All Outputs (141)

Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety (2016)
Journal Article
Cottam, W. J., Condon, L., Alshuft, H., Reckziegel, D., & Auer, D. P. (in press). Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. NeuroImage: Clinical, 12, https://doi.org/10.1016/j.nicl.2016.06.022

Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arteria... Read More about Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety.

Metformin for endometrial hyperplasia (protocol) (2016)
Journal Article
Clement, N., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2016). Metformin for endometrial hyperplasia (protocol). Cochrane Database of Systematic Reviews, 5, Article CD012214. https://doi.org/10.1002/14651858

To determine the efficacy and safety of metformin in treating women with endometrial hyperplasia

Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients (2016)
Journal Article
Heslin, M., Lappin, J., Donoghue, K., Lomas, B., Reininghaus, U., Onyejiaka, A., …Morgan, C. (2016). Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients. Schizophrenia Research, 176(2-3), 417-422. https://doi.org/10.1016/j.schres.2016.04.049

We aimed to investigate long-term outcomes in psychotic major depression patients compared to schizophrenia and bipolar/manic psychosis patients, in an incidence sample, while accounting for diagnostic change. Based on Aetiology and Ethnicity in Schi... Read More about Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients.

Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis (2016)
Journal Article
Kitterick, P. T., Lucas, L., & Smith, S. N. (2016). Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis. Audiology and Neurotology, 20(Supp 1), https://doi.org/10.1159/000380753

Unilateral severe-to-profound hearing loss, or single-sided deafness (SSD), impairs listening abilities supported by the use of two ears, including speech perception in background noise and sound localisation. Hearing-assistive devices can aid listen... Read More about Improving health-related quality of life in single-sided deafness: a systematic review and meta-analysis.

Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings (2016)
Journal Article
Knopf-Marques, H., Singh, S., Htwe, S. S., Wolfova, L., Buffa, R., Bacharouche, J., …Lavalle, P. (2016). Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings. Biomacromolecules, 17(6), 2189-2198. https://doi.org/10.1021/acs.biomac.6b00429

This study aims to design an optimal polyelectrolyte multilayer film of poly-L-lysine (PLL) and hyaluronic acid(HA) as an anti-inflammatory cytokine release system in order to decrease the implant failure due to any immune reactions. The chemical mod... Read More about Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings.

Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial (2016)
Journal Article
Cullington, H., Kitterick, P. T., DeBold, L., Weal, M., Clarke, N., Newberry, E., & Aubert, L. (in press). Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial. BMJ Open, 6(5), Article e011342. https://doi.org/10.1136/bmjopen-2016-011342

Introduction: Many resources are required to provide postoperative care to patients who receive a cochlear implant. The implant service commits to lifetime follow-up. The patient commits to regular adjustment and rehabilitation appointments in the fi... Read More about Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial.

The effect of thermal processing in oil on the macromolecular integrity and acrylamide formation from starch of three potato cultivars organically fertilized (2016)
Journal Article
Varzakas, T., Alghamdi, A., Alghamdi, H., Linforth, R. S., Dinu, V., Besong, T. D., …Israilides, C. (2016). The effect of thermal processing in oil on the macromolecular integrity and acrylamide formation from starch of three potato cultivars organically fertilized. Cogent Food and Agriculture, 2(1), https://doi.org/10.1080/23311932.2016.1180950

Starches from three organically produced cultivars of potato tuber (Lady Rosetta, Spunta and Voyager) have been studied in relation to (i) acrylamide production (ii) macromolecular integrity after frying with extra virgin olive oil, soybean oil and c... Read More about The effect of thermal processing in oil on the macromolecular integrity and acrylamide formation from starch of three potato cultivars organically fertilized.

Benefits to speech perception in noise from the binaural integration of electric and acoustic signals in simulated unilateral deafness (2016)
Journal Article
Ma, N., Morris, S. D., & Kitterick, P. T. (in press). Benefits to speech perception in noise from the binaural integration of electric and acoustic signals in simulated unilateral deafness. Ear and Hearing, 37(3), https://doi.org/10.1097/AUD.0000000000000252

Objectives: This study used vocoder simulations with normal-hearing (NH) listeners to (a) measure their ability to integrate speech information from a NH ear and a simulated cochlear implant (CI); and (b) investigate whether binaural integration is d... Read More about Benefits to speech perception in noise from the binaural integration of electric and acoustic signals in simulated unilateral deafness.

Applying theories of health behaviour and change to hearing health research: time for a new approach (2016)
Journal Article
Coulson, N. S., Ferguson, M. A., Henshaw, H., & Heffernan, E. (in press). Applying theories of health behaviour and change to hearing health research: time for a new approach. International Journal of Audiology, 55(sup3), Article S99-S104. https://doi.org/10.3109/14992027.2016.1161851

Objective: In recent years, there has been an increase in the application of behavioural models, such as social cognition models, to the promotion of hearing health. Despite this, there exists a well-developed body of literature that suggests such m... Read More about Applying theories of health behaviour and change to hearing health research: time for a new approach.

Rethinking therapeutic strategies in cancer: wars, fields, anomalies and monsters (2016)
Journal Article
Stewart, S., & Rauch, C. (in press). Rethinking therapeutic strategies in cancer: wars, fields, anomalies and monsters. Social Theory and Health, https://doi.org/10.1057/sth.2016.4

This article argues that the excessive focus on cancer as an insidious living defect that needs to be destroyed has obscured the fact that cancer develops inside human beings. Therefore, in order to contribute to debates about new cancer therapies, w... Read More about Rethinking therapeutic strategies in cancer: wars, fields, anomalies and monsters.

