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The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study (2013)
Journal Article
Varyani, F., Card, T. R., Kaye, P., Aithal, G. P., & West, J. (2013). The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study. BMC Health Services Research, 13(161), Article 161. https://doi.org/10.1186/1472-6963-13-161

Background Autoimmune Hepatitis is a chronic liver disease which affects young people and can result in liver failure leading to death or transplantation yet there is a lack of information on the incidence and prevalence of this disease and its natu... Read More about The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study.

Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia (2013)
Journal Article
Thomas, S. A., Walker, M. F., Macniven, J. A., Haworth, H., & Lincoln, N. (2013). Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia. Clinical Rehabilitation, 27(5), https://doi.org/10.1177/0269215512462227

Objective: The aim was to evaluate behavioural therapy as a treatment for low mood in people with aphasia. Design: A randomized controlled trial comparing behavioural therapy plus usual care with a usual care control. Potential participants with... Read More about Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia.

Participant experiences of mobile device-based diary studies (2013)
Journal Article
Sun, X., Golightly, D., Cranwell, J., Bedwell, B. D., & Sharples, S. (2013). Participant experiences of mobile device-based diary studies. International Journal of Mobile Human Computer Interaction, 5(2), https://doi.org/10.4018/jmhci.2013040104

Mobile device-based diary studies have potential as contextual data capture methods that address the limitations of the traditional paper-based diary method. While there have been a number of studies that demonstrate the power of the mobile device-ba... Read More about Participant experiences of mobile device-based diary studies.

Accelerating fibre orientation estimation from diffusion weighted magnetic resonance imaging using GPUs (2013)
Journal Article
Hernández, M., Guerrero, G. D., Cecilia, J. M., García, J. M., Inuggi, A., Jbabdi, S., …Sotiropoulos, S. N. (2013). Accelerating fibre orientation estimation from diffusion weighted magnetic resonance imaging using GPUs. PLoS ONE, 8(4), Article e61892. https://doi.org/10.1371/journal.pone.0061892

With the performance of central processing units (CPUs) having effectively reached a limit, parallel processing offers an alternative for applications with high computational demands. Modern graphics processing units (GPUs) are massively parallel pro... Read More about Accelerating fibre orientation estimation from diffusion weighted magnetic resonance imaging using GPUs.

Role of oral teriflunomide in the management of multiple sclerosis (2013)
Journal Article
Tanasescu, R., Evangelou, N., & Constantinescu, C. S. (2013). Role of oral teriflunomide in the management of multiple sclerosis. Neuropsychiatric Disease and Treatment, 9, https://doi.org/10.2147/NDT.S31248

The landscape of the treatment of relapsing–remitting multiple sclerosis is changing fast. Several oral treatments have shown benefit and generate much interest because of the convenience of their administration. Two oral compounds, fingolimod and te... Read More about Role of oral teriflunomide in the management of multiple sclerosis.

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics (2013)
Journal Article
Rodriguez Gutierrez, D., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics. Neuro-Oncology, 15(8), https://doi.org/10.1093/neuonc/not034

Background Assessment of treatment response by measuring tumor size is known to be a late and potentially confounded response index. Serial diffusion MRI has shown potential for allowing earlier and possibly more reliable response assessment in a... Read More about Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics.

Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise (2013)
Journal Article
Simpson, R. C., Thomas, K., Leighton, P., & Murphy, R. (in press). Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. British Journal of Dermatology, 169(2), https://doi.org/10.1111/bjd.12334

Background: There is no defined set of criteria for diagnosing erosive lichen planus affecting the vulva (ELPV) and there is geographical variation in management. Objectives: To reach consensus on clinicopathological diagnostic criteria for ELPV.... Read More about Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise.

Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes (2013)
Journal Article
Matsa, E., Dixon, J. E., Medway, C., Georgiou, O., Patel, M. J., Morgan, K., …Denning, C. (2014). Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. European Heart Journal, 35(16), 1078-1087. https://doi.org/10.1093/eurheartj/eht067

Aims Long-QT syndromes (LQTS) are mostly autosomal-dominant congenital disorders associated with a 1:1000 mutation frequency, cardiac arrest, and sudden death. We sought to use cardiomyocytes derived from human-induced pluripotency stem cells (hiPSCs... Read More about Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.

Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice (2013)
Journal Article
Scullion, G. A., Hewitt, K. N., & Pardon, M. (2013). Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice. Journal of Alzheimer's Disease, 34(3), 781-793. https://doi.org/10.3233/JAD-122164

A lifestyle rich in physical and mental activities protects against Alzheimer's disease (AD) but the underlying mechanisms are unclear. We have proposed that this is mediated by a stress response and have shown that repeated exposure to novelty stres... Read More about Corticotropin-releasing factor receptor 1 activation during exposure to novelty stress protects against alzheimer's disease-like cognitive decline in A?PP/PS1 Mice.

Current status of drug screening and disease modelling in human pluripotent stem cells (2013)
Journal Article
Rajamohan, D., Matsa, E., Kalra, S., Crutchley, J., Patel, A., George, V., & Denning, C. (2013). Current status of drug screening and disease modelling in human pluripotent stem cells. BioEssays, 35(3), https://doi.org/10.1002/bies.201200053

The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overc... Read More about Current status of drug screening and disease modelling in human pluripotent stem cells.

Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: reducing the noise floor using SENSE (2013)
Journal Article
Sotiropoulos, S., Moeller, S., Jbabdi, S., Xu, J., Andersson, J., Auerbach, E., …Lenglet, C. (2013). Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: reducing the noise floor using SENSE. Magnetic Resonance in Medicine, 70(6), https://doi.org/10.1002/mrm.24623

Purpose: To examine the effects of the reconstruction algorithm of magnitude images from multi-channel diffusion MRI on fibre orientation estimation. Theory and Methods: It is well established that the method used to combine signals from different c... Read More about Effects of image reconstruction on fiber orientation mapping from multichannel diffusion MRI: reducing the noise floor using SENSE.

Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack (2013)
Journal Article
Barata, L., Miwa, T., Sato, S., Kim, D., Mohammed, I., & Song, W. (2013). Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack. Journal of Immunology, 190(6), 2886-2895. https://doi.org/10.4049/jimmunol.1202536

Complement receptor 1-related gene/protein y (Crry) and decay-accelerating factor (DAF) are two murine membrane C3 complement regulators with overlapping functions. Crry deletion is embryonically lethal whereas DAF-deficient mice are generally health... Read More about Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack.

Feasibility of offering nicotine replacement therapy as a relapse prevention treatment in routine smoking cessation services (2013)
Journal Article
Turner, J., McNeill, A., Coleman, T., Bee, J. L., & Agboola, S. (2013). Feasibility of offering nicotine replacement therapy as a relapse prevention treatment in routine smoking cessation services. BMC Health Services Research, 13(38), Article 38. https://doi.org/10.1186/1472-6963-13-38

Background: National Health Service stop smoking services (NHS SSS) in the UK offer cost- effective smoking cessation services. Despite high abstinence rates after acute cessation treatment, the majority of clients have relapsed by one year. Severa... Read More about Feasibility of offering nicotine replacement therapy as a relapse prevention treatment in routine smoking cessation services.

A randomised controlled pilot study: the effectiveness of narrative exposure therapy with adult survivors of the Sichuan earthquake (2013)
Journal Article
Zang, Y., Hunt, N., & Cox, T. (2013). A randomised controlled pilot study: the effectiveness of narrative exposure therapy with adult survivors of the Sichuan earthquake. BMC Psychiatry, 13, Article 41. https://doi.org/10.1186/1471-244X-13-41

Background: Post-Traumatic Stress Disorder (PTSD) is a common psychological reaction after large-scale natural disasters. Given the number of people involved and shortage of resources in any major disaster, brief, pragmatic and easily trainable int... Read More about A randomised controlled pilot study: the effectiveness of narrative exposure therapy with adult survivors of the Sichuan earthquake.

