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Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage (2020)
Journal Article
Green, L. R., Al-Rubaiawi, A. A., Al-Maeni, M. A., Harrison, O. B., Blades, M., Oldfield, N. J., …Bayliss, C. D. (2020). Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage. mBio, 11(2), Article e03068-19. https://doi.org/10.1128/mBio.03068-19

© 2020 Green et al. Host persistence of bacteria is facilitated by mutational and recombina-torial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated... Read More about Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage.

Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage (2020)
Journal Article
Bayliss, C. D., Green, L. R., Al-Rubaiawi, A. A., Oldfield, N. J., Turner, D. P. J., Al-Maeni, M. A. R. M., …Maiden, M. C. J. (2020). Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage. mBio, 11(2), Article e03068-19. https://doi.org/10.1128/mBio.03068-19

Host persistence of bacteria is facilitated by mutational and recombina-torial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated during persistent as... Read More about Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage.

Context is everything: extrinsic signalling and gain-of-function p53 mutants (2020)
Journal Article
Amelio, I., & Melino, G. (2020). Context is everything: extrinsic signalling and gain-of-function p53 mutants. Cell Death Discovery, 6, Article 16. https://doi.org/10.1038/s41420-020-0251-x

The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has not been reached. Depending on ca... Read More about Context is everything: extrinsic signalling and gain-of-function p53 mutants.

Membrane Stability in the Presence of Methacrylate Esters (2020)
Journal Article
Yeh, V., Goode, A., Eastham, G., Rambo, R. P., Inoue, K., Doutch, J., & Bonev, B. B. (2020). Membrane Stability in the Presence of Methacrylate Esters. Langmuir, 36(33), 9649-9657. https://doi.org/10.1021/acs.langmuir.9b03759

Bioproduction of poly(methyl methacrylate) is a fast growing global industry that is limited by cellular toxicity of monomeric methacrylate intermediates to the producer strains. Maintaining high methacrylate concentrations during biofermentation, re... Read More about Membrane Stability in the Presence of Methacrylate Esters.

Application of the Random Encounter Model in citizen science projects to monitor animal densities (2020)
Journal Article
Schaus, J., Uzal, A., Gentle, L. K., Baker, P. J., Bearman-Brown, L., Bullion, S., …Yarnell, R. W. (2020). Application of the Random Encounter Model in citizen science projects to monitor animal densities. Remote Sensing in Ecology and Conservation, 6(4), 514-528. https://doi.org/10.1002/rse2.153

© 2020 The Authors. Remote Sensing in Ecology and Conservation published by John Wiley & Sons Ltd on behalf of Zoological Society of London. Abundance and density are vital metrics for assessing a species’ conservation status and for developing eff... Read More about Application of the Random Encounter Model in citizen science projects to monitor animal densities.

Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria (2020)
Other
Taylor, G. M., & Heap, J. T. Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria

Cyanobacteria are simple, efficient, genetically-tractable photosynthetic microorganisms representing ideal biocatalysts for CO2 capture and conversion, in principle. In practice, genetic instability and low productivity are key, linked problems in e... Read More about Combinatorial metabolic engineering platform enabling stable overproduction of lycopene from carbon dioxide by cyanobacteria.

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings (2020)
Journal Article
McColl, B. W., Allan, S. M., McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., …Quinn, T. J. (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), 1402-1414. https://doi.org/10.1177/0271678x20910552

© The Author(s) 2020. Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine unde... Read More about UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings.

A novel allele of ASY3 promotes meiotic stability in autotetraploid Arabidopsis lyrata (2020)
Working Paper
Seear, P. J., France, M. G., Gregory, C. L., Heavens, D., Schmickl, R., Yant, L., & Higgins, J. D. A novel allele of ASY3 promotes meiotic stability in autotetraploid Arabidopsis lyrata

In this study we performed a genotype-phenotype association analysis of meiotic stability in ten autotetraploid Arabidopsis lyrata and A. lyrata/A. arenosa hybrid populations collected from the Wachau region and East Austrian Forealps. The aim was to... Read More about A novel allele of ASY3 promotes meiotic stability in autotetraploid Arabidopsis lyrata.

Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery (2020)
Journal Article
Al-Natour, M. A., Yousif, M. D., Cavanagh, R., Abouselo, A., Apebende, E. A., Ghaemmaghami, A., …Alexander, C. (2020). Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery. ACS Macro Letters, 9(3), 431-437. https://doi.org/10.1021/acsmacrolett.9b01014

Copyright © 2020 American Chemical Society. Poly(lactic-co-glycolic acid) (PLGA) is a versatile synthetic copolymer that is widely used in pharmaceutical applications. This is because it is well-tolerated in the body, and copolymers of varying physic... Read More about Facile Dye-Initiated Polymerization of Lactide–Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery.

A genome-wide approach for identification and characterisation of metabolite-inducible systems (2020)
Journal Article
Hanko, E. K. R., Paiva, A. C., Jonczyk, M., Abbott, M., Minton, N. P., & Malys, N. (2020). A genome-wide approach for identification and characterisation of metabolite-inducible systems. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-14941-6

© 2020, The Author(s). Inducible gene expression systems are vital tools for the advancement of synthetic biology. Their application as genetically encoded biosensors has the potential to contribute to diagnostics and to revolutionise the field of mi... Read More about A genome-wide approach for identification and characterisation of metabolite-inducible systems.

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation (2020)
Journal Article
Barron, M. R., Gartlon, J., Dawson, L. A., Atkinson, P. J., & Pardon, M. (2020). Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. Frontiers in Immunology, 11, https://doi.org/10.3389/fimmu.2020.00293

Copyright © 2020 Barron, Gartlon, Dawson, Atkinson and Pardon. Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To furt... Read More about Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation.

Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men (2020)
Journal Article
Tsintzas, K., Jones, R., Pabla, P., Mallinson, J., Barrett, D. A., Kim, D. H., …Stephens, F. B. (2020). Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men. AJP - Endocrinology and Metabolism, 318(3), E417-E429. https://doi.org/10.1152/ajpendo.00344.2019

Muscle anabolic resistance to dietary protein is associated with obesity and insulin resistance. However, the contribution of excess consumption of fat to anabolic resistance is not well studied. The aim of these studies was to test the hypothesis th... Read More about Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men.

Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair (2020)
Journal Article
Di Giovanni, E., Buonvino, S., Amelio, I., & Melino, S. (2020). Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair. International Journal of Molecular Sciences, 21(5), Article 1638. https://doi.org/10.3390/ijms21051638

The endogenous gasotransmitter H2S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H2S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for card... Read More about Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair.

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex (2020)
Journal Article
Koo, C. Z., Harrison, N., Noy, P. J., Szyroka, J., Matthews, A. L., Hsia, H. E., …Tomlinson, M. G. (2020). The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. Journal of Biological Chemistry, 295(36), 12822-12839. https://doi.org/10.1074/jbc.RA120.012601

© 2020 Koo et al. A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as cancer, Alzheimer's disease, and inflammation. ADAM10 is a "molecular sc... Read More about The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex.

Cost effectiveness of an intervention to increase uptake of hepatitis C virus testing and treatment (HepCATT): cluster randomised controlled trial in primary care (2020)
Journal Article
Roberts, K., Macleod, J., Metcalfe, C., Hollingworth, W., Williams, J., Muir, P., …Hickman, M. (2020). Cost effectiveness of an intervention to increase uptake of hepatitis C virus testing and treatment (HepCATT): cluster randomised controlled trial in primary care. BMJ, 368(368), Article m322. https://doi.org/10.1136/bmj.m322

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. OBJECTIVE: To evaluate the effectiveness and cost effectiveness of... Read More about Cost effectiveness of an intervention to increase uptake of hepatitis C virus testing and treatment (HepCATT): cluster randomised controlled trial in primary care.

The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials (2020)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., Scott, M. J., & Lobo, D. N. (2020). The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials. European Journal of Anaesthesiology, 37(8), 659-670. https://doi.org/10.1097/eja.0000000000001165

BACKGROUND There has recently been increasing interest in the use of peri-operative intravenous lidocaine (IVL) due to its analgesic, anti-inflammatory and opioid-sparing effects. However, these potential benefits are not well established in electi... Read More about The impact of peri-operative intravenous lidocaine on postoperative outcome after elective colorectal surgery: A meta-analysis of randomised controlled trials.

A Simple Polymicrobial Biofilm Keratinocyte Colonization Model for Exploring Interactions Between Commensals, Pathogens and Antimicrobials (2020)
Journal Article
Jordana-Lluch, E., Garcia, V., Kingdon, A. D. H., Singh, N., Alexander, C., Williams, P., & Hardie, K. R. (2020). A Simple Polymicrobial Biofilm Keratinocyte Colonization Model for Exploring Interactions Between Commensals, Pathogens and Antimicrobials. Frontiers in Microbiology, 11, Article 291. https://doi.org/10.3389/fmicb.2020.00291

© 2020 Jordana-Lluch, Garcia, Kingdon, Singh, Alexander, Williams and Hardie. Skin offers protection against external insults, with the skin microbiota playing a crucial defensive role against pathogens that gain access when the skin barrier is breac... Read More about A Simple Polymicrobial Biofilm Keratinocyte Colonization Model for Exploring Interactions Between Commensals, Pathogens and Antimicrobials.

Improved functional connectivity network estimation for brain networks using multivariate partial coherence (2020)
Journal Article
Halliday, D. M., Senik, M. H., Makhtar, S. N., Stevenson, C. W., & Mason, R. (2020). Improved functional connectivity network estimation for brain networks using multivariate partial coherence. Journal of Neural Engineering, 17(2), Article 026013. https://doi.org/10.1088/1741-2552/ab7a50

Objective: Graphical networks and network metrics are widely used to understand and char-acterise brain networks and brain function. These methods can be applied to a range of electro-physiological data including electroencephalography, local field p... Read More about Improved functional connectivity network estimation for brain networks using multivariate partial coherence.

Coinfinder: Detecting significant associations and dissociations in pangenomes (2020)
Journal Article
Whelan, F. J., Rusilowicz, M., & McInerney, J. O. (2020). Coinfinder: Detecting significant associations and dissociations in pangenomes. Microbial Genomics, 6(3), https://doi.org/10.1099/mgen.0.000338

© 2020 The Authors. The accessory genes of prokaryote and eukaryote pangenomes accumulate by horizontal gene transfer, differential gene loss, and the effects of selection and drift. We have developed Coinfinder, a software program that assesses whet... Read More about Coinfinder: Detecting significant associations and dissociations in pangenomes.

Cas3 Protein—A Review of a Multi-Tasking Machine (2020)
Journal Article
He, L., St. John James, M., Radovcic, M., Ivancic-Bace, I., & Bolt, E. L. (2020). Cas3 Protein—A Review of a Multi-Tasking Machine. Genes, 11(2), Article 208. https://doi.org/10.3390/genes11020208

Cas3 has essential functions in CRISPR immunity but its other activities and roles, in vitro and in cells, are less widely known. We offer a concise review of the latest understanding and questions arising from studies of Cas3 mechanism during CRISPR... Read More about Cas3 Protein—A Review of a Multi-Tasking Machine.