All Outputs (27)

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia (2023)
Journal Article
Calthorpe, R. J., Poulter, C., Smyth, A. R., Sharkey, D., Bhatt, J., Jenkins, G., & Tatler, A. L. (2023). Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia. AJP - Lung Cellular and Molecular Physiology, 324(3), L285-L296. https://doi.org/10.1152/ajplung.00106.2021

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from expo... Read More about Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia.

Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation (2023)
Journal Article
Kwok, T. C., Batey, N., Luu, K. L., Prayle, A., & Sharkey, D. (2023). Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation. Pediatric Research, 94, 43–54. https://doi.org/10.1038/s41390-022-02451-8

Abstract: Prediction models could identify infants at the greatest risk of bronchopulmonary dysplasia (BPD) and allow targeted preventative strategies. We performed a systematic review and meta-analysis with external validation of identified models.... Read More about Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation.

Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland (2022)
Journal Article
Kwok, T. C., Dineen, R. A., Whitehouse, W., Lynn, R. M., McSweeney, N., & Sharkey, D. (2022). Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland. Open Medicine, 17(1), 1417-1424. https://doi.org/10.1515/med-2022-0554

Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in olde... Read More about Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland.

Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets (2022)
Conference Proceeding
Leva, M. C., Patelli, E., Podofillini, L., Wilson, S., Tan, A., Remenyte-Prescott, R., …Sharkey, D. (2022). Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets. In M. Chiara Leva, E. Patelli, L. Podofillini, & S. Wilson (Eds.), Proceedings of the 32nd European Safety and Reliability Conference (ESREL 2022) (489-496). https://doi.org/10.3850/978-981-18-5183-4_R12-08-152-cd

This research is conducted to study variations in the Newborn Life Support procedure. This procedure follows an evidence-based protocol to resuscitate and stabilize newborn babies requiring assistance at birth. Errors and ineffective actions in this... Read More about Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets.

Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic (2022)
Journal Article
Hanley, S. J., Jones, A. B., Oberman, J., Baxter, E., Sharkey, D., Gray, J., & Walker, K. F. (2022). Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.018

Background: This study aimed to explore the successes and barriers to the implementation of Public Health England (PHE) infection prevention and control guidance in English maternity units during the COVID-19 pandemic. Methods: Qualitative semi-struc... Read More about Implementation of Public Health England infection prevention and control guidance in maternity units in response to the COVID-19 pandemic.

Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice (2022)
Journal Article
Hanley, S., Raybould, G., Baxter, E., Gray, J., Sharkey, D., & Walker, K. F. (2022). Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2022.04.019

Introduction: The rapidly evolving COVID-19 pandemic required systemic change in how healthcare was delivered to minimize virus transmission whilst maintaining safe service delivery. Deemed at ‘moderate-high risk’, maternity patients are an important... Read More about Maternity services' responses to the COVID-19 pandemic: how Public Health England guidance was implemented in practice.

Application and potential of artificial intelligence in neonatal medicine (2022)
Journal Article
Chang Kwok, T., Henry, C., Saffaran, S., Meeus, M., Bates, D., Van Laere, D., …Sharkey, D. (2022). Application and potential of artificial intelligence in neonatal medicine. Seminars in Fetal and Neonatal Medicine, 27(5), Article 101346. https://doi.org/10.1016/j.siny.2022.101346

Neonatal care is becoming increasingly complex with large amounts of rich, routinely recorded physiological, diagnostic and outcome data. Artificial intelligence (AI) has the potential to harness this vast quantity and range of information and become... Read More about Application and potential of artificial intelligence in neonatal medicine.

Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018 (2022)
Journal Article
Mistry, A., Shipley, L., Ojha, S., & Sharkey, D. (2022). Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(6), 597-602. https://doi.org/10.1136/archdischild-2021-322906

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.... Read More about Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants (2022)
Journal Article
Henry, C., Shipley, L., Morgan, S., Crowe, J. A., Carpenter, J., Hayes-Gill, B., & Sharkey, D. (2022). Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants. Neonatology, 119(2), 264-267. https://doi.org/10.1159/000521530

Background: International newborn resuscitation guidelines recommend electrocardiogram (ECG) heart rate (HR) monitoring at birth. We evaluated the application time of pre-set ECG electrodes fixed to a polyethene patch allowing adhesive-free attachmen... Read More about Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants.

