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All Outputs (190)

One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development (2018)
Journal Article
Clare, C. E., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2019). One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development. Annual Review of Animal Biosciences, 7(1), 263-287. https://doi.org/10.1146/annurev-animal-020518-115206

One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that include the methionine and folate cycles that are central to cellular function, providing 1C units (methyl groups) for the synthesis of DNA, polyamines, amino acids... Read More about One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development.

The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators (2018)
Journal Article
James, C., Asher, L., Herborn, K., & Wiseman, J. (2018). The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators. Applied Animal Behaviour Science, 209, 55-64. https://doi.org/10.1016/j.applanim.2018.10.002

Qualities of the light environment are important for good welfare in a number of species. In chickens, UVA light is visible and may facilitate flock interactions. UVB wavelengths promote endogenous vitamin D synthesis, which could support the rapid s... Read More about The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators.

Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells (2018)
Journal Article
Vargas-Bello-Pérez, E., Loor, J. J., & Garnsworthy, P. C. (2018). Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells. Animal Nutrition, 5(2), 202-208. https://doi.org/10.1016/j.aninu.2018.09.002

The objective of this study was to determine how cytosolic triacylglycerols (TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids (FA). This objective was accomplished by addition of differ... Read More about Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells.

Testicular function and bone in young men with severe childhood-onset obesity. (2018)
Journal Article
Anand-Ivell, R., Ivell, R., Laakso, S., Viljakainen, H., Lipsanen-Nyman, M., Turpeinen, U., …Mäkitie, O. (2018). Testicular function and bone in young men with severe childhood-onset obesity. Hormone Research in Paediatrics, 89(6), 442–449. https://doi.org/10.1159/000489818

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puber... Read More about Testicular function and bone in young men with severe childhood-onset obesity..

Oxytocin (2018)
Book Chapter
Ivell, R., Anand-Ivell, R., Tribe, R., & Ludwig, M. (2018). Oxytocin. In Encyclopedia of reproduction (597-606). (Second Edition). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.64691-3

The small peptide hormone oxytocin has long been recognized as a key factor in the natural induction of the birth process at the end of pregnancy, as well as in the release of milk upon suckling by the infant. It has additional roles within the brain... Read More about Oxytocin.

Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis (2018)
Journal Article
Murrell, J. C., Whay, H. R., Mendl, M., Lascelles, B. D. X., Hunt, J. R., Hunt, J. R., …Murrell, J. C. (2018). Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis. PAIN, 159(11), 2318-2330. https://doi.org/10.1097/j.pain.0000000000001336

In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS... Read More about Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis.

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum (2018)
Journal Article
Anand-Ivell, R., Frederiksen, H., Juul, A., Andersson, A., Albrethsen, J., Nordkap, L., …Jørgensen, N. (2018). Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum. Clinical Chemistry and Laboratory Medicine, 56(11), https://doi.org/10.1515/cclm-2018-0171

BACKGROUND: The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker reflecting Leydig cell function in the male. Few commercial immunoassays of varying quality exist. Therefore, we decided to devel... Read More about Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum.

Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers (2018)
Journal Article
Vanlierde, A., Soyeurt, H., Gengler, N., Colinet, F., Froidmont, E., Kreuzer, M., …Dehareng, F. (2018). Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers. Journal of Dairy Science, 101(8), 7618-7624. https://doi.org/10.3168/jds.2018-14472

Evaluation and mitigation of enteric methane (CH4) emissions from ruminant livestock, in particular from dairy cows, have acquired global importance for sustainable, climate-smart cattle production. Based on CH4 reference measurements obtained with t... Read More about Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers.

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article
Anand-Ivell, R., Cohen, A., Norgaard-Pedersen, B., Joenssen, B., Bonde, J., Hougaard, D. M., …Ivell, R. (2018). Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study. Frontiers in Physiology, 9, Article 408. https://doi.org/10.3389/fphys.2018.00406

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More about Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study.

Adaptive spectral tracking for coherence estimation: the z-tracker (2018)
Journal Article
Halliday, D. M., Brittain, J., Stevenson, C. W., & Mason, R. (2018). Adaptive spectral tracking for coherence estimation: the z-tracker. Journal of Neural Engineering, 15(2), https://doi.org/10.1088/1741-2552/aaa3b4

Objective: A major challenge in non-stationary signal analysis is reliable estimation of correlation. Neurophysiological recordings can be many minutes in duration with data that exhibits correlation which changes over different time scales. Local sm... Read More about Adaptive spectral tracking for coherence estimation: the z-tracker.

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, https://doi.org/10.3389/fphys.2017.01033

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More about Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle.

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article
Corr, S. A., Gardner, D. S., Langley-Hobbs, S., Ness, M. G., Kitchener, A. C., & Sinclair, K. D. (2017). Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 7, Article 15685. https://doi.org/10.1038/s41598-017-15902-8

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More about Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.

A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture (2017)
Journal Article
Bellet, C., Green, M. J., Bradley, A. J., & Kaler, J. (2018). A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture. Journal of Dairy Science, 101(1), https://doi.org/10.3168/jds.2017-12952

The gastrointestinal nematode Ostertagia ostertagi is an important cause of lost production, health, and welfare in cattle. Detailed records were obtained over a 5-yr period (2010–2015) by questionnaires and qualitative interviews to investigate the... Read More about A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture.

Neohormones in milk (2017)
Journal Article
Ivell, R., & Anand-Ivell, R. (2017). Neohormones in milk. Best Practice and Research: Clinical Endocrinology and Metabolism, 31(4), https://doi.org/10.1016/j.beem.2017.10.005

Neohormone systems evolved specifically to regulate those mammalian traits, such as internal fertilization, pregnancy and lactation, which have proved to be central to the success, environmental independence, and adaptability of mammals as a vertebra... Read More about Neohormones in milk.

Effects of insulin like growth factors on early embryonic chick limb myogenesis (2017)
Journal Article
Mohammed, R. H., Anderton, H., Brameld, J. M., & Sweetman, D. (2017). Effects of insulin like growth factors on early embryonic chick limb myogenesis. PLoS ONE, 12(10), Article e0185775. https://doi.org/10.1371/journal.pone.0185775

Limb muscles derive from pax3 expressing precursor cells that migrate from the hypaxial somite into the developing limb bud. Once there they begin to differentiate and express muscle determination genes such as MyoD. This process is regulated by a co... Read More about Effects of insulin like growth factors on early embryonic chick limb myogenesis.

Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin (2017)
Journal Article
Zeebaree, B. K., Kwong, W. Y., Mann, G. E., Gutierrez, C. G., & Sinclair, K. D. (2018). Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin. Theriogenology, 105, https://doi.org/10.1016/j.theriogenology.2017.09.014

Our understanding of the effects of temperature on granulosa cell (GC) physiology is primarily limited to in vitro studies conducted under atmospheric (approx 20% O2) conditions. In the current series of factorial experiments we identify important ef... Read More about Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin.

Sponsorship bias and quality of randomised controlled trials in veterinary medicine (2017)
Journal Article
Wareham, K., Hyde, R., Grindlay, D. J., Brennan, M. L., & Dean, R. S. (in press). Sponsorship bias and quality of randomised controlled trials in veterinary medicine. BMC Veterinary Research, 13(234), https://doi.org/10.1186/s12917-017-1146-9

Background: Randomised controlled trials (RCTs) are considered the gold standard form of evidence for assessing treatment efficacy, but many factors can influence their reliability including methodological quality, reporting quality and funding sourc... Read More about Sponsorship bias and quality of randomised controlled trials in veterinary medicine.

Opinions of UK rescue shelter and rehoming center workers on the problems facing their industry (2017)
Journal Article
Stavisky, J., Brennan, M. L., Downes, M. J., & Dean, R. S. (in press). Opinions of UK rescue shelter and rehoming center workers on the problems facing their industry. Anthrozoös, 30(3), https://doi.org/10.1080/08927936.2017.1326677

Animal shelters exist worldwide to care for and rehome unwanted or straying pets. Previous studies have examined why owners breed unwanted animals, or relinquish their pets to shelters. However, the views of shelter workers, who receive and care for... Read More about Opinions of UK rescue shelter and rehoming center workers on the problems facing their industry.

Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model (2017)
Journal Article
Fiacco, D., Lowe, J., Wiseman, J., & White, G. (in press). Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model. Journal of Animal Physiology and Animal Nutrition, https://doi.org/10.1111/jpn.12764

Recent technological advances in the human food industry with respect to meat processing have decreased the availability of animal proteins to the pet food industry which typically formulates diets with an excess of animal protein. In the long term,... Read More about Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model.