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Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake (2009)
Journal Article
Gardiner, J. V., Bataveljic, A., Patel, N. A., Bewick, G. A., Roy, D., Campbell, D., …Dhillo, W. S. (2010). Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake. Diabetes, 59(2), 397-406. https://doi.org/10.2337/db09-1198

OBJECTIVE-Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis. RESEARCH DESIGN AND METHODS - We inves... Read More about Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.

Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections (2009)
Journal Article
Behnke, J. M., Menge, D., & Noyes, H. (2009). Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections. Parasitology, 136(12), https://doi.org/10.1017/S0031182009006003

The intestinal nematode Heligmosomoides bakeri has undergone 2 name changes during the last 4 decades. Originally, the name conferred on the organism in the early 20th century was Nematospiroides dubius, but this was dropped in favour of Heligmosomoi... Read More about Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections.

Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly (2009)
Journal Article
Lapaquette, P., Glasser, A. L., Huett, A., Xavier, R. J., & Darfeuille-Michaud, A. (2009). Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cellular Microbiology, 12(1), 99-113. https://doi.org/10.1111/j.1462-5822.2009.01381.x

Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate within intestinal epithelial cells. Recent genome-wide association studies have highlighted the autop... Read More about Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly.

The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor (2009)
Journal Article
Lane, J. R., Beukers, M. W., Mulder-Krieger, T., & IJzerman, A. P. (2010). The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor. Biochemical Pharmacology, 79(1), 48-56. https://doi.org/10.1016/j.bcp.2009.07.024

Studies of endogenous cannabinoid agonists, such as 2-arachidonylglycerol (2-AG), have revealed their potential to exert modulatory actions on other receptor systems in addition to their ability to activate cannabinoid receptors. This study investiga... Read More about The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor.

Surviving mass extinction by bridging the benthic/planktic divide (2009)
Journal Article
Darling, K. F., Thomas, E., Kasemann, S. A., Seears, H. A., Smart, C. W., & Wade, C. M. (2009). Surviving mass extinction by bridging the benthic/planktic divide. Proceedings of the National Academy of Sciences, 106(31), 12629-12633. https://doi.org/10.1073/pnas.0902827106

Evolution of planktic organisms from benthic ancestors is commonly thought to represent unidirectional expansion into new ecological domains, possibly only once per clade. For foraminifera, this evolutionary expansion occurred in the Early-Middle Jur... Read More about Surviving mass extinction by bridging the benthic/planktic divide.

Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases (2009)
Journal Article
Huett, A., & Xavier, R. J. (2010). Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases. Inflammatory Bowel Diseases, 16(1), 152-174. https://doi.org/10.1002/ibd.20991

Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently, autophagy has come to prominence as a factor in many disease states, including inflammatory bowel diseases. In this review... Read More about Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases.

Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus (2009)
Journal Article
Behnke, J., Eira, C., Rogan, M., Gilbert, F., Torres, J., Miquel, J., & Lewis, J. (2009). Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus. Parasitology, 136(7), https://doi.org/10.1017/S0031182009006039

We analysed 3 independently collected datasets of fully censused helminth burdens in wood mice, Apodemus sylvaticus, testing the a priori hypothesis of Behnke et al. (2005) that the presence of the intestinal nematode Heligmosomoides polygyrus predis... Read More about Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus.

AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge (2009)
Journal Article
Oldfield, N. J., Worrall, K. E., Rycroft, A. N., Ali, T., Wooldridge, K. G., & Ala'Aldeen, D. A. (2009). AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge. Vaccine, 27(38), 5278-5283. https://doi.org/10.1016/j.vaccine.2009.06.047

Actinobacillus pleuropneumoniae is a major respiratory pathogen of pigs; current vaccines provide only limited protection. AasP, a subtilisin-like serine protease, is a conserved outer membrane-localised autotransporter protein. We hypothesized that... Read More about AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge.

Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen der p 1 (2009)
Journal Article
Horlock, C., Shakib, F., Jones, N. S., Sewell, H. F., & Ghaemmaghami, A. M. (2009). Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen der p 1. International Archives of Allergy and Immunology, 150(3), 237-251. https://doi.org/10.1159/000222676

Background: Dendritic cells (DCs) are sentinels of the immune system and are known to play a key role in allergic responses. However, it is not clear how DCs that have been exposed to an allergen support Th2 type immune responses. It is possible that... Read More about Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen der p 1.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis (2009)
Journal Article
Rutland, C., Warner, L., Thorpe, A., Alibhai, A., Robinson, T., Shaw, B., …Loughna, S. (2009). Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy, 214(6), 905-915. https://doi.org/10.1111/j.1469-7580.2009.01079.x

Atrial septal defects are a common congenital heart defect in humans. Although mutations in different genes are now frequently being described, little is known about the processes and mechanisms behind the early stages of atrial septal development. B... Read More about Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models (2009)
Journal Article
Orihuela, C. J., Mahdavi, J., Thornton, J., Mann, B., Wooldridge, K. G., Abouseada, N., …Tuomanen, E. I. (2009). Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. Journal of Clinical Investigation, 119(6), 1638-1646. https://doi.org/10.1172/JCI36759

A diverse array of infectious agents, including prions and certain neurotropic viruses, bind to the laminin receptor (LR), and this determines tropism to the CNS. Bacterial meningitis in childhood is almost exclusively caused by the respiratory tract... Read More about Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models.

Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse (2009)
Journal Article
Ward, D. R., Dear, F. M., Ward, I. A., Anderson, S. I., Spergel, D. J., Smith, P. A., & Ebling, F. J. (2009). Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse. PLoS ONE, 4(4), https://doi.org/10.1371/journal.pone.0005322

Background: Secretion of gonadotropin-releasing hormone (GnRH) produced in neurons in the basal forebrain is the primary regulator of reproductive maturation and function in mammals. Peptidergic signals relating to circadian timing and energy balance... Read More about Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse.

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements (2009)
Journal Article
Huett, A., Leong, J. M., Podolsky, D. K., & Xavier, R. J. (2009). The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Experimental Cell Research, 315(12), 2001-2011. https://doi.org/10.1016/j.yexcr.2009.04.003

The common gastrointestinal pathogens enteropathogenic Escherichia coli (EPEC) and Salmonella typhimurium both reorganize the gut epithelial cell actin cytoskeleton to mediate pathogenesis, utilizing mimicry of the host signaling apparatus. The PDZ d... Read More about The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy (2009)
Journal Article
Huett, A., Ng, A., Cao, Z., Kuballa, P., Komatsu, M., Daly, M. J., …Xavier, R. J. (2009). A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. Journal of Immunology, 182(8), 4917-4930. https://doi.org/10.4049/jimmunol.0803050

Autophagy is a conserved cellular process required for the removal of defective organelles, protein aggregates, and intracellular pathogens. We used a network analysis strategy to identify novel human autophagy components based upon the yeast interac... Read More about A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women (2009)
Journal Article
Stevenson, E. J., Astbury, N. M., Simpson, E. J., Taylor, M. A., & Macdonald, I. A. (2009). Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women. Journal of Nutrition, 139(5), 890-897. https://doi.org/10.3945/jn.108.101956

Consuming low-glycemic index (LGI) carbohydrates (CHO) before endurance exercise results in increased fat oxidation during exercise in trained men and women. It is not known if this phenomenon occurs during low intensity exercise and in untrained par... Read More about Fat oxidation during exercise and satiety during recovery are increased following a low-glycemic index breakfast in sedentary women.

Store-operated cyclic AMP signalling mediated by STIM1 (2009)
Journal Article
Lefkimmiatis, K., Srikanthan, M., Maiellaro, I., Moyer, M. P., Curci, S., & Hofer, A. M. (2009). Store-operated cyclic AMP signalling mediated by STIM1. Nature Cell Biology, 11(4), 433-442. https://doi.org/10.1038/ncb1850

Depletion of Ca2+ from the endoplasmic reticulum (ER) results in activation of plasma membrane Ca2+ entry channels. This 'store-operated' process requires translocation of a transmembrane ER Ca2+ sensor protein, stromal interaction molecule 1 (STIM1)... Read More about Store-operated cyclic AMP signalling mediated by STIM1.

Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model (2009)
Journal Article
Lewis, R., Behnke, J. M., Stafford, P., & Holland, C. V. (2009). Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model. Journal of Helminthology, 83(1), https://doi.org/10.1017/S0022149X08912402

Ascaris lumbricoides and Ascaris suum are important helminth parasites of humans and pigs, respectively. Although it is now well established that the presence of mature adult worms in the host intestine contributes to significant nutritional morbidit... Read More about Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model.

Low-intensity microwave irradiation does not substantially alter gene expression in late larval and adult Caenorhabditis elegans. (2009)
Journal Article
Dawe, A. S., Bodhicharla, R., Graham, N., May, S., Reader, T., Loader, B., …de Pomerai, D. I. (2009). Low-intensity microwave irradiation does not substantially alter gene expression in late larval and adult Caenorhabditis elegans. Bioelectromagnetics, 30(8), https://doi.org/10.1002/bem.20515

Reports that low-intensity microwave radiation induces heat-shock reporter gene expression in the nematode, Caenorhabditis elegans, have recently been reinterpreted as a subtle thermal effect caused by slight heating. This study used a microwave exp... Read More about Low-intensity microwave irradiation does not substantially alter gene expression in late larval and adult Caenorhabditis elegans..