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Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats (2024)
Journal Article
Gonçalves, S. V., Woodhams, S. G., Li, L., Hathway, G. J., & Chapman, V. (2024). Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats. PAIN Reports, 9(2), Article e1145. https://doi.org/10.1097/pr9.0000000000001145

IntroductionSustained opioid use has long-term negative impacts on future pain experience, particularly in women. This study aimed to investigate the underlying spinal neurobiology of this clinical observation in an experimental model of joint pain.O... Read More about Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats.

Health-related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross-sectional study (2022)
Journal Article
Carter, N., Li, J., Xu, M., Li, L., Fan, X., Zhu, S., …Chattopadhyay, K. (2022). Health-related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross-sectional study. Endocrinology, Diabetes and Metabolism, 5(5), Article e353. https://doi.org/10.1002/edm2.353

Introduction: The burden of type 2 diabetes (T2DM) in China is increasing, with potential impacts on the health-related quality of life (HRQoL) of those who develop the disease. Context-specific assessment of HRQoL and its associated factors informs... Read More about Health-related quality of life of people with type 2 diabetes and its associated factors at a tertiary care clinic in Ningbo, China: A cross-sectional study.

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia (2021)
Journal Article
Lillywhite, A., Woodhams, S. G., Gonçalves, S. V., Watson, D. J. G., Li, L., Burston, J. J., …Chapman, V. (2021). Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. PAIN Reports, 6(4), Article e956. https://doi.org/10.1097/PR9.0000000000000956

Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.... Read More about Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study (2021)
Journal Article
Li, X., Chattopadhyay, K., Xu, S., Chen, Y., Xu, M., Li, L., & Li, J. (2021). Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study. BMJ Open, 11(1), Article e040532. https://doi.org/10.1136/bmjopen-2020-040532

Objectives: To determine the prevalence of comorbidities in patients with type 2 diabetes (T2DM) and identify the factors independently associated with comorbidities in a tertiary care department in Ningbo, China. Design: A computerised medical re... Read More about Prevalence of comorbidities and their associated factors in patients with type 2 diabetes at a tertiary care department in Ningbo, China: a cross-sectional study.

Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain (2020)
Journal Article
Gowler, P. R., Li, L., Woodhams, S. G., Bennett, A. J., Suzuki, R., Walsh, D. A., & Chapman, V. (2020). Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain. PAIN, 161(1), 61-73. https://doi.org/10.1097/j.pain.0000000000001694

Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evidence also... Read More about Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain.

Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study (2019)
Journal Article
Li, J., Chattopadhyay, K., Xu, M., Chen, Y., Hu, F., Wang, X., & Li, L. (2019). Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study. PLoS ONE, 14(7), Article e0220047. https://doi.org/10.1371/journal.pone.0220047

Objectives To determine the prevalence of polypharmacy prescription among type 2 diabetes (T2DM) patients at a tertiary care department in Ningbo, China, and to determine factors that independently predict this polypharmacy prescription. Methods... Read More about Prevalence and predictors of polypharmacy prescription among type 2 diabetes patients at a tertiary care department in Ningbo, China: A retrospective database study.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article
Huang, J., Burston, J. J., Li, L., Ashraf, S., Mapp, P. I., Bennett, A. J., …Chapman, V. (2017). Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis and Rheumatology, 69(5), 996-1008. https://doi.org/10.1002/art.40001

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain (2016)
Journal Article
Xu, L., Nwosu, L. N., Burston, J., Millns, P., Sagar, D. R., Mapp, P. I., …Chapman, V. (2016). The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain. Osteoarthritis and Cartilage, 24(9), 1587-1595. https://doi.org/10.1016/j.joca.2016.05.015

Objective: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this st... Read More about The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1 (2013)
Journal Article
Galbraith, M. D., Saxton, J., Li, L., Shelton, S. J., Zhang, H., Espinosa, J. M., & Shaw, P. E. (2013). ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Research, 41(22), https://doi.org/10.1093/nar/gkt837

The ETS domain transcription factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens. These events require phosphorylation of Elk-1 by extracellular signal-regulated kinase (ERK) and phosphorylation-dependent intera... Read More about ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1.