The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure (2016)
Journal Article
Stacey, P. C., Kitterick, P. T., Morris, S. D., & Sumner, C. J. (2016). The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure. Hearing Research, 336, 17-28. https://doi.org/10.1016/j.heares.2016.04.002

Understanding what is said in demanding listening situations is assisted greatly by looking at the face of a talker. Previous studies have observed that normal-hearing listeners can benefit from this visual information when a talker’s voice is presen... Read More about The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure.

The association between treatment adherence to nicotine patches and smoking cessation in pregnancy: a secondary analysis of a randomised controlled trial (2016)
Journal Article
Vaz, L. R., Aveyard, P., Cooper, S., Leonardi-Bee, J., & Coleman, T. (2016). The association between treatment adherence to nicotine patches and smoking cessation in pregnancy: a secondary analysis of a randomised controlled trial. Nicotine and Tobacco Research, 18(10), https://doi.org/10.1093/ntr/ntw080

Introduction In non-pregnant ‘quitters’, adherence to nicotine replacement therapy (NRT) increases smoking cessation. We investigated relationships between adherence to placebo or NRT patches and cessation in pregnancy, including an assessment of... Read More about The association between treatment adherence to nicotine patches and smoking cessation in pregnancy: a secondary analysis of a randomised controlled trial.

Backbone NMR reveals allosteric signal transduction networks in the ?1-adrenergic receptor (2016)
Journal Article
Isogai, S., Deupi, X., Opitz, C., Heydenreich, F. M., Tsai, C., Brueckner, F., …Grzesiek, S. (in press). Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor. Nature, 530(7589), https://doi.org/10.1038/nature16577

G protein-coupled receptors (GPCRs) are physiologically important transmembrane signalling proteins that trigger intracellular responses upon binding of extracellular ligands. Despite recent breakthroughs in GPCR crystallography1–3, the details of li... Read More about Backbone NMR reveals allosteric signal transduction networks in the ?1-adrenergic receptor.

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis (2016)
Journal Article
Foster, G. R., Irving, W. L., Cheung, M. C., Walker, A. J., Hudson, B. E., Verma, S., …Agarwal, K. (2016). Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 64(6), 1224-1231. https://doi.org/10.1016/j.jhep.2016.01.029

© 2016 European Association for the Study of the Liver. Background & Aims All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared outcom... Read More about Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis.

ESCAPS study protocol: a feasibility randomised controlled trial of ‘Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm’ (2016)
Journal Article
Fletcher-Smith, J. C., Walker, D., Sprigg, N., James, M., Walker, M. F., Allatt, K., …Pandyan, A. D. (2016). ESCAPS study protocol: a feasibility randomised controlled trial of ‘Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm’. BMJ Open, 6(1), Article e010079. https://doi.org/10.1136/bmjopen-2015-010079

Introduction Approximately 70% of patients with stroke experience impaired arm function, which is persistent and disabling for an estimated 40%. Loss of function reduces independence in daily activities and impacts on quality of life. Muscles in thos... Read More about ESCAPS study protocol: a feasibility randomised controlled trial of ‘Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm’.

Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis (2016)
Journal Article
Malin, G., Bugg, G., Takwoingi, Y., Thornton, J., & Jones, N. W. (2016). Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 123(1), https://doi.org/10.1111/1471-0528.13517

BACKGROUND: Fetal macrosomia is associated with an increased risk of adverse maternal and neonatal outcomes. OBJECTIVES: To compare the accuracy of antenatal two-dimensional (2D) ultrasound, three-dimensional (3D) ultrasound, and magnetic... Read More about Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis.

Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair (2015)
Journal Article
Bolt, E. L., Jenkins, T., Russo, V. M., Ahmed, S., Cavey, J., & Cass, S. (2015). Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair. Bioscience Reports, https://doi.org/10.1042/BSR20150249

Using the ASKA (A Complete Set of E. coli K-12 ORF Archive) library for genome-wide screening of E. coli proteins we identified that expression of ygaQ and rpmG promotemitomycin C resistance (MMCR). YgaQ mediated MMCR was independent of homolog... Read More about Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair.

Sequence and partial functional analysis of canine Bcl-2 family proteins (2015)
Journal Article
de Brot, S., Schade, B., Croci, M., Dettwiler, M., & Guscetti, F. (2016). Sequence and partial functional analysis of canine Bcl-2 family proteins. Research in Veterinary Science, 104, https://doi.org/10.1016/j.rvsc.2015.12.001

Dogs present with spontaneous neoplasms biologically similar to human cancers. Apoptotic pathways are deregulated during cancer genesis and progression and are important for therapy. We have assessed the degree of conservation of a set of canine Bcl-... Read More about Sequence and partial functional analysis of canine Bcl-2 family proteins.

Use of biochemical tests of placental function for improving pregnancy outcome (2015)
Journal Article
Heazell, A. E., Whitworth, M., Duley, L., & Thornton, J. (2015). Use of biochemical tests of placental function for improving pregnancy outcome. Cochrane Library, 2015(11), Article CD011202. https://doi.org/10.1002/14651858.CD011202.pub2

BACKGROUND: The placenta has an essential role in determining the outcome of pregnancy. Consequently, biochemical measurement of placentally-derived factors has been suggested as a means to improve fetal and maternal outcome of pregnancy. OBJ... Read More about Use of biochemical tests of placental function for improving pregnancy outcome.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.