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Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China (2017)
Journal Article
Tian, A., Li, G., Elsheikha, H. M., Gardner, D., Zhang, X., Dong, W., …Zhu, X. (2017). Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China. Epidemiology and Infection, 145(11), 2296-2302. https://doi.org/10.1017/S0950268817001327

The role of the protozoan parasite Toxoplasma gondii in the pathogenesis of liver disease has recently gained much interest. The aim of this study was to determine the prevalence and risk factors associated with T. gondii infection in patients with l... Read More about Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China.

Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat (2017)
Journal Article
Posporis, C., Grau-Roma, L., Travetti, O., Oliveira, M., Polledo, L., & Wessmann, A. (2017). Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat. Journal of Feline Medicine and Surgery Open Reports, 3(2), https://doi.org/10.1177/2055116917742812

A 12-year-old domestic shorthair cat was presented with acute non-painful hindlimb proprioceptive ataxia localising to T3–L3 spinal cord segments. MRI revealed paravertebral muscular hyperintensity on T2-weighted images at the level of T7–T8 vertebra... Read More about Meningeal carcinomatosis and spinal cord infiltration caused by a locally invasive pulmonary adenocarcinoma in a cat.

A retrospective review of western lowland gorilla (gorilla, gorilla, gorilla) mortality in European zoological collections between 2004 and 2014 (2017)
Journal Article
Strong, V., Baiker, K., Brennan, M. L., Redrobe, S., Rietkerk, F., Cobb, M., & White, K. (2017). A retrospective review of western lowland gorilla (gorilla, gorilla, gorilla) mortality in European zoological collections between 2004 and 2014. Journal of Zoo and Wildlife Medicine, 48(2), https://doi.org/10.1638/2016-0132R.1

An understanding of the main causes of mortality among captive gorillas is imperative to promoting their optimal care, health, and welfare. A retrospective observational review of mortality among the European zoo–housed western lowland gorilla (Goril... Read More about A retrospective review of western lowland gorilla (gorilla, gorilla, gorilla) mortality in European zoological collections between 2004 and 2014.

Validation of an improved computer-assisted technique for mining free-text electronic medical records (2017)
Journal Article
Duz, M., Marshall, J. F., & Parkin, T. (in press). Validation of an improved computer-assisted technique for mining free-text electronic medical records. JMIR Medical Informatics, 5(2), Article e17. https://doi.org/10.2196/medinform.7123

Background: The use of electronic medical records (EMRs) offers opportunity for clinical epidemiological research. With large EMR databases, automated analysis processes are necessary but require thorough validation before they can be routinely used.... Read More about Validation of an improved computer-assisted technique for mining free-text electronic medical records.

Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice (2017)
Journal Article
Wang, J., Elsheikha, H. M., Zhu, W., Chen, K., Li, T., Yue, D., …Zhu, X. (2017). Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice. Frontiers in Immunology, 8, Article 730. https://doi.org/10.3389/fimmu.2017.00730

Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites... Read More about Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice.

Fatty acids in veterinary medicine and research (2017)
Book Chapter
Rutland, C. S., Mostyn, A., & Simpson, S. (2017). Fatty acids in veterinary medicine and research. In A. Catala (Ed.), Fatty acids. InTechOpen. https://doi.org/10.5772/intechopen.68440

Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the bo... Read More about Fatty acids in veterinary medicine and research.

An evidence-based decision assistance model for predicting training outcome in juvenile guide dogs (2017)
Journal Article
Harvey, N. D., Craigon, P. J., Blythe, S. A., England, G. C., & Asher, L. (2017). An evidence-based decision assistance model for predicting training outcome in juvenile guide dogs. PLoS ONE, 12(6), Article e0174261. https://doi.org/10.1371/journal.pone.0174261

Working dog organisations, such as Guide Dogs, need to regularly assess the behaviour of the dogs they train. In this study we developed a questionnaire-style behaviour assessment completed by training supervisors of juvenile guide dogs aged 5, 8 and... Read More about An evidence-based decision assistance model for predicting training outcome in juvenile guide dogs.

Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations (2017)
Journal Article
Zhang, X., Xu, G., Wang, C., Jiang, M., Gao, W., Wang, M., …Pu, J. (2017). Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations. Journal of General Virology, https://doi.org/10.1099/jgv.0.000770

The H10 subtype of avian influenza viruses (AIVs) circulates globally in wild birds and poultry, and this subtype has been shown to be increasingly prevalent in China. Among the various H10 viruses, H10N7 AIVs have caused repeated mammal and human in... Read More about Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations.

Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken (2017)
Journal Article
Barbosa, F. D. O., Freitas Neto, O. C. D., Batista, D. F. A., Almeida, A. M. D., Rubio, M. D. S., Alves, L. B. R., …Berchieri Junior, A. (in press). Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken. Brazilian Journal of Microbiology, https://doi.org/10.1016/j.bjm.2017.01.012

Salmonella Enteritidis causes fowl paratyphoid in poultry and is frequently associated to outbreaks of food-borne diseases in humans. The role of flagella and flagella-mediated motility into host-pathogen interplay is not fully understood and require... Read More about Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.

Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics (2017)
Journal Article
Wang, Z., Zhou, C., Elsheikha, H. M., He, S., Zhou, D., & Zhu, X. (in press). Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.00985

Toxoplasma gondii has a complex two-host life-cycle between intermediate host and definitive host. Understanding proteomic variations across the life-cycle stages of T. gondii may improve the understanding of molecular adaption mechanism of T. gondii... Read More about Proteomic differences between developmental stages of Toxoplasma gondii revealed by iTRAQ-based quantitative proteomics.

