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All Outputs (1375)

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article
Sargent, C., Ebanks, B., Hardy, I. C., Davies, T. G. E., Chakrabarti, L., & Stöger, R. (2021). Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain. Frontiers in Insect Science, 1, Article 765179. https://doi.org/10.3389/finsc.2021.765179

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo (2021)
Journal Article
James, V., Nizamudeen, Z. A., Lea, D., Dottorini, T., Holmes, T. L., Johnson, B. B., …Smith, J. G. (2021). Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo. Stem Cells and Development, 30(24), 1215-1227. https://doi.org/10.1089/scd.2021.0202

Hypertrophic cardiomyopathy (HCM) is characterised by increased left ventricular wall thickness that can lead to devastating conditions such as heart failure and sudden cardiac death. Despite extensive study, the mechanisms mediating many of the asso... Read More about Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo.

Does clopidogrel or clopidogrel plus aspirin result in longer survival times in cats with hypertrophic cardiomyopathy? (2021)
Journal Article
O'Reilly, H., & Brennan, M. (2021). Does clopidogrel or clopidogrel plus aspirin result in longer survival times in cats with hypertrophic cardiomyopathy?. Veterinary Record, 189(10), 404-404. https://doi.org/10.1002/vetr.1198

An apparently healthy cat has a heart murmur detected at vaccination yet no other abnormalities are found on clinical exam. The owner opts for further investigation and hypertrophic cardiomyopathy is confirmed after performing ultrasound of the heart... Read More about Does clopidogrel or clopidogrel plus aspirin result in longer survival times in cats with hypertrophic cardiomyopathy?.

Cow- and herd-level risk factors for lameness in partly housed pasture-based dairy cows (2021)
Journal Article
Browne, N., Hudson, C., Crossley, R., Sugrue, K., Kennedy, E., Huxley, J., & Conneely, M. (2022). Cow- and herd-level risk factors for lameness in partly housed pasture-based dairy cows. Journal of Dairy Science, 105(2), 1418-1431. https://doi.org/10.3168/jds.2021-20767

Lameness in dairy cows is a major animal welfare concern and has substantial economic impact through reduced production and fertility. Previous risk factor analyses have focused on housed systems, rather than those where cows were grazed for the majo... Read More about Cow- and herd-level risk factors for lameness in partly housed pasture-based dairy cows.

Why Do We Need Maths in Medicine? (2021)
Journal Article
Cockcroft, J., Saigar, M., Dawkins, A., & Rutland, C. S. (2021). Why Do We Need Maths in Medicine?. Frontiers for Young Minds, 9, Article 678802. https://doi.org/10.3389/frym.2021.678802

Maths is a crucial part of medicine. All the graphs, equations, statistics, and general maths we learn at school help us to understand important aspects of human and veterinary medicine, biology, and science in general. People always think that biolo... Read More about Why Do We Need Maths in Medicine?.

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers (2021)
Journal Article
Alblihy, A., Shoqafi, A., Toss, M. S., Algethami, M., Harris, A. E., Jeyapalan, J. N., …Madhusudan, S. (2021). Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers. npj Breast Cancer, 7(1), 1-10. https://doi.org/10.1038/s41523-021-00350-5

The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopathological study o... Read More about Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers.

Improving growth rates in preweaning calves on dairy farms: A randomized controlled trial (2021)
Journal Article
Hyde, R. M., Green, M. J., Hudson, C., & Down, P. M. (2022). Improving growth rates in preweaning calves on dairy farms: A randomized controlled trial. Journal of Dairy Science, 105(1), 782-792. https://doi.org/10.3168/jds.2021-20947

Previous research has identified key factors associated with improved average daily gain (ADG) in preweaning dairy calves and these factors have been combined to create a web app–based calf health plan (www.nottingham.ac.uk/herdhealthtoolkit). A rand... Read More about Improving growth rates in preweaning calves on dairy farms: A randomized controlled trial.

Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors (2021)
Journal Article
Zhu, Y. C., Elsheikha, H. M., Wang, J. H., Fang, S., He, J. J., Zhu, X. Q., & Chen, J. (2021). Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors. Journal for ImmunoTherapy of Cancer, 9(11), Article e002970. https://doi.org/10.1136/jitc-2021-002970

Background: In this study, we hypothesize that the ability of the protozoan Toxoplasma gondii to modulate immune response within the tumor might improve the therapeutic effect of immune checkpoint blockade. We examined the synergetic therapeutic acti... Read More about Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model (2021)
Journal Article
Attoui, H., Monsion, B., Klonjkowski, B., Zientara, S., Mertens, P. P. C., & Mohd Jaafar, F. (2021). Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model. Viruses, 13(11), Article 2208. https://doi.org/10.3390/v13112208

Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges, in which they also replicate. However, “atypical” BTV serotypes (BTV‐25, ‐26, ‐27 and ‐28) have recently been identified that do not infect and replicate in a... Read More about Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model.

