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Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., …Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

The placental renin-angiotensin system and oxidative stress in pre-eclampsia (2012)
Journal Article
Mistry, H., Kurlak, L., & Broughton Pipkin, F. (2013). The placental renin-angiotensin system and oxidative stress in pre-eclampsia. Placenta, 34(2), https://doi.org/10.1016/j.placenta.2012.11.027

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-e... Read More about The placental renin-angiotensin system and oxidative stress in pre-eclampsia.

Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial (2012)
Journal Article
Walker, K. F., Bugg, G., Macpherson, M., McCormick, C., Wildsmith, C., Smith, G., & Thornton, J. (2012). Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial. BMC Pregnancy and Childbirth, 12(Decemb), Article 8. https://doi.org/10.1186/1471-2393-12-145

Background: British women are increasingly delaying childbirth. The proportion giving birth over the age of 35 rose from 12% in 1996 to 20% in 2006. Women over this age are at a higher risk of perinatal death, and antepartum stillbirth accounts for 6... Read More about Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial.

Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway (2012)
Journal Article
Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., …Lovestone, S. (2014). Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. https://doi.org/10.1038/mp.2012.163

Although the mechanism of Abaction in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increasethe expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing ofDkk1blocks Abneur... Read More about Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.

Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol (2012)
Journal Article
Sayal, K., Daley, D., James, M., Yang, M., Batty, M. J., Taylor, J. A., …Hollis, C. (2012). Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol. BMJ Open, 2(5), Article e001783. https://doi.org/10.1136/bmjopen-2012-001783

Introduction Early intervention for childhood behavioural problems may help improve health and educational outcomes in affected children and reduce the likelihood of developing additional difficulties. The National Institute for Health and Clinical... Read More about Protocol evaluating the effectiveness of a school-based group programme for parents of children at risk of ADHD: the ‘PArents, Teachers and CHildren WORKing Together (PATCHWORK)’ cluster RCT protocol.

Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants (2012)
Journal Article
Mistry, H. D., Kurlak, L., Young, S. D., Briley, A., Broughton Pipkin, F., Baker, P., & Poston, L. (2014). Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants. Maternal and Child Nutrition, 10, https://doi.org/10.1111/j.1740-8709.2012.00430.x

Pregnancy during adolescence increases the risk of adverse pregnancy outcome, especially risk of small-for gestational-age (SGA) birth, which has been linked to micronutrient deficiencies. Likewise, smoking has been shown to be related with lower mic... Read More about Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants.

Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis (2012)
Journal Article
Hurley, M., Amin Ariff, A., Bertenshaw, C., Bhatt, J., & Smyth, A. R. (2012). Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis. Journal of Cystic Fibrosis, 11(4), https://doi.org/10.1016/j.jcf.2012.02.006

Introduction: Patients with CF experience pulmonary exacerbations. These are often initially empirically treated with intravenous antibiotics, with antibiotic choice refined after susceptibility testing. Methods: We completed a 5-year retrospectiv... Read More about Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis.

Marked variation in newborn resuscitation practice: a national survey in the UK (2012)
Journal Article
Mann, C., Ward, C., Grubb, M., Hayes-Gill, B., Crowe, J., Marlow, N., & Sharkey, D. (2012). Marked variation in newborn resuscitation practice: a national survey in the UK. Resuscitation, 83(5), https://doi.org/10.1016/j.resuscitation.2012.01.002

Abstract Background Although international newborn resuscitation guidance has been in force for some time, there are no UK data on current newborn resuscitation practices. Objective Establish delivery room (DR) resuscitation practices in the UK... Read More about Marked variation in newborn resuscitation practice: a national survey in the UK.

Systematic review of safety in paediatric drug trials published in 2007 (2012)
Journal Article
Nor Aripin, K. N. B., Choonara, I., & Sammons, H. (2012). Systematic review of safety in paediatric drug trials published in 2007. European Journal of Clinical Pharmacology, 68(2), https://doi.org/10.1007/s00228-011-1112-6

Background: There is now greater involvement of children in drug trials to ensure that paediatric medicines are supported by sound scientific evidence. The safety of the participating children is of paramount importance. Previous research shows that... Read More about Systematic review of safety in paediatric drug trials published in 2007.

Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia (2012)
Journal Article
Williams, P. J., Mistry, H. D., & Morgan, L. (2012). Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertension, 2(2), https://doi.org/10.1016/j.preghy.2011.12.001

The transport of folate across the placenta involves a number of different receptors including folate receptor-alpha (FR-?), reduced folate carrier (RFC) and proton coupled folate transporter (PCFT). In addition there are a number of ATP-dependent tr... Read More about Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia.

Compliance with mandatory reporting of clinical trial results on ClinicalTrials.gov: cross sectional study (2012)
Journal Article
Prayle, A., Hurley, M., & Smyth, A. R. (2012). Compliance with mandatory reporting of clinical trial results on ClinicalTrials.gov: cross sectional study. BMJ, 2011(344), Article d7373. https://doi.org/10.1136/bmj.d7373

Objective To examine compliance with mandatory reporting of summary clinical trial results (within one year of completion of trial) on ClinicalTrials.gov for studies that fall under the recent Food and Drug Administration Amendments Act (FDAAA) legis... Read More about Compliance with mandatory reporting of clinical trial results on ClinicalTrials.gov: cross sectional study.