All Outputs (141)

The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability (2015)
Journal Article
Kay, J. J., Clegg, J. A., Emck, C., & Standen, P. J. (2016). The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability. Journal of Intellectual and Developmental Disability, 41(1), 54-60. https://doi.org/10.3109/13668250.2015.1094037

Background. Psychomotor therapy enables people to reflect on the relationship between experiences and feelings by starting from awareness of bodily responses rather than from awareness of emotion. In this study we examine PsyMot (ID), an assessment t... Read More about The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability.

Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni) (2015)
Journal Article
de Brot, S., Sydler, T., Nufer, L., & Ruetten, M. (2015). Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni). Journal of Zoo and Wildlife Medicine, 46(3), https://doi.org/10.1638/2013-0113.1

A dwarf bearded dragon (Pogona henrylawsoni) was presented with a whitish subcutaneous mandibular mass and multiple nodules in the oral mucosa, heart, liver, kidney, intestine and visceral fat. Histologically, the tumor consisted of densely packed sp... Read More about Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni).

Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition (2015)
Journal Article
Rollie, C., Schneider, S., Brinkmann, A. S., Bolt, E. L., & White, M. F. (2015). Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition. eLife, 4, Article e08716. https://doi.org/10.7554/elife.08716

© Rollie et al. The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements. The fundamental basis of the system is the ability to capture small pieces of foreign DNA for incorporation into the ge... Read More about Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition.

Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer (2015)
Journal Article
Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), https://doi.org/10.1002/cphc.201500367

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagn... Read More about Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer.

Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with ??-tetrahydrocannabinol (THC) (2015)
Journal Article
Olarte-Sánchez, C., Valencia-Torres, L., Cassaday, H. J., Bradshaw, C., & Szabadi, E. (2015). Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC). Behavioural Processes, 113, https://doi.org/10.1016/j.beproc.2015.01.014

Rats’ performance on a progressive-ratio schedule maintained by sucrose (0.6 M, 50 μl) and corn oil (100%, 25 μl) reinforcers was assessed using a model derived from Killeen’s (1994) theory of scheduled-controlled behaviour, ‘Mathematical Principles... Read More about Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with ??-tetrahydrocannabinol (THC).

Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study. (2015)
Journal Article
Cooper, N. A., Clark, T. J., Middleton, L., Diwakar, L., Smith, P., Denny, E., …Thornton, J. (2015). Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study. BMJ, 350, Article h1398. https://doi.org/10.1136/bmj.h1398

© BMJ Publishing Group Ltd 2015. To compare the effectiveness and acceptability of outpatient polypectomy with inpatient polypectomy. Design Pragmatic multicentre randomised controlled noninferiority study. Setting Outpatient hysteroscopy clinics in... Read More about Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study..

What is 'Early intervention' for work related difficulties for people with multiple sclerosis?: a case study report (2014)
Journal Article
Sweetland, J., Playford, D. E., & Radford, K. A. (2014). What is 'Early intervention' for work related difficulties for people with multiple sclerosis?: a case study report. Journal of Neurology and Neurophysiology, 5(6), https://doi.org/10.4172/2155-9562.1000252

Background: Employment matters and at diagnosis most people with multiple sclerosis are in full time work or education. 75% of people with multiple sclerosis report the condition has impacted on this employment or career opportunities. Early interven... Read More about What is 'Early intervention' for work related difficulties for people with multiple sclerosis?: a case study report.

Vocational rehabilitation following traumatic brain injury: what is the evidence for clinical practice? (2014)
Journal Article
Phillips, J., & Radford, K. A. (2014). Vocational rehabilitation following traumatic brain injury: what is the evidence for clinical practice?. Advances in Clinical Neuroscience and Rehabilitation, 14(5),

Traumatic brain injury (TBI) typically affects young adults with potentially many years of working life ahead of them. For people who were in work prior to their injury, return to work (RTW) is a common goal. However, a systematic review of RTW rat... Read More about Vocational rehabilitation following traumatic brain injury: what is the evidence for clinical practice?.

A randomised controlled trial of laser scanning and casting for the construction of ankle–foot orthoses (2014)
Journal Article
Roberts, A., Wales, J., Smith, H., Sampson, C. J., Jones, P., & James, M. (2016). A randomised controlled trial of laser scanning and casting for the construction of ankle–foot orthoses. Prosthetics and Orthotics International, 40(2), 253-261. https://doi.org/10.1177/0309364614550263

Study Design: Randomised controlled trial with blinding of orthotists and patients to the construction technique used. Background: Three-dimensional laser scanning has been used for patient measurement for cranial helmets and spinal braces. Ankle foo... Read More about A randomised controlled trial of laser scanning and casting for the construction of ankle–foot orthoses.

Comparison of the benefits of cochlear implantation versus contra-lateral routing of signal hearing aids in adult patients with single-sided deafness: study protocol for a prospective within-subject longitudinal trial (2014)
Journal Article
Kitterick, P. T., O’Donoghue, G. M., Edmondson-Jones, M., Marshall, A., Jeffs, E., Craddock, L., …Seeber, B. U. (2014). Comparison of the benefits of cochlear implantation versus contra-lateral routing of signal hearing aids in adult patients with single-sided deafness: study protocol for a prospective within-subject longitudinal trial. BMC Ear, Nose and Throat Disorders, 14, Article 7. https://doi.org/10.1186/1472-6815-14-7

Background Individuals with a unilateral severe-to-profound hearing loss, or single-sided deafness, report difficulty with listening in many everyday situations despite having access to well-preserved acoustic hearing in one ear. The standard of... Read More about Comparison of the benefits of cochlear implantation versus contra-lateral routing of signal hearing aids in adult patients with single-sided deafness: study protocol for a prospective within-subject longitudinal trial.

Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities (2014)
Journal Article
Hedgecock, J., Standen, P. J., Beer, C., & Brown, D. (2014). Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities. Journal of Assistive Technologies, 8(3), 111-123. https://doi.org/10.1108/JAT-02-2014-0006

Purpose The purpose of this paper is to identify ways teachers might employ a robot to achieve learning objectives with pupils with intellectual disabilities and potential outcome measures. Design/methodology/approach A series of five case studi... Read More about Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities.

A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients (2014)
Journal Article
Rockliff, H. E., Lightman, S., Rhidian, E., Buchanan, H., Gordon, U., & Vedhara, K. (2014). A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients. Human Reproduction Update, 20(4), https://doi.org/10.1093/humupd/dmu010

BACKGROUND IVF treatment is usually stressful for patients, but individual differences in emotional response do exist. Differences in the stress response may be related to reproductive outcomes as well as to the development of psychiatric problems... Read More about A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients.

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization (2014)
Journal Article
Hill, S. J., May, L. T., Kellam, B., & Woolard, J. (2014). Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization. British Journal of Pharmacology, 171(5), https://doi.org/10.1111/bph.12345

Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological condition... Read More about Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization.

The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study (2014)
Journal Article
Sneller, J., Buchanan, H., & Parekh, S. (2014). The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study. International Journal of Paediatric Dentistry, 24(6), https://doi.org/10.1111/ipd.12086

BACKGROUND: Amelogenesis imperfecta (AI) is a rare inherited dental defect where enamel does not form properly on the teeth. Research has shown that adolescents with AI may experience adverse psychosocial effects; however the impact on parents has n... Read More about The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study.

Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases (2014)
Journal Article
Muñoz-Lobato, F., Rodríguez-Palero, M. J., Naranjo-Galindo, F. J., Shephard, F., Gaffney, C. J., Szewczyk, N. J., …Miranda-Vizuete, A. (2014). Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases. Antioxidants and Redox Signaling, 20(2), 217-235. https://doi.org/10.1089/ars.2012.5051

Aims: Cells have developed quality control systems for protection against proteotoxicity. Misfolded and aggregation-prone proteins, which are behind the initiation and progression of many neurodegenerative diseases (ND), are known to challenge the pr... Read More about Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases.

Update on otitis media – prevention and treatment (2014)
Journal Article
Qureishi, A., Lee, Y., Belfield, K., Birchall, J. P., & Daniel, M. (2014). Update on otitis media – prevention and treatment. Infection and Drug Resistance, 2014(7), https://doi.org/10.2147/IDR.S39637

Acute otitis media and otitis media with effusion are common childhood disorders, a source of significant morbidity, and a leading cause of antibiotic prescription in primary health care. Although effective treatments are available, some shortcomings... Read More about Update on otitis media – prevention and treatment.

Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1? (2013)
Journal Article
Williams, A., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2013). Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?. Arthritis Research and Therapy, 15(6), Article R223. https://doi.org/10.1186/ar4424

Introduction: Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metalloproteinases (MMPs) is partly... Read More about Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1?.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article
Sharquie, I. K., Al-Ghouleh, A., Fitton, P., Clark, M. R., Armour, K. L., Sewell, H. F., …Ghaemmaghami, A. M. (2013). An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells. BMC Immunology, 14(Decemb), Article 12. https://doi.org/10.1186/1471-2172-14-54

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods (2013)
Journal Article
Charman, C., Venn, A., Ravenscroft, J., & Williams, H. (2013). Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods. British Journal of Dermatology, 169(6), https://doi.org/10.1111/bjd.12590

Background: The Patient-Oriented Eczema Measure (POEM) is a validated, patient-derived assessment measure for monitoring atopic eczema severity, although further information on how different POEM scores translate into disease severity categories is n... Read More about Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods.

Risk factors for wheezing in infants born in Cuba (2013)
Journal Article
Venero-Fernandez, S., Suarez-Medina, R., Mora-Faife, E., Garcia-Garcia, G., Valle-Infante, I., Gomez-Marrero, L., …Fogarty, A. W. (2013). Risk factors for wheezing in infants born in Cuba. QJM: An International Journal of Medicine, 106(11), https://doi.org/10.1093/qjmed/hct143

Background: Cuba is a unique country, and despite limited economic development, has an excellent health system. However, the prevalence of asthma symptoms in children in Havana, Cuba, is unusually high. Aim: As early life exposures are critical t... Read More about Risk factors for wheezing in infants born in Cuba.