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All Outputs (21)

Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses (2024)
Journal Article
Elbohy, O. A., Iqbal, M., Daly, J. M., & Dunham, S. P. (2024). Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses. Veterinary Sciences, 11(2), Article 93. https://doi.org/10.3390/vetsci11020093

Avian influenza A virus (AIV) is a significant cause of mortality in poultry, causing substantial economic loss, particularly in developing countries, and has zoonotic potential. For example, highly pathogenic avian influenza (HPAI) viruses of the H5... Read More about Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses.

UK flockdown: A survey of smallscale poultry keepers and their understanding of governmental guidance on highly pathogenic avian influenza (HPAI) (2024)
Journal Article
McClaughlin, E., Elliott, S., Jewitt, S., Smallman-Raynor, M., Dunham, S., Parnell, T., …Tarlinton, R. (2024). UK flockdown: A survey of smallscale poultry keepers and their understanding of governmental guidance on highly pathogenic avian influenza (HPAI). Preventive Veterinary Medicine, 224, Article 106117. https://doi.org/10.1016/j.prevetmed.2024.106117

The scale of the current outbreak of highly pathogenic avian influenza (HPAI) due to the A/H5N1 virus in the United Kingdom is unprecedented. In addition to its economic impact on the commercial poultry sector, the disease has devastated wild bird co... Read More about UK flockdown: A survey of smallscale poultry keepers and their understanding of governmental guidance on highly pathogenic avian influenza (HPAI).

Veterinarians’ knowledge and experience of avian influenza and perspectives on control measures in the UK (2024)
Journal Article
Jewitt, S., McClaughlin, E., Elliott, S., Smallman-Raynor, M., Clark, M., Dunham, S., & Tarlinton, R. (2024). Veterinarians’ knowledge and experience of avian influenza and perspectives on control measures in the UK. Veterinary Record, Article e3713. https://doi.org/10.1002/vetr.3713

Background: The scale of the outbreak of highly pathogenic avian influenza (HPAI) in 2021–23 due to the influenza A/H5N1 virus is unprecedented. Methods: An online survey was designed to explore veterinarians’ experiences of and confidence in treatin... Read More about Veterinarians’ knowledge and experience of avian influenza and perspectives on control measures in the UK.

Veterinarians' knowledge and experience of avian influenza and perspectives on control measures in the United Kingdom (2024)
Journal Article
Jewitt, S., Mcclaughlin, E., Elliott, S., Smallman-Raynor, M., Clark, M., Dunham, S., & Tarlinton, R. (in press). Veterinarians' knowledge and experience of avian influenza and perspectives on control measures in the United Kingdom. Veterinary Record, Article e3713

Background The scale of the outbreak of highly pathogenic avian influenza (HPAI) in 2021–23 due to the influenza A/H5N1 virus is unprecedented. Methods An online survey was designed to explore veterinarians’ experiences of and confidence in trea... Read More about Veterinarians' knowledge and experience of avian influenza and perspectives on control measures in the United Kingdom.

Exploring the responses of smallscale poultry keepers to avian influenza regulations and guidance in the United Kingdom, with recommendations for improved biosecurity messaging (2023)
Journal Article
Jewitt, S., Smallman-Raynor, M., McClaughlin, E., Clark, M., Dunham, S., Elliott, S., …Tarlinton, R. (2023). Exploring the responses of smallscale poultry keepers to avian influenza regulations and guidance in the United Kingdom, with recommendations for improved biosecurity messaging. Heliyon, 9(9), Article E19211. https://doi.org/10.1016/j.heliyon.2023.e19211

Understanding how smallscale (‘backyard’) poultry keepers interpret and respond to governmental directives designed to reduce the transmission of highly pathogenic avian influenza (HPAI) is of paramount importance in preparing for future HPAI outbrea... Read More about Exploring the responses of smallscale poultry keepers to avian influenza regulations and guidance in the United Kingdom, with recommendations for improved biosecurity messaging.

UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI) (2023)
Working Paper
McClaughlin, E., Elliott, S., Jewitt, S., Smallman-Raynor, M., Dunham, S., Parnell, T., …Tarlinton, R. UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI)

The scale of the current outbreak of highly pathogenic avian influenza (HPAI) due to the A/H5N1 virus in the United Kingdom is unprecedented. In addition to its economic impact on the commercial poultry sector, the disease has devastated wild bird co... Read More about UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI).

Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock (2023)
Journal Article
Davies, P., Jones, S., Dunham, S., & Tarlinton, R. E. (2023). Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock. Veterinary Record, 192(11), Article e2731. https://doi.org/10.1002/vetr.2731

Background Small ruminant lentiviruses (SRLVs) are lentiviruses of sheep and goats, formerly known as maedi–visna (MV) in sheep and caprine encephalitis and arthritis in goats. In sheep, SRLVs commonly cause progressive pneumonia, wasting and indura... Read More about Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock.

Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018) (2022)
Journal Article
Curwen, A., Jones, S., Stayley, C., Eden, L., McKay, H., Davies, P., …Tarlinton, R. (2022). Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018). Veterinary Record Open, 9(1), Article e39. https://doi.org/10.1002/vro2.39

Background Schmallenberg virus is a midge borne arbovirus that first emerged in the European ruminant population in 2011 and has since settled to an endemic pattern of disease The impacts of trade restrictions on genetic products (semen, embryos) f... Read More about Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018).

Lipid biophysics and/or soft matter-inspired approach for controlling enveloped virus infectivity (2022)
Journal Article
Al-dalawi, L., Dunham, S. P., & Rauch, C. (2022). Lipid biophysics and/or soft matter-inspired approach for controlling enveloped virus infectivity. Journal of the Royal Society. Interface, 19(189), Article 20210943. https://doi.org/10.1098/rsif.2021.0943

Proven as a natural barrier against viral infection, pulmonary surfactant phospholipids have a biophysical and immunological role within the respiratory system, acting against microorganisms including viruses. Enveloped viruses have, in common, an ou... Read More about Lipid biophysics and/or soft matter-inspired approach for controlling enveloped virus infectivity.

Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry (2022)
Journal Article
Nurzijah, I., Elbohy, O. A., Kanyuka, K., Daly, J. M., & Dunham, S. (2022). Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry. Vaccines, 10(3), Article 478. https://doi.org/10.3390/vaccines10030478

Viral diseases, including avian influenza (AI) and Newcastle disease (ND), are an important cause of morbidity and mortality in poultry, resulting in significant economic losses. Despite the availability of commercial vaccines for the major viral dis... Read More about Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry.

Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele (2022)
Journal Article
Jones, S., McKay, H., Eden, L., Bollard, N., Dunham, S., Davies, P., & Tarlinton, R. (2022). Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele. Journal of Medical Microbiology, 71(2), Article 001506. https://doi.org/10.1099/jmm.0.001506

Maedi-visna (MV) is a lentiviral disease of sheep responsible for severe production losses in affected flocks. There are no vaccination or treatment options with control reliant on test and cull strategies. The most common diagnostic methods used at... Read More about Clearance of Maedi-visna infection in a longitudinal study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele.

Recombinant viruses for cancer therapy (2018)
Journal Article
Chulpanova, D. S., Solovyeva, V. V., Kitaeva, K. V., Dunham, S. P., Khaiboullina, S. F., & Rizvanov, A. A. (2018). Recombinant viruses for cancer therapy. Biomedicines, 6(4), 1-14. https://doi.org/10.3390/biomedicines6040094

Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism allowing gene expression in a wid... Read More about Recombinant viruses for cancer therapy.

Longitudinal study of Asian elephants, Elephas maximus, indicates intermittent shedding of elephant endotheliotropic herpesvirus 1 during pregnancy (2015)
Journal Article
Bennett, L., Dunham, S. P., Yon, L., Chapman, S., Kenaghan, M., Purdie, L., & Tarlinton, R. E. (2015). Longitudinal study of Asian elephants, Elephas maximus, indicates intermittent shedding of elephant endotheliotropic herpesvirus 1 during pregnancy. Veterinary Record Open, 2(1), Article e000088. https://doi.org/10.1136/vetreco-2014-000088

Introduction: EEHV-1 is a viral infection of elephants that has been associated with a fatal haemorrhagic syndrome in Asian elephants. Previous studies have suggested that pregnant animals may shed more virus than non-pregnant animals. Methods: This... Read More about Longitudinal study of Asian elephants, Elephas maximus, indicates intermittent shedding of elephant endotheliotropic herpesvirus 1 during pregnancy.

Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells (2015)
Journal Article
Al-Mubarak, F., Daly, J., Christie, D., Fountain, D., & Dunham, S. P. (2015). Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells. Virus Research, 199, 9-19. https://doi.org/10.1016/j.virusres.2015.01.005

Although wild ducks are considered to be the major reservoirs for most influenza A virus subtypes, they are typically resistant to the effects of the infection. In contrast, certain influenza viruses may be highly pathogenic in other avian hosts such... Read More about Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells.

DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells (2015)
Journal Article
Kuchipudi, S., Chang, K., & Dunham, S. (2015). DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells. Genomics Data, 4, 60-64. https://doi.org/10.1016/j.gdata.2015.03.004

The data described in this article pertain to the article by Kuchipudi et al. (2014) titled “Highly Pathogenic Avian Influenza Virus Infection in Chickens But Not Ducks Is Associated with Elevated Host Immune and Pro-inflammatory Responses” [1]. Whil... Read More about DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells.

Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses (2014)
Journal Article
Kuchipudi, S. V., Tellabati, M., Sebastian, S., Londt, B. Z., Jansen, C., Vervelde, L., …Chang, K. (2014). Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses. Veterinary Research, 45(1), Article 118. https://doi.org/10.1186/s13567-014-0118-3

© 2014 Kuchipudi et al.; licensee BioMed Central Ltd. Highly pathogenic avian influenza (HPAI) H5N1 viruses cause severe infection in chickens at near complete mortality, but corresponding infection in ducks is typically mild or asymptomatic. To unde... Read More about Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses.

A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome (2014)
Journal Article
Moreton, J., Dunham, S. P., & Emes, R. D. (2014). A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome. Frontiers in Genetics, 5, Article 190. https://doi.org/10.3389/fgene.2014.00190

For vertebrate organisms where a reference genome is not available, de novo transcriptome assembly enables a cost effective insight into the identification of tissue specific or differentially expressed genes and variation of the coding part of the g... Read More about A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome.

The challenge of Schmallenberg virus emergence in Europe (2012)
Journal Article
Tarlinton, R., Daly, J. M., Dunham, S. P., & Kydd, J. M. (2012). The challenge of Schmallenberg virus emergence in Europe. Veterinary Journal, 194(1), 10-18. https://doi.org/10.1016/j.tvjl.2012.08.017

The large-scale outbreak of disease across Northern Europe caused by a new orthobunyavirus known as Schmallenberg virus has caused considerable disruption to lambing and calving. Although advances in technology and collaboration between veterinary... Read More about The challenge of Schmallenberg virus emergence in Europe.

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release (2012)
Journal Article
Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Perez, B., Pengxiang, C., …Chang, K. (2012). Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release. Journal of Virology, 86(17), https://doi.org/10.1128/JVI.00244-12

Respiratory epithelial cells and macrophages are the key innate immune cells that play an important role in the pathogenesis of influenza A virus infection. We found that these two cell types from both human and pig showed comparable susceptibilities... Read More about Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release.