All Outputs (2)

Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice (2023)
Journal Article
Othman, O., Marshall, H., Masterson, M., Winlow, P., Gibson, G., Ding, Y., & Pardon, M. (2023). Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice. International Immunopharmacology, 117, Article 109951. https://doi.org/10.1016/j.intimp.2023.109951

Lipopolysaccharide (LPS) produced by the gut during systemic infections and inflammation is thought to contribute to Alzheimer's disease (AD) progression. Since thymosin beta 4 (Tβ4) effectively reduces LPS-induced inflammation in sepsis, we tested i... Read More about Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice.

Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer's disease: implications for object recognition (2016)
Journal Article
Bonardi, C., Pardon, M., & Armstrong, P. (2016). Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer's disease: implications for object recognition. Behavioural Brain Research, 313, https://doi.org/10.1016/j.bbr.2016.07.008

Performance was examined on three variants of the spontaneous object recognition (SOR) task, in 5-month old APPswe/PS1dE9 mice and wild-type littermate controls. A deficit was observed in an object-in-place (OIP) task, in which mice are preexposed to... Read More about Deficits in object-in-place but not relative recency performance in the APPswe/PS1dE9 mouse model of Alzheimer's disease: implications for object recognition.