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Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration (2017)
Journal Article
Phillips-Jones, M. K., Lithgo, R., Dinu, V., Gillis, R. B., Harding, J. E., Adams, G. G., & Harding, S. E. (2017). Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration. Scientific Reports, 7(1), 1-10. https://doi.org/10.1038/s41598-017-12620-z

The reversibility and strength of the previously established dimerization of the important glycopeptide antibiotic vancomycin in four different aqueous solvents (including a medically-used formulation) have been studied using short-column sedimentati... Read More about Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration.

Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with ?-synuclein overexpression and risk of idiopathic Parkinson's disease (2017)
Journal Article
Tarale, P., Daiwile, A. P., Sivanesan, S., Stöger, R., Bafana, A., Naoghare, P. K., …Krishnamurthi, K. (2018). Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease. Toxicology in Vitro, 46, https://doi.org/10.1016/j.tiv.2017.10.003

Manganese is an essential trace element however elevated environmental and occupational exposure to this element has been correlated with neurotoxicity symptoms clinically identical to idiopathic Parkinson's disease. In the present study we chronical... Read More about Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with ?-synuclein overexpression and risk of idiopathic Parkinson's disease.

Birthweight, HIV exposure and infant feeding as predictors of malnutrition in Botswanan infants (2017)
Journal Article
Chalashika, P., Essex, C., Mellor, D., Swift, J., & Langley-Evans, S. (in press). Birthweight, HIV exposure and infant feeding as predictors of malnutrition in Botswanan infants. Journal of Human Nutrition and Dietetics, https://doi.org/10.1111/jhn.12517

Background: A better understanding of the nutritional status of infants who are HIV-Exposed-Uninfected (HEU) and HIV-Unexposed-Uninfected (HUU) during their first 1000 days is a key to improving population health, particularly in sub-Saharan Africa.... Read More about Birthweight, HIV exposure and infant feeding as predictors of malnutrition in Botswanan infants.

The logic of the floral transition: reverse-engineering the switch controlling the identity of lateral organs (2017)
Journal Article
Dinh, J., Farcot, E., & Hodgman, C. (in press). The logic of the floral transition: reverse-engineering the switch controlling the identity of lateral organs. PLoS Computational Biology, 13(9), Article e1005744. https://doi.org/10.1371/journal.pcbi.1005744

Much laboratory work has been carried out to determine the gene regulatory network (GRN) that results in plant cells becoming flowers instead of leaves. However, this also involves the spatial distribution of different cell types, and poses the quest... Read More about The logic of the floral transition: reverse-engineering the switch controlling the identity of lateral organs.

A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus (2017)
Journal Article
Ali, A., Wathes, D. C., Swali, A., Burns, H., & Burns, S. (2017). A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus. Biochemistry and Biophysics Reports, 12, https://doi.org/10.1016/j.bbrep.2017.09.004

Background: Hexokinase and glucokinase enzymes are ubiquitously expressed and use ATP and ADP as substrates in mammalian systems and a variety of polyphosphate substrates and/or ATP in some eukaryotic and microbial systems. Polyphosphate synthesising... Read More about A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus.

A single active site in the mariner transposase cleaves DNA strands of opposite polarity (2017)
Journal Article
Claeys Bouuaert, C., & Chalmers, R. (in press). A single active site in the mariner transposase cleaves DNA strands of opposite polarity. Nucleic Acids Research, gkx826, https://doi.org/10.1093/nar/gkx826

The RNase H structural fold defines a large family of nucleic acid metabolizing enzymes that catalyze phosphoryl transfer reactions using two divalent metal ions in the active site. Almost all of these reactions involve only one strand of the nucleic... Read More about A single active site in the mariner transposase cleaves DNA strands of opposite polarity.

Reconstructing promoter activity from Lux bioluminescent reporters (2017)
Journal Article
Iqbal, M., Doherty, N., Page, A. M., Qazi, S. N., Ajmera, I., Lund, P. A., …Stekel, D. J. (2017). Reconstructing promoter activity from Lux bioluminescent reporters. PLoS Computational Biology, 13(9), Article e1005731. https://doi.org/10.1371/journal.pcbi.1005731

The bacterial Lux system is used as a gene expression reporter. It is fast, sensitive and non-destructive, enabling high frequency measurements. Originally developed for bacterial cells, it has also been adapted for eukaryotic cells, and can be used... Read More about Reconstructing promoter activity from Lux bioluminescent reporters.

Interfacial and emulsifying properties of mealworm protein at the oil/water interface (2017)
Journal Article
Gould, J., & Wolf, B. (2018). Interfacial and emulsifying properties of mealworm protein at the oil/water interface. Food Hydrocolloids, 77, 57-65. https://doi.org/10.1016/j.foodhyd.2017.09.018

The increasing global population and consumer demand for protein will render the provision of protein a serious future challenge. The lower environmental impact of insect farming makes the consumption of insects an appealing solution, although consum... Read More about Interfacial and emulsifying properties of mealworm protein at the oil/water interface.

Efficacy of insect larval meal to replace fish meal in juvenile barramundi, Lates calcarifer reared in freshwater (2017)
Journal Article
Katya, K., Borsra, M. Z. S., Ganesan, D., Kuppusamy, G., Herriman, M., Salter, A., & Ali, S. A. (2017). Efficacy of insect larval meal to replace fish meal in juvenile barramundi, Lates calcarifer reared in freshwater. International Aquatic Research, 9(4), 303-312. https://doi.org/10.1007/s40071-017-0178-x

The present experiment was conducted to evaluate the efficacy of dietary protein from black soldier fly, Hermetia illucens, larval meal (BSFL) to replace fish meal (FM) protein in juvenile barramundi, Lates calcarifer. Larvae of black soldier fly wer... Read More about Efficacy of insect larval meal to replace fish meal in juvenile barramundi, Lates calcarifer reared in freshwater.

Microbial mass movements (2017)
Journal Article
Zhu, Y., Gillings, M., Simonet, P., Stekel, D., Banwart, S., & Penuelas, J. (2017). Microbial mass movements. Science, 357(6356), 1099-1100. doi:10.1126/science.aao3007

Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease (2017)
Journal Article
Boden, K. A., Barber, I. S., Clement, N., Patel, T., Guetta-Baranes, T., Brookes, K., …Bottley, A. (2017). Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 1(1), https://doi.org/10.3233/ADR-170015

A number of genetic loci associate with early onset Alzheimer’s disease (EOAD), however the drivers of this disease remains enigmatic. Genome wide association and in-vivo modelling have shown that loss-of-function e.g. ABCA7, reduced levels of SIRT1,... Read More about Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease.

Shaping 3D root system architecture (2017)
Journal Article
Morris, E. C., Griffiths, M., Golebiowska, A., Mairhofer, S., Burr-Hersey, J., Goh, T., …Bennett, M. J. (2017). Shaping 3D root system architecture. Current Biology, 27(17), R919-R930. https://doi.org/10.1016/j.cub.2017.06.043

Plants are sessile organisms rooted in one place. The soil resources that plants require are often distributed in a highly heterogeneous pattern. To aid foraging, plants have evolved roots whose growth and development are highly responsive to soil si... Read More about Shaping 3D root system architecture.

High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas (2017)
Journal Article
Nica, D., Popescu, C., Draghici, G., Andrica, F., Privistirescu, I., Gergen, I. I., & Stöger, R. (2017). High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas. PLoS ONE, 12(9), Article e0184221. https://doi.org/10.1371/journal.pone.0184221

5-methylcytosine (5mC) is a key epigenetic mark which influences gene expression and phenotype. In vertebrates, this epigenetic mark is sensitive to Cd exposure, but there is no information linking such an event with changes in global 5mC levels in t... Read More about High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas.

Volatile chemical emission as a weapon of rearguard action: a game-theoretic model of contest behavior (2017)
Journal Article
Mesterton-Gibbons, M., Dai, Y., Goubault, M., & Hardy, I. C. (2017). Volatile chemical emission as a weapon of rearguard action: a game-theoretic model of contest behavior. Bulletin of Mathematical Biology, 79(11), 2413–2449. https://doi.org/10.1007/s11538-017-0335-9

We use a game-theoretic model to explore whether volatile chemical (spiroacetal) emissions can serve as a weapon of rearguard action. Our basic model explores whether such emissions serve as a means of temporary withdrawal, preventing the winner of t... Read More about Volatile chemical emission as a weapon of rearguard action: a game-theoretic model of contest behavior.

European Novel Foods Policy at a critical juncture: drawing lessons for future Novel Food Governance through a retrospective examination of Regulation 258/97 (2017)
Journal Article
Hyde, R., Hartley, S., & Millar, K. (2017). European Novel Foods Policy at a critical juncture: drawing lessons for future Novel Food Governance through a retrospective examination of Regulation 258/97. Food and Drug Law Journal, 72(3),

This paper presents a timely analysis of the European Union (EU) Novel Foods Regulation EC 258/97, identifying trends in the policy process and the applications that have been made under the regulation. The ways that the Novel Foods Regulation has fu... Read More about European Novel Foods Policy at a critical juncture: drawing lessons for future Novel Food Governance through a retrospective examination of Regulation 258/97.

Zinc fertilization increases productivity and grain nutritional quality of cowpea (Vigna unguiculata [L.] Walp.) under integrated soil fertility management (2017)
Journal Article
Manzeke, M. G., Mtambanengwe, F., Nezomba, H., Watts, M. J., Broadley, M. R., & Mapfumo, P. (2017). Zinc fertilization increases productivity and grain nutritional quality of cowpea (Vigna unguiculata [L.] Walp.) under integrated soil fertility management. Field Crops Research, 213, 231-244. https://doi.org/10.1016/j.fcr.2017.08.010

© 2017 Cowpea (Vigna unguiculata [L.] Walp.) is an important but under-studied grain legume which can potentially contribute to improved dietary zinc (Zn) intake in sub-Saharan Africa. In this study, surveys were conducted on smallholder farms in Zim... Read More about Zinc fertilization increases productivity and grain nutritional quality of cowpea (Vigna unguiculata [L.] Walp.) under integrated soil fertility management.

Understanding the mechanisms of cooperative physico-chemical treatment and mechanical disintegration of biomass as a route for enhancing enzyme saccharification (2017)
Journal Article
Ibbett, R., Gaddipati, S., & Tucker, G. A. (in press). Understanding the mechanisms of cooperative physico-chemical treatment and mechanical disintegration of biomass as a route for enhancing enzyme saccharification. Biomass Conversion and Biorefinery, https://doi.org/10.1007/s13399-017-0289-z

A novel chemico-kinetic disintegration model has been applied to study the cooperative relationship between physico-chemical treatment and supplementary wet-state milling of biomass, as an efficient process route to achieve high enzyme accessibility.... Read More about Understanding the mechanisms of cooperative physico-chemical treatment and mechanical disintegration of biomass as a route for enhancing enzyme saccharification.

Dissecting the components controlling root-to-shoot arsenic translocation in Arabidopsis thaliana (2017)
Journal Article
Wang, C., Na, G., Bermejo, E. S., Chen, Y., Banks, J. A., Salt, D. E., & Zhao, F. (2018). Dissecting the components controlling root-to-shoot arsenic translocation in Arabidopsis thaliana. New Phytologist, 217(1), 206-218. https://doi.org/10.1111/nph.14761

Arsenic (As) is an important environmental and food-chain toxin. We investigated the key components controlling As accumulation and tolerance in Arabidopsis thaliana. We tested the effects of different combinations of gene knockout, including ar... Read More about Dissecting the components controlling root-to-shoot arsenic translocation in Arabidopsis thaliana.

North, east, south, west: mapping vascular tissues onto the Arabidopsis root (2017)
Journal Article
Vaughan-Hirsch, J., Goodall, B., & Bishopp, A. (2018). North, east, south, west: mapping vascular tissues onto the Arabidopsis root. Current Opinion in Plant Biology, 41, https://doi.org/10.1016/j.pbi.2017.07.011

The Arabidopsis root has provided an excellent model for understanding patterning processes and cell fate specification. Vascular patterning represents an especially interesting process, as new positional information must be generated to transform an... Read More about North, east, south, west: mapping vascular tissues onto the Arabidopsis root.