All Outputs (7)

Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes (2014)
Journal Article
Hdud, I. M., Mobasheri, A., & Loughna, P. (2014). Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes. SpringerPlus, 3, Article 59. https://doi.org/10.1186/2193-1801-3-59

Background Chondrocytes are regularly exposed to load-induced stimuli and have the capability to sense and respond to applied mechanical stress. However, the mechanisms involved in chondrocyte mechanotransduction are not clearly understood. The pu... Read More about Effects of cyclic equibiaxial mechanical stretch on ?-BK and TRPV4 expression in equine chondrocytes.

Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1? (2013)
Journal Article
Williams, A., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2013). Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?. Arthritis Research and Therapy, 15(6), Article R223. https://doi.org/10.1186/ar4424

Introduction: Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metalloproteinases (MMPs) is partly... Read More about Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?.

Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning (2013)
Journal Article
Swan, A. L., Hillier, K. L., Smith, J. R., Allaway, D., Liddell, S., Bacardit, J., & Mobasheri, A. (2013). Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning. BMC Musculoskeletal Disorders, 14, Article 349. https://doi.org/10.1186/1471-2474-14-349

Background: Osteoarthritis (OA) is an inflammatory disease of synovial joints involving the loss and degeneration of articular cartilage. The gold standard for evaluating cartilage loss in OA is the measurement of joint space width on standard radiog... Read More about Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning.

Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes (2012)
Journal Article
Hdud, I. M., El-Shafei, A. A., Loughna, P., Barrett-Jolley, R., & Mobasheri, A. (2012). Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes. International Journal of Molecular Sciences, 13(4), https://doi.org/10.3390/ijms13044433

Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective c... Read More about Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes.

Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY (2011)
Journal Article
Buhrmann, C., Mobasheri, A., Busch, F., Aldinger, C., Stahlmann, R., Montaseri, A., & Shakibaei, M. (2011). Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY. Journal of Biological Chemistry, 286(32), https://doi.org/10.1074/jbc.M111.256180

Inflammatory processes play essential roles in the pathogenesis of tendinitis and tendinopathy. These events are accompanied by catabolic processes initiated by pro-inflammatory cytokines such as interleukin-1? (IL-1?) and tumor necrosis factor-? (TN... Read More about Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY.

From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of mesenchymal stem cells (2011)
Book Chapter
Mobasheri, A., Richardson, S. M., Hoyland, J. A., Buhrmann, C., & Shakibaei, M. (2011). From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of mesenchymal stem cells. In D. Eberli (Ed.), Regenerative medicine and tissue engineering: cells and biomaterials. InTech. https://doi.org/10.5772/837

High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation (2011)
Journal Article
Clutterbuck, A. L., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2011). High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. Journal of Proteomics, 74(5), https://doi.org/10.1016/j.jprot.2011.02.017

This study employed a targeted high-throughput proteomic approach to identify the major proteins present in the secretome of articular cartilage. Explants from equine metacarpophalangeal joints were incubated alone or with interleukin-1beta (IL-1?, 1... Read More about High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation.