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Increased IL-2 and reduced tgf-? upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis (2020)
Journal Article
Aram, J., Frakich, N., Morandi, E., Alrouji, M., Samaraweera, A., Onion, D., …Constantinescu, C. S. (2020). Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis. Biomedicines, 8(7), https://doi.org/10.3390/BIOMEDICINES8070226

© 2020 by the authors. Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investi... Read More about Increased IL-2 and reduced tgf-? upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis.

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia (2018)
Journal Article
Foxler, D. E., Bridge, K. S., Foster, J. G., Grevitt, P., Curry, S., Shah, K. M., …Sharp, T. V. (in press). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Molecular Medicine, Article e8304. https://doi.org/10.15252/emmm.201708304

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and β subunits. Prolonged HIF expression is a key contributor to cellular t... Read More about A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.