Research Repository

See what's under the surface


Multiple abiotic stress, nitrate availability and the growth of wheat (2019)
Journal Article
Ge, Y., Hawkesford, M., Rosolem, C., Mooney, S., Ashton, R., Evans, J., & Whalley, W. (2019). Multiple abiotic stress, nitrate availability and the growth of wheat. Soil and Tillage Research, 191, 171-184. doi:10.1016/j.still.2019.04.005

In the field, wheat experiences a combination of physical and nutrient stresses. There has been a tendency to study root impedance and water stress in separation and less is known about how they might interact. In this study, we investigated the effe... Read More

Process simulation and life cycle assessment of converting autoclaved municipal solid waste into butanol and ethanol as transport fuels (2019)
Journal Article
Meng, F., Ibbett, R., de Vrije, T., Metcalf, P., Tucker, G., & McKechnie, J. (2019). Process simulation and life cycle assessment of converting autoclaved municipal solid waste into butanol and ethanol as transport fuels. Waste Management, 89, 177-189. doi:10.1016/j.wasman.2019.04.003

In 2015/2016, the total municipal solid waste (MSW) collected by local authority in the U.K. was 26 million tonnes and over 57% is still put into landfill or incinerated. MSW is a promising feedstock for bio-butanol production as it has a high lignoc... Read More

Penetration and uptake of Nanoparticles in 3D tumour spheroids (2019)
Journal Article
Tchoryk, A., Taresco, V., Argent, R., Ashford, M. B., Gellert, P., Stolnik, S., …Garnett, M. C. (2019). Penetration and uptake of Nanoparticles in 3D tumour spheroids. Bioconjugate Chemistry, doi:10.1021/acs.bioconjchem.9b00136

Animal models are effective for assessing tumour localisation of nanosystems, but difficult to use for studying penetration beyond the vasculature. Here, we have used well-characterised HCT116 colorectal cancer spheroids to study the effect of nanopa... Read More

Endoreplication as a potential driver of cell wall modifications (2019)
Journal Article
Bhosale, R., Maere, S., & De Veylder, L. (in press). Endoreplication as a potential driver of cell wall modifications. Current Opinion in Plant Biology,

Endoreplication represents a variant of the mitotic cell cycle during which cells replicate their DNA without mitosis and/or cytokinesis, resulting in an increase in the cells' ploidy level. This process is especially prominent in higher plants, wher... Read More

Identification of nitrogen-dependent QTL and underlying genes for root system architecture in hexaploid wheat (2019)
Other
Griffiths, M., Atkinson, J. A., Gardiner, L., Swarup, R., Pound, M. P., Wilson, M. H., …Wells, D. M. (2019). Identification of nitrogen-dependent QTL and underlying genes for root system architecture in hexaploid wheat

The root system architecture (RSA) of a crop has a profound effect on the uptake of nutrients and consequently the potential yield. However, little is known about the genetic basis of RSA and resource dependent response in wheat (Triticum aestivum L.... Read More

Physiological and transcriptomic response of Saccharomyces pastorianus to cold storage (2019)
Journal Article
Somani, A., Box, W. G., Smart, K. A., & Powell, C. D. (2019). Physiological and transcriptomic response of Saccharomyces pastorianus to cold storage. FEMS Yeast Research, 19(4), doi:10.1093/femsyr/foz025

Removal of yeast biomass at the end of fermentation, followed by a period of storage before re-inoculation into a subsequent fermentation, is common in the brewing industry. Storage is typically conducted at cold temperatures to preserve yeast qualit... Read More

Impact of endometritis on post-partum ovarian cyclicity in dairy cows (2019)
Journal Article
Mohammed, Z., Mann, G., & Robinson, R. (2019). Impact of endometritis on post-partum ovarian cyclicity in dairy cows. Veterinary Journal, 248, 8-13. doi:10.1016/j.tvjl.2019.03.008

Endometritis in dairy cows is a major global issue and has been associated with a decrease in reproductive performance. The aim of this study was to quantify the effect of endometritis (as defined by the presence of any abnormal vaginal discharge aft... Read More

Winged bean (Psophocarpus tetragonolobus (L.) DC.) for food and nutritional security: synthesis of past research and future direction (2019)
Journal Article
Tanzi, A. S., Eagleton, G. E., Ho, W. K., Wong, Q. N., Mayes, S., & Massawe, F. (2019). Winged bean (Psophocarpus tetragonolobus (L.) DC.) for food and nutritional security: synthesis of past research and future direction. Planta, doi:10.1007/s00425-019-03141-2

Reliance on a handful of “major” crops has led to decreased diversity in crop species, agricultural systems and human diets. To reverse this trend, we need to encourage the greater use of minor, “orphan”, underutilised species. These could contribute... Read More

A genome-scale model of Clostridium autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide (2019)
Journal Article
Norman, R. O., Millat, T., Schatschneider, S., Henstra, A. M., Breitkopf, R., Pander, B., …Hodgman, C. (in press). A genome-scale model of Clostridium autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide. Engineering Biology,

Clostridium autoethanogenum is an industrial microbe used for the commercial-scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desi... Read More

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats (2019)
Journal Article
Pollard, A. K., Ingram, T. L., Ortori, C. A., Shephard, F., Brown, M., Liddell, S., …Chakrabarti, L. (2019). A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. Aging, doi:10.18632/aging.101861

It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over... Read More

DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples (2019)
Journal Article
Shaw, L. M., Blanchard, A., Chen, Q., An, X., Davies, P., Totemeyer, S., …Stekel, D. J. (2019). DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples. Scientific Reports, 9, doi:10.1038/s41598-019-38873-4

High throughput genomics technologies are applied widely to microbiomes in humans, animals, soil and water, to detect changes in bacterial communities or the genes they carry, between different environments or treatments. We describe a method to test... Read More

Freshwater and airborne textile fibre populations are dominated by ‘natural’, not microplastic, fibres (2019)
Journal Article
Stanton, T., Johnson, M., Nathanail, P., MacNaughtan, W., & Gomes, R. L. (2019). Freshwater and airborne textile fibre populations are dominated by ‘natural’, not microplastic, fibres. Science of the Total Environment, 666, 377-389. doi:10.1016/j.scitotenv.2019.02.278

The potential role of natural textile fibres as environmental pollutants has been speculated upon by some environmental scientists, however, there is a general consensus that their biodegradability reduces their environmental threat. Whilst the risks... Read More

Development and validation of an exome-based SNP marker set for identification of the St, Jr and Jvs genomes of Thinopyrym intermedium in a wheat background (2019)
Journal Article
Cseh, A., Yang, C., Hubbart-Edwards, S., Scholefield, D., Ashling, S. S., Burridge, A. J., …Grewal, S. (2019). Development and validation of an exome-based SNP marker set for identification of the St, Jr and Jvs genomes of Thinopyrym intermedium in a wheat background. TAG Theoretical and Applied Genetics, 132(5), 1555–1570. doi:10.1007/s00122-019-03300-9

Thinopyrum intermedium (2n = 6x = 42, StJrJvs) is one of the most promising reservoirs of useful genes including tolerance to abiotic stresses, perenniality and disease resistance not available in the cultivated bread wheat. The transfer of genetic d... Read More

Gsmodutils: a python based framework for test-driven genome scale metabolic model development (2019)
Journal Article
Gilbert, J., Pearcy, N., Norman, R., Millat, T., Winzer, K., King, J., …Twycross, J. (2019). Gsmodutils: a python based framework for test-driven genome scale metabolic model development. Bioinformatics, doi:10.1093/bioinformatics/btz088

Motivation Genome scale metabolic models (GSMMs) are increasingly important for systems biology and metabolic engineering research as they are capable of simulating complex steady-state behaviour. Constraints based models of this form can include th... Read More

The commercial pig as a model of spontaneously-occurring osteoarthritis (2019)
Journal Article
Macfadyen, M. A., Daniel, Z., Kelly, S., Parr, T., Brameld, J. M., Murton, A. J., & Jones, S. W. (2019). The commercial pig as a model of spontaneously-occurring osteoarthritis. BMC Musculoskeletal Disorders, 20, doi:10.1186/s12891-019-2452-0

Background: Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous osteoarthritis development b... Read More

Development of stable homozygous wheat/Amblyopyrum muticum (Aegilops mutica) introgression lines and their cytogenetic and molecular characterization (2019)
Journal Article
King, J., Newell, C., Grewal, S., Hubbart-Edwards, S., Yang, C., Scholefield, D., …King, I. P. (2019). Development of stable homozygous wheat/Amblyopyrum muticum (Aegilops mutica) introgression lines and their cytogenetic and molecular characterization. Frontiers in Plant Science, 10, 1-10. doi:10.3389/fpls.2019.00034

Wheat is one of the world’s most important sources of food. However, due to its evolution its genetic base has narrowed, which is severely limiting the ability of breeders to develop new higher yielding varieties that can adapt to the changing enviro... Read More

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis (2019)
Journal Article
Ramos-Ibeas, P., Sang, F., Zhu, Q., Wang, W. W., Withey, S., Klisch, D., …Alberio, R. (2019). Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis. Nature Communications, 10, doi:10.1038/s41467-019-08387-8

High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-implantation stages, since early post-implantation embryos are largely ina... Read More

Sex allocation, sex ratios and reproduction (2019)
Book Chapter
Hardy, I. C., & Boulton, R. A. (2019). Sex allocation, sex ratios and reproduction. In J. Choe (Ed.), Encyclopedia of Animal Behavior, 464-471. (2nd edition). Elsevier

Sex allocation theory provides a powerful framework for understanding a range of reproductive behavior, including the numerical sex ratio of the progeny that parents produce. Starting with evolutionary explanations for why many species have unbiased... Read More

A loop-mediated isothermal amplification (LAMP) assay for rapid and specific detection of airborne inoculum of Uromyces betae (sugar beet rust) (2019)
Journal Article
Kaczmarek, A., King, K., West, J., Stevens, M., Sparkes, D., & Dickinson, M. (2019). A loop-mediated isothermal amplification (LAMP) assay for rapid and specific detection of airborne inoculum of Uromyces betae (sugar beet rust). Plant Disease, 103(3), doi:10.1094/PDIS-02-18-0337-RE

Sugar beet rust disease (causal agent Uromyces betae) represents a serious threat to worldwide sugar beet (Beta vulgaris) crops, causing yield losses of up to 10% in the UK. Currently, the disease is managed mainly by application of fungicides after... Read More

Uncertainty in geological interpretations: effectiveness of expert elicitations (2019)
Journal Article
Randle, C. H., Bond, C. E., Lark, R. M., & Monaghan, A. A. (2019). Uncertainty in geological interpretations: effectiveness of expert elicitations. Geosphere, 15(1), doi:10.1130/GES01586.1

Uncertainty in geological interpretations creates and often unquantified risk for sub- surface industries. The challenge of quantifying interpretation uncertainty has been addressed using various methods. For interpretation of borehole data, empirica... Read More