Observational cohort study of changing trends in non-invasive ventilation in very preterm infants and associations with clinical outcomes (2021)
Journal Article
Sand, L., Szatkowski, L., Kwok, T. C., Sharkey, D., Todd, D. A., Budge, H., & Ojha, S. (2022). Observational cohort study of changing trends in non-invasive ventilation in very preterm infants and associations with clinical outcomes. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(2), 150-155. https://doi.org/10.1136/archdischild-2021-322390

Objective: To determine the change in non-invasive ventilation (NIV) use over time in infants born at

Temporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study (2021)
Journal Article
Shipley, L., Hyliger, G., & Sharkey, D. (2022). Temporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(2), 201-205. https://doi.org/10.1136/archdischild-2021-322195

Objective Early postnatal transfer (PNT) of extremely preterm infants is associated with adverse outcomes compared with in utero transfer (IUT). We aimed to explore recent national trends of IUT and early PNT. Design Observational cohort study... Read More about Temporal trends of in utero and early postnatal transfer of extremely preterm infants between 2011 and 2016: a UK population study.

Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis (2021)
Journal Article
Shipley, L., Mistry, A., & Sharkey, D. (2021). Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis. Archives of Disease in Childhood. Fetal and Neonatal Edition, Article fetalneonatal-2020-320966. https://doi.org/10.1136/archdischild-2020-320966

Airflow dispersion during common neonatal resuscitation procedures: A simulation study (2021)
Journal Article
Kwok, T. C., Swaby, R., & Sharkey, D. (2021). Airflow dispersion during common neonatal resuscitation procedures: A simulation study. Pediatric Pulmonology, 56(7), 2057-2066. https://doi.org/10.1002/ppul.25378

Background Aerosol generating medical procedures (AGMPs) are common during newborn resuscitation. Neonates with respiratory viruses such as severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) infection may pose a risk to healthcare workers.... Read More about Airflow dispersion during common neonatal resuscitation procedures: A simulation study.

Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study (2021)
Journal Article
Shipley, L., Gale, C., & Sharkey, D. (2021). Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 106(5), https://doi.org/10.1136/archdischild-2020-320902

Objective: Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of neonatal mortality and neurodisability. We aimed to determine the incidence of HIE and management patterns against national guidelines. Design: Retrospective cohort study... Read More about Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study.

Smartphone monitoring of in-ambulance vibration and noise (2021)
Journal Article
Partridge, T., Gherman, L., Morris, D., Light, R., Leslie, A., Sharkey, D., …Crowe, J. (2021). Smartphone monitoring of in-ambulance vibration and noise. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 235(4), 428-436. https://doi.org/10.1177/0954411920985994

Transferring sick premature infants between hospitals increases the risk of severe brain injury, potentially linked to the excessive exposure to noise, vibration and driving-related accelerations. One method of reducing these levels may be to travel... Read More about Smartphone monitoring of in-ambulance vibration and noise.

Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance (2020)
Journal Article
Gale, C., Quigley, M. A., Placzek, A., Knight, M., Ladhani, S., Draper, E. S., …Kurinczuk, J. J. (2021). Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. Lancet Child and Adolescent Health, 5(2), 113-121. https://doi.org/10.1016/S2352-4642%2820%2930342-4

Background: Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aime... Read More about Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Accurate neonatal heart rate monitoring using a new wireless, cap mounted device (2020)
Journal Article
Henry, C., Shipley, L., Ward, C., Mirahmadi, S., Liu, C., Morgan, S., …Sharkey, D. (2020). Accurate neonatal heart rate monitoring using a new wireless, cap mounted device. Acta Paediatrica, 110(1), 72-78. https://doi.org/10.1111/apa.15303

© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica Aim: A device for newborn heart rate (HR) monitoring at birth that is compatible with delayed cord clamping and minimises hypothermia r... Read More about Accurate neonatal heart rate monitoring using a new wireless, cap mounted device.

Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements (2019)
Journal Article
Pickup, L., Lang, A., Shipley, L., Henry, C., Carpenter, J., McCartney, D., …Sharkey, D. (2019). Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements. JMIR Human Factors, 6(2), Article e12055. https://doi.org/10.2196/12055

Background: A novel medical device has been developed to address an unmet need of standardizing and facilitating heart rate recording during neonatal resuscitation. In a time-critical emergency resuscitation, where failure can mean death of an infant... Read More about Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements.

Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article
Shipley, L. J., Gyorkos, T., Jon, D., Tata, L. J., Lisa, S., & Sharkey, D. (2019). Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age. Pediatric Critical Care Medicine, 20(7), 638-644. https://doi.org/10.1097/PCC.0000000000001937

Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More about Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age.

Postnatal gestational age estimation of newborns using Small Sample Deep Learning (2018)
Journal Article
Torres Torres, M., Valstar, M., Henry, C., Ward, C., & Sharkey, D. (2019). Postnatal gestational age estimation of newborns using Small Sample Deep Learning. Image and Vision Computing, 83-84, 87-99. https://doi.org/10.1016/j.imavis.2018.09.003

© 2018 A baby's gestational age determines whether or not they are premature, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these are expensive, require traine... Read More about Postnatal gestational age estimation of newborns using Small Sample Deep Learning.