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Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1? (2013)
Journal Article
Williams, A., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2013). Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?. Arthritis Research and Therapy, 15(6), Article R223. https://doi.org/10.1186/ar4424

Introduction: Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metalloproteinases (MMPs) is partly... Read More about Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?.

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis (2013)
Journal Article
Hams, E., Armstrong, M. E., Barlow, J. L., Saunders, S. P., Schwartz, C., Cooke, G., …Fallon, P. G. (2014). IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proceedings of the National Academy of Sciences, 111(1), 367-372. https://doi.org/10.1073/pnas.1315854111

Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models we demonstrate a role for inte... Read More about IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.

Mycobacteriosis outbreak caused by Mycobacterium aviumsubsp.avium detected through meat inspection in five porcine fattening farms (2013)
Journal Article
Pérez de Val, B., Grau-Roma, L., Segalés, J., Domingo, M., & Vidal, E. (2013). Mycobacteriosis outbreak caused by Mycobacterium aviumsubsp.avium detected through meat inspection in five porcine fattening farms. Veterinary Record, 174(4), Article 96. https://doi.org/10.1136/vr.101886

Between December 2010 and January 2011 a number (n=20) of cases were submitted to the Slaughterhouse Support Service (Servei de Suport a Escorxadors, SESC-CReSA), consisting of grossly nodular granulomatous and caseous lesions in pig carcasses from f... Read More about Mycobacteriosis outbreak caused by Mycobacterium aviumsubsp.avium detected through meat inspection in five porcine fattening farms.

Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy (2013)
Journal Article
Daly, J. M., & Elton, D. (2013). Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy. Vaccine, 31(51), https://doi.org/10.1016/j.vaccine.2013.06.070

The calculation of pepitope values, a sequence-based measure of antigenic distance between strains, was developed for human influenza. The potential to apply the pepitope value to equine influenza vaccine strain selection was assessed. There was a ne... Read More about Potential of a sequence-based antigenic distance measure to indicate equine influenza vaccine strain efficacy.

The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages (2013)
Journal Article
Warneke, W., Klaus, S., Fink, H., Langley-Evans, S. C., & Voigt, J. (2014). The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages. Pharmacology Biochemistry and Behavior, 116, https://doi.org/10.1016/j.pbb.2013.11.016

There is emerging experimental evidence that hyper-energetic diets not only cause obesity but also impact on behaviour in rodents. A hyper-energetic comfort diet/cafeteria diet (CD) fed during early development programmes anxiety-related behaviour in... Read More about The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages.

Use of contrast-enhanced ultrasonography in chronic pathologic canine testes (2013)
Journal Article
Volta, A., Manfredi, S., Vignoli, M., Russo, M., England, G., Rossi, F., …Gnudi, G. (2014). Use of contrast-enhanced ultrasonography in chronic pathologic canine testes. Reproduction in Domestic Animals, 49(2), https://doi.org/10.1111/rda.12250

Contrast-enhanced ultrasound with sulphur hexafluoride microbubbles was performed in seven healthy dogs without a history of reproductive pathology and with histologically confirmed normal testes and in 42 dogs with chronic scrotal anomalies. All dog... Read More about Use of contrast-enhanced ultrasonography in chronic pathologic canine testes.

The genetics of virus particle shape in equine influenza A virus (2013)
Journal Article
Elton, D., Bruce, E. A., Bryant, N., Wise, H. M., MacRae, S., Rash, A., …Digard, P. (2013). The genetics of virus particle shape in equine influenza A virus. Influenza and Other Respiratory Viruses, 7(s4), https://doi.org/10.1111/irv.12197

Background Many human strains of influenza A virus produce highly pleomorphic virus particles that at the extremes can be approximated as either spheres of around 100 nm diameter or filaments of similar cross-section but elongated to lengths of many... Read More about The genetics of virus particle shape in equine influenza A virus.

Behavioural changes in dairy cows with lameness in an automatic milking system (2013)
Journal Article
Miguel-Pacheco, G., Kaler, J., Remnant, J., Cheyne, L., Abbott, C., French, A. P., …Huxley, J. N. (2014). Behavioural changes in dairy cows with lameness in an automatic milking system. Applied Animal Behaviour Science, 150, 1-8. https://doi.org/10.1016/j.applanim.2013.11.003

There is a tendency worldwide for the automation of farms; this has included the introduction of automatic milking systems (AMS) in the dairy industry. Lameness in dairy cows is highly prevalent and painful. These impacts potentially affect not only... Read More about Behavioural changes in dairy cows with lameness in an automatic milking system.

