All Outputs (2240)

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., …Kashyap, R. S. (2020). Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome. Gut Microbes, 12(1), Article 1752605. https://doi.org/10.1080/19490976.2020.1752605

© 2020, © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal d... Read More about Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort (2020)
Journal Article
Bagasi, A. A., Howson-Wells, H. C., Clark, G., Tarr, A. W., Soo, S., Irving, W. L., & McClure, C. P. (2020). Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort. Journal of Clinical Virology, 129, Article 104453. https://doi.org/10.1016/j.jcv.2020.104453

© 2020 Elsevier B.V. Background: Since its first isolation in 2005, Human Bocavirus (HBoV) has been repeatedly associated with acute respiratory tract infections, although its role in pathogenicity remains unclear due to high co-infection rates. Obje... Read More about Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort.

Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time (2020)
Working Paper
Narayanasamy, K. K., Price, J. C., Mesquita-Riberio, R., Mather, M. L., & Jayasinghe, I. Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time

Stochastic optical reconstruction microscopy (STORM) is one of the most commonly used super-resolution microscopy techniques. Popular implementations of STORM utilize aromatic fluorophores and consist of a number of intrinsic limitations such the fin... Read More about Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time.

Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem (2020)
Journal Article
Choudhury, N., Linley, D., Richardson, A., Anderson, M., Robinson, S. W., Marra, V., …Forsythe, I. D. (2020). Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem. Journal of Physiology, 598(11), 2199-2222. https://doi.org/10.1113/jp279668

Kv3 voltage-gated potassium channels mediate action potential (AP) repolarization. The relative importance of Kv3.1 and Kv3.3 subunits for assembly of functional channels in neurons of the auditory brainstem was examined from the physiological perspe... Read More about Kv3.1 and Kv3.3 subunits differentially contribute to Kv3 channels and action potential repolarization in principal neurons of the auditory brainstem.

The Use of Biomaterials in Internal Radiation Therapy (2020)
Journal Article
Milborne, B., Arafat, A., Layfield, R., Thompson, A., & Ahmed, I. (2020). The Use of Biomaterials in Internal Radiation Therapy. Recent Progress in Materials, 2(2), https://doi.org/10.21926/rpm.2002012

Radiotherapy has become one of the most prominent and effective modalities for cancer treatment and care. Ionising radiation, delivered either from external or internal sources, can be targeted to cancerous cells causing damage to DNA that can induce... Read More about The Use of Biomaterials in Internal Radiation Therapy.

Polyploidy breaks speciation barriers in Australian burrowing frogs Neobatrachus (2020)
Journal Article
Novikova, P. Y., Brennan, I. G., Booker, W., Mahony, M., Doughty, P., Lemmon, A. R., …Donnellan, S. C. (2020). Polyploidy breaks speciation barriers in Australian burrowing frogs Neobatrachus. PLoS Genetics, 16(5), Article e1008769. https://doi.org/10.1371/journal.pgen.1008769

Polyploidy has played an important role in evolution across the tree of life but it is still unclear how polyploid lineages may persist after their initial formation. While both common and well-studied in plants, polyploidy is rare in animals and gen... Read More about Polyploidy breaks speciation barriers in Australian burrowing frogs Neobatrachus.

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction (2020)
Journal Article
Pan, B., Li, J., Parajuli, N., Tian, Z., Wu, P., Lewno, M. T., …Wang, X. (2020). The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction. Circulation Research, 127(4), 502–518. https://doi.org/10.1161/circresaha.119.316007

Rationale: The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway (ALP) are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients... Read More about The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction.

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells (2020)
Journal Article
Chen, I. L., Todd, I., Tighe, P. J., & Fairclough, L. C. (2020). Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells. Archives of Toxicology, 94(6), 2097-2112 . https://doi.org/10.1007/s00204-020-02757-8

© 2020, The Author(s). Dendritic cells (DCs) are professional antigen presenting cells that play a critical role in bridging innate and adaptive immunity. Numerous studies have shown that tobacco constituents present in conventional cigarettes affect... Read More about Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa (2020)
Journal Article
Soukarieh, F., Liu, R., Romero, M., Roberston, S. N., Richardson, W., Lucanto, S., …Stocks, M. J. (2020). Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa. Frontiers in Chemistry, 8, Article 204. https://doi.org/10.3389/fchem.2020.00204

© Copyright © 2020 Soukarieh, Liu, Romero, Roberston, Richardson, Lucanto, Oton, Qudus, Mashabi, Grossman, Ali, Sou, Kukavica-Ibrulj, Levesque, Bergström, Halliday, Mistry, Emsley, Heeb, Williams, Cámara and Stocks. Current treatments for Pseudomonas... Read More about Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa.

The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster (2020)
Journal Article
Thompson, A. J., Verdin, P. S., Burton, M. J., Davies, T. G., Williamson, M. S., Field, L. M., …Duce, I. R. (2020). The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster. Insect Biochemistry and Molecular Biology, 122, Article 103388. https://doi.org/10.1016/j.ibmb.2020.103388

© 2020 Elsevier Ltd Voltage-gated sodium channels (VGSCs) are a major target site for the action of pyrethroid insecticides and resistance to pyrethroids has been ascribed to mutations in the VGSC gene. VGSCs in insects are encoded by only one gene a... Read More about The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster.

Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R (2020)
Journal Article
Richardson, R. R., Richardson, R., Groenen, M., Liu, M., Mountford, S. J., Briddon, S. J., …Thompson, P. E. (2020). Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R. Journal of Medicinal Chemistry, 63(10), 5274-5286. https://doi.org/10.1021/acs.jmedchem.0c00027

The cyclic dimeric peptide 1229U91 (GR231118) has an unusual structure and displays potent, insurmountable antagonism of the Y1 receptor. To probe the structural basis for this activity, we have prepared ring size variants and heterodimeric compounds... Read More about Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R.

Effect of herbage density, height and age on nutrient and invertebrate generalist predator abundance in permanent and temporary pastures (2020)
Journal Article
Toupet, R., Gibbons, A. T., Goodacre, S. L., & Bell, M. J. (2020). Effect of herbage density, height and age on nutrient and invertebrate generalist predator abundance in permanent and temporary pastures. Land, 9(5), https://doi.org/10.3390/LAND9050164

© 2020 by the authors. The aim of this research was to assess differences in the quantity and quality of herbage and invertebrate generalist predator abundance among permanent and temporary pastures. Two permanent pastures and four temporary ley past... Read More about Effect of herbage density, height and age on nutrient and invertebrate generalist predator abundance in permanent and temporary pastures.

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes (2020)
Journal Article
Zoltner, M., Campagnaro, G. D., Taleva, G., Burrell, A., Cerone, M., Leung, K. F., …Field, M. C. (2020). Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), 8331-8347. https://doi.org/10.1074/jbc.ra120.012355

© 2020 Zoltner et al. Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into the causative agent, the protozoan parasite Trypanosoma bru... Read More about Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model (2020)
Journal Article
Ketley, A., Wojciechowska, M., Ghidelli-Disse, S., Bamborough, P., Ghosh, T. K., Morato, M. L., …Brook, J. D. (2020). CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Science Translational Medicine, 12(541), Article eaaz2415. https://doi.org/10.1126/scitranslmed.aaz2415

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Myotonic dystrophy type 1 (DM1) is an RNA-based disease with no current treatment.... Read More about CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation (2020)
Journal Article
Vassey, M. J., Figueredo, G. P., Scurr, D. J., Vasilevich, A. S., Vermeulen, S., Carlier, A., …Alexander, M. R. (2020). Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation. Advanced Science, 7(11), https://doi.org/10.1002/advs.201903392

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material t... Read More about Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. (2020)
Other
Wheatley, S., & Townley, A. R. Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy..

Perioperative nutrition: Recommendations from the ESPEN expert group (2020)
Journal Article
Lobo, D. N., Gianotti, L., Adiamah, A., Barazzoni, R., Deutz, N., Dhatariya, K., …Weimann, A. (2020). Perioperative nutrition: Recommendations from the ESPEN expert group. Clinical Nutrition, 39(11), 3211-3227. https://doi.org/10.1016/j.clnu.2020.03.038

© 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: Malnutrition has been recognized as a major risk factor for adverse postoperative outcomes. The ESPEN Symposium on perioperative nutrition was held in N... Read More about Perioperative nutrition: Recommendations from the ESPEN expert group.

Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose (2020)
Journal Article
van Munster, J. M., Daly, P., Blythe, M. J., Ibbett, R., Kokolski, M., Gaddipati, S., …Archer, D. B. (2020). Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose. Biotechnology for Biofuels, 13(1), Article 69. https://doi.org/10.1186/s13068-020-01702-2

Background Understanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in investigating fungal degradation d... Read More about Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose.

Case for continuing community NIV and CPAP during the COVID-19 epidemic (2020)
Journal Article
Baker, J. G., & Sovani, M. P. (2020). Case for continuing community NIV and CPAP during the COVID-19 epidemic. Thorax, 75(5), 368-368. https://doi.org/10.1136/thoraxjnl-2020-214913

Dear Editor, Recent clinical guidelines regarding the use of home non-invasive ventilation (NIV) and continuous positive airway pressure (CPAP) during the COVID-19 epidemic have tried to balance the risks of stopping NIV or CPAP against the unknown p... Read More about Case for continuing community NIV and CPAP during the COVID-19 epidemic.

Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion disease (2020)
Working Paper
Bourgognon, J., Spiers, J. G., Robinson, S., Scheiblich, H., Ortori, C., Bradley, S. J., …Steinert, J. Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion disease

Background: Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s, Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated post... Read More about Inhibition of neuroinflammatory nitric oxide signalling supresses protein glycation and recovers neuronal dysfunction in prion disease.