Research Repository

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A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions (2019)
Journal Article
Wallace, R. J., Sasson, G., Garnsworthy, P. C., Tapio, I., Gregson, E., Bani, P., …Mizrahi, I. (2019). A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions. Science Advances, 5(7), doi:10.1126/sciadv.aav8391

A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and me... Read More

The overlooked cohort? – Improving the taught postgraduate student experience in higher education (2019)
Journal Article
Coneyworth, L., Jessop, R., Maden, P., & White, G. (2019). The overlooked cohort? – Improving the taught postgraduate student experience in higher education. Innovations in Education and Teaching International, 1-12. doi:10.1080/14703297.2019.1617184

Taught postgraduate students in the UK have a limited timeframe for study, with most full-time courses requiring intense scholarship, typically over a 12-month period. Many of these students face challenges and concerns with the transition from under... Read More

Cannabinoid regulation of fear and anxiety: an update (2019)
Journal Article
Papagianni, E. P., & Stevenson, C. W. (2019). Cannabinoid regulation of fear and anxiety: an update. Current Psychiatry Reports, 21(6), 1-10. doi:10.1007/s11920-019-1026-z

Purpose of Review Anxiety- and trauma-related disorders are prevalent and debilitating mental illnesses associated with a significant socioeconomic burden. Current treatment approaches often have inadequate therapeutic responses, leading to symptom... Read More

Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs (2019)
Journal Article
Harris, J. R., Goff, M., Jenkins, H., Harris, J., Knowles, T. B., Lascelles, B. D., …Murrell, J. C. (2019). Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs. Veterinary Anaesthesia and Analgesia, 46(4), 483-487. doi:10.1016/j.vaa.2018.11.010

Objective: To describe clinically relevant, physiological measurements collected during a 3- hour duration alfaxalone total intravenous anaesthesia. Study design: Case series. Animals: A total of 112 client-owned middle aged or older dogs. Methods... Read More

Effects of distillers dried grains with solubles on amino acid digestibility, growth performance, and carcass characteristics of growing pigs (2019)
Journal Article
Curry, S. M., Blavi, L., Wiseman, J., & Stein, H. H. (2019). Effects of distillers dried grains with solubles on amino acid digestibility, growth performance, and carcass characteristics of growing pigs. Translational Animal Science, 3(2), doi:10.1093/tas/txz005

Two experiments were conducted to compare the standardized ileal digestibility (SID) of AA by growing pigs in European distillers dried grains with solubles (DDGS) produced from wheat, maize, or wheat–maize mixtures and to test the effect of increasi... Read More

Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article
Stubbendorff, C., Hale, E., Cassaday, H. J., Bast, T., & Stevenson, C. W. (2019). Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology, doi:10.1007/s00213-018-5162-7

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More

Karyomapping for simultaneous genomic evaluation and aneuploidy screening of preimplantation bovine embryos: the first live-born calves (2018)
Journal Article
Turner, K. J., Silvestri, G., Black, D. H., Dobson, G., Smith, C., Handyside, A. A., …Griffin, D. K. (2019). Karyomapping for simultaneous genomic evaluation and aneuploidy screening of preimplantation bovine embryos: the first live-born calves. Theriogenology, 125, 249-258. doi:10.1016/j.theriogenology.2018.11.014

In cattle breeding, the development of genomic selection strategies based on single nucleotide polymorphism (SNP) interrogation has led to improved rates of genetic gain. Additionally, the application of genomic selection to in-vitro produced (IVP) e... Read More

One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development (2018)
Journal Article
Clare, C. E., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2019). One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development. Annual Review of Animal Biosciences, 7(1), doi:10.1146/annurev-animal-020518-115206

One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that include the methionine and folate cycles that are central to cellular function, providing 1C units (methyl groups) for the synthesis of DNA, polyamines, amino acids... Read More

The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators (2018)
Journal Article
James, C., Asher, L., Herborn, K., & Wiseman, J. (2018). The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators. Applied Animal Behaviour Science, 209, 55-64. doi:10.1016/j.applanim.2018.10.002

Qualities of the light environment are important for good welfare in a number of species. In chickens, UVA light is visible and may facilitate flock interactions. UVB wavelengths promote endogenous vitamin D synthesis, which could support the rapid s... Read More

Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells (2018)
Journal Article
Vargas-Bello-Pérez, E., Loor, J. J., & Garnsworthy, P. C. (2018). Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells. Animal Nutrition, doi:10.1016/j.aninu.2018.09.002

The objective of this study was to determine how cytosolic triacylglycerols (TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids (FA). This objective was accomplished by addition of differ... Read More

Testicular function and bone in young men with severe childhood-onset obesity. (2018)
Journal Article
Anand-Ivell, R., Ivell, R., Laakso, S., Viljakainen, H., Lipsanen-Nyman, M., Turpeinen, U., …Mäkitie, O. (2018). Testicular function and bone in young men with severe childhood-onset obesity. Hormone Research in Paediatrics, 89(6), (442–449). doi:10.1159/000489818. ISSN 1663-2818

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puber... Read More

Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis (2018)
Journal Article
Hunt, J. R., Goff, M., Jenkins, H., Harris, J., Knowles, T. G., Lascelles, D., …Murrell, J. C. (2018). Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis. PAIN, 159(11), 2318–2330. doi:10.1097/j.pain.0000000000001336

In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS... Read More

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum (2018)
Journal Article
Anand-Ivell, R., Juul, A., & Albrethsen, J. (2018). Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum. Clinical Chemistry and Laboratory Medicine, 56(11), doi:10.1515/cclm-2018-0171

BACKGROUND: The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker reflecting Leydig cell function in the male. Few commercial immunoassays of varying quality exist. Therefore, we decided to devel... Read More

Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers (2018)
Journal Article
Vanlierde, A., Soyeurt, H., Gengler, N., Colinet, F., Froidmont, E., Kreuzer, M., …Dehareng, F. (in press). Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers. Journal of Dairy Science, doi:10.3168/jds.2018-14472

Evaluation and mitigation of enteric methane (CH4) emissions from ruminant livestock, in particular from dairy cows, have acquired global importance for sustainable, climate-smart cattle production. Based on CH4 reference measurements obtained with t... Read More

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article
Anand-Ivell, R., Cohen, A., Norgaard-Pedersen, B., Joenssen, B., Bonde, J., Hougaard, D. M., …Ivell, R. (2018). Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study. Frontiers in Physiology, 9, doi:10.3389/fphys.2018.00406

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More

Adaptive spectral tracking for coherence estimation: the z-tracker (2018)
Journal Article
Halliday, D. M., Brittain, J., Stevenson, C. W., & Mason, R. (2018). Adaptive spectral tracking for coherence estimation: the z-tracker. Journal of Neural Engineering, 15(2), doi:10.1088/1741-2552/aaa3b4

Objective: A major challenge in non-stationary signal analysis is reliable estimation of correlation. Neurophysiological recordings can be many minutes in duration with data that exhibits correlation which changes over different time scales. Local sm... Read More

Insulin-like peptide 3 (INSL3) (2018)
Book Chapter
Anand-Ivell, R., & Ivell, R. (in press). Insulin-like peptide 3 (INSL3). In L. Martini, & I. Huhtaniemi (Eds.), Encyclopedia of Endocrine Diseases, Second EditionElsevier, Waltham MA

Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excellent biomarker for Ley... Read More

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, doi:10.3389/fphys.2017.01033

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More