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All Outputs (2)

Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy (2018)
Journal Article
Saad, N., Alberio, R., Johnson, A. D., Emes, R. D., Giles, T. C., Clarke, P., …Allegrucci, C. (2018). Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget, 9(22), 16008-16027. https://doi.org/10.18632/oncotarget.24664

Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in canc... Read More about Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.