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Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A) (2010)
Journal Article
van Veldhoven, J. P. D., Blad, C. C., Artsen, C. M., Klopman, C., Wolfram, D. R., Abdelkadir, M. J., …IJzerman, A. P. (2011). Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). Bioorganic and Medicinal Chemistry, 21(9), 2736-2739. https://doi.org/10.1016/j.bmcl.2010.11.091

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact w... Read More about Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma (2010)
Journal Article
Bhatti, I., Lee, A., James, V., Hall, R. I., Lund, J. N., Tufarelli, C., …Larvin, M. (2011). Knockdown of microRNA-21 Inhibits Proliferation and Increases Cell Death by Targeting Programmed Cell Death 4 (PDCD4) in Pancreatic Ductal Adenocarcinoma. Journal of Gastrointestinal Surgery, 15(1), 199-208. https://doi.org/10.1007/s11605-010-1381-x

The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells (2010)
Journal Article
Tunio, S. A., Oldfield, N. J., Ala'Aldeen, D. A. A., Wooldridge, K. G., & Turner, D. P. J. (2010). The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells. BMC Microbiology, 10, Article 280. https://doi.org/10.1186/1471-2180-10-280

Background Glyceraldehyde 3-phosphate dehydrogenases (GAPDHs) are cytoplasmic glycolytic enzymes, which although lacking identifiable secretion signals, have also been found localized to the surface of several bacteria (and some eukaryotic organisms... Read More about The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells.

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins (2010)
Journal Article
Coelho, V., Krysov, S., Ghaemmaghami, A. M., Emara, M., Potter, K. N., Johnson, P., …Stevenson, F. K. (2010). Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins. Proceedings of the National Academy of Sciences, 107(43), 18587-18592. https://doi.org/10.1073/pnas.1009388107

Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation a... Read More about Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.

Label-free molecular imaging of immunological synapses between dendritic and T cells by Raman micro-spectroscopy (2010)
Journal Article
Zoladek, A. B., Johal, R. K., Garcia-Nieto, S., Pascut, F., Shakesheff, K. M., Ghaemmaghami, A. M., & Notingher, I. (2010). Label-free molecular imaging of immunological synapses between dendritic and T cells by Raman micro-spectroscopy. Analyst, 135(12), 3205-3212. https://doi.org/10.1039/c0an00508h

Confocal Raman micro-spectroscopy (CRMS) was used to measure spectral images of immunological synapse formation between dendritic and T cells without using molecular labels or other invasive procedures. The purpose-built inverted CRMS instrument inte... Read More about Label-free molecular imaging of immunological synapses between dendritic and T cells by Raman micro-spectroscopy.

Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics (2010)
Journal Article
Kulkarni, B. B., Tighe, P. J., Mohammed, I., Yeung, A. M., Powe, D. G., Hopkinson, A., …Dua, H. S. (2010). Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics. BMC Genomics, 11(1), Article 526. https://doi.org/10.1186/1471-2164-11-526

Background: The Limbal epithelial crypt (LEC) is a solid cord of cells, approximately 120 microns long. It arises from the undersurface of interpalisade rete ridges of the limbal palisades of Vogt and extends deeper into the limbal stroma parallel or... Read More about Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics.

Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage (2010)
Journal Article
Ala'Aldeen, D. A., Flint, M., Oldfield, N. J., Omer, S. A., McNeil, L. K., Jiang, Q., …Anderson, A. S. (2010). Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage. Vaccine, 28(48), 7667-7675. https://doi.org/10.1016/j.vaccine.2010.09.038

Recombinant forms of Neisseria meningitidis factor H binding protein (fHBP) are undergoing clinical trials in candidate vaccines against serogroup B meningococcal disease. Little is known, however, about the host response to fHBP during natural carri... Read More about Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage.

Hormone transport (2010)
Book Chapter
Kerr, I. D., Carrier, D. J., & Twycross, J. (2010). Hormone transport. In The Plant Plasma Membrane, (379-397). Springer. https://doi.org/10.1007/978-3-642-13431-9_17

Hormone transport in plants is a fundamental process governing all aspects of plant development. Identification and functional analysis of plasma membrane proteins, which regulate the import and export of plant hormones, is a requirement if we are to... Read More about Hormone transport.

Pseudomonas aeruginosaHomoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl?Secretion by Human Airway Epithelia (2010)
Journal Article
Schwarzer, C., Wong, S., Shi, J., Matthes, E., Illek, B., Ianowski, J. P., …Machen, T. E. (2010). Pseudomonas aeruginosaHomoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl−Secretion by Human Airway Epithelia. Journal of Biological Chemistry, 285(45), 34850-34863. https://doi.org/10.1074/jbc.m110.167668

The ubiquitous bacterium Pseudomonas aeruginosa frequently causes hospital-acquired infections. P. aeruginosa also infects the lungs of cystic fibrosis (CF) patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacteria... Read More about Pseudomonas aeruginosaHomoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl?Secretion by Human Airway Epithelia.

The new family Diapheridae, a new species of Diaphera Albers from Thailand, and the position of the Diapheridae within a molecular phylogeny of the Streptaxoidea (Pulmonata: Stylommatophora) (2010)
Journal Article
Sutcharit, C., Naggs, F., Wade, C. M., Fontanilla, I., & Panha, S. (2010). The new family Diapheridae, a new species of Diaphera Albers from Thailand, and the position of the Diapheridae within a molecular phylogeny of the Streptaxoidea (Pulmonata: Stylommatophora). Zoological Journal of the Linnean Society, 160(1), 1-16. https://doi.org/10.1111/j.1096-3642.2009.00598.x

The Streptaxoidea are an ancient and species diverse group that is poorly understood. Examination of the reproductive anatomy of Diaphera showed it to be notably distinct from that of most other streptaxid genera but to exhibit similarities with the... Read More about The new family Diapheridae, a new species of Diaphera Albers from Thailand, and the position of the Diapheridae within a molecular phylogeny of the Streptaxoidea (Pulmonata: Stylommatophora).

The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity (2010)
Journal Article
Royer, P. J., Emara, M., Yang, C., Al-Ghouleh, A., Tighe, P., Jones, N., …Ghaemmaghami, A. M. (2010). The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity. Journal of Immunology, 185(3), 1522-1531. https://doi.org/10.4049/jimmunol.1000774

The mannose receptor (MR) is a C-type lectin expressed by dendritic cells (DCs). We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human... Read More about The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity.

A systems biology viewpoint on autophagy in health and disease (2010)
Journal Article
Huett, A., Goel, G., & Xavier, R. J. (2010). A systems biology viewpoint on autophagy in health and disease. Current Opinion in Gastroenterology, 26(4), 302-309. https://doi.org/10.1097/MOG.0b013e32833ae2ed

Purpose of review: The field of autophagy is rapidly expanding to encompass many important areas of cell biology, physiology and disease. Recent discoveries and tools allow the connection of the autophagy pathway to other cellular signals and process... Read More about A systems biology viewpoint on autophagy in health and disease.

Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry (2010)
Journal Article
Brown, K. S., Keogh, M. J., Owsianka, A. M., Adair, R., Patel, A. H., Arnold, J. N., …Hickling, T. P. (2010). Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry. Protein and Cell, 1(7), 664-674. https://doi.org/10.1007/s13238-010-0088-9

Mannan-binding lectin (MBL) is a soluble innate immune protein that binds to glycosylated targets. MBL acts as an opsonin and activates complement, contributing to the destruction and clearance of infecting microorganisms. Hepatitis C virus (HCV) enc... Read More about Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry.

Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor (2010)
Journal Article
Lane, J. R., Klaasse, E., Lin, J., van Bruchem, J., Beukers, M. W., & Ijzerman, A. P. (2010). Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor. Biochemical Pharmacology, 80(8), 1180-1189. https://doi.org/10.1016/j.bcp.2010.06.041

The adenosine A(1) receptor is a promising therapeutic target for neurological disorders such as cognition deficits and is involved in cardiovascular preconditioning. Classically adenosine receptor agonists were all derivatives of adenosine, and thou... Read More about Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor.

Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity (2010)
Journal Article
Ng, A. C., Eisenberg, J. M., Heath, R. J., Huett, A., Robinson, C. M., Nau, G. J., & Xavier, R. J. (2011). Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity. Proceedings of the National Academy of Sciences, 108(SUPPL. 1), 4631-4638. https://doi.org/10.1073/pnas.1000093107

In innate immune sensing, the detection of pathogen-associated molecular patterns by recognition receptors typically involve leucine-rich repeats (LRRs). We provide a categorization of 375 human LRR-containing proteins, almost half of which lack othe... Read More about Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity.

Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum (2010)
Journal Article
Cooksley, C. M., Davis, I. J., Winzer, K., Chan, W. C., Peck, M. W., & Minton, N. P. (2010). Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum. Applied and Environmental Microbiology, 76(13), 4448-4460. https://doi.org/10.1128/AEM.03038-09

A significant number of genome sequences of Clostridium botulinum and related species have now been determined. In silico analysis of these data revealed the presence of two distinct agr loci (agr-1 and agr-2) in all group I strains, each encoding pu... Read More about Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum.

The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: Surface localization and role in host cell adhesion (2010)
Journal Article
Tunio, S. A., Oldfield, N. J., Berry, A., Ala'Aldeen, D. A. A., Wooldridge, K. G., & Turner, D. P. J. (2010). The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: Surface localization and role in host cell adhesion. Molecular Microbiology, 76(3), 605-615. https://doi.org/10.1111/j.1365-2958.2010.07098.x

Fructose-1, 6-bisphosphate aldolases (FBA) are cytoplasmic glycolytic enzymes, which despite lacking identifiable secretion signals, have also been found localized to the surface of several bacteria where they bind host molecules and exhibit non-glyc... Read More about The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: Surface localization and role in host cell adhesion.

Laminin and fibronectin treatment leads to generation of dendritic cells with superior endocytic capacity (2010)
Journal Article
García-Nieto, S., Johal, R. K., Shakesheff, K. M., Emara, M., Pierre-Joseph, R., Chau, D. Y., …Ghaemmaghami, A. M. (2010). Laminin and fibronectin treatment leads to generation of dendritic cells with superior endocytic capacity. PLoS ONE, 5(4), Article e10123. https://doi.org/10.1371/journal.pone.0010123

Background: Sampling the microenvironment at sites of microbial exposure by dendritic cells (DC) and their subsequent interaction with T cells in the paracortical area of lymph nodes are key events for initiating immune responses. Most of our knowled... Read More about Laminin and fibronectin treatment leads to generation of dendritic cells with superior endocytic capacity.

Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene (2010)
Journal Article
Jethwa, P. H., Warner, A., Fowler, M. J., Murphy, M., de Backer, M. W., Adan, R. A., …Ebling, F. J. (2010). Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene. Journal of Neuroendocrinology, 22(6), 564-575. https://doi.org/10.1111/j.1365-2826.2010.02001.x

Many vertebrates express profound annual cycles of body fattening, although it is not clear whether these represent differential activity of the central pathways known to mediate homeostatic control of food intake and energy expenditure, or whether t... Read More about Short-days induce weight loss in siberian hamsters despite overexpression of the agouti-related peptide gene.