Systematic Analysis of Breed, Methodological, and Geographical Impact on Equine Sperm Progressive Motility (2021)
Journal Article
Perrett, J., Harris, I. T., Maddock, C., Farnworth, M., Pyatt, A. Z., & Sumner, R. N. (2021). Systematic Analysis of Breed, Methodological, and Geographical Impact on Equine Sperm Progressive Motility. Animals, 11(11), Article 3088. https://doi.org/10.3390/ani11113088

Over the past five decades, there has been increasing evidence to indicate global declines in human semen quality. Parallel adverse trends measured in male animals indicate a potential environmental aetiology. This study evaluated the progressive mot... Read More about Systematic Analysis of Breed, Methodological, and Geographical Impact on Equine Sperm Progressive Motility.

Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus (2021)
Journal Article
Cho, E. S., Krishnan, P., Loh, H. S., Daly, J. M., Leong, C. O., Mai, C. W., …Lim, K. H. (2022). Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus. Phytochemistry, 193, Article 112988. https://doi.org/10.1016/j.phytochem.2021.112988

Four undescribed cucurbitacins, designated as petiolaticins A–D, and four known cucurbitacins were isolated from the bark and leaves of Elaeocarpus petiolatus (Jack) Wall. Their chemical structures were elucidated based on detailed analyses of the NM... Read More about Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus.

A scoping review of the current evidence on treatment and outcomes following synovial sepsis (2021)
Journal Article
de Souza, T. C., Suthers, J. M., Busschers, E., Burford, J. H., & Freeman, S. L. (2022). A scoping review of the current evidence on treatment and outcomes following synovial sepsis. Equine Veterinary Journal, 54(3), 467-480. https://doi.org/10.1111/evj.13527

Background Synovial sepsis is a frequent cause of morbidity and mortality in horses. Despite advances in diagnostics and treatments, persistent infection or chronic lameness can occur. Objectives To perform a scoping review to identify and evalu... Read More about A scoping review of the current evidence on treatment and outcomes following synovial sepsis.

Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex (2021)
Journal Article
Ebanks, B., Wang, Y., Katyal, G., Sargent, C., Ingram, T. L., Bowman, A., …Chakrabarti, L. (2021). Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. International Journal of Molecular Sciences, 22(21), Article 11606. https://doi.org/10.3390/ijms222111606

Ageing is a major risk factor for many of the most prevalent diseases, including neurode-generative diseases, cancer, and heart disease. As the global population continues to age, behavioural interventions that can promote healthy ageing will improve... Read More about Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex.

Biosecurity and the ornamental fish trade: A stakeholder perspective in England (2021)
Journal Article
Wood, L. E., Guilder, J., Brennan, M. L., Birland, N. J., Taleti, V., Stinton, N., …Thrush, M. A. (2022). Biosecurity and the ornamental fish trade: A stakeholder perspective in England. Journal of Fish Biology, 100(2), 352-365. https://doi.org/10.1111/jfb.14928

The freshwater and marine ornamental fish industry is a primary route of hazard introduction and emergence, including aquatic animal diseases and non-native species. Prevention measures are key to reducing the risk of hazard incursion and establishme... Read More about Biosecurity and the ornamental fish trade: A stakeholder perspective in England.

Genetics of Asthma: Insights From Genome Wide Association Studies (2021)
Book Chapter
Cooper, R. M., Bingham, K., Portelli, M. A., & Sayers, I. (2022). Genetics of Asthma: Insights From Genome Wide Association Studies. In Encyclopedia of Respiratory Medicine (308-325). (Second Edition). Elsevier. https://doi.org/10.1016/B978-0-08-102723-3.00155-4

Asthma is a heterogeneous respiratory disease that can be influenced by genetic and environmental factors leading to disease susceptibility and progression. Genome-wide association studies (GWAS) of asthma have yielded replicated findings and identif... Read More about Genetics of Asthma: Insights From Genome Wide Association Studies.

Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration (2021)
Journal Article
Pesko, B., Habershon-Butcher, J., Muir, T., Gray, B., Taylor, P., Fenwick, S., …Paine, S. (2022). Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration. Journal of Veterinary Pharmacology and Therapeutics, 45(1), 54-62. https://doi.org/10.1111/jvp.13024

Paracetamol is a widely used, non-opioid analgesic and antipyretic drug. Scientific evidence suggests that it is an effective pain treatment in equine medicine. However, there is very little published information about the pharmacokinetics of the dru... Read More about Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration.

Comparative pathology of dog and human prostate cancer (2021)
Journal Article
Ryman-Tubb, T., Lothion-Roy, J. H., Metzler, V. M., Harris, A. E., Robinson, B. D., Rizvanov, A. A., …de Brot, S. (2022). Comparative pathology of dog and human prostate cancer. Veterinary Medicine and Science, 8(1), 110-120. https://doi.org/10.1002/vms3.642

Though relatively rare in dogs, prostate cancer (PCa) is the most common non-cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been propos... Read More about Comparative pathology of dog and human prostate cancer.

Extracellular vesicles, tumor growth, and the metastatic process (2021)
Book Chapter
Wesson, F., Brown, T. J., & James, V. (2022). Extracellular vesicles, tumor growth, and the metastatic process. In D. Heymann (Ed.), Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside (275-284). (3rd). Elsevier. https://doi.org/10.1016/B978-0-12-821666-8.00058-X

Extracellular vesicles (EVs) form an important part of cell-to-cell communication, with roles in both health and disease. Within the cancer setting, this heterogenous population of extracellular messengers can have both pro- and antitumorigenic prope... Read More about Extracellular vesicles, tumor growth, and the metastatic process.