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Renal accumulation of prooxidant mineral elements and CKD in domestic cats (2020)
Journal Article
Alborough, R., Grau-Roma, L., de Brot, S., Hantke, G., Vazquez, S., & Gardner, D. (2020). Renal accumulation of prooxidant mineral elements and CKD in domestic cats. Scientific Reports, 10, https://doi.org/10.1038/s41598-020-59876-6

Felids have a high incidence of chronic kidney disease (CKD), for which the most common renal lesion is chronic interstitial nephritis (CIN). CIN can be induced by tissue oxidative stress, which is determined by the cellular balance of pro- and anti-... Read More about Renal accumulation of prooxidant mineral elements and CKD in domestic cats.

Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers (2020)
Journal Article
Ogden, A., Bhattarai, S., Sahoo, B., Mongan, N. P., Alsaleem, M., Green, A. R., …Aneja, R. (2020). Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Scientific Reports, 10, https://doi.org/10.1038/s41598-020-59514-1

Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) have been investigated as triple-negative breast cancer (TNBC) biomarkers. Reduced EGFR levels can be compensated by increases in HER3; thus, assaying EGFR an... Read More about Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers.

Transcriptional changes in Toxoplasma gondii in response to treatment with monensin (2020)
Journal Article
Zhai, B., He, J., Elsheikha, H. M., Li, J., Zhu, X., & Yang, X. (2020). Transcriptional changes in Toxoplasma gondii in response to treatment with monensin. Parasites and Vectors, 13(1), https://doi.org/10.1186/s13071-020-3970-1

Background Infection with the apicomplexan protozoan parasite T. gondii can cause severe and potentially fatal cerebral and ocular disease, especially in immunocompromised individuals. The anticoccidial ionophore drug monensin has been shown to have... Read More about Transcriptional changes in Toxoplasma gondii in response to treatment with monensin.

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses (2020)
Journal Article
Paine, S. W., Bright, J., Scarth, J. P., Hincks, P. R., Pearce, C. M., Hannan, C., …Hillyer, L. (2020). The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12838

Giving calves 'the best start': Perceptions of colostrum management on dairy farms in England (2020)
Journal Article
Palczynski, L., Bleach, E., Brennan, M., & Robinson, P. (2020). Giving calves 'the best start': Perceptions of colostrum management on dairy farms in England. Animal Welfare Journal, 29(1), 45-58. https://doi.org/10.7120/09627286.29.1.045

Good colostrum management can confer protective immunity to newborn calves, making calves less susceptible to infectious disease, and fundamentally improving both their short- and long-term health, welfare and productivity. Industry recommendations c... Read More about Giving calves 'the best start': Perceptions of colostrum management on dairy farms in England.

Field survey to evaluate space allowances for dairy cows in Great Britain (2020)
Journal Article
Thompson, J. S., Huxley, J. N., Hudson, C. D., Kaler, J., Gibbons, J., & Green, M. J. (2020). Field survey to evaluate space allowances for dairy cows in Great Britain. Journal of Dairy Science, https://doi.org/10.3168/jds.2019-17004

© 2020 American Dairy Science Association Housing conditions can affect health of cows by increasing exposure to biological, chemical, and physical hazards, resulting in increased disease. A report in 2014 indicated that 99% of UK dairy cows are hous... Read More about Field survey to evaluate space allowances for dairy cows in Great Britain.

Differential Expression of HERV-W in Peripheral Blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups (2020)
Journal Article
Khaiboullin, T., Martynova, E., Tarlinton, R., Wang, B., Morandi, E., Gran, B., …Khaiboullina, S. (2020). Differential Expression of HERV-W in Peripheral Blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups. Frontiers in Pharmacology, 10, https://doi.org/10.3389/fphar.2019.01645

Overexpression of the Human endogenous retrovirus W (HERV-W) group of inherited retroviruses has been consistently linked with Multiple Sclerosis (MS). However most of the studies on this link have focused on European genetic groups with a very high... Read More about Differential Expression of HERV-W in Peripheral Blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups.

Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice (2020)
Journal Article
Wang, J., Liang, Q., Li, T., He, J., Bai, M., Cao, X., …Zhu, X. (2020). Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice. Journal of Immunology, 204(4), https://doi.org/10.4049/jimmunol.1900410

In this study, we generated a tkl1 deletion mutant in the Toxoplasma gondii type 1 RH (RHΔtkl1) strain and tested the protective efficacies of vaccination using RHΔtkl1 tachyzoites against acute, chronic, and congenital T. gondii infections in Kunmin... Read More about Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice.

Detrimental effects of uterine disease and lipopolysaccharide on luteal angiogenesis (2020)
Journal Article
Mohammed, Z. A., Robinson, R. S., Harris, R., McLaughlin, Y., Turnbull, K. E., Mann, G., & Woad, K. J. (2020). Detrimental effects of uterine disease and lipopolysaccharide on luteal angiogenesis. Journal of Endocrinology, https://doi.org/10.1530/joe-19-0443

Reproductive tract inflammatory disease (RTID) commonly occurs after the traumatic events of parturition and adversely affects follicular function. This study is the first to describe the cellular and steroidogenic characteristics of corpora lutea fr... Read More about Detrimental effects of uterine disease and lipopolysaccharide on luteal angiogenesis.

An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom (2020)
Journal Article
Atterbury, R., Gigante, A., Tinker, D., Howell, M., & Allen, V. (in press). An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom. Journal of Applied Microbiology, https://doi.org/10.1111/jam.14576

© 2020 The Society for Applied Microbiology Aim: Following previous research on improving the cleaning of crates used to transport broiler chickens from the farm to the abattoir, a demonstration project was undertaken to investigate improvements in c... Read More about An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom.

Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells (2020)
Journal Article
Sarker, N., Tarlinton, R., Owen, H., David Emes, R., Seddon, J., Simmons, G., & Meers, J. (2020). Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells. Gene, 733, https://doi.org/10.1016/j.gene.2020.144366

Koala retrovirus is thought to be an underlying cause of high levels of neoplasia and immunosuppression in koalas. While epidemiology studies suggest a strong link between KoRV and disease it has been difficult to prove causality because of the compl... Read More about Novel insights into viral infection and oncogenesis from Koala Retrovirus (KoRV) infection of HEK293T cells.

Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep (2020)
Journal Article
Kaler, J., Mitsch, J., Vázquez-Diosdado, J. A., Bollard, N., Dottorini, T., & Ellis, K. A. (2020). Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep. Royal Society Open Science, 7(1), https://doi.org/10.1098/rsos.190824

Lameness in sheep is the biggest cause of concern regarding poor health and welfare among sheep producing countries. Best practice for lameness relies on rapid treatment, yet there are no objective measures of lameness detection. Use of accelerometer... Read More about Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep.

Quantitative analysis of calf mortality in Great Britain (2020)
Journal Article
Hyde, R. M., Green, M. J., Sherwin, V. E., Hudson, C., Gibbons, J., Forshaw, T., …Down, P. M. (2020). Quantitative analysis of calf mortality in Great Britain. Journal of Dairy Science, https://doi.org/10.3168/jds.2019-17383

National bodies in Great Britain (GB) have expressed concern over young stock health and welfare and identified calf survival as a priority; however, no national data have been available to quantify mortality rates. The aim of this study was to quant... Read More about Quantitative analysis of calf mortality in Great Britain.

Definition of hourly urine output influences reported incidence and staging of acute kidney injury (2020)
Journal Article
Devonald, M. A. J., Allen, J. C., Gardner, D. S., Skinner, H., Harvey, D., Sharman, A., & Devonald, M. A. (2020). Definition of hourly urine output influences reported incidence and staging of acute kidney injury. BMC Nephrology, 21(1), https://doi.org/10.1186/s12882-019-1678-2

© 2020 The Author(s). Background: Acute kidney injury (AKI) is commonly defined using the KDIGO system, which includes criteria based on reduced urine output (UO). There is no consensus on whether UO should be measured using consecutive hourly readin... Read More about Definition of hourly urine output influences reported incidence and staging of acute kidney injury.

Koala retrovirus viral load and disease burden in distinct northern and southern koala populations (2020)
Journal Article
Trott, D. J., Sarker, N., Fabijan, J., Owen, H., Seddon, J., Simmons, G., …Tarlinton, R. E. (2020). Koala retrovirus viral load and disease burden in distinct northern and southern koala populations. Scientific Reports, 10(1), 263. https://doi.org/10.1038/s41598-019-56546-0

Koala retrovirus (KoRV) displays features of both an endogenous and exogenous virus and is linked to neoplasia and immunosuppression in koalas. This study explores the apparent differences in the nature and impact of KoRV infection between geographic... Read More about Koala retrovirus viral load and disease burden in distinct northern and southern koala populations.

Blood Vessels Under the Microscope (2020)
Journal Article
Machado, M. J. C., Mitchell, C. A., Franklin, J., Thorpe, A., & Rutland, C. S. (2020). Blood Vessels Under the Microscope. Frontiers for Young Minds, 7, https://doi.org/10.3389/frym.2019.00151

This paper looks at blood vessels. All humans and animals have blood vessels, including your pet rabbit or dog, a whale or a giraffe! We need blood vessels to stay alive. This paper answers many questions, including what blood vessels are used for an... Read More about Blood Vessels Under the Microscope.

All-trans retinoic acid (ATRA) induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL) (2020)
Journal Article
Orfali, N., O'Donovan, T. R., Cahill, M. R., Benjamin, D., Nanus, D. M., McKenna, S. L., …Mongan, N. (2020). All-trans retinoic acid (ATRA) induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL). European Journal of Haematology, https://doi.org/10.1111/ejh.13367

Objective In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. Therapeutic concentrations of all-trans-retinoic acid (ATRA) can restore... Read More about All-trans retinoic acid (ATRA) induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).

Appropriate Dairy Calf Feeding from Birth to Weaning: “It’s an Investment for the Future” (2020)
Journal Article
Palczynski, L. J., Bleach, E. C. L., Brennan, M. L., & Robinson, P. A. (2020). Appropriate Dairy Calf Feeding from Birth to Weaning: “It’s an Investment for the Future”. Animals, 10(1), https://doi.org/10.3390/ani10010116

Dairy calves must be fed appropriately to meet their nutritional needs, supporting optimal growth and development to achieve the recommended target age at first calving (AFC) of 24 months. Traditional restricted milk feeding practices suppress growth... Read More about Appropriate Dairy Calf Feeding from Birth to Weaning: “It’s an Investment for the Future”.