Skip to main content

Research Repository

Advanced Search

All Outputs (2)

Developmental functions of the dynamic DNA methylome and hydroxymethylome in the mouse and zebrafish: similarities and differences (2018)
Journal Article
Jessop, P., Ruzov, A., & Gering, M. (2018). Developmental functions of the dynamic DNA methylome and hydroxymethylome in the mouse and zebrafish: similarities and differences. Frontiers in Cell and Developmental Biology, 6, Article 27. https://doi.org/10.3389/fcell.2018.00027

5-methylcytosine (5mC) is the best understood DNA modification and is generally believed to be associated with repression of gene expression. Over the last decade, sequentially oxidized forms of 5mC (oxi-mCs) have been discovered within the genomes o... Read More about Developmental functions of the dynamic DNA methylome and hydroxymethylome in the mouse and zebrafish: similarities and differences.

Detection of modified forms of cytosine using sensitive immunohistochemistry (2016)
Journal Article
Abakir, A., Wheldon, L. M., Johnson, A. D., Laurent, P., & Ruzov, A. (in press). Detection of modified forms of cytosine using sensitive immunohistochemistry. Journal of Visualized Experiments, 114(e54416), https://doi.org/10.3791/54416

Methylation of cytosine bases (5-methylcytosine, 5mC) occurring in vertebrate genomes is usually associated with transcriptional silencing. 5-hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are the recently discov... Read More about Detection of modified forms of cytosine using sensitive immunohistochemistry.