Research Repository

See what's under the surface


Service dogs (2019)
Book Chapter
Harvey, N. (2019). Service dogs. In J. Vonk, & T. K. Shackelford (Eds.), Encyclopedia of Animal Cognition and Behavior

Reptilian skin and its special histological structures (2019)
Book Chapter
Rutland, C. S., Cigler, P., & Kubale Dvojmoč, V. (2019). Reptilian skin and its special histological structures. In C. S. Rutland, & V. Kubale Dvojmoč (Eds.), Veterinary anatomy and physiology, 1-21. InTech. doi:10.5772/intechopen.84212

Reptilian skin is covered with scales forming armor that makes it watertight and enables reptiles to live on land in contrast to amphibians. An important part of the skin is the horny epidermis, with thick stratum corneum in which waxes are arranged... Read More

Veterinary anatomy and physiology (2019)
Book
C. S. Rutland, & V. Kubale Dvojmoč (Eds.), (2019). Veterinary anatomy and physiology

Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the anima... Read More

Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders (2019)
Journal Article
Galieva, L. R., James, V., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019). Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders. Frontiers in Neuroscience, 13, doi:10.3389/fnins.2019.00163

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in E... Read More

Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies (2019)
Journal Article
Harvey, N. D., Shaw, S. C., Blott, S. C., Vàzquez-Diosdado, J. A., & England, G. C. W. (2019). Development and validation of a new standardised data collection tool to aid in the diagnosis of canine skin allergies. Scientific Reports, 9, doi:10.1038/s41598-019-39630-3

Canine atopic dermatitis (cAD) is a common hereditary clinical syndrome in domestic dogs with no definitive diagnostic tests, which causes marked morbidity and has a high economic impact internationally. We created a novel questionnaire for Labrador... Read More

Anatomy and pathology of the Texel sheep larynx (2019)
Journal Article
Waine, K., Strugnell, B., Remnant, J., Lovatt, F., Green, M., Rideout, H., …Baiker, K. (2019). Anatomy and pathology of the Texel sheep larynx. Veterinary Sciences, 6(1), doi:10.3390/vetsci6010021

Laryngeal chondritis, or “Texel throat”, is a disease affecting the upper respiratory tract of sheep with breeds like the Texel appearing to be predisposed. Previous work suggests the conformation of these breeds of sheep may be predisposing these an... Read More

DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples (2019)
Journal Article
Shaw, L. M., Blanchard, A., Chen, Q., An, X., Davies, P., Totemeyer, S., …Stekel, D. J. (2019). DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples. Scientific Reports, 9, doi:10.1038/s41598-019-38873-4

High throughput genomics technologies are applied widely to microbiomes in humans, animals, soil and water, to detect changes in bacterial communities or the genes they carry, between different environments or treatments. We describe a method to test... Read More

All-trans retinoic acid (ATRA) induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL) (2019)
Journal Article
Orfali, N., O'Donovan, T. R., Cahill, M. R., Benjamin, D., Nanus, D. M., McKenna, S. L., …Mongan, N. (in press). All-trans retinoic acid (ATRA) induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL). European Journal of Haematology,

Objective In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. Therapeutic concentrations of all-trans-retinoic acid (ATRA) can restore... Read More

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. doi:10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More

Mitochondrial respiratory states and rates (2019)
Other
Gnaiger, E., & Chakrabarti, L. (2019). Mitochondrial respiratory states and rates

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory es... Read More

Prevalence of feline lungworm Aelurostrongylus abstrusus in England (2019)
Journal Article
Elsheikha, H. M., Wright, I., Wang, B., & Schaper, R. (2019). Prevalence of feline lungworm Aelurostrongylus abstrusus in England. Veterinary Parasitology, doi:10.1016/j.vprsr.2019.100271

Infection of cats with lungworm Aelurostrongylus abstrusus has recentlbeen documented in the UK. Here, we aimed to study the prevalence of A. abstrusus in fecal samples from cats across England. A total of 950 fecal samples were collected from cats t... Read More