Defining the ABC of gene essentiality in streptococci (2017)
Journal Article
Charbonneau, A. R. L., Forman, O. P., Cain, A. K., Newland, G., Robinson, C., Boursnell, M., …Waller, A. S. (2017). Defining the ABC of gene essentiality in streptococci. BMC Genomics, 18(1), Article 426. https://doi.org/10.1186/s12864-017-3794-3

Background: Utilising next generation sequencing to interrogate saturated bacterial mutant libraries provides unprecedented information for the assignment of genome-wide gene essentiality. Exposure of saturated mutant libraries to specific conditions... Read More about Defining the ABC of gene essentiality in streptococci.

An in vitro model for assessing effective scrapie decontamination (2017)
Journal Article
Gough, K. C., Baker, C., & Maddison, B. (2017). An in vitro model for assessing effective scrapie decontamination. Veterinary Microbiology, 207, https://doi.org/10.1016/j.vetmic.2017.05.018

Scrapie infectivity enters the environment via a multiplicity of routes from infected animals. Environmentally associated scrapie persists on farms when infected animals have been removed and is particularly resistant to disinfection. Infectivity wit... Read More about An in vitro model for assessing effective scrapie decontamination.

Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds (2017)
Journal Article
Archer, S. C., Bradley, A. J., Cooper, S., Davies, P., & Green, M. J. (2017). Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds. Preventive Veterinary Medicine, 144, https://doi.org/10.1016/j.prevetmed.2017.05.015

The purpose of this study was to evaluate whether the risk of Streptococcus uberis clinical mastitis at cow level could be predicted from the historical presence of specific strains of S. uberis on dairy farms. Matrix-assisted laser desorption ioniza... Read More about Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds.

Molecular approaches to the diagnosis and monitoring of production diseases in pigs (2017)
Journal Article
Giles, T. A., Belkhiri, A., Barrow, P. A., & Foster, N. (2017). Molecular approaches to the diagnosis and monitoring of production diseases in pigs. Research in Veterinary Science, 114, https://doi.org/10.1016/j.rvsc.2017.05.016

Production disease in pigs is caused by a variety of different pathogens, mainly enteric and respiratory and can result in significant economic loss. Other factors such as stress, poor husbandry and nutrition can also contribute to an animal's suscep... Read More about Molecular approaches to the diagnosis and monitoring of production diseases in pigs.

Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI (2017)
Journal Article
Růžička, K., Zhang, M., Campilho, A., Bodi, Z., Kashif, M., Saleh, M., …Fray, R. G. (2017). Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. New Phytologist, 215(1), 157-172. https://doi.org/10.1111/nph.14586

N6-adenosine methylation (m6A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined methods of genetics, proteomics and RNA biochemis... Read More about Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI.

Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS) (2017)
Journal Article
Oxtoby, C., Mossop, L., White, K., & Ferguson, E. (2017). Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS). Veterinary Record, 180(19), https://doi.org/10.1136/vr.104215

Safety culture is a vital concept in human healthcare because of its influence on staff behaviours in relation to patient safety. Understanding safety culture is essential to ensure the acceptance and sustainability of changes, such as the introducti... Read More about Safety culture: the Nottingham Veterinary Safety Culture Survey (NVSCS).

Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs (2017)
Journal Article
Adamany, J. L., Cross, G. F., Gardner, D., & Dunning, M. D. (2017). Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs. Journal of Small Animal Practice, 58(7), 403-407. doi:10.1111/jsap.12675

Objectives The influence of glucocorticoid therapy on bone resorption in dogs using a urine N?telopeptide assay was investigated. Materials and Methods Thirty?one dogs receiving oral glucocorticoids and 31 age?matched healthy control dogs were e... Read More about Preliminary investigation of urine N-telopeptide concentration as a biomarker of bone resorption in dogs receiving glucocorticoids: Urinary NTx in glucocorticoid treated dogs.

How is Europe positioned for a re-emergence of Schmallenberg virus? (2017)
Journal Article
Tarlinton, R., Gough, K., Maddison, B., Stavrou, A., Daly, J. M., Maddison, B. C., …Tarlinton, R. E. (2017). How is Europe positioned for a re-emergence of Schmallenberg virus?. Veterinary Journal, 230, 45-51. https://doi.org/10.1016/j.tvjl.2017.04.009

The Schmallenberg virus (SBV) caused a large scale epidemic in Europe from 2011–2013 infecting ruminants and causing fetal deformities after infection of pregnant animals. The main impacts of the virus were financial losses due to animal, meat and se... Read More about How is Europe positioned for a re-emergence of Schmallenberg virus?.

Effect of claw horn lesion type and severity at the time of treatment on outcome of lameness in dairy cows (2017)
Journal Article
Miguel-Pacheco, G. G., Thomas, H. J., Huxley, J. N., Newsome, R. F., & Kaler, J. (2017). Effect of claw horn lesion type and severity at the time of treatment on outcome of lameness in dairy cows. Veterinary Journal, 225, 16-22. https://doi.org/10.1016/j.tvjl.2017.04.015

Prompt diagnosis and treatment of claw horn lesions in cattle affects the likelihood of recovery; however, it is unknown if the type of lesion influences the likelihood of recovery. The aim of this study was to investigate whether the type, severity... Read More about Effect of claw horn lesion type and severity at the time of treatment on outcome of lameness in dairy cows.