Determinants of arterial stiffness in chronic kidney disease stage 3 (2013)
Journal Article
McIntyre, N. J., Fluck, R. J., McIntyre, C. W., Fakis, A., & Taal, M. W. (2013). Determinants of arterial stiffness in chronic kidney disease stage 3. PLoS ONE, 8(1), Article 6. https://doi.org/10.1371/journal.pone.0055444

Background: Early chronic kidney disease (CKD) is associated with increased cardiovascular (CV) risk but underlying mechanisms remain uncertain. Arterial stiffness (AS) is associated with increased CV risk in advanced CKD, but it is unclear whether A... Read More about Determinants of arterial stiffness in chronic kidney disease stage 3.

RubiX: combining spatial resolutions for Bayesian inference of crossing fibers in diffusion MRI (2013)
Journal Article
Sotiropoulos, S., Jbabdi, S., Andersson, J., Woolrich, M., Ugurbil, K., & Behrens, T. (2013). RubiX: combining spatial resolutions for Bayesian inference of crossing fibers in diffusion MRI. IEEE Transactions on Medical Imaging, 32(6), https://doi.org/10.1109/TMI.2012.2231873

The trade-off between signal-to-noise ratio (SNR) and spatial specificity governs the choice of spatial resolution in magnetic resonance imaging (MRI); diffusion-weighted (DW) MRI is no exception. Images of lower resolution have higher signal to nois... Read More about RubiX: combining spatial resolutions for Bayesian inference of crossing fibers in diffusion MRI.

Cost-effectiveness of supported self-management for CFS/ME patients in primary care (2013)
Journal Article
Richardson, G., Epstein, D., Chew-Graham, C., Dowrick, C., Bentall, R. P., Morriss, R. K., …Wearden, A. J. (2013). Cost-effectiveness of supported self-management for CFS/ME patients in primary care. BMC Family Practice, 14(Januar), Article 9. https://doi.org/10.1186/1471-2296-14-12

Background: Nurse led self-help treatments for people with chronic fatigue syndrome/myalgic encephalitis (CFS/ME) have been shown to be effective in reducing fatigue but their cost-effectiveness is unknown. Methods: Cost-effectiveness analysis... Read More about Cost-effectiveness of supported self-management for CFS/ME patients in primary care.

The topographic connectome (2013)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., & Behrens, T. E. (2013). The topographic connectome. Current Opinion in Neurobiology, 23(2), https://doi.org/10.1016/j.conb.2012.12.004

Central to macro-connectomics and much of systems neuroscience is the idea that we can summarise macroscopic brain connectivity using a network of ‘nodes’ and ‘edges’ — functionally distinct brain regions and the connections between them. This is an... Read More about The topographic connectome.

Native Apps versus Web Apps: which is best for healthcare applications? (2013)
Journal Article
Selvarajah, K., Craven, M. P., Massey, A., Crowe, J., Vedhara, K., & Raine-Fenning, N. (2013). Native Apps versus Web Apps: which is best for healthcare applications?. Lecture Notes in Artificial Intelligence, 8005, https://doi.org/10.1007/978-3-642-39262-7_22

Smartphone applications (Apps) provide a new way to deliver healthcare, illustrated by the fact that healthcare Apps are estimated to make up over 30% of new Apps currently being developed; with this number seemingly set to increase as the benefits b... Read More about Native Apps versus Web Apps: which is best for healthcare applications?.

Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study (2012)
Journal Article
Garrud, P., & Yates, J. (2012). Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study. BMC Medical Education, 12(Decemb), Article 8. https://doi.org/10.1186/1472-6920-12-124

Background 10-15% of students struggle at some point in their medicine course. Risk factors include weaker academic qualifications, male gender, mental illness, UK ethnic minority status, and poor study skills. Recent research on an undergraduate... Read More about Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study.