Comparison of the effects of buprenorphine and methadone in combination with medetomidine followed by intramuscular alfaxalone for anaesthesia of cats undergoing ovariohysterectomy (2019)
Journal Article
Mahdmina, A., Evans, A., Yates, D., & White, K. L. (2019). Comparison of the effects of buprenorphine and methadone in combination with medetomidine followed by intramuscular alfaxalone for anaesthesia of cats undergoing ovariohysterectomy. Journal of Feline Medicine and Surgery, doi:10.1177/1098612x19826357

Objectives The aim of this study was to compare quality of anaesthesia and analgesia between methadone and buprenorphine in combination with medetomidine after induction with intramuscular (IM) alfaxalone in cats undergoing ovariohysterectomy.... Read More

A review of paratuberculosis in dairy herds — Part 2: On-farm control (2019)
Journal Article
McAloon, C. G., Roche, S., Ritter, C., Barkema, H. W., Whyte, P., More, S. J., …Doherty, M. L. (2019). A review of paratuberculosis in dairy herds — Part 2: On-farm control. Veterinary Journal, 246, 54-58. doi:10.1016/j.tvjl.2019.01.009

Bovine paratuberculosis is a chronic infectious disease of cattle, caused by Mycobacterium avium subspecies paratuberculosis (MAP). This is the second in a two-part review of the epidemiology and control of paratuberculosis in dairy herds. Several ne... Read More

A review of paratuberculosis in dairy herds — Part 1: Epidemiology (2019)
Journal Article
McAloon, C. G., Roche, S., Ritter, C., Barkema, H. W., Whyte, P., More, S. J., …Doherty, M. L. (2019). A review of paratuberculosis in dairy herds — Part 1: Epidemiology. Veterinary Journal, 246, 59-65. doi:10.1016/j.tvjl.2019.01.010

Bovine paratuberculosis is a chronic infectious disease of cattle caused by Mycobacterium avium subspecies paratuberculosis (MAP). This is the first in a two-part review of the epidemiology and control of paratuberculosis in dairy herds. Paratubercul... Read More

Introductory chapter: veterinary anatomy and physiology (2019)
Book Chapter
Kubale, V., Cousins, E., Bailey, C., El-Gendy, S. A., & Rutland, C. S. (2019). Introductory chapter: veterinary anatomy and physiology. In C. S. Rutland, & V. Kubale (Eds.), Veterinary anatomy and physiology, 1-13. InTech. doi:10.5772/intechopen.82412

Responsible use of antibiotics on sheep farms: application at farm level (2019)
Journal Article
Lovatt, F., Duncan, J., & Hinde, D. (2019). Responsible use of antibiotics on sheep farms: application at farm level. In Practice, 41(1), 23-33. doi:10.1136/inp.k5370

There is currently global concern over rising levels of antibiotic resistance among commensal and pathogenic bacteria in human and animal populations. Unless urgent action is taken by the medical and veterinary professions, it is thought that we will... Read More

Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus? (2019)
Journal Article
Morandi, E., Tanasescu, R., Tarlington, R., Constantin-Teodosiu, D., & Gran, B. (2019). Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus?. Frontiers in Immunology, 9, doi:10.3389/fimmu.2018.03092

The expression of human endogenous retroviruses (HERVs) has been associated with Multiple Sclerosis (MS). The MS-related retrovirus (MSRV/HERV-W) has the potential to activate inflammatory immunity, which could promote both susceptibility and progres... Read More

The interaction between viral and environmental risk factors in the pathogenesis of multiple sclerosis (2019)
Journal Article
Tarlinton, R., Khaibullin, T., Granatov, E., Martynova, E., Rizvanov, A., & Khaiboullina, S. (2019). The interaction between viral and environmental risk factors in the pathogenesis of multiple sclerosis. International Journal of Molecular Sciences, 20(2), 1-16. doi:10.3390/ijms20020303

Multiple sclerosis (MS) is a chronic debilitating inflammatory disease of unknown ethology targeting the central nervous system (CNS). MS has a polysymptomatic onset and is usually first diagnosed between the ages of 20–40 years. The pathology of the... Read More