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All Outputs (12)

Methodology for Digital Transformation: A Continuous Improvement Approach (2023)
Conference Proceeding
Hernández Oliver, K., Martínez-Arellano, G., & Segal, J. (2023). Methodology for Digital Transformation: A Continuous Improvement Approach. In 1st Workshop on Low-Cost Digital Solutions for Industrial Automation

Digital technologies have the potential to significantly transform the manufacturing industry by achieving improvements in productivity, quality and sustainability. Despite this, the uptake is relatively low as companies face a number of challenges i... Read More about Methodology for Digital Transformation: A Continuous Improvement Approach.

Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study (2023)
Conference Proceeding
Hernández Oliver, K. H., Martínez-Arellano, G., & Segal, J. (2023). Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study. In 1st Workshop on Low-Cost Digital Solutions for Industrial Automation

The use of digital technologies around the world has increased considerably, modifying the way in which daily activities are conducted. The manufacturing sector is no exception. Over the last decade, digital technologies have become a key element for... Read More about Low-cost System for Visual Inspection of Corrosion: An Industrial Case Study.

Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma (2020)
Journal Article
Sabri, A. H., Cater, Z., Gurnani, P., Ogilvie, J., Segal, J., Scurr, D. J., & Marlow, M. (2020). Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma. International Journal of Pharmaceutics, 589, Article 119808. https://doi.org/10.1016/j.ijpharm.2020.119808

Despite being one of the most efficacious drugs used in the treatment of basal cell carcinoma (BCC), imiquimod has limited cutaneous permeation. The current work presents the development of polyvinylpyrrolidone-co-vinyl acetate (PVPVA) microneedles l... Read More about Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma.

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules (2020)
Journal Article
Sabri, A., Ogilvie, J., McKenna, J., Segal, J., Scurr, D., & Marlow, M. (2020). Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules. Molecular Pharmaceutics, 17(8), 2925–2937. https://doi.org/10.1021/acs.molpharmaceut.0c00347

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in humans. One of the most efficacious drugs used in the management of BCC is the immunomodulator, imiquimod. However, imiquimod has physiochemical properties that limit its permeatio... Read More about Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules.

Characterisation of mechanical insertion of commercial microneedles (2020)
Journal Article
Sabri, A. H., Cater, Z., Ogilvie, J., Scurr, D. J., Marlow, M., & Segal, J. (2020). Characterisation of mechanical insertion of commercial microneedles. Journal of Drug Delivery Science and Technology, 58, https://doi.org/10.1016/j.jddst.2020.101766

The protection provided by the human skin is mostly attributed to the stratum corneum. However, this barrier also limits the range of molecules that can be delivered into and across the skin. One of the methods to overcome this physiological barrier... Read More about Characterisation of mechanical insertion of commercial microneedles.

Multi-material 3D bioprinting of porous constructs for cartilage regeneration (2019)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2020). Multi-material 3D bioprinting of porous constructs for cartilage regeneration. Materials Science and Engineering: C, 109, https://doi.org/10.1016/j.msec.2019.110578

© 2020 Elsevier B.V. The current gold standard for nasal reconstruction after rhinectomy or severe trauma includes transposition of autologous cartilage grafts in conjunction with coverage using an autologous skin flap. Harvesting autologous cartilag... Read More about Multi-material 3D bioprinting of porous constructs for cartilage regeneration.

Improving children’s and their visitors’ hand hygiene compliance (2019)
Journal Article
Lary, D., Calvert, A., Nerlich, B., Segal, J., Vaughan, N., Randle, J., & Hardie, K. (2020). Improving children’s and their visitors’ hand hygiene compliance. Journal of Infection Prevention, 21(2), 60-67. https://doi.org/10.1177/1757177419892065

Background: Numerous interventions have tried to improve healthcare workers' hand hygiene compliance, however little attention has been paid to children's and their visitors’ compliance. Aim: To increase children’s and visitors’ compliance using in... Read More about Improving children’s and their visitors’ hand hygiene compliance.

VOLCO: a predictive model for 3D printed microarchitecture (2018)
Journal Article
Gleadall, A., Ashcroft, I., & Segal, J. (in press). VOLCO: a predictive model for 3D printed microarchitecture. Additive Manufacturing, 21, https://doi.org/10.1016/j.addma.2018.04.004

Extrusion-based 3D printing is widely used for porous scaffolds in which polymer filaments are extruded in the form of log-pile structures. These structures are typically designed with the assumption that filaments have a continuous cylindrical profi... Read More about VOLCO: a predictive model for 3D printed microarchitecture.

Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses (2017)
Journal Article
Stuart, B. W., Gimeno-Fabra, M., Segal, J., Ahmed, I., & Grant, D. M. (2017). Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses. Applied Surface Science, 416, 605-617. https://doi.org/10.1016/j.apsusc.2017.04.110

Here we show the deposition of 2.7 μm thick phosphate based glass films produced by magnetron sputtering, followed by post heat treatments at 500 °C. Variations in degradation properties pre and post heat treatment were attributed to the formation of... Read More about Mechanical, structural and dissolution properties of heat treated thin-film phosphate based glasses.

Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing (2016)
Journal Article
Ruiz-Cantu, L., Gleadall, A., Faris, C., Segal, J., Shakesheff, K., & Yang, J. (2016). Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing. Biofabrication, 8(1), Article 015016. https://doi.org/10.1088/1758-5090/8/1/015016

© 2016 IOP Publishing Ltd. 3D printing is of great interest for tissue engineering scaffolds due to the ability to form complex geometries and control internal structures, including porosity and pore size. The porous structure of scaffolds plays an i... Read More about Characterisation of the surface structure of 3D printed scaffolds for cell infiltration and surgical suturing.

A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing (2014)
Journal Article
Rogers, C. M., Morris, G. E., Gould, T. W., Bail, R., Toumpaniari, S., Harrington, H., …Rose, F. R. A. J. (2014). A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing. Biofabrication, 6(3), 035003. https://doi.org/10.1088/1758-5082/6/3/035003

Electrospinning is a common technique used to fabricate fibrous scaffolds for tissue engineering applications. There is now growing interest in assessing the ability of collector plate design to influence the patterning of the fibres during the elect... Read More about A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing.