Research Repository

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Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives (2018)
Journal Article
Soukarieh, F., Williams, P., Stocks, M. J., & Camara, M. (in press). Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives. Journal of Medicinal Chemistry, doi:10.1021/acs.jmedchem.8b00540

Antimicrobial resistance (AMR) is a serious threat to public health globally, manifested by the frequent emergence of multi-drug resistant pathogens that render current chemotherapy inadequate. Health organizations worldwide have recognized the sever... Read More

Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve (2018)
Journal Article
Rich, L., & Brown, A. M. (2018). Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve. Journal of Physiology, 596(10), doi:10.1113/JP275680

The stimulus evoked compound action potential (CAP), recorded using suction electrodes, provides an index of the relative number of conducting axons within a nerve trunk. As such the CAP has been used to elucidate the diverse mechanisms of injury res... Read More

Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis (2017)
Journal Article
Chapman, V., Markides, H., Sagar, D. R., Xu, L., Burston, J. J., Mapp, P., …El Haj, A. J. (2017). Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis. Stem Cells International, 2017, doi:10.1155/2017/2905104

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi... Read More

Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis (2017)
Journal Article
Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), doi:10.1002/acr.23091

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications. Met... Read More

Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma (2017)
Journal Article
Sandham, D. A., Barker, L., Brown, L., Brown, Z., Budd, D., Charlton, S. J., …Willis, J. (2017). Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma. ACS Medicinal Chemistry Letters, 8, doi:10.1021/acsmedchemlett.7b00157

Further optimization of an initial DP2 receptor antagonist clinical candidate NVPQAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2- (trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11,... Read More

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA (2017)
Journal Article
Nwosu, L. N., Allen, M., Wyatt, L., Huebner, J., Chapman, V., Walsh, D. A., & Kraus, V. (2017). Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. Osteoarthritis and Cartilage, 25(6), doi:10.1016/j.joca.2017.01.002

Objectives: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Methods: Sera and... Read More

Prior consumption of a fat meal in healthy adults modulates the brain’s response to fat (2016)
Journal Article
Eldeghaidy, S., Marciani, L., Hort, J., Hollowood, T. A., Singh, G., Bush, D., …Francis, S. T. (in press). Prior consumption of a fat meal in healthy adults modulates the brain’s response to fat. Journal of Nutrition, doi:10.3945/jn.116.234104

Background: Consumption of fat is regulated by reward and homeostatic pathways, but no studies have examined the role of the intake of a high fat meal (HFM) on subsequent brain activation to oral stimuli. Objective: We evaluated how prior consumptio... Read More

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat (2016)
Journal Article
Alsalem, M., Millns, P., Altarifi, A., El-Salem, K., Chapman, V., & Kendall, D. A. (in press). Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat. BMC Pharmacology and Toxicology, 17, doi:10.1186/s40360-016-0074-9

Background: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic c... Read More

SBRC-Nottingham: sustainable routes to platform chemicals from C1 wastes Gases (2016)
Journal Article
Burbidge, A., & Minton, N. P. (2016). SBRC-Nottingham: sustainable routes to platform chemicals from C1 wastes Gases. Biochemical Society Transactions, 44(3), (684-686). doi:10.1042/BST20160010. ISSN 0300-5127

SBRC-Nottingham (www.sbrc-nottingham.ac.uk) was one of the first three UK university-based Synthetic Biology Research Centres (SBRCs) to be funded by the BBSRC and EPSRC as part of the recommendations made in the UKs Synthetic Biology Roadmap. It was... Read More

Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer's disease: implications for object recognition (2016)
Journal Article
Bonardi, C., Pardon, M., & Armstrong, P. (2016). Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer's disease: implications for object recognition. Behavioural Brain Research, 313, doi:10.1016/j.bbr.2016.07.008

Performance was examined on three variants of the spontaneous object recognition (SOR) task, in 5-month old APPswe/PS1dE9 mice and wild-type littermate controls. A deficit was observed in an object-in-place (OIP) task, in which mice are preexposed to... Read More

Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes (2016)
Journal Article
Murton, A. J., Maddocks, M., Stephens, F. B., Marimuthu, K., England, R., & Wilcock, A. (in press). Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes. Clinical Lung Cancer, doi:10.1016/j.cllc.2016.06.003

Introduction: Loss of muscle is common in patients with advanced non-small cell lung cancer (NSCLC), and contributes to the high morbidity and mortality of this group. The exact mechanisms behind the loss of muscle are unclear. Patients and methods... Read More

Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats (2016)
Journal Article
Shortall, S. E., Green, A. R., Fone, K. C., & King, M. V. (2016). Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. Journal of Psychopharmacology, 30(7), doi:10.1177/0269881116650408

Administration of caffeine with 3,4-methylenedioxymethamphetamine (MDMA) alters the pharmacological properties of MDMA in rats. The current study examined whether caffeine alters the behavioural and neurochemical effects of mephedrone, which has simi... Read More

Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding (2016)
Journal Article
Dickson, C. J., Hornak, V., Velez-Vega, C., McKay, D. J., Reilly, J., Sandham, D. A., …Duca, J. S. (2016). Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding. Journal of Medicinal Chemistry, 59(12), doi:10.1021/acs.jmedchem.6b00358

Ligand binding to membrane proteins may be significantly influenced by the interaction of ligands with the membrane. In particular, the microscopic ligand concentration within the membrane surface solvation layer may exceed that in bulk solvent, resu... Read More

On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury (2016)
Journal Article
Cole, M., Abd Jamil, A. H., Heather, L. C., Murray, A. J., Sutton, E. R., Slingo, M., …Clarke, K. (2016). On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. FASEB Journal, 30(8), doi:10.1096/fj.201500094R

The role of peroxisome proliferator activated alpha (PPARα) -mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 weeks before in vivo contractile function was measured using c... Read More

Non-destructive characterisation of mesenchymal stem cell differentiation using LC-MS-based metabolite footprinting (2016)
Journal Article
Surrati, A., Linforth, R. S., Fisk, I. D., Sottile, V., & Kim, D. (in press). Non-destructive characterisation of mesenchymal stem cell differentiation using LC-MS-based metabolite footprinting. Analyst, 12, doi:10.1039/c6an00170j

Bone regeneration is a complex biological process where major cellular changes take place to support the osteogenic differentiation of mesenchymal bone progenitors. To characterise these biological changes and better understand the pathways regulatin... Read More

Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury (2016)
Journal Article
Carter, W., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., …Kharbanda, K. (2016). Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Biochemical and Biophysical Research Communications, 458(3), doi:10.1016/j.bbrc.2015.01.158

We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl methyltransferase (PIMT), an enzyme that triggers repair of isoaspartate protein damage. To furt... Read More

Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS (2016)
Journal Article
Majsec, K., Bolt, E. L., & Ivančić-Baće, I. (in press). Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS. BMC Microbiology, 16(28), doi:10.1186/s12866-016-0643-5

Background: CRISPR-Cas systems provide adaptive immunity to mobile genetic elements in prokaryotes. In many bacteria, including E. coli, a specialized ribonucleoprotein complex called Cascade enacts immunity by “an interference reaction" between CRIS... Read More