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The microbiological testing regulations for cannabis products in Canada: Are they enough from food safety and public health point of view? (2020)
Journal Article
Sudhakar Bhandare. (2020). The microbiological testing regulations for cannabis products in Canada: Are they enough from food safety and public health point of view?. Journal of Food, Agriculture and Environment, 18(2), 42-44. https://doi.org/10.1234/4.2020.5672

Canada has recently legalised cannabis for its production, sale and usage in various ways viz. medicinal, recreational and edible. The Access to Cannabis for Medical Purposes Regulations (ACMPR) suggests that the microbial and chemical contaminants o... Read More about The microbiological testing regulations for cannabis products in Canada: Are they enough from food safety and public health point of view?.

The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma (2020)
Journal Article
Joseph, C., Alsaleem, M. A., Toss, M. S., Kariri, Y. A., Althobiti, M., Alsaeed, S., …Rakha, E. A. (2020). The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma. Cancers, 13(1), 1-19. https://doi.org/10.3390/cancers13010080

Background: The leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) plays a role in immune response homeostasis, extracellular matrix remodelling and it is overexpressed in many high-grade cancers. This study aimed to elucidate the biologica... Read More about The ITIM-Containing Receptor: Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) Modulates Immune Response and Confers Poor Prognosis in Invasive Breast Carcinoma.

RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers (2020)
Journal Article
Alblihy, A., Alabdullah, M. L., Toss, M. S., Algethami, M., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2020). RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers. Molecular Biomedicine, 1(1), Article 19. https://doi.org/10.1186/s43556-020-00023-y

Intrinsic or acquired resistance seriously limits the use of platinating agents in advanced epithelial ovarian cancers. Increased DNA repair capacity is a key route to platinum resistance. RAD50 is a critical component of the MRN complex, a ‘first re... Read More about RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2020)
Journal Article
Blake, H., Corner, J., Cirelli, C., Hassard, J., Briggs, L., Daly, J. M., …Ball, J. (2021). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. International Journal of Environmental Research and Public Health, 18(1), 1-26. https://doi.org/10.3390/ijerph18010188

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. We aimed to explore student and staff perceptions and experiences of a pilot SARS-CoV-2 asymptomatic testing service (P-ATS) in a UK university campus setting. This was a mixed-method study co... Read More about Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study.

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells (2020)
Journal Article
Stokes, S., Almire, F., Tatham, M. H., McFarlane, S., Mertens, P., Pondeville, E., & Boutell, C. (2020). The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PLoS Pathogens, 16(12), Article e1009134. https://doi.org/10.1371/journal.ppat.1009134

Mosquitoes are responsible for the transmission of many clinically important arboviruses that cause significant levels of annual mortality and socioeconomic health burden worldwide. Deciphering the mechanisms by which mosquitoes modulate arbovirus in... Read More about The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells (2020)
Journal Article
Brearley, M. C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2020). The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Scientific Reports, 10, Article 22177. https://doi.org/10.1038/s41598-020-79324-9

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells... Read More about The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.

Current Trends in Cancer Immunotherapy (2020)
Journal Article
Filin, I. Y., Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Current Trends in Cancer Immunotherapy. Biomedicines, 8(12), 1-36. https://doi.org/10.3390/biomedicines8120621

The search for an effective drug to treat oncological diseases, which have become the main scourge of mankind, has generated a lot of methods for studying this affliction. It has also become a serious challenge for scientists and clinicians who have... Read More about Current Trends in Cancer Immunotherapy.

The Importance of Anatomy (2020)
Journal Article
Stanford, K., Rutland, S., Sturrock, C. J., & Rutland, C. S. (2020). The Importance of Anatomy. Frontiers for Young Minds, 8, Article 546763. https://doi.org/10.3389/frym.2020.546763

Anatomy is the knowledge about the structure of the bodies of animals and people. This includes information about blood vessels, organs, the skeleton, and nerves. But have you ever wondered where the anatomical information in science books and websit... Read More about The Importance of Anatomy.

Quantitative Analysis of Colostrum Bacteriology on British Dairy Farms (2020)
Journal Article
Hyde, R. M., Green, M. J., Hudson, C., & Down, P. M. (2020). Quantitative Analysis of Colostrum Bacteriology on British Dairy Farms. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.601227

© Copyright © 2020 Hyde, Green, Hudson and Down. Total bacterial counts (TBC) and coliform counts (CC) were estimated for 328 colostrum samples from 56 British dairy farms. Samples collected directly from cows' teats had lower mean TBC (32,079) and C... Read More about Quantitative Analysis of Colostrum Bacteriology on British Dairy Farms.

Association of magnetic resonance assessed disc degeneration and late clinical recurrence in dogs treated surgically for thoracolumbar intervertebral disc extrusions (2020)
Journal Article
Longo, S., Gomes, S. A., Briola, C., Duffy, K., Targett, M., Jeffery, N. D., & Freeman, P. (2021). Association of magnetic resonance assessed disc degeneration and late clinical recurrence in dogs treated surgically for thoracolumbar intervertebral disc extrusions. Journal of Veterinary Internal Medicine, 35(1), 378-387. https://doi.org/10.1111/jvim.15989

Background: Radiographic signs of intervertebral disc mineralization are thought to indicate sites of future recurrence of disc extrusion (Hansen type I) but the relationship between evidence of disc degeneration on magnetic resonance imaging (MRI) a... Read More about Association of magnetic resonance assessed disc degeneration and late clinical recurrence in dogs treated surgically for thoracolumbar intervertebral disc extrusions.

Test Record (2020)
Journal Article
Veasey, B., CREATORS_FN: Price, C. V., CREATORS_FN: Green, C. J., CREATORS_FN: Sperring, C. D., CREATORS_FN: Houghton, C. L., Bloggs, & Person, N. U. (2020). Test Record. Nature Communications, https://doi.org/10.1000/xyz123

ABSTRACT: This is a test record for the purposes of analysis of collected meta against particular input fieldname titles and how it is exposed through JSON export from eprints (Everything Version) ------ This is an adjusted abstract with two ne... Read More about Test Record.

Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica (2020)
Journal Article
Shi, W., He, J., Mei, X., Lu, K., Zeng, Z., Zhang, Y., …Zhu, X. (2020). Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica. PLoS Neglected Tropical Diseases, 14(12), Article e0008951. https://doi.org/10.1371/journal.pntd.0008951

The excretory-secretory products released by the liver fluke Fasciola gigantica (FgESPs) play important roles in regulating the host immune response during the infection. Identification of hepatic miRNAs altered by FgESPs may improve our understandin... Read More about Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica.

ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell (2020)
Journal Article
Li, J., He, J., Elsheikha, H. M., Ma, J., Xu, X., & Zhu, X. (2020). ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell. Frontiers in Cellular and Infection Microbiology, 10, Article 586946. https://doi.org/10.3389/fcimb.2020.586946

Toxoplasma gondii secretes a number of virulence-related effector proteins, such as the rhoptry protein 18 (ROP18). To further broaden our understanding of the molecular functions of ROP18, we examined the transcriptional response of human embryonic... Read More about ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell.

Early postnatal exposure to a cafeteria diet interferes with recency and spatial memory, but not open field habituation in adolescent rats (2020)
Journal Article
Wait, J., Burns, C., Jones, T., Harper, Z., Allen, E., Langley-Evans, S. C., & Voigt, J. (2021). Early postnatal exposure to a cafeteria diet interferes with recency and spatial memory, but not open field habituation in adolescent rats. Developmental Psychobiology, 63(3), 572-581. https://doi.org/10.1002/dev.22063

The cafeteria diet (CD), an experimental diet that mimics the obesogenic Western diet, can impair memory in adult rats. However, the suckling period is also particularly susceptible to diet?induced behavioural modification. Here, following exposure t... Read More about Early postnatal exposure to a cafeteria diet interferes with recency and spatial memory, but not open field habituation in adolescent rats.

A paradox in bacterial pathogenesis: Activation of the local macrophage inflammasome is required for virulence of streptococcus uberis (2020)
Journal Article
Archer, N., Egan, S. A., Coffey, T. J., Emes, R. D., Addis, M. F., Ward, P. N., …Leigh, J. A. (2020). A paradox in bacterial pathogenesis: Activation of the local macrophage inflammasome is required for virulence of streptococcus uberis. Pathogens, 9(12), 1-23. https://doi.org/10.3390/pathogens9120997

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Streptococcus uberis is a common cause of intramammary infection and mastitis in dairy cattle. Unlike other mammary pathogens, S. uberis evades detection by mammary epithelial cells, and the h... Read More about A paradox in bacterial pathogenesis: Activation of the local macrophage inflammasome is required for virulence of streptococcus uberis.

Understanding farmers' naturalistic decision making around prophylactic antibiotic use in lambs using a grounded theory and natural language processing approach (2020)
Journal Article
Doidge, C., Ferguson, E., Lovatt, F., & Kaler, J. (2021). Understanding farmers' naturalistic decision making around prophylactic antibiotic use in lambs using a grounded theory and natural language processing approach. Preventive Veterinary Medicine, 186, Article 105226. https://doi.org/10.1016/j.prevetmed.2020.105226

The routine use of antibiotics for prevention of disease in neonatal lambs has been highlighted as inappropriate, yet research suggests that many farmers in the UK still carry out this practice. The aim of the study was to understand farmers' natural... Read More about Understanding farmers' naturalistic decision making around prophylactic antibiotic use in lambs using a grounded theory and natural language processing approach.

Molecular prevalence, risk factors and genotypes of Toxoplasma gondii DNA in wild marine snails collected from offshore waters in eastern China (2020)
Journal Article
Cong, W., Elsheikha, H. M., Li, M., Ma, J., Zou, Y., & Jiang, Z. (2021). Molecular prevalence, risk factors and genotypes of Toxoplasma gondii DNA in wild marine snails collected from offshore waters in eastern China. Acta Tropica, 214, https://doi.org/10.1016/j.actatropica.2020.105779

Increasing evidence exisits for the role that shellfish play in the epidemiology of Toxoplasma gondii in marine environment. However, limited information is available on the level of T. gondii infection in wild marine snails, which can play a role in... Read More about Molecular prevalence, risk factors and genotypes of Toxoplasma gondii DNA in wild marine snails collected from offshore waters in eastern China.

Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis (2020)
Journal Article
Elsheikha, H. M., Marra, C. M., & Zhu, X. (2020). Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis. Clinical Microbiology Reviews, 34(1), https://doi.org/10.1128/CMR.00115-19

Toxoplasma gondii is known to infect a considerable number of mammalian and avian species and a substantial proportion of the world’s human population. The parasite has an impressive ability to disseminate within the host’s body and employs various t... Read More about Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis.