Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype. Journal of Lipid Research, 54, https://doi.org/10.1194/jlr.M036699

Artherosis of spiral arteries in uteroplacental beds from pre-eclamptic women resemble those of atherosclerosis, characterised by increased plasma lipids and lipoproteins. We hypothesised 1) lipoproteins receptors/transporter in placenta would be up-... Read More about Is the atherosclerotic phenotype of pre-eclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors?: role of a small-for-gestational-age phenotype.

Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. (2013)
Journal Article
Churchill, D., Duley, L., Thornton, J., & Jones, L. (2013). Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. Cochrane Library, 7, Article CD003106. https://doi.org/10.1002/14651858.CD003106.pub2

Background: Severe pre-eclampsia can cause significant mortality and morbidity for both mother and child, particularly when it occurs remote from term, between 24 and 34 weeks' gestation. The only known cure for this disease is delivery. Some obstetr... Read More about Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation..

Interventions for treating cholestasis in pregnancy (Review) (2013)
Journal Article
Gurung, V., Stokes, M., Middleton, P., Milan, S. J., Hague, W., & Thornton, J. (2013). Interventions for treating cholestasis in pregnancy (Review). Cochrane Library, 6, Article CD000493. https://doi.org/10.1002/14651858.CD000493.pub2

BACKGROUND: Obstetric cholestasis has been linked to adverse maternal and fetal/neonatal outcomes. As the pathophysiology is poorly understood, therapies have been empiric. The first version of this review, published in 2001, and including nine rand... Read More about Interventions for treating cholestasis in pregnancy (Review).

Elective preterm birth for fetal gastroschisis (Review) (2013)
Journal Article
Grant, N. H., Dorling, J., & Thornton, J. (2013). Elective preterm birth for fetal gastroschisis (Review). Cochrane Database of Systematic Reviews, 2013(6), Article CD009394. https://doi.org/10.1002/14651858.CD009394.pub2

Background: Gastroschisis is an uncommon congenital defect of the interior abdominal wall that results in herniation of intestinal loops outside the abdominal cavity. Babies with gastroschisis generally do well, but there remains a mortality rate of... Read More about Elective preterm birth for fetal gastroschisis (Review).

What is a good midwife? Some historical considerations (2013)
Journal Article
Borrelli, S. E. (2013). What is a good midwife? Some historical considerations. Evidence Based Midwifery, 11(2),

AIM: This review takes into account some of the historical considerations around characteristics of a good midwife throughout the centuries in relation to historical and professional factors, tracing changing concepts from the definition of Soranus o... Read More about What is a good midwife? Some historical considerations.

What is the easier and more reliable dose calculation for iv Phenytoin in children at risk of developing convulsive status epilepticus, 18 mg/kg or 20 mg/kg? (2013)
Journal Article
Prasad, M., Shenton, P., Dietz, S., Saroha, V., & Whitehouse, W. P. (2013). What is the easier and more reliable dose calculation for iv Phenytoin in children at risk of developing convulsive status epilepticus, 18 mg/kg or 20 mg/kg?. BMC Pediatrics, 13(60), https://doi.org/10.1186/1471-2431-13-60

Background: With the Convulsive Status Guidelines due for renewal, we wondered if a phenytoin dose of ‘20 mg/kg’ would be easier to calculate correctly and therefore safer than the current ‘18 mg/kg’. An educational exercise in dose calculation was... Read More about What is the easier and more reliable dose calculation for iv Phenytoin in children at risk of developing convulsive status epilepticus, 18 mg/kg or 20 mg/kg?.

Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy (2013)
Journal Article
Kurlak, L., Mistry, H., Kaptein, E., Visser, T., & Broughton Pipkin, F. (2013). Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy. Placenta, 34(5), https://doi.org/10.1016/j.placenta.2013.02.009

Pre-eclampsia is associated with lower serum selenium concentrations and glutathione peroxidase expression/activity; total thyroid hormones are also lower. Objectives, study design and main outcome measures: We hypothesised that the placental seleno... Read More about Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy.