All Outputs (141)

Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC (2013)
Journal Article
Verma, C., Eremin, J. M., Robins, A., Bennett, A. J., Cowley, G. P., El-Sheemy, M. A., …Eremin, O. (2013). Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC. Journal of Translational Medicine, 11(16), https://doi.org/10.1186/1479-5876-11-16

Background: Host defences play a key role in tumour growth. Some of the benefits of chemotherapy may occur through modulation of these defences. The aim of this study was to define the status of regulatory cells in women with large and locally advanc... Read More about Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC.

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study (2013)
Journal Article
Enocson, A., Hubbard, R., McKeever, T. M., Russell, N., Byrne, J., Das-Gupta, E., …Fogarty, A. W. (2013). The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study. BMC Pulmonary Medicine, 13(Januar), Article 6. https://doi.org/10.1186/1471-2466-13-2

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function. Methods: Using a prospective study design, we quantified the changes in... Read More about The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study.

Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning (2013)
Journal Article
Swan, A. L., Hillier, K. L., Smith, J. R., Allaway, D., Liddell, S., Bacardit, J., & Mobasheri, A. (2013). Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning. BMC Musculoskeletal Disorders, 14, Article 349. https://doi.org/10.1186/1471-2474-14-349

Background: Osteoarthritis (OA) is an inflammatory disease of synovial joints involving the loss and degeneration of articular cartilage. The gold standard for evaluating cartilage loss in OA is the measurement of joint space width on standard radiog... Read More about Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning.

Returning to work after stroke: perspectives of employer stakeholders, a qualitative study. (2012)
Journal Article
Coole, C., Radford, K., Grant, M., & Terry, J. Returning to work after stroke: perspectives of employer stakeholders, a qualitative study. Journal of Occupational Rehabilitation, 23(3), https://doi.org/10.1007/s10926-012-9401-1

Purpose: More than 40 % of working age adults with stroke fail to return to work. The work context is a key factor in return to work, but little is known about the experiences of employers in supporting employees with stroke. The aim of this study wa... Read More about Returning to work after stroke: perspectives of employer stakeholders, a qualitative study..

Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells (2012)
Journal Article
France, L., Scotchford, C., Grant, D., Rashidi, H., Popov, A., & Sottile, V. (2014). Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine, 8(8), https://doi.org/10.1002/term.1567

Human mesenchymal stem cells (MSCs), which can generate both osteoblasts and chondrocytes, represent an ideal resource for orthopaedic repair using tissue-engineering approaches. One major difficulty for the development of osteochondral constructs us... Read More about Transient serum exposure regimes to support dual differentiation of human mesenchymal stem cells.

5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary (2012)
Journal Article
Alioui, A., Wheldon, L. M., Abakir, A., Ferjentsik, Z., Johnson, A. D., & Ruzov, A. (2012). 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary. Nucleus, 3(6), https://doi.org/10.4161/nucl.22799

5-Methylcytosine (5-mC) is an epigenetic modification associated with gene repression. Recent studies demonstrated that 5-mC can be enzymatically oxidised into 5-hydroxymethylcytosine and further into 5-formylcytosine (5-fC) and 5-carboxylcytsine (5-... Read More about 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary.

What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod?: a discrete choice experiment survey from the SINS trial (2012)
Journal Article
Tinelli, M., Ozolins, M., Bath-Hextall, F., & Williams, H. C. (2012). What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod?: a discrete choice experiment survey from the SINS trial. BMC Dermatology, 12(Octobe), Article 11. https://doi.org/10.1186/1471-5945-12-19

Background: The SINS trial (Controlled Clinical Trials ISRCTN48755084; Eudract No. 2004-004506-24) is a randomised controlled trial evaluating long term success of excisional surgery vs. imiquimod 5% cream for low risk nodular and superficial basal... Read More about What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod?: a discrete choice experiment survey from the SINS trial.

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article
Guttery, D. S., Poulin, B., Ferguson, D. J. P., Szöőr, B., Wickstead, B., Carroll, P. L., …Tewari, R. (2012). A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathogens, 8(9), Article e1002948. https://doi.org/10.1371/journal.ppat.1002948

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More about A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion.

Thin slice sampling of video footage for mother/child interaction: application to single cases (2012)
Journal Article
James, D. M., Wadnerkar, M. B., Lam-Cassettari, C., Kang, S., & Telling, A. L. (2012). Thin slice sampling of video footage for mother/child interaction: application to single cases. Journal of Psychopathology and Behavioral Assessment, 34(3), https://doi.org/10.1007/s10862-012-9282-9

The purpose was to test the reliability of short samples of parent/child interaction for use in single-subject research. Four variable pairs of mother/child behaviour were coded for seven mother/child play sessions. Each session lasted 20 min and 18... Read More about Thin slice sampling of video footage for mother/child interaction: application to single cases.

5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development (2012)
Journal Article
Almeida, R. D., Loose, M., Sottile, V., Matsa, E., Denning, C., Young, L., …Ruzov, A. (2012). 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics, 7(4), https://doi.org/10.4161/epi.19375

5-hydroxymethyl-cytosine (5-hmc) is a cytosine modification that is relatively abundant in mammalian pre-implantation embryos and embryonic stem cells (Esc) derived from mammalian blastocysts. Recent observations imply that both 5-hmc and Tet1/2/... Read More about 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development.

Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health (2012)
Journal Article
Mobasheri, A., Henrotin, Y., Biesalski, H., & Shakibaei, M. (2012). Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. International Journal of Molecular Sciences, 13(4), https://doi.org/10.3390/ijms13044202

Interleukin 1? (IL-1?) and tumor necrosis factor ? (TNF-?) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surfac... Read More about Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

A systematic review of studies measuring and reporting hearing aid usage in older adults since 1999: a descriptive summary of measurement tools (2012)
Journal Article
Perez, E., & Edmonds, B. A. (2012). A systematic review of studies measuring and reporting hearing aid usage in older adults since 1999: a descriptive summary of measurement tools. PLoS ONE, 7(3), Article e31831. https://doi.org/10.1371/journal.pone.0031831

Objective: A systematic review was conducted to identify and quality assess how studies published since 1999 have measured and reported the usage of hearing aids in older adults. The relationship between usage and other dimensions of hearing aid out... Read More about A systematic review of studies measuring and reporting hearing aid usage in older adults since 1999: a descriptive summary of measurement tools.

Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms (2012)
Journal Article
Tan, T. C., Rahman, R., Jaber-Hijazi, F., Felix, D. A., Chen, C., Louis, E. J., & Aboobaker, A. (2012). Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms. Proceedings of the National Academy of Sciences, 109(11), https://doi.org/10.1073/pnas.1118885109

In most sexually reproducing animals, replication and maintenance of telomeres occurs in the germ line and during early development in embryogenesis through the use of telomerase. Somatic cells generally do not maintain telomere sequences, and these... Read More about Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms.

Additional interventions to enhance the effectiveness of individual placement and support: a rapid evidence assessment (2012)
Journal Article
Boycott, N., Schneider, J. M., & McMurran, M. (2012). Additional interventions to enhance the effectiveness of individual placement and support: a rapid evidence assessment. Rehabilitation Research and Practice, 2012(382420), https://doi.org/10.1155/2012/382420

Topic: Additional interventions used to enhance the e?ectiveness of individual placement and support (IPS). Aim: To establish whether additional interventions improve the vocational outcomes of IPS alone for people with severe mental illness. Method:... Read More about Additional interventions to enhance the effectiveness of individual placement and support: a rapid evidence assessment.

A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms (2011)
Journal Article
Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., …Reymond, J. (2011). A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50(45), https://doi.org/10.1002/anie.201104342

Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P.?aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the l... Read More about A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms.

Graduate entry to medicine: widening psychological diversity (2009)
Journal Article
James, D., Ferguson, E., Powis, D., Bore, M., Munro, D., Symonds, I., & Yates, J. (2009). Graduate entry to medicine: widening psychological diversity. BMC Medical Education, 9(Novemb), Article 8. https://doi.org/10.1186/1472-6920-9-67

Abstract Background: At Nottingham University more than 95% of entrants to the traditional 5-year medical course are school leavers. Since 2003 we have admitted graduate entrants (GEM) to a shortened (4-year) course to 'widen access to students from... Read More about Graduate entry to medicine: widening psychological diversity.

Atomic force microscopy study of human amylin (20-29) fibrils (2005)
Journal Article
Sedman, V. L., Allen, S., Chan, W. C., Davies, M. C., Roberts, C. J., Tendler, S. J., & Williams, P. M. (2005). Atomic force microscopy study of human amylin (20-29) fibrils. Protein and Peptide Letters, 12(1), 79-83. https://doi.org/10.2174/0929866053406129

Here we present atomic force microscopy images of the fibrils formed by human amylin(20-29). This peptide is a fragment of the polypeptide amylin, the major proteinaceous component of amyloid deposits found in cases of type-II diabetes mellitus. Our... Read More about Atomic force microscopy study of human amylin (20-29) fibrils.

Improving quality of life and end of life care for people with dementia using the soundtrack to my life tool: evaluation report, University of Nottingham
Book
Argyle, E., & Kelly, T. (in press). Improving quality of life and end of life care for people with dementia using the soundtrack to my life tool: evaluation report, University of Nottingham. University of Nottingham

Good support at home for people with dementia and their carers is crucial to maintaining their quality of life and helping them to remain in their own home. Person centred packages of care have been shown to be an effective means of providing this su... Read More about Improving quality of life and end of life care for people with dementia using the soundtrack to my life tool: evaluation report, University of Nottingham.

Text messaging to encourage uptake of HIV testing amongst African communities: findings from a theory-based feasibility study [abstract]
Conference Proceeding
Evans, C., Turner, K., Juma, A., Suggs, L. S., & Blake, H. (in press). Text messaging to encourage uptake of HIV testing amongst African communities: findings from a theory-based feasibility study [abstract].

Configuring the caller in ambiguous encounters: volunteer handling of calls to Samaritans emotional support services
Journal Article
Pollock, K., Moore, J., Coveney, C., & Armstrong, S. Configuring the caller in ambiguous encounters: volunteer handling of calls to Samaritans emotional support services. Communication and Medicine, 9(2), https://doi.org/10.1558/cam.v9i2.113

This paper discusses volunteer strategies for handling and assessing calls to Samaritans emotional support services for the suicidal and despairing. It presents findings from the qualitative components of a two year mixed methods study based on an o... Read More about Configuring the caller in ambiguous encounters: volunteer handling of calls to Samaritans emotional support services.