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A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding (2020)
Journal Article
White, C. W., Kilpatrick, L. E., Pfleger, K. D., & Hill, S. J. (2021). A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding. iScience, 24(1), Article 102011. https://doi.org/10.1016/j.isci.2020.102011

© 2020 The Author(s) Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quanti... Read More about A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2020)
Journal Article
Blake, H., Corner, J., Cirelli, C., Hassard, J., Briggs, L., Daly, J. M., …Ball, J. (2021). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. International Journal of Environmental Research and Public Health, 18(1), 1-26. https://doi.org/10.3390/ijerph18010188

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. We aimed to explore student and staff perceptions and experiences of a pilot SARS-CoV-2 asymptomatic testing service (P-ATS) in a UK university campus setting. This was a mixed-method study co... Read More about Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study.

Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells (2020)
Journal Article
Crossland, H., Smith, K., Idris, I., Phillips, B. E., Atherton, P. J., & Wilkinson, D. J. (2021). Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells. Experimental Physiology, 106(3), 585-592. https://doi.org/10.1113/EP089223

New Findings: What is the central question of this study? The compound sodium phenylbutyrate (PB) has been shown to promote branched-chain amino acid (BCAA) catabolism, and as such has been proposed as a treatment for disorders with enhanced BCAA lev... Read More about Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells.

Transmission, Tropism, and Biological Impacts of Torix Rickettsia in the Common Bed Bug Cimex lectularius (Hemiptera: Cimicidae) (2020)
Journal Article
Thongprem, P., Evison, S. E. F., Hurst, G. D. D., & Otti, O. (2020). Transmission, Tropism, and Biological Impacts of Torix Rickettsia in the Common Bed Bug Cimex lectularius (Hemiptera: Cimicidae). Frontiers in Microbiology, 11, Article 608763. https://doi.org/10.3389/fmicb.2020.608763

The torix group of Rickettsia have been recorded from a wide assemblage of invertebrates, but details of transmission and biological impacts on the host have rarely been established. The common bed bug (Cimex lectularius) is a hemipteran insect which... Read More about Transmission, Tropism, and Biological Impacts of Torix Rickettsia in the Common Bed Bug Cimex lectularius (Hemiptera: Cimicidae).

Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort (2020)
Working Paper
Jia, R., Knight, H., Blake, H., Corner, J., Denning, C., Ball, J., …Vedhara, K. Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort

Objective: This study examined the COVID-19 risk perceptions and mental health of university students on returning to campus in the midst of the COVID-19 pandemic. Methods: An online survey was completed during the first four weeks of the academic... Read More about Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort.

Neuromolecular Mechanisms of Cannabis Action (2020)
Book Chapter
Adel, Y., & Alexander, S. P. (2021). Neuromolecular Mechanisms of Cannabis Action. In Cannabinoids and Neuropsychiatric Disorders (15-28). Springer International Publishing. https://doi.org/10.1007/978-3-030-57369-0_2

Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain,... Read More about Neuromolecular Mechanisms of Cannabis Action.

Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ [International Journal of Pharmaceutics: X Volume 1 (2019) 100036] (2020)
Journal Article
Al-Natour, M. A., Alazzo, A., Ghaemmaghami, A. M., Kim, D. H., & Alexander, C. (2020). Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ [International Journal of Pharmaceutics: X Volume 1 (2019) 100036]. International Journal of Pharmaceutics: X, 2, Article 100044. https://doi.org/10.1016/j.ijpx.2020.100044

© 2020 The Author(s) The authors regret that the original version of Fig. 3 incorrect. The updated figure is below for reference. [Figure presented] Fig. 3 Super-resolution microscopy image of methotrexate loaded PLGA nanoparticles (green) (92 μg/mL,... Read More about Corrigendum to ‘LC-MS metabolomics comparisons of cancer cell and macrophage responses to methotrexate and polymer-encapsulated methotrexate’ [International Journal of Pharmaceutics: X Volume 1 (2019) 100036].

The Evolutionary Genomics of Serpentine Adaptation (2020)
Journal Article
Konečná, V., Yant, L., & Kolář, F. (2020). The Evolutionary Genomics of Serpentine Adaptation. Frontiers in Plant Science, 11, Article 574616. https://doi.org/10.3389/fpls.2020.574616

© Copyright © 2020 Konečná, Yant and Kolář. Serpentine barrens are among the most challenging settings for plant life. Representing a perfect storm of hazards, serpentines consist of broadly skewed elemental profiles, including abundant toxic metals... Read More about The Evolutionary Genomics of Serpentine Adaptation.

Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank (2020)
Journal Article
Sandoval-Plata, G., Nakafero, G., Chakravorty, M., Morgan, K., & Abhishek, A. (2021). Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank. Rheumatology, 60(7), 3243-3251. https://doi.org/10.1093/rheumatology/keaa773

Objectives To examine the association between comorbidities and serum urate (SU), gout and comorbidities, and to determine whether the association between gout and comorbidities is independent of SU. Methods We performed a case-control study using UK... Read More about Association between serum urate, gout and comorbidities: a case–control study using data from the UK Biobank.

The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses (2020)
Journal Article
Lezhnyova, V. R., Martynova, E. V., Khaiboullin, T. I., Urbanowicz, R. A., Khaiboullina, S. F., & Rizvanov, A. A. (2020). The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses. Biology, 9(12), 1-16. https://doi.org/10.3390/biology9120464

Two human endogenous retroviruses of the HERV‐W family can act as cofactors triggering multiple sclerosis (MS): MS‐associated retrovirus (MSRV) and ERVWE1. Endogenous retroviral elements are believed to have integrated in our ancestors’ DNA millions... Read More about The Relationship of the Mechanisms of the Pathogenesis of Multiple Sclerosis and the Expression of Endogenous Retroviruses.

