All Outputs (7)

Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii (2022)
Journal Article
Fakae, L. B., Harun, M. S., Ting, D. S. J., Dua, H. S., Cave, G. W., Zhu, X. Q., …Elsheikha, H. M. (2023). Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii. Acta Tropica, 237, Article 106729. https://doi.org/10.1016/j.actatropica.2022.106729

We examined the anti-acanthamoebic efficacy of green tea Camellia sinensis solvent extract (SE) or its chemical constituents against Acanthamoeba castellanii by using anti-trophozoite, anti-encystation, and anti-excystation assays. C. sinensis SE (62... Read More about Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii.

Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro (2020)
Journal Article
Al-Sandaqchi, A. T., Marsh, V., Williams, H. E. L., Stevenson, C. W., & Elsheikha, H. M. (2020). Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro. Microorganisms, 8(9), Article 1386. https://doi.org/10.3390/microorganisms8091386

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Toxoplasma gondii (T. gondii), the causative agent of toxoplasmosis, is a frequent cause of brain infection. Despite its known ability to invade the brain, there is still a dire need to better... Read More about Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro.

In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii (2020)
Journal Article
Fakae, L. B., Stevenson, C. W., Zhu, X. Q., & Elsheikha, H. M. (2020). In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii. International Journal for Parasitology: Drugs and Drug Resistance, 13, 59-72. https://doi.org/10.1016/j.ijpddr.2020.05.001

© 2020 The Author(s) The effect of Camellia sinensis (green tea) on the growth of Acanthamoeba castellanii trophozoites was examined using a microplate based-Sulforhodamine B (SRB) assay. C. sinensis hot and cold brews at 75% and 100% concentrations... Read More about In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii.

Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection (2017)
Journal Article
Cong, W., Zhang, X., He, J., Li, F., Elsheikha, H. M., & Zhu, X. (2017). Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection. Oncotarget, 8(15), https://doi.org/10.18632/oncotarget.16108

Although microRNAs (miRNAs) play an important role in liver homeostasis, the extent to which they can be altered by Toxoplasma gondii infection is unknown. Here, we utilized small RNA sequencing and bioinformatic analyses to characterize miRNA expres... Read More about Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.

Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica (2017)
Journal Article
Zhang, F., Zhang, X., Elsheikha, H. M., He, J., Sheng, Z., Zheng, W., …Zhu, X. (2017). Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica. Parasites and Vectors, 10(1), Article 56. https://doi.org/10.1186/s13071-017-1990-2

Background Fasciola gigantica, the tropical liver fluke, infects buffaloes in Asian and African countries and causes significant economic losses and poses public health threat in these countries. However, little is known of the transcriptional respo... Read More about Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.

Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain (2017)
Journal Article
Wang, J., Li, T., Elsheikha, H. M., Chen, K., Zhu, W., Yue, D., …Huang, S. (in press). Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain. Frontiers in Microbiology, 8, Article 84. https://doi.org/10.3389/fmicb.2017.00084

Toxoplasma gondii is an obligatory intracellular apicomplexan protozoan which can infect any warm-blooded animal and causes severe diseases in immunocompromised individuals or infants infected in utero. The survival and success of this parasite requi... Read More about Functional characterization of rhoptry kinome in the virulent toxoplasma gondii RH strain.

Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system (2017)
Journal Article
Liu, Q., Li, F., Elsheikha, H. M., Sun, M., & Zhu, X. (2017). Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system. Parasites and Vectors, 10(1), https://doi.org/10.1186/s13071-016-1943-1

Background Toxoplasma gondii, an obligate intracellular protozoan parasite, possesses the remarkable ability to co-opt host cell machinery in order to maintain its intracellular survival. This parasite can modulate signaling pathways of its host t... Read More about Identification of host proteins interacting with Toxoplasma gondii GRA15 (TgGRA15) by yeast two-hybrid system.