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors (2013)
Journal Article
Chan, C. M., Fulton, J., Montiel-Duarte, C., Collins, H. M., Bharti, N., Wadelin, F. R., …Heery, D. M. (2013). A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Research, 41(21), https://doi.org/10.1093/nar/gkt761

Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates... Read More about A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data? (2013)
Journal Article
Lewis, R., May, H., Mobasheri, A., & Barrett-Jolley, R. (2013). Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?. Channels, 7(6), https://doi.org/10.4161/chan.26071

To date, a range of ion channels have been identified in chondrocytes using a number of different techniques, predominantly electrophysiological and/or biomolecular; each of these has its advantages and disadvantages. Here we aim to compare and contr... Read More about Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?.

The educational impact of assessment: a comparison of DOPS and MCQs (2013)
Journal Article
Cobb, K. A., Brown, G., Jaarsma, D. A., & Hammond, R. A. (2013). The educational impact of assessment: a comparison of DOPS and MCQs. Medical Teacher, 35(1), Article e1598-e1607. https://doi.org/10.3109/0142159X.2013.803061

Aim: To evaluate the impact of two different assessment formats on the approaches to learning of final year veterinary students. The relationship between approach to learning and examination performance was also investigated. Method: An 18-item ve... Read More about The educational impact of assessment: a comparison of DOPS and MCQs.

A retrospective study of pyometra at five RSPCA hospitals in the United Kingdom: 1,728 cases from 2006-2011 (2013)
Journal Article
Gibson, A., Dean, R. S., Yates, D., & Stavisky, J. (2013). A retrospective study of pyometra at five RSPCA hospitals in the United Kingdom: 1,728 cases from 2006-2011. Veterinary Record, 173(16), https://doi.org/10.1136/vr.101514

A retrospective cross-sectional study was used to analyse pyometra cases at five RSPCA Animal Hospitals across the UK from 2006 to 2011. A total of 1728 cases of pyometra were recovered from a female dog outpatient caseload of 78,469 animals, giv... Read More about A retrospective study of pyometra at five RSPCA hospitals in the United Kingdom: 1,728 cases from 2006-2011.

Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses (2013)
Journal Article
Sun, H., Sun, Y., Pu, J., Zhang, Y., Zhu, Q., Li, J., …Liu, J. (2014). Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses. Journal of Virology, 88(1), https://doi.org/10.1128/JVI.02510-13

Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2, and 7 are the dominant cocirculating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A... Read More about Comparative virus replication and host innate responses in human cells infected with three prevalent clades (2.3.4, 2.3.2, and 7) of highly pathogenic avian influenza H5N1 viruses.

Association between somatic cell count after first parturition and cumulative milk yield in dairy cows (2013)
Journal Article
Archer, S. C., McCoy, F., Wapenaar, W., & Green, M. J. (2013). Association between somatic cell count after first parturition and cumulative milk yield in dairy cows. Veterinary Record, 173(13), https://doi.org/10.1136/vr.101558

The aim was to assess the association between the somatic cell count of parity 1 cows between 5 and 30 days in milk (SCC1), and subsequent cumulative milk yield over approximately two years for cows in English and Welsh dairy herds. The dataset inclu... Read More about Association between somatic cell count after first parturition and cumulative milk yield in dairy cows.

Rate of transmission: a major determinant of the cost of clinical mastitis (2013)
Journal Article
Down, P., Green, M. J., & Hudson, C. (2013). Rate of transmission: a major determinant of the cost of clinical mastitis. Journal of Dairy Science, 96(10), https://doi.org/10.3168/jds.2012-6470

The aim of this research was to use probabilistic sensitivity analysis to evaluate the relative importance of different components of a model designed to estimate the cost of clinical mastitis (CM). A particular focus was placed on the importance... Read More about Rate of transmission: a major determinant of the cost of clinical mastitis.

Sheep farmer opinions on the current and future role of veterinarians in flock health management on sheep farms: a qualitative study (2013)
Journal Article
Kaler, J., & Green, L. (2013). Sheep farmer opinions on the current and future role of veterinarians in flock health management on sheep farms: a qualitative study. Preventive Veterinary Medicine, 112(3-4), https://doi.org/10.1016/j.prevetmed.2013.09.009

A 2009 UK Government report on veterinary expertise in food animal production highlighted that there was insufficient herd health expertise among veterinarians and lack of appropriate business models to deliver veterinary services to the livestock se... Read More about Sheep farmer opinions on the current and future role of veterinarians in flock health management on sheep farms: a qualitative study.

The future of osteoarthritis therapeutics: targeted pharmacological therapy (2013)
Journal Article
Mobasheri, A. (2013). The future of osteoarthritis therapeutics: targeted pharmacological therapy. Current Rheumatology Reports, 15(10), Article 13. https://doi.org/10.1007/s11926-013-0364-9

Osteoarthritis (OA) is one of the most common forms of degenerative joint disease and a major cause of pain and disability affecting the aging population. It is estimated that more than 20 million Americans and 35 to 40 million Europeans suffer from... Read More about The future of osteoarthritis therapeutics: targeted pharmacological therapy.