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Prediction of nitrogen excretion from data on dairy cows fed a wide range of diets compiled in an intercontinental database: A meta-analysis (2022)
Journal Article
Bougouin, A., Hristov, A., Dijkstra, J., Aguerre, M. J., Ahvenjärvi, S., Arndt, C., …Kebreab, E. (2022). Prediction of nitrogen excretion from data on dairy cows fed a wide range of diets compiled in an intercontinental database: A meta-analysis. Journal of Dairy Science, 105(9), 7462-7481. https://doi.org/10.3168/jds.2021-20885

Manure nitrogen (N) from cattle contributes to nitrous oxide and ammonia emissions and nitrate leaching. Measurement of manure N outputs on dairy farms is laborious, expensive, and impractical at large scales; therefore, models are needed to predict... Read More about Prediction of nitrogen excretion from data on dairy cows fed a wide range of diets compiled in an intercontinental database: A meta-analysis.

Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva (2022)
Journal Article
Jenkins, H. H., Lopez, A. A. T., Tarantini, F. S., Tomlin, H., Scales, D., Lee, I., …Seedhouse, C. (2022). Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva. Scientific Reports, 12(1), Article 11553. https://doi.org/10.1038/s41598-022-15616-6

Polymerase chain reaction (PCR) has proven to be the gold-standard for SARS-CoV-2 detection in clinical settings. The most common approaches rely on nasopharyngeal specimens obtained from swabs, followed by RNA extraction, reverse transcription and q... Read More about Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva.

Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs (2022)
Journal Article
Elcombe, C. S., Monteiro, A., Elcombe, M. R., Ghasemzadeh-Hasankolaei, M., Sinclair, K. D., Lea, R., …Bellingham, M. (2022). Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs. Environmental Toxicology and Pharmacology, 94, Article 103913. https://doi.org/10.1016/j.etap.2022.103913

Current declines in male reproductive health may, in part, be driven by anthropogenic environmental chemical (EC) exposure. Using a biosolids treated pasture (BTP) sheep model, this study examined the effects of gestational exposure to a translationa... Read More about Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs.

Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos (2022)
Journal Article
Silvestri, G., Turner, K. J., Silcock, J. L., Sinclair, K. D., & Griffin, D. K. (2022). Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos. The European Zoological Journal, 89(1), 680-689. https://doi.org/10.1080/24750263.2022.2077994

Embryo splitting can be used in cattle in vitro production (IVP) to improve embryo availability and to increase selection intensity. Despite this widespread utility, a comparative investigation of the viability of IVP embryos split at Day 2 (2-cell s... Read More about Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos.

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing (2022)
Journal Article
Rubini, E., Schenkelaars, N., Rousian, M., Sinclair, K. D., Wekema, L., Faas, M. M., …Schoenmakers, S. (2022). Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing. American Journal of Obstetrics and Gynecology, 227(3), 392-400. https://doi.org/10.1016/j.ajog.2022.04.013

A healthy diet prior to and during pregnancy is beneficial in acquiring essential B vitamins involved in one-carbon metabolism, and to maintain a healthy gut microbiota. Each play important roles in fetal development, immune-system remodeling and pre... Read More about Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing.

Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle (2022)
Journal Article
Negussie, E., González-Recio, O., Battagin, M., Bayat, A., Boland, T., de Haas, Y., …Biscarini, F. (2022). Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle. Journal of Dairy Science, 105(6), 5124-5140. https://doi.org/10.3168/jds.2021-20158

Direct measurements of methane (CH4) from individual animals are difficult and expensive. Predictions based on proxies for CH4 are a viable alternative. Most prediction models are based on multiple linear regressions (MLR) and predictor variables tha... Read More about Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle.

In vitro culture of ovine embryos up to early gastrulating stages (2022)
Journal Article
Ramos-Ibeas, P., González-Brusi, L., Used, M. T., Cocero, M. J., Marigorta, P., Alberio, R., & Bermejo-Álvarez, P. (2022). In vitro culture of ovine embryos up to early gastrulating stages. Development, 149(6), Article dev199743. https://doi.org/10.1242/dev.199743

Developmental failures occurring shortly after blastocyst hatching from the zona pellucida constitute a major cause of pregnancy losses in both humans and farm ungulates. The developmental events occurring following hatching in ungulates include the... Read More about In vitro culture of ovine embryos up to early gastrulating stages.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., …Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial (2022)
Journal Article
Joy, E. J., Kalimbira, A. A., Sturgess, J., Banda, L., Chiutsi-Phiri, G., Manase, H., …Allen, E. (2022). Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial. Frontiers in Nutrition, 8, Article 788096. https://doi.org/10.3389/fnut.2021.788096

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agron... Read More about Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.

Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation (2022)
Journal Article
Wainwright, J., Millar, K. M., & White, G. A. (2022). Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13469

Objectives: To investigate owners’ views around canine nutrition and wellbeing, how these beliefs may differ according to the weight status of the dog and the implications for owner support approaches. Materials and Methods: A researcher-mediated que... Read More about Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation.

Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)
Journal Article
Kinoshita, M., Kobayashi, T., Planells, B., Klisch, D., Spindlow, D., Masaki, H., …Smith, A. (2021). Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species. Development, 148(23), Article dev199901. https://doi.org/10.1242/dev.199901

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em... Read More about Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article
Sargent, C., Ebanks, B., Hardy, I. C., Davies, T. G. E., Chakrabarti, L., & Stöger, R. (2021). Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain. Frontiers in Insect Science, 1, Article 765179. https://doi.org/10.3389/finsc.2021.765179

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells? (2021)
Journal Article
Savage, A. M., Alberio, R., & Johnson, A. D. (2021). Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?. Biology Open, 10(10), Article bio058890. https://doi.org/10.1242/bio.058890

In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of... Read More about Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?.

Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study (2021)
Journal Article
Silvestri, G., Canedo-Ribeiro, C., Serrano-Albal, M., Labrecque, R., Blondin, P., Larmer, S. G., …Griffin, D. K. (2021). Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study. Cells, 10(9), Article 2284. https://doi.org/10.3390/cells10092284

Approximately one million in vitro produced (IVP) cattle embryos are transferred world-wide each year as a way to improve the rates of genetic gain. The most advanced programmes also apply genomic selection at the embryonic stage by SNP genotyping an... Read More about Preimplantation genetic testing for aneuploidy improves live birth rates with in vitro produced bovine embryos: A blind retrospective study.

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Waite, L., Bonardi, C., Stevenson, C. W., & Cassaday, H. J. (2021). Strain comparisons in inhibitory discrimination learning and novel object recognition procedures. Physiology and Behavior, 240, Article 113557. https://doi.org/10.1016/j.physbeh.2021.113557

Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article
Alberio, R., & Wolf, E. (2021). Nuclear transfer and the development of genetically modified/gene edited livestock. Reproduction, 162(1), F59-F68. https://doi.org/10.1530/REP-21-0078

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article
Alberio, R., & Wolf, E. (2021). Nuclear transfer and the development of genetically modified/gene edited livestock. Reproduction, 162(1), F59-F68. https://doi.org/10.1530/REP-21-0078

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Conserved features of non-primate bilaminar disc embryos and the germline (2021)
Journal Article
Alberio, R., Kobayashi, T., & Surani, M. A. (2021). Conserved features of non-primate bilaminar disc embryos and the germline. Stem Cell Reports, 16(5), 1078-1092. https://doi.org/10.1016/j.stemcr.2021.03.011

Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar d... Read More about Conserved features of non-primate bilaminar disc embryos and the germline.

In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction (2021)
Journal Article
Warren, W. G., Papagianni, E. P., Stevenson, C. W., & Stubbendorff, C. (2022). In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction. European Journal of Neuroscience, 55(4), 952-970. https://doi.org/10.1111/ejn.15200

Anxiety and trauma-related disorders, such as post-traumatic stress disorder (PTSD), are debilitating mental illnesses with great personal and socioeconomic costs. Examining memory formation and relevant behavioural responding associated with aversiv... Read More about In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction.