Research Repository

See what's under the surface


Cannabinoid regulation of fear and anxiety: an update (2019)
Journal Article
Papagianni, E. P., & Stevenson, C. W. (2019). Cannabinoid regulation of fear and anxiety: an update. Current Psychiatry Reports, 21(6), 1-10. doi:10.1007/s11920-019-1026-z

Purpose of Review Anxiety- and trauma-related disorders are prevalent and debilitating mental illnesses associated with a significant socioeconomic burden. Current treatment approaches often have inadequate therapeutic responses, leading to symptom... Read More

Effects of distillers dried grains with solubles on amino acid digestibility, growth performance, and carcass characteristics of growing pigs (2019)
Journal Article
Curry, S. M., Blavi, L., Wiseman, J., & Stein, H. H. (2019). Effects of distillers dried grains with solubles on amino acid digestibility, growth performance, and carcass characteristics of growing pigs. Translational Animal Science, 3(2), doi:10.1093/tas/txz005

Two experiments were conducted to compare the standardized ileal digestibility (SID) of AA by growing pigs in European distillers dried grains with solubles (DDGS) produced from wheat, maize, or wheat–maize mixtures and to test the effect of increasi... Read More

Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article
Stubbendorff, C., Hale, E., Cassaday, H. J., Bast, T., & Stevenson, C. W. (2019). Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology, doi:10.1007/s00213-018-5162-7

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More

Karyomapping for simultaneous genomic evaluation and aneuploidy screening of preimplantation bovine embryos: the first live-born calves (2018)
Journal Article
Turner, K. J., Silvestri, G., Black, D. H., Dobson, G., Smith, C., Handyside, A. A., …Griffin, D. K. (2019). Karyomapping for simultaneous genomic evaluation and aneuploidy screening of preimplantation bovine embryos: the first live-born calves. Theriogenology, 125, 249-258. doi:10.1016/j.theriogenology.2018.11.014

In cattle breeding, the development of genomic selection strategies based on single nucleotide polymorphism (SNP) interrogation has led to improved rates of genetic gain. Additionally, the application of genomic selection to in-vitro produced (IVP) e... Read More

One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development (2018)
Journal Article
Clare, C. E., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2019). One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development. Annual Review of Animal Biosciences, 7(1), doi:10.1146/annurev-animal-020518-115206

One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that include the methionine and folate cycles that are central to cellular function, providing 1C units (methyl groups) for the synthesis of DNA, polyamines, amino acids... Read More

The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators (2018)
Journal Article
James, C., Asher, L., Herborn, K., & Wiseman, J. (2018). The effect of supplementary ultraviolet wavelengths on broiler chicken welfare indicators. Applied Animal Behaviour Science, 209, 55-64. doi:10.1016/j.applanim.2018.10.002

Qualities of the light environment are important for good welfare in a number of species. In chickens, UVA light is visible and may facilitate flock interactions. UVB wavelengths promote endogenous vitamin D synthesis, which could support the rapid s... Read More

Testicular function and bone in young men with severe childhood-onset obesity. (2018)
Journal Article
Anand-Ivell, R., Ivell, R., Laakso, S., Viljakainen, H., Lipsanen-Nyman, M., Turpeinen, U., …Mäkitie, O. (2018). Testicular function and bone in young men with severe childhood-onset obesity. Hormone Research in Paediatrics, 89(6), (442–449). doi:10.1159/000489818. ISSN 1663-2818

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puber... Read More

Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis (2018)
Journal Article
Hunt, J. R., Goff, M., Jenkins, H., Harris, J., Knowles, T. G., Lascelles, D., …Murrell, J. C. (2018). Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis. PAIN, 159(11), 2318–2330. doi:10.1097/j.pain.0000000000001336

In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS... Read More

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum (2018)
Journal Article
Anand-Ivell, R., Juul, A., & Albrethsen, J. (2018). Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum. Clinical Chemistry and Laboratory Medicine, 56(11), doi:10.1515/cclm-2018-0171

BACKGROUND: The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker reflecting Leydig cell function in the male. Few commercial immunoassays of varying quality exist. Therefore, we decided to devel... Read More

Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers (2018)
Journal Article
Vanlierde, A., Soyeurt, H., Gengler, N., Colinet, F., Froidmont, E., Kreuzer, M., …Dehareng, F. (in press). Short communication: Development of an equation for estimating methane emissions of dairy cows from milk Fourier transform mid-infrared spectra by using reference data obtained exclusively from respiration chambers. Journal of Dairy Science, doi:10.3168/jds.2018-14472

Evaluation and mitigation of enteric methane (CH4) emissions from ruminant livestock, in particular from dairy cows, have acquired global importance for sustainable, climate-smart cattle production. Based on CH4 reference measurements obtained with t... Read More

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article
Anand-Ivell, R., Cohen, A., Norgaard-Pedersen, B., Joenssen, B., Bonde, J., Hougaard, D. M., …Ivell, R. (2018). Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study. Frontiers in Physiology, 9, doi:10.3389/fphys.2018.00406

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More

Adaptive spectral tracking for coherence estimation: the z-tracker (2018)
Journal Article
Halliday, D. M., Brittain, J., Stevenson, C. W., & Mason, R. (2018). Adaptive spectral tracking for coherence estimation: the z-tracker. Journal of Neural Engineering, 15(2), doi:10.1088/1741-2552/aaa3b4

Objective: A major challenge in non-stationary signal analysis is reliable estimation of correlation. Neurophysiological recordings can be many minutes in duration with data that exhibits correlation which changes over different time scales. Local sm... Read More

Insulin-like peptide 3 (INSL3) (2018)
Book Chapter
Anand-Ivell, R., & Ivell, R. (in press). Insulin-like peptide 3 (INSL3). In L. Martini, & I. Huhtaniemi (Eds.), Encyclopedia of Endocrine Diseases, Second EditionElsevier, Waltham MA

Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excellent biomarker for Ley... Read More

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, doi:10.3389/fphys.2017.01033

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article
Corr, S. A., Gardner, D. S., Langley-Hobbs, S., Ness, M. G., Kitchener, A. C., & Sinclair, K. D. (2017). Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 7, doi:10.1038/s41598-017-15902-8

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More

A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture (2017)
Journal Article
Bellet, C., Green, M. J., Bradley, A. J., & Kaler, J. (2018). A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture. Journal of Dairy Science, 101(1), doi:10.3168/jds.2017-12952

The gastrointestinal nematode Ostertagia ostertagi is an important cause of lost production, health, and welfare in cattle. Detailed records were obtained over a 5-yr period (2010–2015) by questionnaires and qualitative interviews to investigate the... Read More

Neohormones in milk (2017)
Journal Article
Ivell, R., & Anand-Ivell, R. (2017). Neohormones in milk. Best Practice and Research: Clinical Endocrinology and Metabolism, 31(4), doi:10.1016/j.beem.2017.10.005

Neohormone systems evolved specifically to regulate those mammalian traits, such as internal fertilization, pregnancy and lactation, which have proved to be central to the success, environmental independence, and adaptability of mammals as a vertebra... Read More

Oxytocin (2017)
Book Chapter
Ivell, R., Anand-Ivell, R., Tribe, R., & Ludwig, M. (in press). Oxytocin. In Encyclopedia of reproduction, Second EditionElsevier

Effects of insulin like growth factors on early embryonic chick limb myogenesis (2017)
Journal Article
Mohammed, R. H., Anderton, H., Brameld, J. M., & Sweetman, D. (2017). Effects of insulin like growth factors on early embryonic chick limb myogenesis. PLoS ONE, 12(10), doi:10.1371/journal.pone.0185775

Limb muscles derive from pax3 expressing precursor cells that migrate from the hypaxial somite into the developing limb bud. Once there they begin to differentiate and express muscle determination genes such as MyoD. This process is regulated by a co... Read More