Skip to main content

Research Repository

Advanced Search

All Outputs (1372)

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies (2018)
Journal Article
Wu, P., Farrell, W. E., Haworth, K. E., Emes, R. D., Kitchen, M. O., Glossop, J. R., …Fryer, A. A. (2018). Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 13(2), 122-128. https://doi.org/10.1080/15592294.2016.1166321

Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450Karray analysis to dete... Read More about Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Novel Entamoeba findings in nonhuman primates (2018)
Journal Article
Elsheikha, H. M., Regan, C. S., & Clark, C. G. (2018). Novel Entamoeba findings in nonhuman primates. Trends in Parasitology, 34(4), https://doi.org/10.1016/j.pt.2017.12.008

In addition to well-known human-infecting species, Entamoeba species not found in humans have been identified recently in nonhuman primates (NHPs). Importantly, it has become clear that the organism identified as Entamoeba histolytica in NHPs is usua... Read More about Novel Entamoeba findings in nonhuman primates.

True cowmen and commercial farmers: exploring vets’ and dairy farmers’ contrasting views of ‘good farming’ in relation to biosecurity (2018)
Journal Article
Shortall, O., Sutherland, L., Ruston, A., & Kaler, J. (in press). True cowmen and commercial farmers: exploring vets’ and dairy farmers’ contrasting views of ‘good farming’ in relation to biosecurity. Sociologia Ruralis, https://doi.org/10.1111/soru.12205

Responsibility for biosecurity in UK farming is being devolved from government to industry, with a greater emphasis on the veterinarian (vet)-farmer relationship. Although social science has shown that care for animals is part of ‘good farming’, the... Read More about True cowmen and commercial farmers: exploring vets’ and dairy farmers’ contrasting views of ‘good farming’ in relation to biosecurity.

Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong (2018)
Journal Article
Alzola, R., Easter, C., Riggs, C., Gardner, D., & Freeman, S. (2018). Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong. Equine Veterinary Journal, 50(5), 602-608. https://doi.org/10.1111/evj.12810

Background: Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, predictive ultrasonographic features have not been reported. Objectives: To determi... Read More about Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong.

Owners and veterinary surgeons in the United Kingdom disagree about what should happen during a small animal vaccination consultation (2018)
Journal Article
Belshaw, Z., Robinson, N. J., Dean, R. S., & Brennan, M. L. (2018). Owners and veterinary surgeons in the United Kingdom disagree about what should happen during a small animal vaccination consultation. Veterinary Sciences, 5(1), https://doi.org/10.3390/vetsci5010007

Dog and cat vaccination consultations are a common part of small animal practice in the United Kingdom. Few data are available describing what happens during those consultations or what participants think about their content. The aim of this novel st... Read More about Owners and veterinary surgeons in the United Kingdom disagree about what should happen during a small animal vaccination consultation.

Quantitative outcomes of a One Health approach to study global health challenges (2018)
Journal Article
Falzon, L. C., Lechner, I., Chantziaras, I., Collineau, L., Courcoul, A., Filippitzi, M., …Brennan, M. L. (2018). Quantitative outcomes of a One Health approach to study global health challenges. EcoHealth, 15(1), 209-227. https://doi.org/10.1007/s10393-017-1310-5

Having gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative eviden... Read More about Quantitative outcomes of a One Health approach to study global health challenges.

Epidemiological survey of equine influenza in Andalusia, Spain (2018)
Journal Article
Jurado-Tarifa, E., Daly, J. M., Pérez-Écija, A., Barba-Recreo, M., Mendoza, F., Al-Shuwaikh, A., & García-Bocanegra, I. (2018). Epidemiological survey of equine influenza in Andalusia, Spain. Preventive Veterinary Medicine, 151, https://doi.org/10.1016/j.prevetmed.2018.01.003

Equine influenza is a highly contagious respiratory disease considered the most important respiratory disease in equids. Although influenza A virus (IAV) has caused outbreaks in equids worldwide, surveillance on these species in Spain has not been co... Read More about Epidemiological survey of equine influenza in Andalusia, Spain.

HumanMethylation450K array–identified biomarkers predict tumour recurrence/progression at initial diagnosis of high-risk non-muscle Invasive bladder cancer (2018)
Journal Article
Kitchen, M. O., Bryan, R. T., Emes, R. D., Luscombe, C. J., Cheng, K., Zeegers, M. P., …Fryer, A. A. (in press). HumanMethylation450K array–identified biomarkers predict tumour recurrence/progression at initial diagnosis of high-risk non-muscle Invasive bladder cancer. Biomarkers in Cancer,

Background: High-risk non-muscle invasive bladder cancer (HR-NMIBC) is a clinically unpredictable disease. Despite clinical risk estimation tools, many patients are undertreated with intra-vesical therapies alone, whereas others may be over-treated w... Read More about HumanMethylation450K array–identified biomarkers predict tumour recurrence/progression at initial diagnosis of high-risk non-muscle Invasive bladder cancer.

Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs (2018)
Journal Article
White, C., Downes, M. J., Jones, G., Wigfall, C., Dean, R. S., & Brennan, M. L. (2018). Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs. Veterinary Record, 182(1), https://doi.org/10.1136/vr.104390

There is little peer-reviewed research assessing therapeutic effectiveness in canine eye disease. Current treatments used in first opinion and ophthalmology referral practices are also somewhat poorly documented. The aim of this study was to investig... Read More about Use of clinical vignette questionnaires to investigate the variation in management of keratoconjunctivitis sicca and acute glaucoma in dogs.

Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry (2018)
Journal Article
Zhou, C., Cong, W., Chen, X., He, S., Elsheikha, H. M., & Zhu, X. (2018). Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02612

Toxoplasma gondii is an obligate intracellular parasite causing severe diseases in immunocompromised individuals and congenitally infected neonates, such as toxoplasmosis encephalitis and toxoplasmic chorioretinitis. This study aimed to determine whe... Read More about Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry.

Drivers for precision livestock technology adoption: a study of factors associated with adoption of electronic identification technology by commercial sheep farmers in England and Wales (2018)
Journal Article
Lima, E., Hopkins, T., Gurney, E., Shortall, O., Lovatt, F., Davies, P., …Kaler, J. (2018). Drivers for precision livestock technology adoption: a study of factors associated with adoption of electronic identification technology by commercial sheep farmers in England and Wales. PLoS ONE, 13(1), Article e0190489. https://doi.org/10.1371/journal.pone.0190489

The UK is the largest lamb meat producer in Europe. However, the low profitability of sheep farming sector suggests production efficiency could be improved. Although the use of technologies such as Electronic Identification (EID) tools could allow a... Read More about Drivers for precision livestock technology adoption: a study of factors associated with adoption of electronic identification technology by commercial sheep farmers in England and Wales.

Taking a broader view of things: towards a transdisciplinary approach to cancer (2017)
Journal Article
Rauch, C., Blott, S., & Stewart, S. (2017). Taking a broader view of things: towards a transdisciplinary approach to cancer. https://doi.org/10.13133/2532-5876_2.10

Cancer is widely considered an abnormality that emerges from within the body and which must be destroyed and defeated. But we still do not know precisely how and why cancer starts, and while a ‘magic bullet’ cure has failed to materialise, those adop... Read More about Taking a broader view of things: towards a transdisciplinary approach to cancer.

The SEISICAT study: a pilot study assessing 1 efficacy and safety of spironolactone in cats with congestive heart failure secondary to cardiomyopathy (2017)
Journal Article
James, R., Guillot, E., Garelli-Paar, C., Huxley, J., Grassi, V., & Cobb, M. (2018). The SEISICAT study: a pilot study assessing 1 efficacy and safety of spironolactone in cats with congestive heart failure secondary to cardiomyopathy. Journal of Veterinary Cardiology, 20(1), https://doi.org/10.1016/j.jvc.2017.11.001

Introduction The pathophysiology of heart failure involves activation of several neurohormonal systems including the renin-angiotensin-aldosterone system. The mineralocorticoid receptor antagonist spironolactone has been shown to be beneficial in hu... Read More about The SEISICAT study: a pilot study assessing 1 efficacy and safety of spironolactone in cats with congestive heart failure secondary to cardiomyopathy.

Quantitative analysis of antimicrobial use on British dairy farms (2017)
Journal Article
Hyde, R. M., Remnant, J. G., Bradley, A. J., Breen, J. E., Hudson, C. D., Davies, P. L., …Green, M. J. (in press). Quantitative analysis of antimicrobial use on British dairy farms. Veterinary Record, 181(25), https://doi.org/10.1136/vr.104614

Antimicrobial resistance has been reported to represent a growing threat to both human and animal health, and concerns have been raised around levels of antimicrobial usage (AMU) within the livestock industry. To provide a benchmark for dairy cattle... Read More about Quantitative analysis of antimicrobial use on British dairy farms.

Is Your Extra X Chromosome Holding You Back? An Insight into Female Education and Academic Careers in STEMM (2017)
Book Chapter
Alibhai, A., Saigar, M. M., Harding, E., & Rutland, C. S. (2017). Is Your Extra X Chromosome Holding You Back? An Insight into Female Education and Academic Careers in STEMM. In New pedagogical challenges in the 21st century. InTech. https://doi.org/10.5772/intechopen.71898

This review discusses whether gender inequality still exists within medical, scientific and engineering academia, with regards to the career development of academic staff. In the 1970s it was suggested that women who are talented and educated with fa... Read More about Is Your Extra X Chromosome Holding You Back? An Insight into Female Education and Academic Careers in STEMM.

The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms (2017)
Journal Article
Bradley, A. J., Leach, K. A., Green, M. J., Gibbons, J., Ohnstad, I. C., Black, D. H., …Breen, J. E. (in press). The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms. International Journal of Food Microbiology, https://doi.org/10.1016/j.ijfoodmicro.2017.12.022

The introduction of bedding dairy cows on recycled manure solids (RMS) in the UK led to concern by competent authorities that there could be an increased, unacceptable risk to animal and human health. A cross-sectional study was designed to evaluate... Read More about The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms.

Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability (2017)
Journal Article
Alzola Domingo, R., Riggs, C. M., Gardner, D. S., & Freeman, S. (2017). Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability. Veterinary Record, 181(24), https://doi.org/10.1136/vr.104233

Superficial digital flexor tendon (SDFT) tendinopathy is an important musculoskeletal problem in horses. The study objective was to validate an ultrasonographic scoring system for SDFT injuries. Ultrasonographic images from 14 Thoroughbred racehorses... Read More about Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability.

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, https://doi.org/10.3389/fphys.2017.01033

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More about Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle.