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A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut (2017)
Journal Article
Chai, H., Ho, W., Graham, N., May, S., Massawe, F., & Mayes, S. (2017). A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut. Genes, 8(3), https://doi.org/10.3390/genes8020084

Bambara groundnut (Vigna subterranea (L.) Verdc.) is an underutilised legume crop, which has long been recognised as a protein-rich and drought-tolerant crop, used extensively in Sub-Saharan Africa. The aim of the study was to identify quantitative t... Read More about A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut.

Integrating genetic maps in bambara groundnut [Vigna subterranea (L) Verdc.] and their syntenic relationships among closely related legumes (2017)
Journal Article
Ho, W. K., Chai, H. H., Kendabie, P., Ahmad, N. S., Jani, J., Massawe, F., …Mayes, S. (2017). Integrating genetic maps in bambara groundnut [Vigna subterranea (L) Verdc.] and their syntenic relationships among closely related legumes. BMC Genomics, 18, Article 192. https://doi.org/10.1186/s12864-016-3393-8

Background Bambara groundnut [Vigna subterranea (L) Verdc.] is an indigenous legume crop grown mainly in subsistence and small-scale agriculture in sub-Saharan Africa for its nutritious seeds and its tolerance to drought and poor soils. Given that... Read More about Integrating genetic maps in bambara groundnut [Vigna subterranea (L) Verdc.] and their syntenic relationships among closely related legumes.

Changing plastid dynamics within early root and shoot apical meristem-derived tissue of A. thaliana (2017)
Journal Article
Bramham, L., & Pyke, K. (2017). Changing plastid dynamics within early root and shoot apical meristem-derived tissue of A. thaliana. Bioscience Horizons, 10(2017), https://doi.org/10.1093/biohorizons/hzx001

Whilst plastids are fundamental to many aspects of plant biology and the production of enhanced crop cultivars, research into the dynamics of non-green plastids has remained somewhat disregarded by the scientific community compared to chloroplasts. T... Read More about Changing plastid dynamics within early root and shoot apical meristem-derived tissue of A. thaliana.

Using isotope dilution assays to understand speciation changes in Cd, Zn, Pb and Fe in a soil model system under simulated flooding conditions (2017)
Journal Article
Izquierdo, M., Tye, A., & Chenery, S. (2017). Using isotope dilution assays to understand speciation changes in Cd, Zn, Pb and Fe in a soil model system under simulated flooding conditions. Geoderma, 295, https://doi.org/10.1016/j.geoderma.2017.02.006

Flooded soils are systems with complex chemistry and understanding the mechanisms that control the mobility and bioavailability of metals in these soils is important for their management. This work uses stable metal multi-element isotopic dilution co... Read More about Using isotope dilution assays to understand speciation changes in Cd, Zn, Pb and Fe in a soil model system under simulated flooding conditions.

Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice (2017)
Journal Article
Salter, A. M., Langley-Evans, S. C., Gates, L., Lock, A. L., & Kraft, J. (2017). Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice. British Journal of Nutrition, 117(3), 377-385. https://doi.org/10.1017/S0007114517000137

Nutrition during pregnancy can impact on the susceptibility of the offspring to cardiovascular disease. Postnatal consumption of trans fatty acids (TFA), associated with partially hydrogenated vegetable oil (PHVO), increases the risk of atheroscleros... Read More about Fetal and neonatal exposure to trans fatty acids impacts on susceptibility to atherosclerosis in apolipoprotein E*3 Leiden mice.

Identifying seedling root architectural traits associated with yield and yield components in wheat (2017)
Journal Article
Xie, Q., Fernando, K., Mayes, S., & Sparkes, D. L. (in press). Identifying seedling root architectural traits associated with yield and yield components in wheat. Annals of Botany, 119(7), https://doi.org/10.1093/aob/mcx001

Background and Aims: Plant roots growing underground are critical for soil resource acquisition, anchorage and plant-environment interactions. In wheat (Triticum aestivum), however, the target root traits to improve yield potential still remain large... Read More about Identifying seedling root architectural traits associated with yield and yield components in wheat.

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease (2017)
Journal Article
Stöger, R., Scaife, P., Shephard, F., & Chakrabarti, L. (in press). Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease. npj Parkinson's Disease, 3(6), https://doi.org/10.1038/s41531-017-0007-3

5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immu... Read More about Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease.

A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion (2017)
Journal Article
White, K. L., Paine, S., & Harris, J. (2017). A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion. Veterinary Anaesthesia and Analgesia, 44(4), https://doi.org/10.1016/j.vaa.2017.01.001

Objective: To characterise, as a clinical study, the pharmacokinetics and pharmacodynamics and describe the hypnotic effect of the neurosteroid alfaxalone (3?-hydroxy-5 ?-pregnane-11, 20-dione) formulated with 2-hydroxypropyl-?-cyclodextrin in male a... Read More about A clinical evaluation of the pharmacokinetics and pharmacodynamics of intravenous alfaxalone in cyclodextrin in male and female rats following a loading dose and constant rate infusion.

The impact of competition on elephant musth strategies: a game–theoretic model (2017)
Journal Article
Wyse, J. M., Hardy, I. C., Yon, L., & Mesterton-Gibbons, M. (in press). The impact of competition on elephant musth strategies: a game–theoretic model. Journal of Theoretical Biology, https://doi.org/10.1016/j.jtbi.2017.01.025

Mature male African Savannah elephants are known to periodically enter a temporary state of heightened aggression called “musth,” often linked with increased androgens, particularly testosterone. Sexually mature males are capable of entering musth at... Read More about The impact of competition on elephant musth strategies: a game–theoretic model.

Image-based 3D canopy reconstruction to determine potential productivity in complex multi-species crop systems (2017)
Journal Article
Burgess, A. J., Retkute, R., Pound, M. P., Mayes, S., & Murchie, E. H. (2017). Image-based 3D canopy reconstruction to determine potential productivity in complex multi-species crop systems. Annals of Botany, 119(4), 517-532. https://doi.org/10.1093/aob/mcw242

Background and Aims: Intercropping systems contain two or more species simultaneously in close proximity. Due to contrasting features of the component crops, quantification of the light environment and photosynthetic productivity is extremely difficu... Read More about Image-based 3D canopy reconstruction to determine potential productivity in complex multi-species crop systems.

Shared characteristics underpinning C 4 leaf maturation derived from analysis of multiple C 3 and C 4 species of Flaveria (2017)
Journal Article
Kümpers, B. M., Burgess, S. J., Reyna-Llorens, I., Smith-Unna, R., Boursnell, C., & Hibberd, J. M. (2017). Shared characteristics underpinning C 4 leaf maturation derived from analysis of multiple C 3 and C 4 species of Flaveria. Journal of Experimental Botany, 68(2), https://doi.org/10.1093/jxb/erw488

Most terrestrial plants use C3 photosynthesis to fix carbon. In multiple plant lineages a modified system known as C4 photosynthesis has evolved. To better understand the molecular patterns associated with induction of C4 photosynthesis, the genus Fl... Read More about Shared characteristics underpinning C 4 leaf maturation derived from analysis of multiple C 3 and C 4 species of Flaveria.

Electromagnetic heating for industrial kilning of malt: a feasibility study (2016)
Journal Article
Ferrari-John, R., Katrib, J., Zerva, E., Davies, N., Cook, D. J., Dodds, C., & Kingman, S. (in press). Electromagnetic heating for industrial kilning of malt: a feasibility study. Food and Bioprocess Technology, https://doi.org/10.1007/s11947-016-1849-0

Industrial malting operations use ~800kWh/t of energy to produce the heat required to kiln malt. Electromagnetic heating technologies are suggested as a way to potentially improve the energy efficiency of the kilning processing. In this work, the pot... Read More about Electromagnetic heating for industrial kilning of malt: a feasibility study.

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction (2016)
Journal Article
Tubby, C., Negm, O. H., Harrison, T. W., Tighe, P. J., Todd, I., & Fairclough, L. C. (2017). Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. Journal of Asthma, 54(5), 456-466. https://doi.org/10.1080/02770903.2016.1236941

Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obs... Read More about Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction.

A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples (2016)
Journal Article
Zaky, A. S., Pensupa, N., Andrade-Eiroa, Á., Tucker, G. A., & Du, C. (2017). A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples. Journal of Food Composition and Analysis, 56, https://doi.org/10.1016/j.jfca.2016.12.010

This paper introduces an original, rapid, efficient and reliable HPLC method for the accurate and simultaneous quantification (g/L) of chloride in samples containing sugars, organic acids and alcohols. Separation was achieved using a HI-Plex H column... Read More about A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples.

Reproductive biology of Holepyris sylvanidis (Hymenoptera: Bethylidae) (2016)
Journal Article
Amante, M., Schöller, M., Hardy, I. C., & Russo, A. (2017). Reproductive biology of Holepyris sylvanidis (Hymenoptera: Bethylidae). Biological Control, 106, https://doi.org/10.1016/j.biocontrol.2016.12.004

Holepyris sylvanidis (Hymenoptera: Bethylidae) is reported as a cosmopolitan parasitoid of coleopteran including a major pest of stored products, the confused flour beetle Tribolium confusum. The reproductive biology, and hence biocontrol potential o... Read More about Reproductive biology of Holepyris sylvanidis (Hymenoptera: Bethylidae).

Exogenous N-acyl-homoserine lactones enhance the expression of flagella of Pseudomonas syringae and activate defence responses in plants (2016)
Journal Article
Cheng, F., Ma, A., Zhuang, G., & Fray, R. G. (2017). Exogenous N-acyl-homoserine lactones enhance the expression of flagella of Pseudomonas syringae and activate defence responses in plants. Molecular Plant Pathology, 19(1), 104-115. https://doi.org/10.1111/mpp.12502

In order to cope with pathogens, plants have evolved sophisticated mechanisms to sense pathogenic attacks and to induce defence responses. The N-acyl-homoserine lactone (AHL)-mediated quorum sensing in bacteria regulates diverse physiological process... Read More about Exogenous N-acyl-homoserine lactones enhance the expression of flagella of Pseudomonas syringae and activate defence responses in plants.

Food and bioenergy: exploring ideotype traits of a dual-purpose wheat cultivar (2016)
Journal Article
Townsend, T. J., Roy, J., Wilson, P., Tucker, G. A., & Sparkes, D. L. (2017). Food and bioenergy: exploring ideotype traits of a dual-purpose wheat cultivar. Field Crops Research, 201, https://doi.org/10.1016/j.fcr.2016.11.007

Lignocellulosic biofuels, such as those produced from crop residues, offer the possibility of reducing GHG emissions in the transport sector. Wheat straw is one potential feedstock for these fuels but grain yield has been prioritised over straw yield... Read More about Food and bioenergy: exploring ideotype traits of a dual-purpose wheat cultivar.

Impact of gonadectomy on blood pressure regulation in ageing male and female rats (2016)
Journal Article
Pijacka, W., Clifford, B., Walas, D., Tilburgs, C., Joles, J. A., McMullen, S., & Langley-Evans, S. C. (2016). Impact of gonadectomy on blood pressure regulation in ageing male and female rats. Biology of Sex Differences, 7, Article 64. https://doi.org/10.1186/s13293-016-0111-9

Sexual dimorphism in blood pressure has been associated with differential expression of the angiotensin II (AII) receptors and with activity of the nervous system. It is generally accepted that aging affects kidney function as well as autonomic nervo... Read More about Impact of gonadectomy on blood pressure regulation in ageing male and female rats.

Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes (2016)
Journal Article
Tarale, P., Sivanesan, S., Daiwile, A. P., Stöger, R., Bafana, A., Naoghare, P. K., …Kannan, K. (2017). Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes. Archives of Toxicology, 91(7), 2629-2641. https://doi.org/10.1007/s00204-016-1899-0

Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulti... Read More about Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes.