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All Outputs (20)

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target (2011)
Journal Article
Sanhaji, M., Friel, C. T., Wordeman, L., Louwen, F., & Yuan, J. (2011). Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget, 2(12), 935-947. https://doi.org/10.18632/oncotarget.416

The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability. The kinesin-13 family is critical in... Read More about Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures (2011)
Journal Article
Sheridan, G. K., & Dev, K. K. (2012). S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia, 60(3), 382-392. https://doi.org/10.1002/glia.22272

Sphingosine-1-phosphate receptors (S1PRs) are drug targets for the compound FTY720, which is the first oral therapy developed for treatment of relapsing-remitting multiple sclerosis. S1PRs play a variety of functional roles in the differentiation, pr... Read More about S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures.

Biomimetic tissues on a chip for drug discovery (2011)
Journal Article
Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., & Khademhosseini, A. (2012). Biomimetic tissues on a chip for drug discovery. Drug Discovery Today, 17(3-4), 173-181. https://doi.org/10.1016/j.drudis.2011.10.029

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale... Read More about Biomimetic tissues on a chip for drug discovery.

Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK) (2011)
Journal Article
Glazebrook, C., Batty, M. J., Mullan, N., MacDonald, I., Nathan, D., Sayal, K., …Hollis, C. (2011). Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK). BMC Public Health, 11, Article 830. https://doi.org/10.1186/1471-2458-11-830

Background Low levels of physical activity in children have been linked to an increased risk of obesity, but many children lack confidence in relation to exercise (exercise self-efficacy). Factors which can impact on confidence include a chronic hea... Read More about Evaluating the effectiveness of a schools-based programme to promote exercise self-efficacy in children and young people with risk factors for obesity: Steps to active kids (STAK).

A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria (2011)
Journal Article
Standley, C. J., Wade, C. M., & Stothard, J. R. (2011). A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria. PLoS ONE, 6(10), Article e26563. https://doi.org/10.1371/journal.pone.0026563

Lake Victoria is a known hot-spot for Schistosoma mansoni, which utilises freshwater snails of the genus Biomphalaria as intermediate hosts. Different species of Biomphalaria are associated with varying parasite compatibility, affecting local transmi... Read More about A fresh insight into transmission of schistosomiasis: A misleading tale of biomphalaria in Lake Victoria.

Cell death pathology: Cross-talk with autophagy and its clinical implications (2011)
Journal Article
Amelio, I., Melino, G., & Knight, R. A. (2011). Cell death pathology: Cross-talk with autophagy and its clinical implications. Biochemical and Biophysical Research Communications, 414(2), 277-281. https://doi.org/10.1016/j.bbrc.2011.09.080

Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, “autophagic... Read More about Cell death pathology: Cross-talk with autophagy and its clinical implications.

The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors (2011)
Journal Article
Valant, C., Lane, J. R., Sexton, P. M., & Christopoulos, A. (2012). The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors. Annual Review of Pharmacology and Toxicology, 52, 153-178. https://doi.org/10.1146/annurev-pharmtox-010611-134514

It is now acknowledged that G protein-coupled receptors, the largest class of drug targets, adopt multiple active states that can be preferentially stabilized by orthosteric ligands or allosteric modulators, thus giving rise to the phenomenon of path... Read More about The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors.

The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization (2011)
Journal Article
Friel, C. T., & Howard, J. (2011). The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization. EMBO Journal, 30(19), 3928-3939. https://doi.org/10.1038/emboj.2011.290

Unlike other kinesins, members of the kinesin-13 subfamily do not move directionally along microtubules but, instead, depolymerize them. To understand how kinesins with structurally similar motor domains can have such dissimilar functions, we elucida... Read More about The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.

The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles (2011)
Journal Article
Rufini, S., Lena, A. M., Cadot, B., Mele, S., Amelio, I., Terrinoni, A., …Candi, E. (2011). The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochemical Pharmacology, 82(10), 1262-1268. https://doi.org/10.1016/j.bcp.2011.07.087

The transcription factor p63 plays pivotal roles in epidermal barrier formation and in embryonic development. The protein structures of TAp63 and ΔNp63α isoforms include a C-terminal steril alpha-motif (SAM) involved in protein–protein interaction. I... Read More about The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.

Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry (2011)
Journal Article
Intranuovo, F., Howard, D., White, L. J., Johal, R. K., Ghaemmaghami, A. M., Favia, P., …Alexander, M. R. (2011). Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry. Acta Biomaterialia, 7(9), 3336-3344. https://doi.org/10.1016/j.actbio.2011.05.020

Uniform cellular distribution is a prerequisite to forming tissue within porous scaffolds, but the seeding process often results in preferential adhesion of cells at the periphery. We develop a vapour phase coating strategy which is readily applicabl... Read More about Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry.

Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype (2011)
Journal Article
Tarr, A. W., Urbanowicz, R. A., Hamed, M. R., Albecka, A., McClure, C. P., Brown, R. J., …Ball, J. K. (2011). Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype. Journal of Virology, 85(9), 4246-4257. https://doi.org/10.1128/JVI.01332-10

Neutralizing antibodies have a role in controlling hepatitis C virus (HCV) infection. A successful vaccine will need to elicit potently neutralizing antibodies that are capable of preventing the infection of genetically diverse viral isolates. Howeve... Read More about Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: Genetic subtype defines antigenic but not neutralization serotype.

Crohn disease: A current perspective on genetics, autophagy and immunity (2011)
Journal Article
Stappenbeck, T. S., Rioux, J. D., Mizoguchi, A., Saitoh, T., Huett, A., Darfeuille-Michaud, A., …Xavier, R. J. (2011). Crohn disease: A current perspective on genetics, autophagy and immunity. Autophagy, 7(4), 355-374. https://doi.org/10.4161/auto.7.4.13074

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract.1 Prevalence in western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any ag... Read More about Crohn disease: A current perspective on genetics, autophagy and immunity.

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article
Foxler, D. E., James, V., Shelton, S. J., de A. Vallim, T. Q., Shaw, P. E., & Sharp, T. V. (2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Letters, 585(7), 1089-1096. https://doi.org/10.1016/j.febslet.2011.03.013

LIMD1 is a tumour suppressor gene (TSG) down regulated in ?80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

Biomimetic bone scaffolds based on chitosan and calcium phosphates (2011)
Journal Article
Tanase, C., Popa, M., & Verestiuc, L. (2011). Biomimetic bone scaffolds based on chitosan and calcium phosphates. Materials Letters, 65(11), 1681-1683. https://doi.org/10.1016/j.matlet.2011.02.077

This paper reports a novel biomimetic technique for obtaining chitosan–calcium phosphate composite scaffolds (Cs–CP) by calcium phosphate precipitation from its precursors,CaCl2 and NaH2PO4 in the presence of ammonia and Cs, followed by product freez... Read More about Biomimetic bone scaffolds based on chitosan and calcium phosphates.

Identification of new functional regions in hepatitis C virus envelope glycoprotein E2 (2011)
Journal Article
Albecka, A., Montserret, R., Krey, T., Tarr, A. W., Diesis, E., Ball, J. K., …Dubuisson, J. (2011). Identification of new functional regions in hepatitis C virus envelope glycoprotein E2. Journal of Virology, 85(4), 1777-1792. https://doi.org/10.1128/JVI.02170-10

Little is known about the structure of the envelope glycoproteins of hepatitis C virus (HCV). To identify new regions essential for the function of these glycoproteins, we generated HCV pseudoparticles (HCVpp) containing HCV envelope glycoproteins, E... Read More about Identification of new functional regions in hepatitis C virus envelope glycoprotein E2.