The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison

Smyth, A.R.; Knox, A.J.; Prayle, A.P.; Jain, K.; Touw, D.J.; Koch, B.C.P.; Knox, Alan J.; Watson, A.; Smyth, Alan R.

doi:10.1016/j.jcf.2015.07.012

All Outputs (1)

The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison (2015)
Journal Article
Smyth, A., Knox, A., Prayle, A., Jain, K., Touw, D., Koch, B., …Smyth, A. R. (2016). The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison. Journal of Cystic Fibrosis, 15(4), 510-517. https://doi.org/10.1016/j.jcf.2015.07.012

Background: Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity.... Read More about The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison.