Research Repository

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Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase (2019)
Journal Article
Cadby, I. T., Basford, S. M., Nottingham, R., Meek, R., Lowry, R., Lambert, C., …Lovering, A. L. (2019). Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase. EMBO Journal, doi:10.15252/embj.2018100772

Bacterial usage of the cyclic dinucleotide c-di-GMP is widespread, governing the transition between motile/sessile and unicellular/ multicellular behaviors. There is limited information on c-di-GMP metabolism, particularly on regulatory mechanisms go... Read More

Inter and Intra Varietal Variation in Textural Characteristics of Carrots: a Standard Food in Chewing Studies (2019)
Journal Article
Morrell, R., & Rosenthal, A. J. (2019). Inter and Intra Varietal Variation in Textural Characteristics of Carrots: a Standard Food in Chewing Studies. Global Journal of Nutrition & Food Science, 2(1), doi:10.33552/GJNFS.2019.02.000530

Carrots have been widely used as a model food in chewing studies yet inter and intra varietal variation have not been considered, treating them as a standard material whose rheological and breakdown characteristics are constant. Using a texture analy... Read More

Knockdown of Arabidopsis ROOT UVB SENSITIVE4 Disrupts Anther Dehiscence by Suppressing Secondary Thickening in the Endothecium (2019)
Journal Article
Zhao, S., Li, W., Zhang, Y., Tidy, A. C., & Wilson, Z. A. (2019). Knockdown of Arabidopsis ROOT UVB SENSITIVE4 Disrupts Anther Dehiscence by Suppressing Secondary Thickening in the Endothecium. Plant and Cell Physiology, doi:10.1093/pcp/pcz127

ROOT UV-B SENSITIVE4 (RUS4) encodes a protein with no known function that contains a conserved Domain of Unknown Function 647 (DUF647). The DUF647-containing proteins RUS1 and RUS2 have previously been associated with root UV-B-sensing pathway that p... Read More

An enzymatically controlled mucoadhesive for enhancing flavour during food oral processing (2019)
Journal Article
Dinu, V., Gadon, A., Hurst, K., Lim, M., Ayed, C., Gillis, R. B., …Fisk, I. D. (2019). An enzymatically controlled mucoadhesive for enhancing flavour during food oral processing. npj Science of Food, 3, doi:10.1038/s41538-019-0043-y

While a good mucoadhesive biopolymer must adhere to a mucus membrane, it must also have a good unloading ability. Here, we demonstrate that the biopolymer pullulan is partially digested by human salivary α-amylase, thus acting as a controlled release... Read More

A novel high sensitivity bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis (2019)
Journal Article
Verma, R., Swift, B. M., Handley-Hartill, W., Lee, J. K., Woltmann, G., Rees, C. E., & Haldar, P. (2019). A novel high sensitivity bacteriophage-based assay identifies low level Mycobacterium tuberculosis bacteraemia in immunocompetent patients with active and incipient tuberculosis. Clinical Infectious Diseases, doi:10.1093/cid/ciz548

Haematogenous dissemination of M. tuberculosis (Mtb) is critical to pathogenesis of progressive tuberculous infection in animal models. Using a novel phage-based blood assay, we report the first concordant evidence in well-characterised immunocompete... Read More

Lubrication by biomacromolecules: mechanisms and biomimetic strategies (2019)
Journal Article
Pradal, C., Yakubov, G., Williams, M., McGuckin, M., & Stokes, J. (2019). Lubrication by biomacromolecules: mechanisms and biomimetic strategies. Bioinspiration and Biomimetics, doi:10.1088/1748-3190/ab2ac6

Biomacromolecules play a key role in protecting human biointerfaces from friction and wear, and thus enable painless motion. Biomacromolecules give rise to remarkable tribological properties that researchers have been eager to emulate. In this review... Read More

Non-chemically modified waxy rice starch stabilised wow emulsions for salt reduction (2019)
Journal Article
Kasprzak, M., Wilde, P., Hill, S. E., Harding, S. E., Ford, R., & Wolf, B. (2019). Non-chemically modified waxy rice starch stabilised wow emulsions for salt reduction. Food and Function, 10(7), 4242-4255 . doi:10.1039/c8fo01938j

Water-in-oil-in-water emulsions containing an internalised salt solution were stabilised with non-chemically modified waxy rice starch (WRS), and octinyl succinic anhydride (OSA) as reference, to release salt during oral processing due to amylase-ind... Read More

Emergent Protective Organogenesis in Date Palms: A Morpho-devo-dynamic Adaptive Strategy During Early Development (2019)
Journal Article
Xiao, T., Raygoza, A. A., Pérez, J. C., Kirschner, G., Deng, Y., Atkinson, B., …Blilou, I. (2019). Emergent Protective Organogenesis in Date Palms: A Morpho-devo-dynamic Adaptive Strategy During Early Development. Plant Cell, doi:10.1105/tpc.19.00008

Desert plants have developed mechanisms for adapting to hostile desert conditions, yet these mechanisms remain poorly understood. Here, we describe two unique modes used by desert date palms (Phoenix dactylifera L.) to protect their meristematic tiss... Read More

Hunting for answers: Linking lectures with the real world using a mobile treasure hunt app (2019)
Journal Article
Hartman, T., Lydon, S. J., & Rasmussen, A. (2019). Hunting for answers: Linking lectures with the real world using a mobile treasure hunt app. Plants, People, Planet, doi:10.1002/ppp3.33

Plants underpin our society providing food, fuel, medicines, clean air and water, positive mental health, and are central to biodiversity conservation. Despite this importance and an increasing need for people with plant-identification skills, many s... Read More

The overlooked cohort? – Improving the taught postgraduate student experience in higher education (2019)
Journal Article
Coneyworth, L., Jessop, R., Maden, P., & White, G. (2019). The overlooked cohort? – Improving the taught postgraduate student experience in higher education. Innovations in Education and Teaching International, 1-12. doi:10.1080/14703297.2019.1617184

Taught postgraduate students in the UK have a limited timeframe for study, with most full-time courses requiring intense scholarship, typically over a 12-month period. Many of these students face challenges and concerns with the transition from under... Read More

Investigating the use of microdialysis and SEC-UV-ICP-MS to assess iodine interactions in soil solution (2019)
Journal Article
Humphrey, O., Young, S., Bailey, E., Crout, N., Ander, E., Hamilton, E., & Watts, M. (2019). Investigating the use of microdialysis and SEC-UV-ICP-MS to assess iodine interactions in soil solution. Chemosphere, 229, 41-50. doi:10.1016/j.chemosphere.2019.04.215

Element cycling in the terrestrial environment is heavily reliant upon processes that occur in soil solution. Here we present the first application of microdialysis to sample iodine from soil solution. In comparison to conventional soil solution extr... Read More

Human oral processing and texture profile analysis parameters: bridging the gap between the sensory evaluation and the instrumental measurements (2019)
Journal Article
Nishinari, K., Fang, Y., & Rosenthal, A. (2019). Human oral processing and texture profile analysis parameters: bridging the gap between the sensory evaluation and the instrumental measurements. Journal of Texture Studies, doi:10.1111/jtxs.12404

Studies in food oral processing are becoming increasingly important with the advent of the aged society. The food oral processing model of Hutchings and Lillford (Journal of Texture Studies, 19, 1988, 103–115) describes the structural breakdown and l... Read More

Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide (2019)
Journal Article
Norman, R. O., Millat, T., Schatschneider, S., Henstra, A. M., Breitkopf, R., Pander, B., …Hodgman, C. (2019). Genome-scale model of C. autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide. Engineering Biology, 3(2), 32-40. doi:10.1049/enb.2018.5003

Clostridium autoethanogenum is an industrial microbe used for the commercial-scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desi... Read More

Multiple abiotic stress, nitrate availability and the growth of wheat (2019)
Journal Article
Ge, Y., Hawkesford, M., Rosolem, C., Mooney, S., Ashton, R., Evans, J., & Whalley, W. (2019). Multiple abiotic stress, nitrate availability and the growth of wheat. Soil and Tillage Research, 191, 171-184. doi:10.1016/j.still.2019.04.005

In the field, wheat experiences a combination of physical and nutrient stresses. There has been a tendency to study root impedance and water stress in separation and less is known about how they might interact. In this study, we investigated the effe... Read More

Process simulation and life cycle assessment of converting autoclaved municipal solid waste into butanol and ethanol as transport fuels (2019)
Journal Article
Meng, F., Ibbett, R., de Vrije, T., Metcalf, P., Tucker, G., & McKechnie, J. (2019). Process simulation and life cycle assessment of converting autoclaved municipal solid waste into butanol and ethanol as transport fuels. Waste Management, 89, 177-189. doi:10.1016/j.wasman.2019.04.003

In 2015/2016, the total municipal solid waste (MSW) collected by local authority in the U.K. was 26 million tonnes and over 57% is still put into landfill or incinerated. MSW is a promising feedstock for bio-butanol production as it has a high lignoc... Read More

Penetration and uptake of Nanoparticles in 3D tumour spheroids (2019)
Journal Article
Tchoryk, A., Taresco, V., Argent, R., Ashford, M. B., Gellert, P., Stolnik, S., …Garnett, M. C. (2019). Penetration and uptake of Nanoparticles in 3D tumour spheroids. Bioconjugate Chemistry, 30(5), 1371-1384. doi:10.1021/acs.bioconjchem.9b00136

Animal models are effective for assessing tumour localisation of nanosystems, but difficult to use for studying penetration beyond the vasculature. Here, we have used well-characterised HCT116 colorectal cancer spheroids to study the effect of nanopa... Read More