All Outputs (5)

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells (2020)
Journal Article
Brearley, M. C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2020). The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Scientific Reports, 10, Article 22177. https://doi.org/10.1038/s41598-020-79324-9

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells... Read More about The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.

Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2019)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2019). Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 9(1), Article 15412. https://doi.org/10.1038/s41598-019-43807-1

© 2019, The Author(s). In the Supplementary Information file originally published with this Article, Table 2 was omitted. This error has been corrected in the Supplementary Information that now accompanies the Article.

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells (2019)
Journal Article
Brearley, M. C., Li, C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2019). Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells. Biochemistry and Biophysics Reports, 20, Article 100694. https://doi.org/10.1016/j.bbrep.2019.100694

Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is... Read More about Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells.

The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2018)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2018). The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 8, Article 15915. https://doi.org/10.1038/s41598-018-34315-9

Synthetic beta-adrenergic agonists (BA) have broad biomedical and agricultural application for increasing lean body mass, yet a poor understanding of the biology underpinning these agents is limiting further drug discovery potential. Growing female p... Read More about The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., …Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombi... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.