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All Outputs (118)

Service dogs (2019)
Book Chapter
Harvey, N. (2019). Service dogs. In J. Vonk, & T. K. Shackelford (Eds.), Encyclopedia of Animal Cognition and Behavior

Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits (2019)
Journal Article
Tsoleridis, T., Chappell, J. G., Monchatre-Leroy, E., Umhang, G., Shi, M., Bennett, M., …Ball, J. K. (2019). Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses, 12(1), Article 47. https://doi.org/10.3390/v12010047

The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited. We used unbiased metagenomic sequencing... Read More about Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits.

Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys (2019)
Journal Article
El-Gendy, S. A., Alsafy, M. A., Rutland, C. S., EL-Khamary, A. N., Abu-Ahmed, H. M., & El-Kammar, M. H. (2020). Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys. Journal of Equine Veterinary Science, 88, https://doi.org/10.1016/j.jevs.2019.102904

The donkey is of socio-economic value yet imaging techniques in both healthy and abnormal limbs are a limiting factor in research and medicine. The objective was to determine anatomical features of both healthy and clinically abnormal donkey metacarp... Read More about Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys.

Environmental and field characteristics associated with lameness in sheep: a study using a smartphone lameness app for data recording (2019)
Journal Article
Vittis, Y., & Kaler, J. (2019). Environmental and field characteristics associated with lameness in sheep: a study using a smartphone lameness app for data recording. Veterinary Record, https://doi.org/10.1136/vr.105476

Background: Sheep lameness is a major concern among farmers and policymakers with significant impacts on animal welfare standards as well as financial and production performance. The present study attempts to identify the relative importance of envir... Read More about Environmental and field characteristics associated with lameness in sheep: a study using a smartphone lameness app for data recording.

Antioxidant enzymes as biomarkers of Cu and Pb exposure in the ground spiders Lycosa terrestris and Pardosa birmanica (2019)
Journal Article
Elsheikha, H. M., Aziz, N., & Butt, A. (2020). Antioxidant enzymes as biomarkers of Cu and Pb exposure in the ground spiders Lycosa terrestris and Pardosa birmanica. Ecotoxicology and Environmental Safety, 190, https://doi.org/10.1016/j.ecoenv.2019.110054

© 2019 Elsevier Inc. Heavy metal exposure induces oxidative stress in terrestrial organisms, which they counteract via activation of antioxidant biomarkers. The present study investigated the effects of copper (Cu) and lead (Pb) on the total antioxid... Read More about Antioxidant enzymes as biomarkers of Cu and Pb exposure in the ground spiders Lycosa terrestris and Pardosa birmanica.

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells (2019)
Journal Article
Abakir, A., Giles, T. C., Cristini, A., Foster, J. M., Dai, N., Starczak, M., …Ruzov, A. (2020). N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature Genetics, 52(1), 48-55. https://doi.org/10.1038/s41588-019-0549-x

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells1–4. Her... Read More about N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes (2019)
Journal Article
Aziz, N., Butt, A., & Elsheikha, H. M. (2020). Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes. Environmental Science and Pollution Research, 27, 3309–3319. https://doi.org/10.1007/s11356-019-07055-0

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Major concerns exist regarding the environmental and human health risks caused by exposure to heavy metals. Spiders are often used as a model in ecotoxicological studies to assess soil po... Read More about Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes.

The ‘dark matter’ of ubiquitin-mediated processes: opportunities and challenges in the identification of ubiquitin-binding domains (2019)
Journal Article
Radley, E., Long, J., Gough, K., & Layfield, R. (2019). The ‘dark matter’ of ubiquitin-mediated processes: opportunities and challenges in the identification of ubiquitin-binding domains. Biochemical Society Transactions, 47(6), 1949-1962. https://doi.org/10.1042/bst20190869

Ubiquitin modifications of target proteins act to localise, direct and specify a diverse range of cellular processes, many of which are biomedically relevant. To allow this diversity, ubiquitin modifications exhibit remarkable complexity, determined... Read More about The ‘dark matter’ of ubiquitin-mediated processes: opportunities and challenges in the identification of ubiquitin-binding domains.

Veterinary use of bacteriophage therapy in intensively-reared livestock (2019)
Journal Article
Gigante, A., & Atterbury, R. J. (2019). Veterinary use of bacteriophage therapy in intensively-reared livestock. Virology Journal, 16(1), https://doi.org/10.1186/s12985-019-1260-3

Zoonoses are infectious diseases transmitted directly or indirectly between animals and humans. Several important zoonotic pathogens colonize farm animals asymptomatically, which may lead to contamination of the food chain and public health hazards.... Read More about Veterinary use of bacteriophage therapy in intensively-reared livestock.

Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia (2019)
Journal Article
Parry, H. M., Mirajkar, N., Cutmore, N., Zuo, J., Long, H., Kwok, M., …Moss, P. (2019). Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia. Frontiers in Immunology, 10, 1-7. https://doi.org/10.3389/fimmu.2019.02832

Chronic Lymphocytic Leukaemia (CLL) is associated with immune suppression and susceptibility to infection. CD8+ T cell numbers are increased and demonstrate elevated expression of PD-1 and impaired function. The mechanisms driving these features of e... Read More about Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia.

Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA?induced differentiation of leukemic cells (2019)
Journal Article
Orfali, N., Shan‐Krauer, D., O'Donovan, T. R., Mongan, N. P., Gudas, L. J., Cahill, M. R., …McKenna, S. L. (2020). Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells. Molecular Oncology, 14(6), 1297-1309. https://doi.org/10.1002/1878-0261.12614

Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene exp... Read More about Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA?induced differentiation of leukemic cells.

All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL) (2019)
Journal Article
Orfali, N., O'Donovan, T. R., Cahill, M. R., Benjamin, D., Nanus, D. M., McKenna, S. L., …Mongan, N. P. (2020). All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL). European Journal of Haematology, 104(3), 236-250. https://doi.org/10.1111/ejh.13367

Objective In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. Therapeutic concentrations of all-trans-retinoic acid (ATRA) can restore... Read More about All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).

Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii (2019)
Journal Article
Cao, X., Wang, J., Elsheikha, H. M., Li, T., Sun, L., Liang, Q., …Lin, R. (2019). Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology, 9, Article 418. https://doi.org/10.3389/fcimb.2019.00418

In this study, we characterized the role of amylo-alpha-1,6-glucosidase (Aa16GL) in the biology and infectivity of Toxoplasma gondii, using Aa16GL-deficient parasites of type I RH and type II Prugniaud (Pru) strains. The subcellular localization of A... Read More about Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii.

Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China (2019)
Journal Article
Cong, W., Zhang, N., Hu, R., Zou, F., Zou, Y., Zhong, W., …Elsheikha, H. M. (2020). Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China. Ecotoxicology and Environmental Safety, 189, Article 109999. https://doi.org/10.1016/j.ecoenv.2019.109999

Copyright © 2019 Elsevier Inc. All rights reserved. In the present study, we performed a cross-sectional survey to determine the occurrence and genotype distribution of T. gondii DNA in soil samples collected from different sources from six geographi... Read More about Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China.

The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne’s disease-infected animals (2019)
Journal Article
Swift, B. M., Meade, N., Barron, E. S., Bennett, M., Perehenic, T., Hughes, V., …Rees, C. E. (2020). The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne’s disease-infected animals. Microbial Biotechnology, 13(3), 738-746. https://doi.org/10.1111/1751-7915.13518

© 2019 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. Here, we describe the development of a method that exploits bacteriophage D29 as a lysis agent for efficient DNA extraction from lo... Read More about The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne’s disease-infected animals.

A novel approach to welfare interventions in problem multi-cat households (2019)
Journal Article
Hill, K., Yates, D., Dean, R., & Stavisky, J. (2019). A novel approach to welfare interventions in problem multi-cat households. BMC Veterinary Research, 15, https://doi.org/10.1186/s12917-019-2183-3

Background Thousands of injured, stray and relinquished cats are received at the RSPCA Greater Manchester Animal Hospital each year. A significant and challenging proportion of these cats are confiscated from multicat households by RSPCA Inspectors,... Read More about A novel approach to welfare interventions in problem multi-cat households.

Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models (2019)
Journal Article
Mukhamedshina, Y., Shulman, I., Ogurcov, S., Kostennikov, A., Zakirova, E., Akhmetzyanova, E., …Rizvanov, A. (2019). Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models. Biomolecules, 9(12), Article 811. https://doi.org/10.3390/biom9120811

Here, we provide a first comparative study of the therapeutic potential of allogeneic mesenchymal stem cells derived from bone marrow (BM-MSCs), adipose tissue (AD-MSCs), and dental pulp (DP-MSCs) embedded in fibrin matrix, in small (rat) and large (... Read More about Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models.

Best practice versus farm practice: Perspectives of lecturers and students at agricultural colleges in England on management of lameness in sheep (2019)
Journal Article
Clifton, R., Reeves, M. C., Kaler, J., & Green, L. E. (2019). Best practice versus farm practice: Perspectives of lecturers and students at agricultural colleges in England on management of lameness in sheep. Journal of Rural Studies, https://doi.org/10.1016/j.jrurstud.2019.11.014

We use the concepts of trust and knowledge to explore translation of scientific evidence about treatment of ovine footrot to students studying at agricultural colleges. We explore the role of different forms of trust (companion, competence and commit... Read More about Best practice versus farm practice: Perspectives of lecturers and students at agricultural colleges in England on management of lameness in sheep.

A scoping review of the current literature exploring the nature of the horse-human relationship (2019)
Journal Article
Clough, H. .., Burford, J., England, G., & Freeman, S. L. (2019). A scoping review of the current literature exploring the nature of the horse-human relationship. Veterinary Evidence, 4(4), https://doi.org/10.18849/ve.v4i4.240

Objective: To perform a scoping review of the current evidence on the horse-human relationship. Background: The horse-human relationship has a significant impact on how horse owners care for and make decisions for their horse. Evidentiary value... Read More about A scoping review of the current literature exploring the nature of the horse-human relationship.