All Outputs (6)

An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice (2017)
Journal Article
De Matteis, C. I., Randall, M. D., Harvey, E. J., Morris, A., Winkler, G. S., & Boardman, H. F. (2019). An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice. American Journal of Pharmaceutical Education, 83(1), Article 6508. https://doi.org/10.5688/ajpe6508

Objective: To design an integrated dyspepsia module for first year pharmacy undergraduates, which combines clinical and professional practice with fundamental sciences, in five different science subject areas, as a prototype for future disease- or sy... Read More about An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice.

Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs (2017)
Journal Article
Ahmad, A. A., Randall, M. D., & Roberts, R. E. (2017). Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs. Journal of Physiology, 595(21), https://doi.org/10.1113/JP274831

Previous studies have demonstrated that perivascular adipose tissue (PVAT) causes vasoconstriction. In this present study, we determined the role of cyclooxygenase-derived prostanoids in this contractile response and determined whether there were any... Read More about Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs.

Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin? (2017)
Journal Article
Ahmad, A., Randall, M. D., & Roberts, R. E. (in press). Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin?. British Journal of Pharmacology, 174(16), https://doi.org/10.1111/bph.13902

Background and Purpose- As there is sexual dimorphism in the regulation of vascular tone, the aim of this present study was to determine whether there are sex differences in perivascular adipose tissue (PVAT) - mediated regulation of the porcine coro... Read More about Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin?.

Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide (2014)
Journal Article
Wong, P. S., Roberts, R. E., & Randall, M. D. (2015). Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological Research, 91, https://doi.org/10.1016/j.phrs.2014.11.001

Oxygenation with 95%O2is routinely used in organ bath studies. However, hyperoxia may affect tissueresponses, particularly in studies which involve reactive oxygen species (ROS). Here, the effects of theantioxidant, Tiron, were investigated under dif... Read More about Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, https://doi.org/10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions? (2014)
Journal Article
Wong, P., Roberts, R., & Randall, M. (2014). Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?. British Journal of Pharmacology, 171(11), https://doi.org/10.1111/bph.12595

BACKGROUND AND PURPOSE: Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in endothelial function. Here, sex differences in endothelial function of porcine coronary art... Read More about Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?.