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Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders (2020)
Journal Article
Goh, J. Y., O'Sullivan, S. E., Shortall, S. E., Zordan, N., Piccinini, A. M., Potter, H. G., …King, M. V. (2020). Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders. Brain, Behavior, and Immunity, 89, 100-117. https://doi.org/10.1016/j.bbi.2020.05.076

© 2020 Elsevier Inc. Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents,... Read More about Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders.

Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival (2020)
Journal Article
Joseph, C., Alsaleem, M., Orah, N., Narasimha, P. L., Miligy, I. M., Kurozumi, S., …Rakha, E. A. (2020). Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast Cancer Research and Treatment, 182, 267–282. https://doi.org/10.1007/s10549-020-05670-x

Purpose: MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion molecules and cytokines. This study aims to assess the prognostic value of... Read More about Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival.

Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir (2020)
Journal Article
Beji, O., Gillis, R. B., Dinu, V., Jiwani, S. I., Gyasi-Antwi, P., Fisk, I. D., …Adams, G. G. (2020). Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir. European Journal of Pharmaceutics and Biopharmaceutics, 152, 340-347. https://doi.org/10.1016/j.ejpb.2020.05.016

© 2020 Elsevier B.V. Purpose: Insulin, in typical use, undergoes multiple changes in temperature; from refrigerator, to room temperature, to body temperature. Although long-term storage temperature has been well-studied, the short term changes to ins... Read More about Exploration of temperature and shelf-life dependency of the therapeutically available Insulin Detemir.

Correlation between breast cancer and lifestyle within the Gulf Cooperation Council countries: A systematic review (2020)
Journal Article
Tanner, L. T. A., & Cheung, K. L. (2020). Correlation between breast cancer and lifestyle within the Gulf Cooperation Council countries: A systematic review. World Journal of Clinical Oncology, 11(4), 217-242. https://doi.org/10.5306/wjco.v11.i4.217

BACKGROUND In the six Gulf Cooperation Council countries (GCCCs), Bahrain, Saudi Arabia, Kuwait, Oman, Qatar and the United Arab Emirates, breast cancer (BC) is the greatest cause of cancer incidence and mortality. Obesity and physical inactivity ar... Read More about Correlation between breast cancer and lifestyle within the Gulf Cooperation Council countries: A systematic review.

Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose (2020)
Journal Article
van Munster, J. M., Daly, P., Blythe, M. J., Ibbett, R., Kokolski, M., Gaddipati, S., …Archer, D. B. (2020). Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose. Biotechnology for Biofuels, 13(1), Article 69. https://doi.org/10.1186/s13068-020-01702-2

Background Understanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in investigating fungal degradation d... Read More about Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose.

Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups (2020)
Journal Article
Taylor, C., Tan, S., McClaughry, R., & Sharkey, D. (2020). Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups. Neonatology, 117(4), 513–516. https://doi.org/10.1159/000506427

Background: Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as... Read More about Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups.

The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men (2020)
Journal Article
Davies, R. W., Bass, J. J., Carson, B. P., Norton, C., Kozior, M., Wilkinson, D. J., …Jakeman, P. M. (2020). The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men. Nutrients, 12(3), Article 845. https://doi.org/10.3390/nu12030845

Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). Methods: In a double-blind random... Read More about The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men.

Treatment strategies and survival outcomes in breast cancer (2020)
Journal Article
Cheung, K. L. (2020). Treatment strategies and survival outcomes in breast cancer. Cancers, 12(3), https://doi.org/10.3390/cancers12030735

Treatment strategies for breast cancer are wide-ranging and often based on a multi-modality approach, depending on the stage and biology of the tumour and the acceptance and tolerance of the patient. They may include surgery, radiotherapy, and system... Read More about Treatment strategies and survival outcomes in breast cancer.

A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids (2020)
Journal Article
Stamatopoulos, K., Pathak, S., Marciani, L., & Turner, D. (2020). A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids. Molecular Pharmaceutics, 17(4), 1310-1323. https://doi.org/10.1021/acs.molpharmaceut.0c00019

In vivo studies have shown cyclic bile salt (BS) outputs during fasting whereas higher amounts have been observed in fed states. This leads to fluctuations of intestinal BS concentrations ([BS]) that can affect the rate and extent of absorption of li... Read More about A Population-based PBPK Model for the Prediction of Time-Variant Bile Salt Disposition within GI Luminal Fluids.

Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review (2020)
Journal Article
Meek, C., Topcu, G., Moghaddam, N., & das Nair, R. (2021). Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review. Disability and Rehabilitation, 43(22), 3135-3146 . https://doi.org/10.1080/09638288.2020.1734105

Purpose: To provide an overview of the experiences and needs of patients adjusting to life after receiving a diagnosis of secondary progressive multiple sclerosis (SPMS). Method: We conducted a meta-ethnographic synthesis of qualitative studies on... Read More about Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review.

High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial (2020)
Journal Article
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., …Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate Cancer and Prostatic Diseases, 23, 696–704. https://doi.org/10.1038/s41391-020-0219-1

Objectives To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks. Subjects/patients and methods A randomised... Read More about High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial.

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings (2020)
Journal Article
McColl, B. W., Allan, S. M., McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., …Quinn, T. J. (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), 1402-1414. https://doi.org/10.1177/0271678x20910552

© The Author(s) 2020. Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine unde... Read More about UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings.

Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men (2020)
Journal Article
Swiecicka, A., Piasecki, M., Stashuk, D., Jones, D., Wu, F., McPhee, J., & Rutter, M. K. (2020). Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men. Journal of Clinical Endocrinology and Metabolism, 105(7), https://doi.org/10.1210/clinem/dgaa100

Context Anabolic hormones are important factors in maintaining muscle mass for ageing men, but their role in overall motor unit structure and function is unclear. Objective To determine associations of anabolic and reproductive hormone levels wi... Read More about Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men.

Evaluation of liver function tests and risk score assessment to screen patients for significant liver disease prior to bariatric and metabolic surgery (2020)
Journal Article
Antipass, A., Austin, A., Awad, S., Hughes, D., & Idris, I. (2020). Evaluation of liver function tests and risk score assessment to screen patients for significant liver disease prior to bariatric and metabolic surgery. Obesity Surgery, 30, 2840–2843. https://doi.org/10.1007/s11695-020-04486-4

Bariatric and metabolic surgery is associated with significant improvement in obesity-related comorbidities, but for patients with non-alcoholic fatty liver disease (NAFLD), clinical outcomes are dependent on the severity of liver disease, i.e. impro... Read More about Evaluation of liver function tests and risk score assessment to screen patients for significant liver disease prior to bariatric and metabolic surgery.

European Society for Sexual Medicine Position Statement “Assessment and Hormonal Management in Adolescent and Adult Trans People, With Attention for Sexual Function and Satisfaction” (2020)
Journal Article
T'Sjoen, G., Arcelus, J., De Vries, A. L. C., Fisher, A. D., Nieder, T. O., Motmans, J., & Ozer, M. (2020). European Society for Sexual Medicine Position Statement “Assessment and Hormonal Management in Adolescent and Adult Trans People, With Attention for Sexual Function and Satisfaction”. Journal of Sexual Medicine, 17(4), 570-584. https://doi.org/10.1016/j.jsxm.2020.01.012

Background There is a general lack of recommendations for and basic information tailored at sexologists and other health-care professionals for when they encounter trans people in their practice. Aim We present to clinicians an up-to-date over... Read More about European Society for Sexual Medicine Position Statement “Assessment and Hormonal Management in Adolescent and Adult Trans People, With Attention for Sexual Function and Satisfaction”.

The student is key: a realist review of educational interventions to develop analytical and non-analytical clinical reasoning ability (2020)
Journal Article
Richmond, A., Cooper, N., Gay, S., Atiomo, W., & Patel, R. (2020). The student is key: a realist review of educational interventions to develop analytical and non-analytical clinical reasoning ability. Medical Education, 54(8), 709-719. https://doi.org/10.1111/medu.14137

Background Clinical reasoning refers to the cognitive processes used by individuals as they formulate a diagnosis or treatment plan. Clinical reasoning is dependent on formal and experiential knowledge. Developing the ability to acquire and recall k... Read More about The student is key: a realist review of educational interventions to develop analytical and non-analytical clinical reasoning ability.

Lifestyle matters randomized controlled trial of a preventive health intervention for older people: Qualitative sub study with participants and intervention facilitators (2020)
Journal Article
Mountain, G., Sprange, K., & Chatters, R. (2020). Lifestyle matters randomized controlled trial of a preventive health intervention for older people: Qualitative sub study with participants and intervention facilitators. Clinical Interventions in Aging, 15, 239-253. https://doi.org/10.2147/CIA.S232108

© 2020 Mountain et al. Objective: This qualitative study embedded within a randomized controlled trial was conducted to explore the acceptability, experiences of, and short-term impact of a preventive health intervention (Lifestyle Matters) from the... Read More about Lifestyle matters randomized controlled trial of a preventive health intervention for older people: Qualitative sub study with participants and intervention facilitators.

Exploring participation after paediatric acquired brain injury (2020)
Journal Article
Keetley, R., Westwater-Wood, S., & Manning, J. C. (2021). Exploring participation after paediatric acquired brain injury. Journal of Child Health Care, 25(1), 81-92. https://doi.org/10.1177/1367493520905673

This study aimed to explore the levels of participation in a UK sample of children and young people (CYP) with an acquired brain injury (ABI) at home, school and in the community. The purpose of this study was to assess the feasibility of undertaking... Read More about Exploring participation after paediatric acquired brain injury.

Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI (2020)
Journal Article
Iwabuchi, S. J., Xing, Y., Cottam, W. J., Drabek, M. M., Tadjibaev, A., Fernandes, G. S., …Auer, D. P. (2020). Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI. PAIN, 161(6), 1255-1263. https://doi.org/10.1097/j.pain.0000000000001829

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity, for example, in postoperative pain after knee replacement. Other factors such as low mood,... Read More about Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Intermachine Variation of Ultrasound Strain Elastographic Measures of the Quadriceps and Patellar Tendons in Healthy Participants: Implications for Clinical Practice (2020)
Journal Article
Dickson, D. M., Fawole, H. O., Hendry, G. J., & Smith, S. L. (2020). Intermachine Variation of Ultrasound Strain Elastographic Measures of the Quadriceps and Patellar Tendons in Healthy Participants: Implications for Clinical Practice. Journal of Ultrasound in Medicine, 39(7), 1343-1353. https://doi.org/10.1002/jum.15228

Objectives To evaluate intermachine variation and compare intraoperator and interoperator agreement and repeatability characteristics of 2 ultrasound (US) systems for measurements of quadriceps and patellar tendons by strain elastography (SE). Me... Read More about Intermachine Variation of Ultrasound Strain Elastographic Measures of the Quadriceps and Patellar Tendons in Healthy Participants: Implications for Clinical Practice.