Physical inactivity and health inequality during coronavirus: a novel opportunity or total lockdown? (2020)
Journal Article
Shur, N., Johns, . D., Kluzek, S., & Peirce, N. (2020). Physical inactivity and health inequality during coronavirus: a novel opportunity or total lockdown?. BMJ Open Sport and Exercise Medicine, 6(1), Article e000903. https://doi.org/10.1136/bmjsem-2020-000903

Government-restricted movement during the coronavirus pandemic in various countries around the world has led to rapid and fundamental changes in our health behaviour. As well as being at a higher risk of contracting and being hospitalised with COVID-... Read More about Physical inactivity and health inequality during coronavirus: a novel opportunity or total lockdown?.

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK (2020)
Journal Article
Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., …Alves, M. P. (2021). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet, 397(10269), 99-111. https://doi.org/10.1016/S0140-6736%2820%2932661-1

© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverag... Read More about Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease (2020)
Journal Article
Davies, A., Nixon, A., Tsintzas, K., Stephens, F. B., & Moran, G. W. (2021). Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease. Clinical Nutrition ESPEN, 41, 305-313. https://doi.org/10.1016/j.clnesp.2020.11.014

© 2020 European Society for Clinical Nutrition and Metabolism Background and aims: We have previously shown reduced protein balance in response to nutrition in paediatric Crohn's disease (CD) in remission, associated with reduced lean mass (sarcopeni... Read More about Skeletal muscle anabolic and insulin sensitivity responses to a mixed meal in adult patients with active Crohn's disease.

Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders (2020)
Journal Article
Holmes, J. C., Green, L. R., Oldfield, N. J., Turner, D. P., & Bayliss, C. D. (2020). Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders. Frontiers in Genetics, 11, https://doi.org/10.3389/fgene.2020.579411

© Copyright © 2020 Holmes, Green, Oldfield, Turner and Bayliss. Rapid transmission, a critical contributory factor in outbreaks of invasive meningococcal disease, requires naïve populations of sufficient size and intermingling. We examined genomic va... Read More about Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders.

MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life (2020)
Journal Article
Guttery, D. S., Ramaprasad, A., Ferguson, D. J. P., Zeeshan, M., Pandey, R., Brady, D., …Tewari, R. (2020). MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life. Cells, 9(12), Article 2590. https://doi.org/10.3390/cells9122590

The meiotic recombination 11 protein (MRE11) plays a key role in DNA damage response and maintenance of genome stability. However, little is known about its function during development of the malaria parasite Plasmodium. Here, we present a functional... Read More about MRE11 Is Crucial for Malaria Parasite Transmission and Its Absence Affects Expression of Interconnected Networks of Key Genes Essential for Life.

Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis (2020)
Journal Article
Vedhara, K., Royal, S., Sunger, K., Caldwell, D. M., Halliday, V., Taylor, C. M., …Welton, N. J. (2021). Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis. Health Psychology Review, 15(2), 245-271. https://doi.org/10.1080/17437199.2020.1854050

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Psychological and behavioural may enhance vaccine effectiveness. We conducted a systematic review and network meta-analysis (NMA) to examine the effects of non-pharmacologi... Read More about Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis.

A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis (2020)
Journal Article
Azimi, S., Wheldon, L. M., Oldfield, N. J., Ala'Aldeen, D. A., & Wooldridge, K. G. (2020). A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis. Microbial Pathogenesis, 149, Article 104534. https://doi.org/10.1016/j.micpath.2020.104534

Neisseria meningitidis (the meningococcus) remains an important cause of human disease, including meningitis and sepsis. Adaptation to the host environment includes many interactions with specific cell surface receptors, resulting in intracellular si... Read More about A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis.

Intercontinental genomic parallelism in multiple three-spined stickleback adaptive radiations (2020)
Journal Article
Magalhaes, I. S., Whiting, J. R., D’Agostino, D., Hohenlohe, P. A., Mahmud, M., Bell, M. A., …MacColl, A. D. (2020). Intercontinental genomic parallelism in multiple three-spined stickleback adaptive radiations. Nature Ecology and Evolution, 5, 251–261. https://doi.org/10.1038/s41559-020-01341-8

© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Parallelism, the evolution of similar traits in populations diversifying in similar conditions, provides strong evidence of adaptation by natural selection. Many studies of pa... Read More about Intercontinental genomic parallelism in multiple three-spined stickleback adaptive radiations.

Readfish enables targeted nanopore sequencing of gigabase-sized genomes (2020)
Journal Article
Payne, A., Holmes, N., Clarke, T., Munro, R., Debebe, B., & Loose, M. (2021). Readfish enables targeted nanopore sequencing of gigabase-sized genomes. Nature Biotechnology, 39, 442-450. https://doi.org/10.1038/s41587-020-00746-x

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Nanopore sequencers can be used to selectively sequence certain DNA molecules in a pool by reversing the voltage across individual nanopores to reject specific sequences,... Read More about Readfish enables targeted nanopore sequencing of gigabase-sized genomes.

Y-box binding protein-1: A neglected target in pediatric brain tumors? (2020)
Journal Article
Taylor, L., Kerr, I. D., & Coyle, B. (2021). Y-box binding protein-1: A neglected target in pediatric brain tumors?. Molecular Cancer Research, 19(3), 375-387. https://doi.org/10.1158/1541-7786.MCR-20-0655

© 2020 American Association for Cancer Research. Brain and central nervous system tumors represent the most common childhood solid tumors. Comprising 21% of all pediatric cancers, they remain the leading cause of cancer-related mortality and morbidit... Read More about Y-box binding protein-1: A neglected target in pediatric brain tumors?.